Health Articles, Medical Innovations | Popular Science https://www.popsci.com/category/health/ Awe-inspiring science reporting, technology news, and DIY projects. Skunks to space robots, primates to climates. That's Popular Science, 145 years strong. Mon, 06 May 2024 16:00:00 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.2 https://www.popsci.com/uploads/2021/04/28/cropped-PSC3.png?auto=webp&width=32&height=32 Health Articles, Medical Innovations | Popular Science https://www.popsci.com/category/health/ 32 32 Inside California’s $500 million investment in therapy apps for young people https://www.popsci.com/health/therapy-apps-young-people/ Mon, 06 May 2024 16:00:00 +0000 https://www.popsci.com/?p=612956
teen using phone therapy app
The rollout has been slow. DepositPhotos

Advocates fear it won’t pay off.

The post Inside California’s $500 million investment in therapy apps for young people appeared first on Popular Science.

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teen using phone therapy app
The rollout has been slow. DepositPhotos

This article was originally published on KFF Health News.

With little pomp, California launched two apps at the start of the year offering free behavioral health services to youths to help them cope with everything from living with anxiety to body acceptance.

Through their phones, young people and some caregivers can meet BrightLife Kids and Soluna coaches, some who specialize in peer support or substance use disorders, for roughly 30-minute virtual counseling sessions that are best suited to those with more mild needs, typically those without a clinical diagnosis. The apps also feature self-directed activities, such as white noise sessions, guided breathing, and videos of ocean waves to help users relax.

“We believe they’re going to have not just great impact, but wide impact across California, especially in places where maybe it’s not so easy to find an in-person behavioral health visit or the kind of coaching and supports that parents and young people need,” said Gov. Gavin Newsom’s health secretary, Mark Ghaly, during the Jan. 16 announcement.

The apps represent one of the Democratic governor’s major forays into health technology and come with four-year contracts valued at $498 million. California is believed to be the first state to offer a mental health app with free coaching to all young residents, according to the Department of Health Care Services, which operates the program.

However, the rollout has been slow. Only about 15,000 of the state’s 12.6 million children and young adults have signed up for the apps, school counselors say they’ve never heard of them, and one of the companies isn’t making its app available on Android phones until summer.

Advocates for youth question the wisdom of investing taxpayer dollars in two private companies. Social workers are concerned the companies’ coaches won’t properly identify youths who need referrals for clinical care. And the spending is drawing lawmaker scrutiny amid a state deficit pegged at as much as $73 billion.

An app for that

Newsom’s administration says the apps fill a need for young Californians and their families to access professional telehealth for free, in multiple languages, and outside of standard 9-to-5 hours. It’s part of Newsom’s sweeping $4.7 billion master plan for kids’ mental health, which was introduced in 2022 to increase access to mental health and substance use support services. In addition to launching virtual tools such as the teletherapy apps, the initiative is working to expand workforce capacity, especially in underserved areas.

“The reality is that we are rarely 6 feet away from our devices,” said Sohil Sud, director of Newsom’s Children and Youth Behavioral Health Initiative. “The question is how we can leverage technology as a resource for all California youth and families, not in place of, but in addition to, other behavioral health services that are being developed and expanded.”

The virtual platforms come amid rising depression and suicide rates among youth and a shortage of mental health providers. Nearly half of California youths from the ages of 12 to 17 report having recently struggled with mental health issues, with nearly a third experiencing serious psychological distress, according to a 2021 study by the UCLA Center for Health Policy Research. These rates are even higher for multiracial youths and those from low-income families.

But those supporting youth mental health at the local level question whether the apps will move the needle on climbing depression and suicide rates.

“It’s fair to applaud the state of California for aggressively seeking new tools,” said Alex Briscoe of California Children’s Trust, a statewide initiative that, along with more than 100 local partners, works to improve the social and emotional health of children. “We just don’t see it as fundamental. And we don’t believe the youth mental health crisis will be solved by technology projects built by a professional class who don’t share the lived experience of marginalized communities.”

The apps, BrightLife Kids and Soluna, are operated by two companies: Brightline, a 5-year-old venture capital-backed startup; and Kooth, a London-based publicly traded company that has experience in the U.K. and has also signed on some schools in Kentucky and Pennsylvania and a health plan in Illinois. In the first five months of Kooth’s Pennsylvania pilot, 6% of students who had access to the app signed up.

Brightline and Kooth represent a growing number of health tech firms seeking to profit in this space. They beat out dozens of other bidders including international consulting companies and other youth telehealth platforms that had already snapped up contracts in California.

Although the service is intended to be free with no insurance requirement, Brightline’s app, BrightLife Kids, is folded into and only accessible through the company’s main app, which asks for insurance information and directs users to paid licensed counseling options alongside the free coaching. After KFF Health News questioned why the free coaching was advertised below paid options, Brightline reordered the page so that, even if a child has high-acuity needs, free coaching shows up first.

The apps take an expansive view of behavioral health, making the tools available to all California youth under age 26 as well as caregivers of babies, toddlers, and children 12 and under. When KFF Health News asked to speak with an app user, Brightline connected a reporter with a mother whose 3-year-old daughter was learning to sleep on her own.

‘It’s like crickets’

Despite being months into the launch and having millions in marketing funds, the companies don’t have a definitive rollout timeline. Brightline said it hopes to have deployed teams across the state to present the tools in person by midyear. Kooth said developing a strategy to hit every school would be “the main focus for this calendar year.”

“It’s a big state—58 counties,” Bob McCullough of Kooth said. “It’ll take us a while to get to all of them.”

So far BrightLife Kids is available only on Apple phones. Brightline said it’s aiming to launch the Android version over the summer.

“Nobody’s really done anything like this at this magnitude, I think, in the U.S. before,” said Naomi Allen, a co-founder and the CEO of Brightline. “We’re very much in the early innings. We’re already learning a lot.”

The contracts, obtained by KFF Health News through a records request, show the companies operating the two apps could earn as much as $498 million through the contract term, which ends in June 2027, months after Newsom is set to leave office. And the state is spending hundreds of millions more on Newsom’s virtual behavioral health strategy. The state said it aims to make the apps available long-term, depending on usage.

The state said 15,000 people signed up in the first three months. When KFF Health News asked how many of those users actively engaged with the app, it declined to say, noting that data would be released this summer.

KFF Health News reached out to nearly a dozen California mental health professionals and youths. None of them were aware of the apps.

“I’m not hearing anything,” said Loretta Whitson, executive director of the California Association of School Counselors. “It’s like crickets.”

Whitson said she doesn’t think the apps are on “anyone’s” radar in schools, and she doesn’t know of any schools that are actively advertising them. Brightline will be presenting its tool to the counselor association in May, but Whitson said the company didn’t reach out to plan the meeting; she did.

Concern over referrals

Whitson isn’t comfortable promoting the apps just yet. Although both companies said they have a clinical team on staff to assist, Whitson said she’s concerned that the coaches, who aren’t all licensed therapists, won’t have the training to detect when users need more help and refer them to clinical care.

This sentiment was echoed by other school-based social workers, who also noted the apps’ duplicative nature—in some counties, like Los Angeles, youths can access free virtual counseling sessions through Hazel Health, a for-profit company. Nonprofits, too, have entered this space. For example, Teen Line, a peer-to-peer hotline operated by Southern California-based Didi Hirsch Mental Health Services, is free nationwide.

While the state is also funneling money to the schools as part of Newsom’s master plan, students and school-based mental health professionals voiced confusion at the large app investment when, in many school districts, few in-person counseling roles exist, and in some cases are dwindling.

Kelly Merchant, a student at College of the Desert in Palm Desert, noted that it can be hard to access in-person therapy at her school. She believes the community college, which has about 15,000 students, has only one full-time counselor and one part-time bilingual counselor. She and several students interviewed by KFF Health News said they appreciated having engaging content on their phone and the ability to speak to a coach, but all said they’d prefer in-person therapy.

“There are a lot of people who are seeking therapy, and people close to me that I know. But their insurances are taking forever, and they’re on the waitlist,” Merchant said. “And, like, you’re seeing all these people struggle.”

Fiscal conservatives question whether the money could be spent more effectively, like to bolster county efforts and existing youth behavioral health programs.

Republican state Sen. Roger Niello, vice chair of the Senate Budget and Fiscal Review Committee, noted that California is forecasted to face deficits for the next three years, and taxpayer watchdogs worry the apps might cost even more in the long run.

“What starts as a small financial commitment can become uncontrollable expenses down the road,” said Susan Shelley of the Howard Jarvis Taxpayers Association.

This article was produced by KFF Health News, which publishes California Healthline, an editorially independent service of the California Health Care Foundation. 

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

Subscribe to KFF Health News’ free Morning Briefing.

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Why are some people faster than others? https://www.popsci.com/health/why-are-some-people-faster-than-others/ Sat, 04 May 2024 16:00:00 +0000 https://www.popsci.com/?p=612945
Physical ability isn’t just about muscle. Your brain plays an important role, too.
Physical ability isn’t just about muscle. Your brain plays an important role, too. DepositPhotos

Exercise scientists explain the secrets of running speed.

The post Why are some people faster than others? appeared first on Popular Science.

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Physical ability isn’t just about muscle. Your brain plays an important role, too.
Physical ability isn’t just about muscle. Your brain plays an important role, too. DepositPhotos

This article was originally featured on The Conversation.

Usain Bolt, the world’s fastest human, ran a 100-meter sprint at a speed of 23.35 miles per hour (37.57 kilometers per hour).

That’s mind-blowingly fast for a human. It’s about the same speed as cruising in a car through your neighborhood or in a school zone. It might not seem that fast when you’re in the car, but for a person? Few runners in the world can even come close.

There are several reasons why some people can run very fast while others tend to run more slowly. Genetics–the traits you inherit from your parents–play a role, but so do your choices and experiences.

As pediatric exercise scientists, we create and evaluate programs that help children be healthy. The exciting news is that while you have no control over your genetics, you can train to improve your speed.

Fast twitch, slow twitch

One major factor that influences your ability to run fast is the structure of your body, including how your muscles work.

The human body has more than 600 muscles that work together, allowing you to move in different directions and at various speeds. These muscles are made up of groups of fibers. There are two main types: fast twitch and slow twitch.

Muscles have different mixes of these fiber types. For example, two muscles make up the calf: One is predominantly fast twitch–that’s the gastrocnemius, used for sprinting and jumping. The other is mostly slow twitch–that’s the soleus, used for walking and jogging.

Fast-twitch muscle fibers are larger and help your body move quickly and generate significant force. Sprinters tend to have an abundance of fast-twitch muscle fibers. However, this muscle fiber type also tires quickly, which limits how long you can run at top speed to relatively short distances.

Slow-twitch muscle fibers are smaller and help you run at slower speeds, but with greater endurance. Long-distance runners and competitive cyclists tend to have a lot of these muscles.

How much you have of each type of muscle fiber–fast twitch and slow twitch–is mostly determined by your genes, so you’ll have to work with what you’re born with when it comes to muscle types. But exercises can help train those muscles.

Your brain plays a big role

Physical ability isn’t just about muscle. Your brain plays an important role, too.

Your skeletal muscles are controlled by your brain–you think about your actions and then execute the movements. For example, you can control how long your stride is, how your arms move, how your feet hit the ground and even the techniques you use to breathe.

You can teach your body to use the best running techniques. That includes proper posture, so your body is standing tall, and an economical stride, so your feet land below you rather than too far out in front, where they can slow you down.

Why are some people faster than others?

You can also improve your running form by using your whole body, with your arms pumping in opposition to the legs, running on your toes and maximizing the time spent in flight phase with both feet off the ground. Using proper running techniques helps the muscles create more force and work together, which helps you run faster.

The more you practice an activity, the better you will get. As your ability to run fast increases, challenge yourself to run even faster.

How to train to run faster–myth-busting!

You may have heard your friends chatting about ways to boost your speed or searched the internet for tips on getting faster. Time to bust some of those myths.

Myth 1: You have to run as fast as you can to train to be faster. That’s false!

You don’t have to run as fast as you can to get faster, and it actually helps to take short breaks to recover in between activities where you are sprinting.

Myth 2: You need to lift heavy weights to get faster. False!

Functional strength training involves performing exercises that help you get better at specific movements. They involve using either medium weights or just the resistance of your own body weight. Doing plankslungesstep-ups or jump squats are great examples. These activities focus on the muscles that are instrumental during running.

Myth 3: You need to specialize in running early in life to become a fast runner. False!

Picking one activity to focus on early in life may actually limit your ability to develop into a fast runner. Doing a variety of physical activities can help you develop new skills that improve your running. For example, the movements and endurance used in soccer may translate into the ability to run faster.

Myth 4: Training isn’t fun. False!

Training programs can take many shapes and forms. You can play running games with your friends, work on fast footwork using an agility ladder or create obstacle courses. There’s nothing like a little healthy competition to motivate your training.

What’s important is having fun while training and participating in activities that promote running speed on a regular basis.

So, whether you want to be the next Usain Bolt or you just want to win a race against your friend, remember that with a little bit of genetic luck and hard work, it may just be possible.

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Roll the tape: What KT Tape taught me about muscles, magnesium, and my limitations https://www.popsci.com/gear/kt-tape-activate-recover-ice-experience/ Fri, 03 May 2024 17:30:00 +0000 https://www.popsci.com/?p=613463
Fitness & Exercise photo
Tony Ware

I spent two days in Utah wrapped up in high-output activity, new KT Health recovery product reveals, and getting iced out in kinesiology tape.

The post Roll the tape: What KT Tape taught me about muscles, magnesium, and my limitations appeared first on Popular Science.

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Fitness & Exercise photo
Tony Ware

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It was nearing the peak of PorcUclimb, right before Downward Dog, when I came up with what I was sure was a career-defining concept: Ware ’N Tear’s Salve for Wounded Pride. Here I was fat biking along the groomed singletrack of Round Valley on a perfect bluebird day in early March and I was just gassed, totally holding back our small guided group of snow cyclists. Coming off a recent illness, my altitude-ravaged lungs just couldn’t deliver what my legs demanded. 

I quickly turned to my fellow rider, KT CEO Jessica Klodnicki, and asked if R&D could get started on what could be my legacy. The chances are less than zero, I was quickly told, but that didn’t mean there weren’t plentiful new recovery products to discover. After all, that’s why I was in Park City, Utah, just up the road from American Fork and the headquarters of the brand synonymous with kinesiology tape and its growing KT Ice and KT Health portfolio.

how it started ... how it's going
how it started … how it’s going KT Tape

Prepare

Maybe you’re an elite athlete. If so, chances are you’ve used KT Tape. Maybe you’ve seen elite athletes. If so, chances are you’ve seen strips of elastic KT Tape crisscrossing an elbow, knee, shoulder, etc. Maybe you’re sitting at a desk reading this in between emails and trips to the coffee station. If so, chances are you’re wondering if KT products can benefit everybody and every body, not just Olympians and other elevated competitors. Before my trip to Utah, I was firmly in that last group. I knew the brand because, with over 80 percent market share in the taping category and a big, bright logo, KT is hard to miss even if you’ve just dabbled in couch-to-5k programs and ended up limping through CVS aisles searching for muscle soreness relief.

Just because I had seen KT Tape, however, didn’t mean I had tried KT Tape. I honestly never even glanced at it because I wasn’t Athletic—emphasis on that capital A. Sure, I stay active, biking and hiking, but I was a little too quick to let muscle soreness convince me to slow down, or maybe grind to a complete stop. I hadn’t really considered the potential benefits of gentle support, modulating pain signals, and promoting blood flow and lymphatic drainage for swelling relief that could come from kinesiology tape. Sure, I knew the R.I.C.E. method of dealing with obvious inflammation—rest, ice, compression, and elevation—but I didn’t think enough about how to lessen the chance of overuse aches or even microtraumas in the first place. I didn’t know as much about how to aid working out as I did how to react when things don’t work out.

So here I was at 7,000 feet elevation—6,700 feet higher than back home on the East Coast, give or take a few—ready to reevaluate my approach to activity. And to test a therapeutic routine, you need to put some muscles to work. That’s why KT brought a small group of journalists to this mountain town known for winter sports—a high desert covered in deep powder thanks to lake effect storms. That’s how I ended up embarrassing myself on a bike. But the shame of crapping out on the cord wasn’t the only thing leaving me feeling tingly.

Perform

Much like my typical delayed onset muscle soreness, KT’s reveals built up gradually. And our first introduction, prior to carving some corners, was to the new KT Health magnesium creams—KT Health Activate, specifically. Magnesium cream isn’t new—just ask anyone with restless leg syndrome. But KT Health Activate has worked with a local Utah partner on a cream that combines magnesium with Arnica—as well as skin-friendly aloe, vitamin-e, shea butter, and jojoba oil—to provide multiple benefits. 

According to Dr. Erin Hassler, a member of the KT Sports Medicine Advisory Board who led our presentations on the physiological impact of the products, magnesium is the counterbalance to calcium in the tug-of-war that is muscle contractions. Whereas calcium activates muscle, magnesium relaxes it. Applying magnesium cream prior to exercise loosens the muscles, reducing stiffness and, hopefully, injuries. Adding in Arnica is an additional prophylactic tactic, creating a warming sensation and promoting opioid receptor activity to make you feel better about your gains and pains. 

And it certainly worked. Still feeling the long flight in my lower back, I applied some KT Health Activate to the base of my spine prior to our ride (10-20 minutes before activity is recommended). Sure, it was a “warm” day in the low- to mid-30s and we were doing high-output activity, but we were barely into the course before I was striping down almost to my Arc’Teryx Rho Merino wool crew neck because I was primed (and more than a little afraid sweat would trickle some of the cream into a precarious crevice). And while my lungs could have used some soothing going up the trail, my lower back felt great as I eventually caught my breath and ripped the descent. 

My upper back, on the other hand, hasn’t felt great since I was first introduced to personal computing in the early ’90s. Luckily, a second product was unveiled once we returned to the hotel: KT Tape Pro Ice. This new addition infuses Menthol into the established KT Tape Pro adhesive, appealing to consumers who use pain relief patches but find that they bunch or peel or just don’t work well on joints, etc. 

As we’ve established, however, I’d never used KT Tape despite the company’s retail dominance since it launched in 2008. So I wasn’t sure how to apply it. Yes, KT has created a mobile app with guided instructions on anchoring and angles for any anatomy. But, since the team was already there, they invited everyone to identify a problem area and someone would address it for us. Citing my laptop hunch, I had strips put on my neck and across my shoulders and, in a relatively short time, started to experience pain relief, or an excellent approximation of it. What Menthol does, among other things, is create the illusion of cooling by activating the thermoreceptor that senses cold. Triggering ole TRPM8, in turn, activates vasoconstriction—like icing without the ice—and decreases pain receptor sensations. All the while the tape helps open up that dermis and move any prior fluid build-up along.

Much like with the KT Health Activate cream, it wasn’t long before I felt the KT Tape Pro Ice in action—a relief response that gradually faded during some hotel room downtime. What was even more surprising, however, was that the tape reactivated later that evening. Dinner took place in a yurt located at the Soldier Hollow Nordic Center in Midway, the “Little Switzerland” of Utah. To access the yurt, however, you had to snowshoe a half-mile. And that exertion reacted with the tape, cooling me down and firing my opioid receptors up. Maybe it was the rich food and robust pairings from Parallel Wines or maybe it was the Menthol and stretchy support, but I slept well that night. 

Recover

I woke up the next morning with very little residual tenderness, which was good because it was time for two more products and one more test. First, there was KT Health Recover magnesium cream, which swaps the Arnica for Menthol, pre-workout application for post-workout (after your shower, or you’ll wash it all away). But it still energizes nerve endings in its own way. Compared to the KT Tape Pro Ice, I felt less immediate stimulation (YMMV, as it comes down to skin type), but there’s just something about the smell of Menthol that I find appealing and appeasing (and that makes me put on some old skool breakbeat hardcore). Plus, the cream can go where KT Tape Pro Ice can’t—i.e., where there is body hair—just don’t combine the two, as the cream will make the tape less adhesive.

The other new introduction in the KT Health line was the new Ice Sleeve. If you’ve ever entertained exercising, even briefly, you’ve surely dedicated some space in your freezer to ice packs. And you’ve surely grabbed one of those stiff packets, wrapped it in a ratty dish rag, and awkwardly balanced it on some sore appendage propped up on a pillow. The KT Health Ice Sleeve aims to mitigate the swelling and cursing that comes from activity and subpar ice therapy.

Wrapped in microfiber, the water-based glycol gel in the infinitely reusable Ice Sleeve remains pliant even when frozen, making it perfect for 360 degrees of cold compression of ankles, knees, and elbows (potentially even thighs if using the XXL size). There’s no condensation, and 20 minutes or so of cold it gives off lines up with the medically recommended application on joints and tendons. Plus it stores neatly in its insulated portable pouch, a lil localized ice bath that doesn’t confine you to the couch.

As for that last test, it was my Real Housewives of Salt Lake City [Season 2, Ep. 14] moment, according to a coworker who watches the show. Sold as a final recovery activity but really its own core-strength challenge to maintain balance, we participated in stand-up paddle board yoga on the Homestead Crater hot spring. Here I was 24 hours later, yet thinking again about breath control and settling into a Downward Dog, my muscles warm as I tackled another activity that became easier over time. I may not have left Utah with a future in designing recovery products for the recreational athlete. Still, I can now see how KT products and I have a future together whether I’m hunched over a computer, handlebars, a yoga mat, etc. 

keep telling yourself you got this, dawg ... try hard enough and you can be just like that lady above
keep telling yourself you got this, dawg … try hard enough and you can be just like that lady above KT Tape

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Orangutan observed using a plant to treat an open wound https://www.popsci.com/environment/ape-treat-wound-plant/ Thu, 02 May 2024 15:00:00 +0000 https://www.popsci.com/?p=613341
Close up of orangutan
How the great ape first learned to use the plant is still unclear. Deposit Photos

It's the first time this behavior was observed in the animal world.

The post Orangutan observed using a plant to treat an open wound appeared first on Popular Science.

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Close up of orangutan
How the great ape first learned to use the plant is still unclear. Deposit Photos

Observers have documented multiple animal species using plants for self-medicinal purposes, such as great apes eating plants that treat parasitic infections or rubbing vegetation on sore muscles. But a wild orangutan recently displayed something never observed before—he treated his own open wound by activating a plant’s medical properties using his own spit. As detailed in a study published May 2 in Scientific Reports, evolutionary biologists believe the behavior could point toward a common ancestor shared with humans.

The discovery occurred within a protected Indonesian rainforest at the Suaq Balimbing research site. This region, currently home to roughly 150 critically endangered Sumatran orangutans, is utilized by an international team of researchers from the Max Planck Institute of Animal Behavior to monitor the apes’ behavior and wellbeing. During their daily observations, cognitive and evolutionary biologists noticed a sizable injury on the face of one of the local males named Rakus. Such wounds are unsurprising among the primates, since they frequently spar with one another—but then Rakus did something three days later that the team didn’t expect.

Endangered Species photo

After picking leaves off of a native plant known as an Akar Kuning (Fibraurea tinctoria), well-known for its anti-inflammatory, anti-fungal, and antioxidant properties, as well as its use in traditional malaria medicines, Rakus began to chew the plant into a paste. He then rubbed it directly on his facial injury for several minutes before covering it entirely with the mixture. Over the next few days, researchers noted the self-applied natural bandage kept the wound from showing signs of infection or exacerbation. Within five days, the injury scabbed over before healing entirely.

Such striking behavior raises a number of questions, particularly how Rakus first learned to treat his face using the plant. According to study senior author Caroline Schuppli, one possibility is that it simply comes down to “individual innovation.”

“Orangutans at [Suaq] rarely eat the plant,” she said in an announcement. “However, individuals may accidentally touch their wounds while feeding on this plant and thus unintentionally apply the plant’s juice to their wounds. As Fibraurea tinctoria has potent analgesic effects, individuals may feel an immediate pain release, causing them to repeat the behavior several times.”

[Related: Gorillas like to scramble their brains by spinning around really fast.]

If this were the case, it could be that Rakus is one of the few orangutans to have discovered the benefits of Fibraurea tinctoria. At the same time, adult orangutan males never live where they were born—they migrate sizable distances either during or after puberty to establish new homes. So it’s also possible Rakus may have learned this behavior from his relatives, but given observers don’t know where he is originally from, it’s difficult to follow up on that theory just yet.

Still, Schuppli says other “active wound treatment” methods have been noted in other African and Asian great apes, even when they aren’t used to disinfect or help heal an open wound. Knowing that, “it is possible that there exists a common underlying mechanism for the recognition and application of substances with medical or functional properties to wounds and that our last common ancestor already showed similar forms of ointment behavior.”

Given how much humans already have in common with their great ape relatives, it’s easy to see how this could be a likely explanation. But regardless of how Rakus knew how to utilize the medicinal plant, if he ever ends up scrapping with another male orangutan again, he’ll at least know how to fix himself up afterwards.

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Denmark will ban clothing with ‘forever chemicals’ https://www.popsci.com/health/forever-chemicals-clothing-ban/ Tue, 30 Apr 2024 19:15:11 +0000 https://www.popsci.com/?p=613090
clothing on a rack
Certain oil, water, and stain repellents are associated with health issues. DepositPhotos

Regulations take effect in 2026.

The post Denmark will ban clothing with ‘forever chemicals’ appeared first on Popular Science.

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clothing on a rack
Certain oil, water, and stain repellents are associated with health issues. DepositPhotos

The Danish government is sending a message on PFAS, a class of artificial substances known as “forever chemicals,” as they don’t break down easily in nature.

[ Related: 2 ways of knowing if there are PFAS in your drinking water ]

Denmark’s Ministry of the Environment said it plans to ban all clothes, shoes, and waterproofing agents that contain Per and Polyfluoroalkyl Substances, citing myriad health risks linked to the oil, water, and stain repellents. Developed in the 1930s, PFAS became widely used in the ‘50s, appearing in everything from cars and carpets to food packaging and beauty products. Studies have linked PFAS to reproductive health problems, child developmental delays, cancers, and high cholesterol, per the EPA.

Denmark intends for its PFAS clothing ban to kick in on July 1, 2026, in order to offer businesses a “transition period,” the environmental regulator said in an April 25 announcement. The ban will encompass both imported and Danish-made clothing, but it won’t affect “professional” or “safety clothing.” Denmark had already banned PFAS in food packaging as of 2020.

“The proposal for a ban will be subject to consultation,” the Ministry said in a statement. “It will be possible for companies to register if there are special challenges that must be taken into account.”

PFAS’ are specifically common in clothing labeled as water- and stain-resistant, such as rain jackets and athletic wear. A 2022 report, from environmental advocacy group Toxic-Free Future, estimated that 72% of products with such labels contain PFAS. The same year, a study by the non-profit American Chemical Society found significant concentrations of the chemicals in childrens’ school uniforms, CBS reported.

Still commonly used globally, the chemicals persist in the environment, accumulating across the food chain. They are found today in fish, cattle, vegetables, and drinking water

[ Related: 8 new types of ‘forever chemicals’ found in river linked to US cancer cluster ]

In the US, the agency banned some PFAS from food packaging and introduced new PFAS-related tap water regulations earlier this month. At the time, the EPA said that limiting exposure would “prevent thousands of premature deaths, tens of thousands of serious illnesses, including certain cancers and liver and heart impacts in adults, and immune and developmental impacts to infants and children.” 

The EPA’s website states that “research is still ongoing to determine how different levels of exposure to different PFAS can lead to a variety of health effects.”

Other nations have moved to outlaw the chemicals. New Zealand will ban them from use in cosmetics as of 2026, and five European countries—Denmark, Germany, the Netherlands, Norway, and Sweden—introduced a proposal last year to eventually restrict the use of PFAS across the European Union.

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Surprise! That futuristic COVID mask was even sketchier than we thought https://www.popsci.com/health/razer-zephyr-covid-refund/ Tue, 30 Apr 2024 15:53:07 +0000 https://www.popsci.com/?p=612975
Woman wearing Razer Zephyr Mask
The Razer Zephyr base model sold for $99. Credit: Razer

Razer owes $1 million in refunds for false N95 claims about Zephyr.

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Woman wearing Razer Zephyr Mask
The Razer Zephyr base model sold for $99. Credit: Razer

The Federal Trade Commission has ordered Razer to issue over $1.1 million in full refunds for its Razer Zephyr facemasks after alleging the PC gaming accessory company falsely billed its futuristic “wearable air purifier” as equivalent to N95-grade respirators. In truth, the FTC says Zephyr’s makers never even submitted their product for testing to either the FDA or the National Institute for Occupational Safety and Health (NIOSH). 

Razer is best known for its sleek, futuristic, luminescent video gaming accessories—but during the height of COVID-19, the company specializing in RGB backlit keyboards and headphones thought it wise to wade into pandemic healthcare. Released in October 2021 following nearly a year of internet hype, the Razer Zephyr looked more like a cyberpunk cosplay accessory than an actual “wearable air purifier.” Still, the transparent, twin-fan mask included three replaceable filters supposedly functioned together as equivalents to existing N95-grade products.

Outlets approached the odd healthcare accessory with a mix of anticipation and skepticism after plans were revealed in January 2021, later considered the pandemic’s deadliest month in the US. In the months leading up to its official launch, Razer co-founder and CEO Min-Liang Tan repeatedly posted on social media “linking the mask to the rise of the COVID-19 Delta variant, making explicit health claims, positioning the mask as a reusable N95, and claiming that Razer was seeking certification… [but] knew that they had never sought—and were not seeking—such certification,” according to the FTC’s complaint.

[Related: Calling TurboTax ‘free’ is ‘deceptive advertising,’ says FTC.]

To qualify for N95 certification, filters must guard against at least 95-percent of ambient air particles between 0.1 and 0.3 micrometers in size, while also providing higher filtration rates for larger particulates. Although COVID-19 virus cells measure around just 0.1 micrometers or smaller, they are always bonded to larger bodies such as water molecules and other biological material, and thus are effectively blocked by N95-rated masks and filters.

Razer consulted with a Singapore-based quality assurance company during Zephyr’s development, and in emails wrote they intended to market the wearable as “N95 grade.” Subsequent reviews showed Razer’s design only achieved around 83 percent particulate filtration efficiency (PFE) while its fans were off, with just a three percent improvement with the fans enabled. Even then, FTC documents state the Razer Zephyr “frequently tested much lower” and “did not come close to consistently reaching a PFE of 95 percent.” The quality testing company even went so far as to warn against mentioning N95 ratings “as it is not relevant to this product, and the claim will cause confusion.” 

Despite this, Razer moved forward with its marketing and released Razer Zephyr in October 2021, amid spiking global COVID-19 rates due to the Delta variant. Masks and filter packs were made available online through limited drop releases, as well as at three physical locations in Seattle, San Francisco, and Las Vegas. A single mask and three sets of filter replacements retailed for $99.99, while a mask alongside 33 filter sets sold for $149.99. A single, 10-set filter pack cost its wearers $29.99. The company even announced plans for a “Pro” version featuring voice amplification in early January 2022.

Razer Zephyr break apart concept art
Credit: Razer

Barely a week later, however, Razer began walking back its N95-grade marketing for Zephyr amid mounting scrutiny and criticism. The Pro edition never saw the light of day, and federal regulators eventually opened its official investigation into the situation. In addition to the more than $1.1 million in refunds, Razer must pay a $100,000 civil penalty, and is forbidden from making any future “COVID-related health misrepresentations or unsubstantiated health claims about protective health equipment.” All references to the sleek, shoddy masks now appear scrubbed from Razer’s official website.

“Products like the Zephyr invite a lot of scrutiny. Is this an honest, good-faith attempt to create an upgraded device for people who plan to wear masks in public long-term, or is it a cash grab? Does it work at all?” PopSci wrote in its official review from January 2022. “These are all good, fair questions to ask when a company with no history making medical technology quickly develops and launches an expensive piece of kit.”

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Bird flu virus traces detected in 1 in 5 pasteurized cow milk samples https://www.popsci.com/health/bird-flu-milk/ Fri, 26 Apr 2024 16:18:01 +0000 https://www.popsci.com/?p=612681
white cow's milk on a grocery store shelf
The FDA believes that the commercial milk supply remains safe. The agency's testing revealed small genetic traces of bird flu and not live virus that causes infections. Deposit Photos

H5N1 has been detected in 33 herds in six states.

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white cow's milk on a grocery store shelf
The FDA believes that the commercial milk supply remains safe. The agency's testing revealed small genetic traces of bird flu and not live virus that causes infections. Deposit Photos

Genetic material from a particularly virulent strain of bird flu virus has been found in 1 in 5 samples of pasteurized milk, according to an April 25 update from the Food and Drug Administration. The tested milk came from a nationally representative sample and the positive results came from milk in areas with herds of dairy cows where Highly Pathogenic Avian Influenza (HPAI) or H5N1 infections have been detected. The FDA’s new test results indicate that the virus has spread further among dairy cows than previously indicated.

As of April 25, bird flu had been detected in 33 herds in Idaho, Kansas, Michigan, New Mexico, North Carolina, South Dakota, Ohio, and Texas. This particular virus strain has caused a devastating outbreak in wild and commercial birds since 2021. It first spread to mammals in 2022 and can occasionally infect humans. Only two human cases of HPAI have been reported in the United States, according to the Centers for Disease Control (CDC). 

The FDA used quantitative polymerase chain reaction (qPCR) testing to inspect the milk samples. While the findings are concerning, it does not necessarily mean that the milk was contaminated with live virus–which can cause infection. 

[Related: Bird flu detected in dairy cow milk samples.]

“With qPCR tests, the genetic material, not necessarily the whole active or infectious virus, is what is detected,” clinical pathologist Nam Tran said in a statement. “In the case of food, the genetic material, the RNA found in the grocery store milk samples, may not be the infectious H5N1 virus, but fragments from it.” Tram is a professor at the University of California Davis and senior director of clinical pathology at UC Davis Health.

The FDA believes that the commercial milk supply remains safe, since the testing only revealed small genetic traces of bird flu and not live virus that causes infections. The virus itself was first detected in dairy cows in the US in March and the FDA announced on April 23 that it had found viral fragments in commercially sold milk. 

Milk sold in grocery stores is pasteurized. This process kills harmful bacteria and viruses by heating milk to a specific temperature for a set period of time. The viral particles detected by highly sensitive qPCR tests were likely the remnants of viruses that had already been killed during the pasteurization process. 

To determine if any active, infectious virus remains in the milk samples, the FDA is going to perform egg inoculation tests. These rests are often considered the “gold standard” for determining a virus’ viability. In these tests, scientists will inject the virus sample into a raw chicken egg to see if it replicates or not. This test provides the most sensitive results, but it will take longer than other methods.

“Virus isolation propagates viruses, and needs a live virus particle to start with,” UC Davis School of Veterinary Medicine professor of clinical diagnostic virology Beate Crossley said in a statement. “A virus isolation positive result of a sample would indicate a live, infectious virus is present in the sample.”

[Related: Seal pup die-off from avian flu in Argentina looks ‘apocalyptic.’]

The World Health Organization has also urged public health officials to prepare for a potential spillover to humans in the future. While cases of humans getting infected and seriously ill from bird flu are rare, the more it spreads among mammals, the easier it will be for the virus to evolve to spread. 

Health officials continue to believe that commercial milk is unlikely to help spread the virus to humans and that pasteurization is the best line of defense. Consuming raw or unpasteurized milk is dangerous, no matter what the internet says. Raw milk has no added nutritional benefits and it can be contaminated with harmful germs. The CDC even considers raw milk one of the riskiest foods a person can consume.

As an evolving situation, the USDA and FDA will continue to share updates. 

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A new button battery dyes kids’ mouths blue if swallowed https://www.popsci.com/health/button-battery-dye/ Fri, 26 Apr 2024 15:42:35 +0000 https://www.popsci.com/?p=612665
Little boy biting his nails on grey background
The number of emergencies involving children ingesting batteries has spiked in recent years. Deposit Photos

The 'color alert technology' could save lives.

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Little boy biting his nails on grey background
The number of emergencies involving children ingesting batteries has spiked in recent years. Deposit Photos

Energizer has designed a new lithium coin battery that releases a blue dye immediately upon interacting with moisture such as saliva. The marker offers parents a visible way to determine if their children accidentally swallowed one of these toxic products.

After two decades of steady integration into everything from key fobs and remote controls to cooking thermometers and smart watches, lithium button batteries are now extremely commonplace household items. Unfortunately, their ubiquity coincides with a major, ongoing spike in the number of children ingesting the small batteries. Over 70,300 emergency doctor visits were reported for children’s battery-related issues between 2010 and 2019. Of those, nearly 85 percent involved button batteries.

Apart from the choking hazard, the US Consumer Product Safety Commission warns a battery’s chemicals can cause severe bodily injury, and even death, within a matter of hours if ingested. Additionally, the electric current generated by saliva’s interactions with a battery can simultaneously burn through body tissue, leading to even more potentially lethal complications. Every year, thousands of emergency hospital visits occur because of ingesting batteries.

[Related: What to expect if your child swallows a button battery.]

To help address the continuing public health concern, Energizer recently partnered with the children’s safety nonprofit Reese’s Purpose to design a safer button battery, as well as even stronger childproof packaging.

Apart from a bitter-tasting, nontoxic coating increasingly found on similar products, the company’s newest coin-shaped batteries are also wrapped in a container that requires scissors to open. But even if a child does get their hands on one, parents and caretakers will almost instantly be able to see if they need to contact emergency medical services.

Described as a “color alert technology,” the battery’s dotted, negative underside releases a nontoxic, food grade blue dye when mixed with moisture, such as spit. According to Energizer’s website, the batteries contain about as much dye as an ounce of a flavored sports drink, and will disappear after a few water rinses or teeth brushing.

Hamsmith started the nonprofit advocacy group in honor of her 18-month-old daughter who died in 2020 after swallowing a remote control’s coin battery.

Regardless of childproofing innovations, however, caretakers should immediately take a child to medical professionals if they suspect battery ingestion. The National Capital Poison Center warns against inducing vomiting and instead suggests having any child over 12 months old to swallow honey. Doing so can coat the ingested battery, and thus help delay some chemical burning of internal tissue while en route to receiving medical attention. That said, children younger than 1-year-old shouldn’t eat honey, so rushing them immediately to the emergency room for an X-ray is the best approach.

In the event of suspected emergencies, parents are encouraged to call the National Battery Ingestion Hotline (800-498-8666) or Poison Control Center (800-222-1222).

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Nearsightedness is at epidemic levels https://www.popsci.com/health/nearsightedness-is-at-epidemic-levels/ Fri, 26 Apr 2024 12:00:00 +0000 https://www.popsci.com/?p=612298
Nearsightedness is also known as myopia.
Nearsightedness is also known as myopia. DepositPhotos

The problem begins in childhood.

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Nearsightedness is also known as myopia.
Nearsightedness is also known as myopia. DepositPhotos

This article was originally featured on The Conversation.

Myopia, or the need for corrected vision to focus or see objects at a distance, has become a lot more common in recent decades. Some even consider myopia, also known as nearsightedness, an epidemic.

Optometry researchers estimate that about half of the global population will need corrective lenses to offset myopia by 2050 if current rates continue–up from 23% in 2000 and less than 10% in some countries.

The associated health care costs are huge. In the United States alone, spending on corrective lenses, eye tests and related expenses may be as high as US$7.2 billion a year.

What explains the rapid growth in myopia?

I’m a vision scientist who has studied visual perception and perceptual defects. To answer that question, first let’s examine what causes myopia–and what reduces it.

Nearsightedness is at epidemic levels

How myopia develops

While having two myopic parents does mean you’re more likely to be nearsighted, there’s no single myopia gene. That means the causes of myopia are more behavioral than genetic.

Optometrists have learned a great deal about the progression of myopia by studying visual development in infant chickens. They do so by putting little helmets on baby chickens. Lenses on the face of the helmet cover the chicks’ eyes and are adjusted to affect how much they see.

Just like in humans, if visual input is distorted, a chick’s eyes grow too large, resulting in myopia. And it’s progressive. Blur leads to eye growth, which causes more blur, which makes the eye grow even larger, and so on.

Two recent studies featuring extensive surveys of children and their parents provide strong support for the idea that an important driver of the uptick in myopia is that people are spending more time focusing on objects immediately in front of our eyes, whether a screen, a book or a drawing pad. The more time we spend focusing on something within arm’s length of our faces, dubbed “near work,” the greater the odds of having myopia.

So as much as people might blame new technologies like smartphones and too much “screen time” for hurting our eyes, the truth is even activities as valuable as reading a good book can affect your eyesight.

Outside light keeps myopia at bay

Other research has shown that this unnatural eye growth can be interrupted by sunlight.

A 2022 study, for example, found that myopia rates were more than four times greater for children who didn’t spend much time outdoors–say, once or twice a week–compared with those who were outside daily. At the same time, kids who spent more than three hours a day while not at school reading or looking at a screen close-up were four times more likely to have myopia than those who spent an hour or less doing so.

In another paper, from 2012, researchers conducted a meta-analysis of seven studies that compared duration of time spent outdoors with myopia incidence. They also found that more time spent outdoors was associated with lower myopia incidence and progression. The odds of developing myopia dropped by 2% for each hour spent outside per week.

Other researchers have reported similar effects and argued for much more time outdoors and changes in early-age schooling to reduce myopia prevalence.

Nearsightedness is at epidemic levels

What’s driving the epidemic

That still doesn’t explain why it’s on the rise so rapidly.

Globally, a big part of this is due to the rapid development and industrialization of countries in East Asia over the last 50 years. Around that time, young people began spending more time in classrooms reading and focusing on other objects very close to their eyes and less time outdoors.

This is also what researchers observed in the North American Arctic after World War II, when schooling was mandated for Indigenous people. Myopia rates for Inuit went from the single digits before the 1950s to upwards of 70% by the 1970s as all children began attending schools for the first time.

Countries in Western Europe, North America and Australia have shown increased rates of myopia in recent years but nothing approaching what has been observed recently in China, Japan, Singapore and a few other East Asian countries. The two main factors identified as leading to increased myopia are increased reading and other activities that require focusing on an object close to one’s eyes and a reduction in time spent outdoors.

The surge in myopia cases will likely have its worst effects 40 or 50 years from now because it takes time for the young people being diagnosed with nearsightedness now to experience the most severe vision problems.

Treating myopia

Fortunately, just a few minutes a day with glasses or contact lenses that correct for blur stops the progression of myopia, which is why early vision testing and vision correction are important to limit the development of myopia. Eye checks for children are mandatory in some countries, such as the U.K. and now China, as well as most U.S. states.

People with with high myopia, however, have increased risk of blindness and other severe eye problems, such as retinal detachment, in which the retina pulls away from the the back of the eye. The chances of myopia-related macular degeneration increase by 40% for each diopter of myopia. A diopter is a unit of measurement used in eye prescriptions.

But there appear to be two sure-fire ways to offset or delay these effects: Spend less time focusing on objects close to your face, like books and smartphones, and spend more time outside in the bright, natural light. Given the first one is difficult advice to take in our modern age, the next best thing is taking frequent breaks–or perhaps spend more time reading and scrolling outside in the sun.

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Oura Ring Gen3 health tracker review: It’s a complicated relationship https://www.popsci.com/gear/oura-ring-gen3-health-tracker-review/ Thu, 25 Apr 2024 20:00:00 +0000 https://www.popsci.com/?p=612224
The Oura Ring Heritage on top of a couple of rocks.
The Oura Ring is a fashionable take on a health tracker. We wore it for most of eight months to find out if it prioritizes style over substance. Abby Ferguson / Popular Science

There’s a lot to like about the Oura Ring, but is it … well-rounded? Here’s a look at the features and frustrations.

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The Oura Ring Heritage on top of a couple of rocks.
The Oura Ring is a fashionable take on a health tracker. We wore it for most of eight months to find out if it prioritizes style over substance. Abby Ferguson / Popular Science

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The market is absolutely flooded with devices designed to track your health, most of which reside on the wearer’s wrist. Relatively newer to the health-tracking game, though, are smart rings. The Oura Ring was first released in 2015 but didn’t gain widespread recognition and popularity until roughly 2020. Its main function at the time was sleep tracking, but it has since broadened its applications, offering general health and fitness data for those who don’t want a screen on their wrist.  

I was not exactly sold when I first heard of the Oura Ring. I didn’t understand the benefit of a smart ring when you could just wear a watch. When Oura reached out to see if I would be interested in testing one, however, I decided to see what all the hype was about. I’ve been wearing it since the end of August 2023, giving me just over eight months of time living with it. And I have developed a complicated relationship with it. 

Abby Ferguson / Popular Science

SEE IT

Overview

  • Though bulky for a ring, the Oura Ring offers a more discreet profile than smartwatches.
  • The Oura Ring tracks a range of health metrics, including heart rate, temperature, sleep, and more.
  • The durable and waterproof design means it can stand up to the rigors of daily life. 

Pros

  • Collects lots of data
  • Mostly accurate sleep info
  • App is full of helpful insights and tools
  • Durable and waterproof
  • Features specific to women’s health
  • Frequent updates and new features
  • May be eligible for FSA/HSA funds

Cons

  • Needs to be removed frequently
  • Fairly bulky
  • Tethered GPS is quite inaccurate
  • Requires a monthly subscription to access all features

Verdict: The Oura Ring is a minimalistic health tracker that helps you better understand your sleep and overall health.  

The Oura Ring’s design & build

The Oura ring comes in several different finishes and two different designs. The Heritage, the original Oura Ring, features a rectangular plateaued top. For an additional $50, you can opt for the Horizon version, which offers a typical, fully round ring. All of the rings, regardless of finish, are made with titanium on the outside, which is strong, non-allergenic, and lighter than most other metals. On the inside is a medical-grade, BPA-free molding. I’ve been wearing the Horizon in rose gold, which is manufactured using a vapor deposition (PVD) coating for added durability. 

The ring feels like, well, a ring, albeit quite bulky compared to rings that I wear. It’s 2.55mm thick (the Heritage will be slightly thicker on the top), roughly the thickness of most wedding bands. It’s worth stating that I have tiny hands, so all but the most dainty rings feel bulky on me. The band is 7.9mm wide and, depending on the size, weighs 0.14 to 0.21 ounces. 

There’s a subtle notch on the outside that indicates the orientation of the ring, as the sensors should be on the palm side of your finger. There are also three little bumps on the inside of the ring that sit against the finger, which aren’t noticeable at all during normal wear. 

The Oura ring is waterproof to 330 feet, so you can wear it when you shower, swim, and snorkel. However, Oura says it doesn’t recommend the ring for scuba diving and that it shouldn’t be submerged for more than 12 hours. Even though it’s waterproof, I typically remove the ring if I’m washing lots of dishes or cleaning, mostly because water tends to get trapped under the band. 

The rose gold finish has noticeable scratches and some patina these days, but I haven’t been super precious with it. I take it off when I’m lifting weights, at the beach, or during any other activity that requires using my hands because of the bulkiness, but otherwise live my normal life with it on. Most of the scratches are on the palm side of the ring, which makes sense as that’s the area that makes contact with things nearly constantly throughout the day. The top of the ring still looks rather shiny and smooth despite eight months of wear. 

Fitness & Exercise photo
The Oura ring is certainly smaller than a fitness tracker, but it’s bulky enough that I don’t like wearing it for most activities that use my hands.  Abby Ferguson / Popular Science

Sensors 

Naturally, as a smart ring, the Oura Ring is built with a few sensors. The infrared photoplethysmography sensors (PPG) use LED light to measure heart rate and respiration. If you sleep with the ring, don’t be alarmed when you see your finger glowing in the middle of the night. Oura says this sensor samples 250 times per second and is 99.9% reliable compared to a medical-grade electrocardiogram (ECG). It uses the heart rate data also to tell you your resting heart rate, heart rate variability, and respiration. 

There’s also a negative temperature coefficient (NTC) sensor that measures your nighttime temperature. It won’t tell you what your actual temperature is, but will tell you how much your temperature changes overnight. It’s sensitive enough to pick up changes of just 0.1° Celsius. The temperature data is useful if you are sick, but it also helps those with cycles track what phase of their cycle they are in, as there are predictable rises and falls in temperature for each phase. 

Finally, a 3D accelerometer detects your activity during the day. Keep in mind, though, that there is no GPS in the Oura Ring. Instead, the ring relies on tethered GPS, meaning it pulls location data from your phone. Beyond activity, the accelerometer also tracks nighttime restlessness and helps identify your sleep stages. 

Rose Gold Oura Ring Horizon sitting upright on a piece of driftwood, three interior sensor bubbles visible
Despite the ring’s tiny size relative to a watch, it still packs in multiple sensors to detect a range of health metrics. Abby Ferguson / Popular Science

Sensor accuracy

My testing process didn’t involve any lab time for testing the sensors, but I was able to compare them to the best fitness watches and heart rate monitors I use. I found the heart rate pretty spot on with what I get from my watches and even higher fidelity chest-based monitors. In fact, on a recent run, both my Oura Ring and Garmin HRM-Fit (chest-based strap) said my average heart rate was 153. 

I wasn’t taking my temperature every day to compare what the Oura Ring was picking up, but I tend to get pretty sick from the COVID-19 vaccine and was wearing the ring when I got my last booster. The ring detected that my temperature was 2.3 degrees higher than normal, and sure enough, I had a fever of 101 degrees Fahrenheit. In terms of accelerometer accuracy, it mostly picks up when I’ve had a restless night, though not perfectly. 

Battery & connectivity

To use any of your data, the ring needs to sync to the phone app using a Bluetooth Low Energy connection. This happens frequently in the background, but you can also open the app and prompt it to sync with the ring. The app is also how you’ll update the firmware and see all your data.

The ring uses an integrated 15mAh (US6) – 22mAh (US13) Lipo battery. In the original Heritage ring, the battery sits in the rectangular top, while the newer Horizon-style ring uses a flexible battery to maintain the fully rounded shape. Oura promises a battery life of seven days, though it does warn that having blood oxygen sensing turned on will deplete the battery faster. I have Blood Oxygen Sensing turned on and typically get about five to six days on a single charge. The app will remind you to charge the ring before bed if the battery gets low, which is helpful. 

Luckily, charging is fairly quick. I noticed the battery was at roughly 15% before popping out for a run, so I tossed it on the charger to see if I could get enough power to track my activity. I was able to get up to 48% battery in 25 minutes of charging, which was plenty for my 30-minute run. If the battery is fully dead, a full charge takes closer to two hours. I tend to put the ring on the proprietary charger when I’m taking a shower or doing any sort of activity that isn’t conducive to wearing the ring to keep it topped off so I can always wear it to bed for sleep tracking. 

Fitness & Exercise photo
The ring slots onto the charging stand in only one way to accommodate the sensor bumps. It features a light that tells you when it’s actively charging or fully charged.  Abby Ferguson / Popular Science

The Oura Ring’s features

The Oura ring may look simple, but it offers quite a few features. Between the data it gathers and the app, Oura makes it pretty easy to get a snapshot of your health and wellness.

Sleep tracking

One of the primary features of the Oura Ring is its sleep-tracking abilities. The ring collects heart rate, respiration, heart rate variability, and movement data throughout the night and then provides a score to let you know the quality of your sleep. It can also pick up what time you go to bed and wake up and detect naps. I fell asleep on the couch one night while watching TV, and the app asked if I took a 20-minute nap from 10:20 to 10:40 pm, which was exactly when I was asleep. That nap was then added to my sleep score since it was so close to when I went to bed. 

Beyond tracking, there are some other helpful sleep tools in the Oura app that I’ve enjoyed. My favorites are the Body Clock and chronotype tools. To provide your chronotype (a fancy way of saying if you are a morning or night person), Oura looks at sleep, activity, and body temperature data over a three-month period of consistent use. It then gives you suggestions on when the ideal time to work out or perform certain types of tasks would be based on your chronotype. While this information is more interesting than earth-shattering in terms of how it impacts my life, it could make a difference for some. 

Fitness tracking

Calling the Oura Ring a fitness tracker is generous, but it does have activity-tracking capabilities. It can automatically detect 40 activities, including housework, but I found the automatic detection to be very hit-and-miss. It almost always thinks I was walking as well, even though there are other options.  

Since there are no buttons or interactive controls on the ring itself, you need the app to do any tracking. Once in the app, you tap the plus sign in the bottom right corner and select “Record workout HR.” Then, you can choose between indoor or outdoor cycling, indoor or outdoor running, or walking. The record button starts tracking, and you’ll need to open the app again to end tracking. 

While Oura relies on your phone’s GPS for anything related to distance and mapping, each company handles tethered GPS differently, resulting in various levels of accuracy. Unfortunately, Oura’s tethered GPS is the worst I’ve come across. A 30-minute run with the Oura Ring and my Garmin epix Pro (which has multi-band GPS and is known for accuracy) showed a distance of 0.3 miles for the ring and 2.6 miles for the watch. I know I’m no speed demon, but I definitely did more than 0.3 miles in 32 minutes while running.

Comparing two tethered devices, I wore the Oura ring along with my Garmin Lily 2, which also relies on tethered GPS. Both were on the left hand. Oura had my distance at 0.7, while the Garmin was 1.67. This route is one I do some variation of multiple times a day, and 1.67 is definitely very close to the correct distance. 

Because of the GPS inaccuracy, I would not recommend the Oura for fitness tracking. Distance and pace data influence a handful of fitness and readiness-related tools, so inaccurate data on those items will throw a lot of stuff off. Luckily, you can connect to Strava and import that data so your Oura account can utilize more accurate information for its health and wellness features.  

A comparison between the Oura Ring's GPS (left) and data recorded with my Garmin Lily 2 on the same walk.
A comparison between the Oura Ring’s GPS (left) and data recorded with my Garmin Lily 2 on the same walk. Abby Ferguson / Popular Science

Women’s health

The women’s health features appeared relatively recently in the Oura’s arsenal. The app offers the ability to track cycles and now offers pregnancy insights as well. For cycle tracking, the Oura app will prompt you to to input if you use hormonal contraceptives or other hormones. If you use hormones of any type, you won’t be able to see your cycle phases. I really wanted to see my phases, so despite having a hormonal IUD, I selected “none” for hormones. 

It’s been very interesting to watch my temperature shift nightly over the course of my cycle. Plus, even with my hormonal birth control, Oura has been pretty spot on at predicting when my period will start and how long it will last. This information is more interesting for me than actionable, but I could see how it would be useful if something odd started happening or I had concerns that I wanted to show my doctor. 

Oura app

The Oura Ring’s sensors collect data, which the app compiles into a more digestible, usable format. The app’s homepage has different sections showing your sleep, activity goal, stress levels, heart rate, and more. You can click into the different sections to see graphs and track trends over time. Alternatively, you can open the Trends portion of the app for a quick glance at sleep, readiness, activity, and stress trends over time. 

On top of all your data, the app provides suggestions for activity levels based on your information. There are guided meditations and breathing exercises, and plenty of tips on improving sleep, time meals, and understanding your data. 

Unfortunately, a subscription is required to access most features and insights in the app. You get one month free, but after that, it is $5.99 a month. Without an Oura membership, you’ll only be able to see Sleep, Readiness, and Activity scores without any in-depth analysis. 

Fitness & Exercise photo
The Oura Ring is a nice-looking device, blending seamlessly into daily life, even for fancier occasions.  Abby Ferguson / Popular Science

Final thoughts on my Oura Ring experience

As a bit of a data junky, I certainly appreciate the information I get from the Oura Ring. It’s helped me understand my body a bit better, especially from a women’s health and sleep perspective. I also just think it’s fascinating to see trends over time. Plus, Oura makes it easy to export the data should you want to share something with your doctor, which is really nice. 

My main issue is with the experience of actually wearing the ring, which is more so a personal preference. I find myself taking the ring off quite frequently. Water gets trapped underneath when washing my hands, so I at least need to take it off after to dry it. I don’t like to wear it when cooking since ingredients can get under it, and I wash my hands frequently in the process. Though it can be worn in the shower, I don’t enjoy it, so it comes off. The same goes for when I’m applying lotion. It is too bulky to wear while weight lifting or biking, so I remove it for those activities. You get the gist. Then, in all those times of taking the ring off, I am typically not the best about remembering to put it back on. 

Despite my frustrations with constantly needing to remove the ring, I still see its benefits. There’s no denying that the Oura Ring looks nice, blending into the day-to-day more than an aggressive fitness watch. The smaller form factor is also more comfortable to sleep in, especially if you aren’t used to constantly wearing a watch. And sometimes, it’s nice to separate from a screen and smartwatch notifications while still collecting data. Plus, Oura is actively rolling out new features and researching new ways to use the ring, so investment-wise, you’ll continue to get a lot out of it.
Overall, like anything, there are pros and cons. There are enough pros to keep wearing the ring, and I will continue to do so even after writing this review. In my opinion, the benefits outweigh the occasional annoyance of wearing it. So, my complicated relationship with the Oura Ring will continue for the foreseeable future.

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Chemical pollutants can change your skin bacteria and increase your eczema risk https://www.popsci.com/health/chemical-pollutants-eczema-risk/ Wed, 24 Apr 2024 12:00:00 +0000 https://www.popsci.com/?p=612068
skin irritated
Chemicals involved in clothing production can be hazardous to health. SBenitez/Moment via Getty Images

Certain chemicals in synthetic fabrics such as spandex, nylon, and polyester can alter the skin microbiome.

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skin irritated
Chemicals involved in clothing production can be hazardous to health. SBenitez/Moment via Getty Images

This article was originally featured on The Conversation.

“We haven’t had a full night’s sleep since our son was born eight years ago,” said Mrs. B, pointing to her son’s dry, red and itchy skin.

Her son has had eczema his entire life. Also known as atopic dermatitis, this chronic skin disease affects about 1 in 5 children in the industrialized world. Some studies have found rates of eczema in developing nations to be over thirtyfold lower compared with industrialized nations.

However, rates of eczema didn’t spike with the Industrial Revolution, which began around 1760. Instead, eczema in countries such as the U.S.Finland and other countries started rapidly rising around 1970.

What caused eczema rates to spike?

I am an allergist and immunologist working with a team of researchers to study trends in U.S. eczema rates. Scientists know that factors such as diets rich in processed foods as well as exposure to specific detergents and chemicals increase the risk of developing eczema. Living near factories, major roadways or wildfires increase the risk of developing eczema. Environmental exposures may also come from inside the house through paint, plastics, cigarette smoke or synthetic fabrics such as spandex, nylon and polyester.

While researchers have paid a lot of attention to genetics, the best predictor of whether a child will develop eczema isn’t in their genes but the environment they lived in for their first few years of life.

There’s something in the air

To figure out what environmental changes may have caused a spike in eczema in the U.S., we began by looking for potential eczema hot spots – places with eczema rates that were much higher than the national average. Then we looked at databases from the U.S. Environmental Protection Agency to see which chemicals were most common in those areas.

For eczema, along with the allergic diseases that routinely develop with it – peanut allergy and asthma – two chemical classes leaped off the page: diisocyanates and xylene.

Diisocyanates were first manufactured in the U.S. around 1970 for the production of spandex, nonlatex foam, paint and polyurethane. The manufacture of xylene also increased around that time, alongside an increase in the production of polyester and other materials.

The chemically active portion of the diisocyanates and xylene molecules are also found in cigarette smoke and wildfires. After 1975, when all new cars became outfitted with a new technology that converted exhaust gas to less toxic chemicals, isocyanate and xylene both became components of automobile exhaust.

Research has found that exposing mice to isocyanates and xylene can directly cause eczemaitch and inflammation by increasing the activity of receptors involved in itch, pain and temperature sensation. These receptors are also more active in mice placed on unhealthy diets. How directly exposing mice to these toxins compares to the typical levels of exposure in people is still unclear.

How and why might these chemicals be linked to rising rates of eczema?

Skin microbiome and pollution

Every person is coated with millions of microorganisms that live on the skin, collectively referred to as the skin microbiome. While researchers don’t know everything about how friendly bacteria help the skin, we do know that people need these organisms to produce certain types of lipids, or oils, that keep the skin sealed from the environment and stave off infection.

You’ve probably seen moisturizers and other skin products containing ceramides, a group of lipids that play an important role in protecting the skin. The amount of ceramides and related compounds on a child’s skin during their first few weeks of life is a consistent and significant predictor of whether they will go on to develop eczema. The less ceramides they have on their skin, the more likely they’ll develop eczema.

To see which toxins could prevent production of the beneficial lipids that prevent eczema, my team and I used skin bacteria as canaries in the coal mine. In the lab, we exposed bacteria that directly make ceramides (such as Roseomonas mucosa), bacteria that help the body make its own ceramides (such as Staphylococcus epidermidis) and bacteria that make other beneficial lipids (such as Staphylococcus cohnii) to isocyanates and xylene. We made sure to expose the bacteria to levels of these chemicals that are similar to what people might be exposed to in the real world, such as the standard levels released from a factory or the fumes of polyurethane glue from a hardware store.

We found that exposing these bacteria to isocyanates or xylene led them to stop making ceramides and instead make amino acids such as lysine. Lysine helps protect the bacteria from the harms of the toxins but doesn’t provide the health benefits of ceramides.

We then evaluated how bed sheets manufactured using isocyanates or xylene affect the skin’s bacteria. We found that harmful bacteria such as Staphylococcus aureus proliferated on nylon, spandex and polyester but could not survive on cotton or bamboo. Bacteria that help keep skin healthy could live on any fabric, but, just as with air pollution, the amount of beneficial lipids they made dropped to less than half the levels made when grown on fabrics like cotton.

Addressing pollution’s effects on skin

What can be done about the connection between pollution and eczema?

Detectors capable of sensing low levels of isocyanate or xylene could help track pollutants and predict eczema flare-ups across a community. Better detectors can also help researchers identify air filtration systems that can scrub these chemicals from the environment. Within the U.S., people can use the EPA Toxics Tracker to look up which pollutants are most common near their home.

In the meantime, improving your microbial balance may require avoiding products that limit the growth of healthy skin bacteria. This may include certain skin care products, detergents and cleansers. Particularly for kids under 4, avoiding cigarette smoke, synthetic fabrics, nonlatex foams, polyurethanes and some paints may be advised.

Replacing bacteria that has been overly exposed to these chemicals may also help. For example, my research has shown that applying Roseomonas mucosa, a ceramide-producing bacterium that lives on healthy skin, can lead to a monthslong reduction in typical eczema symptoms compared with placebo. Researchers are also studying other potential probiotic treatments for eczema.

Evaluating the environmental causes of diseases that have become increasingly common in an increasingly industrialized world can help protect children from chemical triggers of conditions such as eczema. I believe that it may one day allow us to get back to a time when these diseases were uncommon.


Ian Myles is Chief of the Epithelial Therapeutics Unit at the National Institute of Allergy and Infectious Diseases. Ian Myles receives funding from the Department of Intramural Research at the National Institute of Allergy and Infectious Diseases. He is the author of, and receives royalties for, the book GATTACA Has Fallen: How population genetics failed the populace. Although he is the co-discoverer of Roseomonas mucosa RSM2015 for eczema, he has donated the patent to the public and has no current conflict of interest for its sales.

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How psychedelic-assisted therapies can be more effective https://www.popsci.com/health/how-psychedelic-assisted-therapies-can-be-more-effective/ Tue, 23 Apr 2024 18:37:04 +0000 https://www.popsci.com/?p=612061
Therapy session
The efficacy of psilocybin treatment increases over the long-term when a patient feels more connected to their clinician. The clinician provides hours or preparation and also guides the patient through the experience and dissects it days and weeks later. DepositPhotos

A new study of psilocybin patients zeroes in on a crucial element of treatment.

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Therapy session
The efficacy of psilocybin treatment increases over the long-term when a patient feels more connected to their clinician. The clinician provides hours or preparation and also guides the patient through the experience and dissects it days and weeks later. DepositPhotos

In just a few short years, psychedelic-assisted therapy involving controlled substances like ketamine, MDMA, and psilocybin (the psychoactive compound found in “magic mushrooms”) have evolved from relative obscurity to the far edges of mainstream medical acceptance. Clinical studies have shown that their medical use can have positive effects for patients living with depression and post-traumatic stress disorder. Sometimes, these treatments prove effective where other, more widely-prescribed medications fall short. But new research suggests close bonds with a trained therapist is a key element contributing to effective psychedelic-assisted treatment, specifically psilocybin.

[Related: 4 visionaries on the history and future of psychedelic medicine ]

A surge in interest in therapeutic use of psychedelics has fostered a burgeoning industry of startups specializing in treatments. As of today, according to the psychedelics industry tracker Psilocybin Alpha, more than 50 publicly traded companies currently offer psychedelic therapy (mostly ketamine) and psychedelic retreats. Yet, the exact ways these companies administer psychedelics can vary widely. While some require patients to consume or inject the substance in the presence of a trained clinician, others lean on loose, pandemic-era health regulations to let patients take the medication at home, typically as pills and lozenges. The latter method can carry risks. In some cases, the Federal Drug Administration, which has yet to approve psychedelic drugs for therapy, claims it has received reports of patients experiencing adverse health effects after they’ve taken medically prescribed ketamine at home without a clinician’s supervision. There are currently no legal at-home psilocybin treatments available however individuals in Oregon were able to begin accessing the compound without a prescription last year. 

A new study published in the journal PLOS ONE this week suggests that strong relationships between patients and their therapists could play a crucial role determining whether or not psychedelic-assisted therapy can prove useful as treatments for depression. The study, which analyzed a 2021 clinical study involving 24 patients using psilocybin-assisted therapy to treat severe depression, found that participants with stronger self-reported connections with their therapist were more likely to report a decrease in depression over time.

In other words, the efficacy of psilocybin treatment increases over the long-term when a patient feels more connected to their clinician. The clinician provides hours or preparation and also guides the patient through the experience and dissects it days and weeks later. Findings like these could help influence treatment standards for psychedelic-assisted therapy treatments, especially as the practice gains more widespread clinical acceptance and adoption. 

Patients with stronger connections to their therapists reported better results 

Researchers from Ohio State University examined data from a 2021 clinical trial where 24 adults seeking treatment for severe depression received two doses of psilocybin paired with 11 hours of psychotherapy. Patients completed survey questionnaires where they assessed the strength of the relationship with their therapists, which the researchers refer to as their “therapeutic alliance.” The patients also noted down any mystical or insightful psychological experience they had during the treatment. Researchers say at times these experiences tend to yield positive therapeutic outcomes, particularly in the short and medium term. In this case, these experiences led to positive outcomes around four-weeks after introducing the psilocybin into treatment.

Higher alliance scores, or stronger relationships with therapists, correlated with longer-term psychological insights. One year after the treatments, patients who reported strong connections with their therapist also crucially provided lower self-reported depression scores one year following treatment than those who reported weaker relationships. The research builds off of past studies that show how a strong therapeutic alliance between a therapist and a patient often leads to a more effective outcome following therapy. This new study suggests those same basic findings similarly apply to psychedelic-assisted therapy. 

“This concept is not novel. What is novel is that very few people have explored this concept as part of psychedelic-assisted therapy,” paper senior author and Center for Psychedelic Drug Research and Education associate professor Alan Davis said in a statement. “This data suggests that psychedelic-assisted therapy relies heavily on the therapeutic alliance, just like any other treatment.”

The findings also reinforce the role a patient’s environment and mindset, known colloquially as “set and setting” can have on influencing positive experiences. In this case, hours of preparatory psychotherapy prior to administering psilocybin, along with “supportive, no direct” therapy during the actual psychedelic experience posed to be significant variables contributing to the drug’s overall effectiveness. Patients who were more comfortable with their clinician may be more receptive to the therapy.

“That’s why I think the relationship has been shown to be impactful in this analysis–because, really, the whole intervention is designed for us to establish the trust and rapport that’s needed for someone to go into an alternative consciousness safely,” Davis added.

The study’s findings come during what could be an inflection point for psychedelic-assisted therapy research and treatment in the US. Despite still being labeled a Schedule 1 drug on the national level, several cities including Denver, Oakland, and Washington have decriminalized psilocybin. On the medical front, the FDA in 2019 approved the use of a nasal spray called Spravato, which uses a derivative of ketamine, for treating depression. Just last year, the FDA released its first-ever draft guidance outlining considerations for researchers looking to conduct clinical trials for psychedelic treatments. An MDMA therapy from the MAPS Public Benefit Corporation could reportedly receive FDA approval by the end of the year

Ohio State University College of Medicine resident and paper lead author Adam Levin notes he and his fellow researchers’ findings could highlight the importance of maintaining strong connections between patients and physicians, especially with treatments posed to gain wider adoption in the coming years. Levin, and others critical of attempts to rush out access to psychedelic drugs without proper therapeutic support warn such an approach could lead to unintended consequences and even set back efforts to make psychedelic-assisted therapy more widely available. 

“Our concern is that any effort to minimize therapeutic support could lead to safety concerns or adverse events,” Levin said. “…What we showed in this study is evidence for the importance of the alliance in not just preventing those types of events, but also in optimizing therapeutic outcomes.”

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Don’t bring us the snake that bit you, Australian hospital says https://www.popsci.com/environment/dont-bring-snake-to-hospital/ Tue, 23 Apr 2024 17:43:49 +0000 https://www.popsci.com/?p=612109
A deadly Australia eastern brown snake
A deadly Australia eastern brown snake. WILLIAM WEST/AFP via Getty Images

'That becomes a huge disaster.'

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A deadly Australia eastern brown snake
A deadly Australia eastern brown snake. WILLIAM WEST/AFP via Getty Images

Subjecting hospital staff and patients to the snake that bit you won’t help your treatment–and it might even obstruct your care, doctors told the Australian Broadcasting Corporation (ABC) earlier this month.

Australia is home to some of the most venomous snakes on Earth, including the inland taipan and eastern brown snakes, yet reports of fatal snake bites are relatively rare on the continent, with bites documented only a couple times per year. Still, there are around 3,000 reported snake bites per year in Australia and as many as 500 of those cases require antivenom treatment, as noted by Business Insider.

After any snake bite, Australian health officials say victims should immediately seek medical care; but trying to catch, kill, or photograph the snake after a bite “just puts people at risk,” said Dr. Adam Michael, the emergency medicine director at Bundaberg Hospital in the north-eastern state of Queensland. 

“We want people to be able to get seen and assessed quickly and having a live snake in the department slows up that process,” the director told ABC. He spoke to the news outlet after a patient brought in a “not very well secured” eastern brown, which he said had frightened staff and ultimately caused delays.

Hospital staff aren’t trained to identify snakes, said Dr. Geoff Isbister, who leads clinical toxicology research at the University of Newcastle near Sydney. Still, the researcher told ABC that he’d heard of multiple incidents in which victims brought snakes along with them to the hospital after a bite. “If that snake gets out in an emergency department, that becomes a huge disaster,” Dr. Isbister said.

Instead of inspecting the snake itself, medical staff assess if victims need anti-venom “based on clinical signs, blood tests and also the snake venom detection kits that we keep here at the hospital,” Dr. Michael added. 

Neither doctor spoke to the exact number of incidents they’d observed in which a snakebite patient brought their assailant in tow. However, local snake catcher Jonas Murphy told ABC that he’s personally “relocated several snakes brought into the Bundaberg Hospital,” the outlet wrote. Murphy echoed the doctors’ reasoning in a comment to ABC.

“You are risking a follow-up bite and you’re putting everyone around you in danger as well,” the snake catcher explained.

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The bombastic 19th-century anti-vaxxer who fueled Montreal’s smallpox epidemic https://www.popsci.com/health/19th-century-anti-vaxxer/ Tue, 23 Apr 2024 12:00:00 +0000 https://www.popsci.com/?p=611830
Alexander Milton Ross
Misinformation about diseases is a timeless human challenge. Images: A page out of the 19th-century Anti-Vaccinator magazine; naturalist and anti-vaccination activist Alexander Milton Ross. MIT Press Reader

Alexander Milton Ross's tale reveals striking similarities to today's vaccine hesitancy and the enduring challenge of combating misinformation campaigns.

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Alexander Milton Ross
Misinformation about diseases is a timeless human challenge. Images: A page out of the 19th-century Anti-Vaccinator magazine; naturalist and anti-vaccination activist Alexander Milton Ross. MIT Press Reader

This article was originally featured on MIT Press Reader.

This article is excerpted from Sabrina Sholts’s book “The Human Disease: How We Create Pandemics, from Our Bodies to Our Beliefs.“

“VACCINATE! VACCINATE!! VACCINATE!!! THERE’S MONEY IN IT!!! TWENTY THOUSAND VICTIMS!!! will be Vaccinated within the next ten days in this City under the present ALARM!!! That will put $10,000 into the pockets of the Medical Profession.” In case all the exclamation points and capitalized letters didn’t do the trick, Alexander Milton Ross embellished his poster with a large drawing of a police officer restraining a mother while Death vaccinated her child. It was terrifying, no doubt. For extra emphasis, the police officer held a piece of paper that read “Vaccination for the Jenner-ation of Disease,” a reference to the English physician Edward Jenner, who developed and promoted vaccination.

In 1885, Canada had no greater adversary of smallpox vaccination than Ross, an Anglo-Canadian physician and naturalist whose medical training was informed by the sanitary movement of the 19th century. Opposed to the germ theory emerging in Europe (that same year, Louis Pasteur’s rabies vaccine was announced to the world), Ross believed that smallpox was a filth disease and its only antidote was cleanliness. And though it’s true that smallpox could spread through soiled fabrics used by smallpox patients (such as bedding and clothing), its primary route of transmission was virus-laden respiratory droplets. The real danger thus lay in close and prolonged contact with smallpox patients, independent of how clean the setting was.

Vaccination, in Ross’s mind, was poisonous. He wanted everyone to know it too. Besides papering the city of Montreal with antivaccination posters and pamphlets, writing letters to newspapers and professional journals, and founding a magazine called the Anti-Vaccinator, he formed the Canadian Anti-Vaccination League as part of an international antivaccination crusade. “Though Police and the Profession cry Vaccinate! Vaccinate!! Vaccinate!!! and people in thousands follow their blind leaders, — I still say, DON’T,” Ross urged in a circular that he distributed throughout the city.

Ross believed that smallpox was a filth disease and its only antidote was cleanliness.

At the time, Montreal was struggling to fight off the largest epidemic of smallpox that it would ever face. For almost a century, smallpox vaccination had been widely used to prevent the disease, but many of the city’s inhabitants had refused the procedure.

Some of the holdouts were surely persuaded by Ross and his English-only propaganda. But most of the unvaccinated population and therefore the bulk of the cases consisted of French Canadians. To convince them of the evils of vaccination, French Canadian physician Joseph Emery Coderre formed the first Canadian antivaccination society in Montreal and published numerous antivaccination pamphlets in French in the 1870s. His ardent antivaccination views fed the fervor of protesters who attacked the city council in 1875, halting efforts to enact mandatory smallpox vaccination in Montreal and leaving the city vulnerable to devastating disease 10 years later. When compulsory vaccination was attempted again in 1885, the riot was even bigger. Shortly thereafter, Coderre and colleagues created an antivaccination journalL’Antivaccinateur canadien-français, the Francophone counterpart to Ross’s magazine.

Antivaccination poster in 1885. Created by Alexander Milton Ross during the smallpox epidemic in Montreal, the text accuses medical doctors of profiting from smallpox vaccination and urges citizens to refuse it, while the image suggests that the smallpox vaccine is deadly. Source: Michael Bliss, “Plague: The Story of Smallpox in Montreal” (Toronto: HarperCollins, 1991).
Antivaccination poster in 1885. Created by Alexander Milton Ross during the smallpox epidemic in Montreal, the text accuses medical doctors of profiting from smallpox vaccination and urges citizens to refuse it, while the image suggests that the smallpox vaccine is deadly. Source: Michael Bliss, “Plague: The Story of Smallpox in Montreal” (Toronto: HarperCollins, 1991).

The misinformation promoted by Ross, Coderre, and their contemporaries should be familiar to anyone with a social media account in the 21st century. First off, they downplayed the threat of the epidemic in Montreal. Francophone newspapers wrote little about it, except to dismiss the panic, while Ross stressed in one of his pamphlets, “CAUTION. Do not be alarmed by the smallpox.” Simultaneously, they insisted that vaccination was the true danger. In the Anti-VaccinatorRoss explained that vaccination didn’t prevent smallpox and actually infected people with the smallpox virus, along with other equally lethal pathogens. Coderre likewise insisted that victims of vaccination were everywhere. His writings included pages of individuals whom he believed were sickened or killed by the vaccine, either from contracting smallpox or some other malady such as gangrene and syphilis.

And then, of course, they spouted conspiracy theories. Provaccination doctors were accused of profiting from the practice, as Ross broadcast in his poster. One French Canadian doctor, in an open letter to Coderre published by the medical journal L’Union Médicale du Canada in 1875, laid out the same charge. He also perceived another conspiracy among English physicians in particular, attributing their advocacy of the smallpox vaccine to nationalistic conflicts of interest given that English physician Jenner was associated with it. Coderre replied in agreement, affirming that English doctors and public vaccinators practiced vaccination par intérêt — purely out of self-interest. These beliefs were consistent with a general distrust of the Anglophone elite, whose vaccines were seen as both poisoning and punishing the French Canadian community, which mostly lived in overcrowded tenements in the poorest quarters of the city.

Their arguments are reminiscent of misinformation during subsequent epidemics and pandemics, all the way up to the present. It’s also noteworthy that while Ross thought sanitation was the answer to smallpox, Francophone newspapers printed recipes for at-home remedies, such as buckwheat root or mixtures of zinc sulfate, digitalis, and sugar. (A cure was never found for smallpox before its eradication, and treatments generally consisted of cleaning the wounds and easing the pain of the ill.) These ideas are akin to the popularization in the United States of non-FDA-approved treatments for COVID-19, such as ivermectin (an antiparasitic agent used to treat patients with certain worm infections and head lice) and hydroxychloroquine (a medication used for malaria and autoimmune conditions such as lupus and rheumatoid arthritis), which many people learned about through the internet, social media, and celebrity testimonials. Despite early hopes, neither of them turned out to be effective for preventing or treating COVID-19. But without any specific treatments for COVID-19 until long into the pandemic, it’s not surprising that some patients opted to take risks with these unproven remedies rather than heed public health warnings against them. Some physicians even participated in misinformation about the efficacy of these drugs and continued to prescribe them for COVID-19. And although many studies haven’t observed that ivermectin and hydroxychloroquine cause serious adverse effects in COVID-19 patients, they can still be dangerous if the patients forgo evidence-based COVID-19 treatments or vaccination against SARS-CoV-2 as a result of using them, as editors at the Journal of the American Medical Association pointed out last year.

To be fair, smallpox vaccination was far from perfectly safe in the late 19th century. Even Jenner himself couldn’t explain how his vaccine worked, and some methods (such as passing infectious material directly from the arm of a vaccinated person to an unvaccinated one) undoubtedly had the potential to introduce other infections. There were also some cases where children may have died as a result of faulty vaccine preparations. Furthermore, even if the vaccination was successful, it didn’t guarantee complete or lifelong immunity. Antivaccinationists, though, were incorrect about the risks and effects of the vaccine. And their dishonesty, at least in the case of Ross, raised questions about their own motives.

One State Board of Health report called him “a monster in human form who desired that a most terrible disease should decimate his patrons, that he might grow fat on their putrid bodies.”

Ross, the bombastic pamphleteer, was apparently a hypocrite at heart. In October 1885, while the smallpox epidemic was still raging in Montreal, he boarded a train to Toronto. As reported afterward by the Gazette, a medical inspector at the Ontario border asked Ross to show proof of recent smallpox vaccination, either in the form of a certificate or scar. It was a standard policy for travelers, but Ross tried his best to get out of it. Then when he couldn’t produce a certificate, he reluctantly took off his coat, rolled off his sleeve, and revealed “three perfect vaccination marks” on his arm. One of them was relatively fresh, and the others were from infancy and childhood, according to Ross. The article about the incident offered little by way of commentary, except to note the long history of doctors who believed in the efficacy of vaccination but opposed the practice since they would lose a source of revenue if smallpox declined. (Similarly, during the COVID-19 pandemic, the Fox News channel was a top broadcaster of vaccine skepticism in the United States, even though nearly all of the corporation’s employees were vaccinated.)

The news about Ross reached the United States, where it was met with outrage among the public health community. One State Board of Health report called him “a monster in human form who desired that a most terrible disease should decimate his patrons, that he might grow fat on their putrid bodies.”

By the end of the smallpox epidemic in Montreal in 1886, more than 3,200 people had died from the disease. The city lost almost 2 percent of its total population in 1885 alone, and more than 3 percent of its French Canadian community. Most of them were children. There were numerous blunders that helped the disease spread, as historian Michael Bliss recounts in his book “Plague: How Smallpox Devastated Montreal,” and the large population of unvaccinated children created by fear and ignorance was a major factor. Every one of the deaths could have been prevented, Bliss emphasizes. Unfortunately, it wasn’t until the disease ran out of unvaccinated or otherwise vulnerable hosts that the epidemic finally waned.

Misinformation about diseases is a timeless human challenge. Some opinions offered about the antivaccination riot in Montreal, such as in a New York Times editorial in 1875, ring a bell 150 years later. With shock that anyone would harbor such an absurd preconception against vaccination, a triumph of modern medicine, the editorial lamented that “in spite of all our boasted progress, curious revelations of popular ignorance and superstition are constantly showing us how little progress has been made.” But after laying blame on the fortune tellers in large cities, the quacks in medicine that flourished everywhere, and even the scientific research and scholarly writings that went above the heads of the public, there was still optimism: “When knowledge is more evenly distributed, there will be less of this fantastic and ignorant prejudice.”

Evenly distributed knowledge? That sounds a lot like the internet to me.


Sabrina Sholts is the curator of biological anthropology at the Smithsonian’s National Museum of Natural History, where she developed the major exhibit “Outbreak: Epidemics in a Connected World.” She is the author of “The Human Disease,” from which this article is excerpted.

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The world’s first successful limb re-attachment is a fascinating story of science and human ingenuity https://www.popsci.com/health/first-limb-re-attachment/ Mon, 22 Apr 2024 20:38:00 +0000 https://www.popsci.com/?p=611551
photo of young boy on an illustrated backdrop with the words "The boy who lost his arm--and got it back"
In the November 1962 issue of 'Popular Science,' Eddy's story was told in a double-length feature. Popular Science

A team of doctors did something in real life that had only ever existed in mythology and science fiction.

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photo of young boy on an illustrated backdrop with the words "The boy who lost his arm--and got it back"
In the November 1962 issue of 'Popular Science,' Eddy's story was told in a double-length feature. Popular Science

On May 23, 1962, 12-year-old little league pitcher Everette “Eddy” Woodrow Knowles III survived a traumatic accident that would change the medical world.

On that sunny spring day in the Boston suburb of Somerville, Eddy was trainhopping—hitching a ride by gripping the side of a moving train car—when his arm was torn from his body right below the shoulder. Eddy couldn’t remember the details of exactly what happened, but a local store clerk named Alice Chmielewski jumped into action, applying pressure to the wound while another bystander phoned emergency services. In just seven minutes, he arrived at Massachusetts General Hospital where the medical team attempted something unprecedented and more than 30,000 years in the making.

In the latest Popular Science video, we tell the incredible story of what happened next and how everything aligned perfectly to make history.

The world’s first successful limb re-attachment is a fascinating story of science and human ingenuity

Want more Popular Science videos? Check out “The revolutionary toy technology of ‘Captain Power’ that time forgot” and “The Buried Treasure That Took Us To The Moon.” And don’t forget to subscribe on YouTube.

The post The world’s first successful limb re-attachment is a fascinating story of science and human ingenuity appeared first on Popular Science.

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Should you take vitamin D? Here’s the science https://www.popsci.com/health/should-you-take-vitamin-d-how-much/ Sun, 21 Apr 2024 16:00:00 +0000 https://www.popsci.com/?p=611734
Vitamin D capsule in the sun
Determining who needs vitamin D supplements, and how much, is complicated. DepositPhotos

Some people take too much, and too many get too little. Experts explain who needs D supplements, and why.

The post Should you take vitamin D? Here’s the science appeared first on Popular Science.

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Vitamin D capsule in the sun
Determining who needs vitamin D supplements, and how much, is complicated. DepositPhotos

This article was originally featured on Knowable Magazine.

Nutritional science is supposed to chart a course to our healthier selves. But contradictory scientific results and interpretations can muddy the waters—and few nutrients have recently demonstrated that more clearly than vitamin D.

At one point, it seemed that everyone should be taking vitamin D supplements, and that doing so would protect against a whole host of maladies, from bone problems to heart disease and cancer. More recently, new studies appear to have debunked many of those claims.

But a closer look at the research reveals a more nuanced message around vitamin D supplements: They can be key to correcting deficiencies, though people who already have enough—which is most of the American public—are generally unlikely to see benefits from taking large doses. Experts have come to worry about supplement enthusiasts overdosing in the belief that more is better or, at the other extreme, some nutrient-deprived people shunning them altogether.

Ultimately, says Roger Bouillon, an endocrinologist at KU Leuven in Belgium, “it’s like for most things. You need an optimal amount: not too little, not too much.”

Yet working out who needs vitamin D supplements, how much, and what the specific health benefits are, remains tricky, with questions remaining. Here’s some of what we know.

What does vitamin D do, and where does it come from?

The importance of vitamin D came to light at the start of the Industrial Revolution in the late 1700s, when people in northern climes crowded in dark, polluted cities and spent more time working indoors. The majority of children in cities like Boston developed rickets, wherein bones soften, weaken and often deform.

Scientists eventually discovered that exposure to sunlight would cure and prevent the disease. Later, researchers learned that UV light from the Sun kick-starts a reaction that generates vitamin D. The vitamin gets converted into its active form in the kidneys and then is shuttled to the intestine, where it stimulates cells to move calcium, a key building block of bones, into the bloodstream. “The most important thing vitamin D does is intestinal calcium absorption,” says Sylvia Christakos, a biochemist at Rutgers New Jersey Medical School.

Though the effects are most severe in children, vitamin D deficiencies can also cause a softening of adult bones called osteomalacia, and increase the risk of osteoporosis, where bones become weak, brittle and more prone to fractures. Though experts debate what exactly constitutes a vitamin D deficiency—and know that healthy levels may vary from person to person—everyone agrees that blood levels should not go below 12 nanograms per milliliter to avoid severe deficiency.

Such severe deficiencies—and the bone ailments they cause—are still rampant across the world. Surprisingly, more than 30 percent of people in some sunny Middle Eastern countries are severely deficient, which may be partly attributed to skin-covering traditional clothing. By contrast, in Finland, a sun-deprived country with dark winters, severe deficiencies are relatively rare, thanks to government policies to fortify dairy products with extra vitamin D.

In contrast, around 20 percent of the United Kingdom’s population is severely deficient by some estimates, due to its northern, cloudy weather and a lack of fortified foods. The United States, where many dairy products, and some juices and breakfast cereals, are fortified, falls somewhere in the middle: Around 6 percent of people are severely deficient. “For the most part in the US, we don’t see frank nutrient deficiencies,” says Regan Bailey, a nutrition expert at Texas A&M University who recently coauthored a review on supplement use among the public in the Annual Review of Nutrition. (Some research groups have produced much larger deficiency estimates by using blood level thresholds that many experts say are too high to qualify as nutrient deficiencies.)

Since 2010, the National Academy of Medicine has recommended relatively modest daily doses: 400 international units (IUs) for babies, 600 IUs for everyone up to age 70 and 800 IUs for older people. These doses are designed to achieve levels of 20 nanograms per milliliter—more than enough to avoid severe deficiencies—for otherwise healthy people in the United States.

Most people should be able to get these doses through brief sun exposure, says John Christopher Gallagher, an endocrinologist at Creighton University in Omaha, Nebraska. Measuring vitamin D production in the skin is not an exact science, but five to 10 minutes’ daily exposure without sunblock of just the face, neck, hands and arms should do the trick in the sunnier months, even in temperate places like Boston. While it’s entirely possible to get enough vitamin D this way, the official stance of the American Academy of Dermatology is to not get vitamin D from sun exposure.

Fortified dairy products and other foods will also provide enough. Foods that naturally contain vitamin D, such as fatty fish, egg yolks, red meat, liver and irradiated or sun-dried mushrooms, which are especially rich in vitamin D due to their increased exposure to UV light, can also help. “If you’re out and about and you have sun exposure during some months of the year,” Gallagher says, “you probably get plenty of vitamin D.” That’s especially true if you have enough dairy in your diet.

A few common food items can deliver a significant portion of your daily vitamin D needs, either because they are naturally rich in it or because they are fortified with the vitamin. Credit: Knowable Magazine
A few common food items can deliver a significant portion of your daily vitamin D needs, either because they are naturally rich in it or because they are fortified with the vitamin. Credit: Knowable Magazine

Does anyone need supplements?

Generally, people need supplements only when they’re not likely to get enough from natural or dietary sources, health experts say. Deficiency-prone populations include breastfed infants who don’t get fortified formula, elderly people (whose skin makes vitamin D less efficiently) and pregnant women. People with dark skin tones should also take care to get sufficient vitamin D, because melanin pigmentation in the skin blocks UV light. People in northern latitudes like England “should all take a supplement during the winter,” adds nutritional scientist Susan Lanham-New of the University of Surrey in the UK, although that’s less important in places like the United States that have food fortification.

Experts worry that it’s often the people already getting enough vitamin D through diet and lifestyle who are the most likely to take supplements, Christakos notes. Meanwhile, communities who need vitamin D supplements the most might not realize their need and may have read news reports suggesting that the supplements aren’t necessary.

That’s an especially dangerous message in countries where deficiencies are common—for instance in the UK, where physicians still see children with deficiency-related ailments, says Martin Hewison, a molecular endocrinologist at the University of Birmingham in that country. One of his UK colleagues is struggling to persuade some of her vitamin D-deficient patients to take supplements because they believe it is a waste of time.

For anyone concerned that they’re not getting enough vitamin D, experts say that up to 1,000 IUs a day would more than suffice. If possible, Lanham-New adds, make sure it’s vitamin D3, a version typically extracted from sheep wool that appears to be better at raising vitamin D blood levels than D2, which is often vegan and mushroom-based.

But avoid the high doses—of 5,000, 10,000 or 20,000 IUs, or even higher—that can be found in drugstores or online, stresses JoAnn Manson, an endocrinologist and epidemiologist at Brigham and Women’s Hospital and Harvard Medical School. Too much vitamin D, even when taken occasionally, can sometimes cause bone health to deteriorate and lead to an overdose of calcium in the blood and urine, resulting in nausea and even kidney failure. There are reports of people in the UK and US ending up in the hospital after taking excessive doses.

Some experts have advised that Black Americans, in particular, take higher doses of supplements—for instance, 2,500 IUs—as they’re especially prone to low levels. But here’s a mystery: Even though 17.5 percent of African Americans have deficient levels of vitamin D, those vitamin-deficient Blacks tend to have better bone health than comparably deficient white Americans, notes biomedical scientist LaVerne Brown of the National Institutes of Health. It’s possible, she says, that African Americans need less vitamin D than other populations, perhaps because they’re better at metabolizing vitamin D to its final active form. If that’s true, then high doses may have a greater risk of causing harm in African Americans.

“We just don’t have the studies that are focusing on these populations in order to come up with definitive answers,” Brown says. In the meantime, an expert panel meeting in 2017 concluded that the current recommended intake should be enough for African Americans, the same as everyone else. “Anything above 800 IU, it’s not clear that there’s a real need for that,” Brown says.

Could higher doses have benefits?

More than two decades ago, scientists began to make observations suggesting that vitamin D at higher doses could have benefits beyond bone health. Dozens of studies described strong correlations between people’s vitamin D levels and a range of diseases like cardiovascular disease, type 2 diabetes and certain cancers. The lower someone’s vitamin D levels were, the likelier they were to have these diseases, while higher levels were associated with being healthier.

Other research showed that many cell types—in the lungs, heart and immune system—have receptors for the vitamin to dock onto, hinting at far-reaching effects across the body. Giving vitamin D to lab mice with conditions mimicking human diseases could often improve their ailments. Vitamin D, it seemed, might help to tackle the major diseases of our time.

From New Zealand to Europe to North America, scientists launched large clinical trials, enrolling thousands of people over multiple years, to test whether vitamin D supplements would decrease their risk of disease. Importantly, the studies focused on members of the general public, who were largely healthy and had adequate levels of vitamin D. These people then received relatively large doses, of 2,000 or 4,000 IUs or even higher. The studies asked whether there were benefits from getting more than the recommended dietary allowance and ending up with blood levels even higher than 20 or 30 nanograms per milliliter, Manson explains.

To the disappointment of many scientists, giving these generous doses to healthy people didn’t change their risk of developing cancer, heart disease or asthma, nor did it significantly prevent the progression to type 2 diabetes. Extra vitamin D beyond the recommended levels didn’t even do anything to improve bone health or reduce the risk of fractures.

Experts recommend relatively modest daily doses of vitamin D supplements. Credit: Knowable Magazine
Experts recommend relatively modest daily doses of vitamin D supplements. Credit: Knowable Magazine

There may be a simple biological reason why more vitamin D isn’t necessarily better: The version of vitamin D found in supplements needs to be converted in the liver and kidneys to reach its final, active form—and that process is probably tightly controlled, says Bouillon. “The body regulates that so you have the exact amount, and not more than what you need.”

The takeaway, many experts agree, is that most healthy people aren’t going to benefit from high doses of vitamin D if they already have enough. The tantalizing associations that led researchers to suspect additional powers of vitamin D could have been an illusion: People with illnesses may end up with lower vitamin D levels because of the diseases themselves, or the unhealthy lifestyles that caused them, says Bouillon.

Are larger doses ever helpful?

A few of the recent trials hinted that some groups of people may benefit from higher doses, but these possible benefits need to be confirmed in further studies, says Manson, who ran one of the trials, called VITAL, which studied nearly 26,000 US adults over five years and looked at supplements of 2,000 IUs of vitamin D as well as omega-3 fatty acids. In that study, participants didn’t have a lower risk of developing cancer but they did have a 25 percent lower chance of it metastasizing or becoming fatal. Perhaps, says Manson, vitamin D makes tumors less likely to metastasize and kill. VITAL also reported that high doses of vitamin D made people less likely to develop certain autoimmune conditions like rheumatoid arthritis, psoriasis and lupus.

Manson notes that these benefits appeared to be most visible among people with a healthy weight, compared to overweight or obese participants. But she cautions that more research is needed to understand these observations and confirm the observed benefits of larger doses.

Physicians in clinical practice, of course, have leeway in prescribing higher doses to certain people as they see fit, such as for osteoporosis patients, or people with conditions that hamper the absorption of vitamin D through the diet, like Crohn’s disease and ulcerative colitis.

What don’t we know yet?

As they probe potential effects of higher doses in non-deficient people, researchers still don’t know how many roles vitamin D might have. The trouble is that recent trials don’t tell us whether having enough vitamin D is important for maintaining healthy heart function or avoiding cancer, for instance—only that having more than that won’t help in most cases.

To prove that adequate vitamin D has health benefits beyond keeping bones strong, scientists need more research in which some deficient people receive supplements and the rest receive a placebo. But such studies are hard to conduct in places like the US, where severe deficiencies are relatively rare. It’s also not ethically justifiable to seek out people who are deficient and then deprive half of them of much-needed supplements, because of the risk of poor bone health in vitamin D-deficient people.

Some scientists believe that having enough vitamin D could be key to maintaining heart and immune system health and preventing diabetes and cancer—and perhaps even be important for brain function, athletic performance and other claims. The evidence is particularly strong in the immune system, says Hewison, whose research points to key roles of vitamin D in immune cells; and indeed, human trials that by chance included some deficient people show benefits of supplementation in warding off infections.

But there just aren’t enough data yet, Hewison says. “I think this is the issue facing the field as a whole.”

This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.

Editor’s note: This story was updated on April 23, 2024, to correct editorial style for identifying racial groups.

The post Should you take vitamin D? Here’s the science appeared first on Popular Science.

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Amazon has a bulk snack sale going on just in time for 4/20 https://www.popsci.com/health/amazon-420-bulk-snack-sale/ Sat, 20 Apr 2024 14:00:00 +0000 https://www.popsci.com/?p=611790
An ice cream sandwich made between two cookies with sprinkles on the outside close-up
Amazon

Save on Red Bull, Barilla pasta, Animal Crackers, Perfect Bars, Kodiak Cakes, and more. This is a solid chance to stock up.

The post Amazon has a bulk snack sale going on just in time for 4/20 appeared first on Popular Science.

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An ice cream sandwich made between two cookies with sprinkles on the outside close-up
Amazon

Groceries are expensive right now, which means a bad case of the munchies can really set you back. That’s bad timing for this 4/20 holiday, which typically involves copious snack consumption. Amazon, however, has decided to be a chill bro and put a bunch of bulk snacks on discount. Even if you’re not doing any 4/20 celebrating, you can appreciate saving a couple bucks on a case of Red Bull, a doomsday-worthy cache of Fig Newtons, and enough Goldfish Crackers to satisfy an entire Kindergarten class for an entire day (those little ones really hammer down the Goldfish). These aren’t wimpy deals, either. Most of these prices are the lowest we’ve seen all year.

The post Amazon has a bulk snack sale going on just in time for 4/20 appeared first on Popular Science.

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Why do some people always get lost? https://www.popsci.com/science/why-do-some-people-always-get-lost/ Tue, 16 Apr 2024 12:00:00 +0000 https://www.popsci.com/?p=611081
getting lost
Scientists are homing in on how navigation skills develop. Knowable Magazine

Research suggests that experience may matter more than innate ability when it comes to a sense of direction.

The post Why do some people always get lost? appeared first on Popular Science.

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getting lost
Scientists are homing in on how navigation skills develop. Knowable Magazine

This article was originally featured on Knowable Magazine.

Like many of the researchers who study how people find their way from place to place, David Uttal is a poor navigator. “When I was 13 years old, I got lost on a Boy Scout hike, and I was lost for two and a half days,” recalls the Northwestern University cognitive scientist. And he’s still bad at finding his way around.

The world is full of people like Uttal—and their opposites, the folks who always seem to know exactly where they are and how to get where they want to go. Scientists sometimes measure navigational ability by asking someone to point toward an out-of-sight location—or, more challenging, to imagine they are someplace else and point in the direction of a third location—and it’s immediately obvious that some people are better at it than others.

“People are never perfect, but they can be as accurate as single-digit degrees off, which is incredibly accurate,” says Nora Newcombe, a cognitive psychologist at Temple University who coauthored a look at how navigational ability develops in the 2022 Annual Review of Developmental Psychology. But others, when asked to indicate the target’s direction, seem to point at random. “They have literally no idea where it is.”

While it’s easy to show that people differ in navigational ability, it has proved much harder for scientists to explain why. There’s new excitement brewing in the navigation research world, though. By leveraging technologies such as virtual reality and GPS tracking, scientists have been able to watch hundreds, sometimes even millions, of people trying to find their way through complex spaces, and to measure how well they do. Though there’s still much to learn, the research suggests that to some extent, navigation skills are shaped by upbringing.

Nurturing navigation skills

The importance of a person’s environment is underscored by a recent look at the role of genetics in navigation. In 2020, Margherita Malanchini, a developmental psychologist at Queen Mary University of London, and her colleagues compared the performance of more than 2,600 identical and nonidentical twins as they navigated through a virtual environment, to test whether navigational ability runs in families. It does, they found—but only modestly. Instead, the biggest contributor to people’s performance was what geneticists call the “nonshared environment”—that is, the unique experiences each person accumulates as their life unfolds. Good navigators, it appears, are mostly made, not born.

A remarkable, large-scale experiment led by Hugo Spiers, a cognitive neuroscientist at University College London, gave researchers a glimpse at how experience and other cultural factors might influence wayfinding skills. Spiers and his colleagues, in collaboration with the telecom company T-Mobile, developed a game for cellphones and tablets, Sea Hero Quest, in which players navigate by boat through a virtual environment to locate a series of checkpoints. The game app asked participants to provide basic demographic data, and nearly 4 million worldwide did so. (The app is no longer accepting new participants except by invitation of researchers.)

Through the app, the researchers were able to measure wayfinding ability by the total distance each player traveled to reach all the checkpoints. After completing some levels of the game, players also had to shoot a flare back toward their point of origin—a dead-reckoning test analogous to the pointing-to-out-of-sight-locations task. Then Spiers and his colleagues could compare players’ performance to the demographic data.

Several cultural factors were associated with wayfinding skills, they found. People from Nordic countries tended to be slightly better navigators, perhaps because the sport of orienteering, which combines cross-country running and navigation, is popular in those countries. Country folk did better, on average, than people from cities. And among city-dwellers, those from cities with more chaotic street networks such as those in the older parts of European cities did better than those from cities like Chicago, where the streets form a regular grid, perhaps because residents of grid cities don’t need to build such complex mental maps.

Results like these suggest that an individual’s life experience may be one of the biggest determinants of how well they navigate. Indeed, experience may even underlie one of the most consistent findings—and clichés—in navigation: that men tend to perform better than women. Turns out this gender gap is more a question of culture and experience than of innate ability.

Nordic countries, for example, where gender equality is greatest, show almost no gender difference in navigation. In contrast, men far outperform women in places where women face cultural restrictions on exploring their environment on their own, such as Middle Eastern countries.

This cultural aspect, and the importance of experience, are also supported by studies of the Tsimane, a traditional Indigenous community in the Bolivian Amazon. Anthropologist Helen Elizabeth Davis of Arizona State University and her colleagues put GPS trackers on 305 Tsimane adults to measure their daily movements over a three-day period, and found no difference in the distance moved by men and women. Men and women also were equally adept at pointing to out-of-sight locations, they reported in Topics in Cognitive Science. Even children performed extremely well at this navigation task—a result, Davis thinks, of growing up in a culture that encourages children to range widely and explore the forest.

Most cultures aren’t like the Tsimane, though, and women and girls tend to be more cautious about exploring, for good reasons of personal safety. Not only do they gather less experience at navigating, but nervousness about security or getting lost also has a direct effect on navigation. “Anxiety gets in the way of good navigation, so if you’re worried about your personal safety, you’re a poor navigator,” says Newcombe.

The Santa Barbara Sense of Direction Scale is widely used in navigation research. Studies suggest that people are fairly accurate at evaluating their own sense of direction. Credit: Knowable Magazine
The Santa Barbara Sense of Direction Scale is widely used in navigation research. Studies suggest that people are fairly accurate at evaluating their own sense of direction. Credit: Knowable Magazine

Personality, too, appears to play a role in developing navigational ability. “To get good at navigating, you have to be willing to explore,” says Uttal. “Some people do not enjoy the experience of wandering, and others enjoy it very much.”

Indeed, people who enjoy outdoor activities, such as hiking and biking, tend to have a better sense of direction, notes Mary Hegarty, a cognitive psychologist at the University of California, Santa Barbara. So do people who play a lot of video games, many of which involve exploring virtual spaces.

To Uttal, this accumulating evidence suggests that inclination and early experience nudge some people toward activities that involve navigation, while those who are temperamentally less inclined to explore, who have less opportunity to wander or who have an initial bad experience may be less likely to engage in activities that require exploration. It all snowballs from there, Uttal speculates. “I think a combination of personality and ability pushes you in certain directions. It’s a developmental cascade.”

Mental mappers

That cascade presumably influences acquisition of the specific skills that are hallmarks of good navigators. These include the ability to estimate how far you’ve traveled, to read and remember maps (both printed and mental), to learn routes based on a sequence of landmarks and to understand where points are relative to one another.

Much of the research, though, has focused on two specific subskills: route-following by using landmarks—for example, turn left at the gas station, then go three blocks and turn right just past the red house—and what’s often termed “survey knowledge,” the ability to build and consult a mental map of a place.

Of the two, route following is by far the easier task, and most people do pretty well at it once they’ve taken a route a few times, says Dan Montello, a geographer and psychologist also at UC Santa Barbara. In a classic experiment from almost two decades ago, Montello’s student Toru Ishikawa drove 24 volunteers, once a week for 10 weeks, on two twisting routes in a tony residential area of Santa Barbara that they’d never visited before.

Later, almost every person could accurately state the order of landmarks along each route and roughly estimate the distance travelled between them. But they varied widely in their ability to identify shortcuts between the two routes, point to landmarks not visible from where they stood, or sketch a map of the routes. Those who couldn’t identify shortcuts or find landmarks may suffer from an inability to create accurate mental maps, the researchers think.

Research by Newcombe and her then graduate student Steven Weisberg underscores the importance of such mental maps in navigation. They asked 294 volunteers to use a mouse and computer screen to navigate along two routes through a virtual town. Once the volunteers had learned the routes and the landmarks they contained, the researchers asked them to stand at one landmark and point to others on both routes.

People fell into three classes, the researchers reported in 2018 in Current Directions in Psychological Science. Some people had formed a good mental map: They could point accurately to landmarks on both the same and different routes. Others had good route knowledge but struggled to create an integrated map: They were good at pointing within a route, but poor between routes. A third group was poor at all the pointing tasks.

That ability to build and refer to a mental map—a person’s survey knowledge—goes a long way toward explaining why they’re better navigators, Montello says. “When the only skill you have is the ability to think in terms of routes, you can’t be creative to get around barriers.” Survey knowledge gives the ability to navigate creatively, he says. “That’s a pretty stunning difference.”

Not surprisingly, better navigators may also be better at switching modes and choosing the most appropriate navigational strategy for the situation they find themselves in, says cognitive neuroscientist Weisberg, now at the University of Florida. This could mean using landmarks when they are obvious and mental maps when more sophisticated calculations are needed.

“I’ve moved toward thinking that our better navigators are also using a lot of alternate strategies,” Weisberg says. “And they’re doing so in a much more flexible way that affords different kinds of navigation, so that when they find themselves in a new situation, they’re better able to find their way.”

When Weisberg moves around Gainesville where he lives now, for example, he keeps track of north, because that works well in a city with a regular street grid; when he goes home to the winding streets of Philadelphia, he relies more on other cues to stay oriented.

Researchers do not yet know whether every bad navigator is simply poor at survey knowledge, or whether some of the lost might be failing at other navigational subskills instead, such as remembering landmarks or estimating distance traveled. Either way, what can poor navigators do to improve? That’s still an open question. “We all have our pet theories,” says Elizabeth Chrastil, a cognitive neuroscientist at the University of California, Irvine, “but they haven’t reached the level of testing yet.”

Pros and cons of GPS

Simply practicing seems like it should work—and, indeed, it does in lab experiments. “We can improve people’s navigational abilities in virtual environments,” says Arne Ekstrom, a cognitive neuroscientist at the University of Arizona. It takes about two weeks to show fairly dramatic gains—but it’s not yet clear whether people are really becoming better navigators or just getting better at finding their way through the particular virtual environments used in the experiments.

Support for the notion that people might improve with practice also comes from studies of what happens when people stop using their navigation skills. In a 2020 study published in Scientific Reports, for example, neuroscientists Louisa Dahmani and Véronique Bohbot of McGill University in Montreal recruited 50 young adults and questioned them about their lifetime experience of driving with GPS. Then they tested the volunteers in a virtual world that required them to navigate without GPS. The heaviest GPS users did worse, they found.

A follow-up with 13 of the volunteers three years later revealed that those who had used GPS the most during the intervening period experienced greater declines in their ability to navigate without GPS, strongly suggesting that GPS reliance causes diminished skills, rather than poor skills leading to greater GPS use.

Experts also suggest that struggling navigators like Uttal could try paying closer attention to compass directions or prominent landmarks as a way to integrate their movements into a mental map. For Weisberg, the only way he learns spaces in an integrated way is by paying attention to major cardinal directions or prominent landmarks like the ocean. “The more attention I pay, the better I can link things to the map in my head.” He recommends that struggling navigators ask themselves which way is north 10 times a day, referring to a map if necessary. This, he suggests, could help them move beyond mere route knowledge.

There’s another option for those who don’t really care about improving their skills as long as they just don’t get lost, Weisberg notes: Just make sure your GPS is handy.

This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.

The post Why do some people always get lost? appeared first on Popular Science.

Articles may contain affiliate links which enable us to share in the revenue of any purchases made.

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Are you wearing the right sunglasses? How to prevent eye sunburn. https://www.popsci.com/diy/eye-sunburn/ Sun, 14 Apr 2024 17:28:00 +0000 https://www.popsci.com/?p=610803
Dog sitting in nature in sunglasses
Start with proper eyewear. DepositPhotos

Optometrists share expert tips for avoiding sunburned eyes this summer.

The post Are you wearing the right sunglasses? How to prevent eye sunburn. appeared first on Popular Science.

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Dog sitting in nature in sunglasses
Start with proper eyewear. DepositPhotos

As a child, you were probably told not to stare directly at the sun. If you weren’t told or refused to listen, you may have learned the hard way. The human eye is one of the most sensitive structures in the body. Even a few seconds of direct sun exposure can dry out the eyes and temporarily blind you. That said, just because you’re not staring directly doesn’t mean you’re immune to the sun’s UV rays. It is entirely possible to get a sunburn on your eyes. 

You should always take some precautionary measures when venturing outside, especially as we approach summer’s longer days and more intense sunshine. We asked optometrists to break down how to best protect your eyes from the sun.

Why do the eyes sunburn easily?

The sun can damage your eyes in two different ways. The most common is a sunburn to the front part of the eye, also known as photokeratitis. Catherine Heyman, the founding dean at the High Point University School of Optometry in North Carolina, says photokeratitis happens when the sun’s UV rays damage the cornea. This clear, thin layer covers your iris and pupil. Excessive exposure to the sun also temporarily injures the conjunctiva, a mucous membrane that covers the white part of your eye. 

illustration of eyeball anatomy
Diagram of human eye anatomy. Image: DepositPhotos

People with photokeratitis usually experience pain that’s akin to the feeling of having sand in your eye. They also frequently report redness, sensitivity to bright light, and blurry vision. Additionally, the eyelids appear swollen. While discomforting, the symptoms are temporary. Heyman says the cornea heals fast, with symptoms resolving in about 24 hours.

Another way the sun can hurt your eyes is when UV rays damage the retina. The retina is the layer of tissue at the back of your eye that catches light throughout the day, which is then converted into electrical signals for your brain to process vision. Jessilin Quint, a member of the American Optometric Association and co-owner of Smart Eye Care in Maine, explains that the UV light from the sun is intense. When it is too concentrated, the UV rays can cause extensive damage to light-sensitive cells housed in the retina. “The UV rays change how those cells behave and when they are not behaving properly, that can permanently cause tissue damage and trigger inflammation.” 

Also known as solar retinopathy, retinal damage occurs when a person stares directly at the sun. Quint explains that damaged light-sensitive cells in the retina tend to be in an area called the macula. The macula handles central vision, allowing people to see clear shapes and colors. A person with retinal damage commonly reports distorted vision or vision loss. 

Depending on how much eye protection a person had on or how long they were sungazing, Quint says there is a small chance for some cells to regenerate, but usually, retinal damage is permanent. This is because the retina does not carry pain receptors. People may not realize they are hurting their eyes at the moment and continue to sungaze for a few seconds to a few minutes. The aftereffects occur hours after the time of injury or after a couple of days.

How to protect the eyes from the sun’s UV rays

Purchase UV-blocking sunglasses

To avoid sunburn, buy a pair of sunglasses that 100 percent block UVA and UVB rays. Both ultraviolet rays are linked to skin burning. Heyman says you’re going to want to have sunglasses on whenever you’re outside in the daytime. Additionally, you’ll want to have your shades on for activities such as surfing, boating, and skiing, as the water and snow reflect the sun’s UV radiation. If you’re going to be in the sun for long periods of time, wraparound sunglasses are another option for protecting the entire face from the sun’s glare. 

“Putting on sunglasses without UV protection is worse than not having any glasses at all.”

Not all sunglasses have the same protection against UV rays. Quint says many over-the-counter sunglasses are not regulated and do a poor job of properly filtering light. These sunglasses enlarge your pupils when it is dark, allowing more light to enter and potentially hurting your retina. “It’s like when you have your eyes dilated at the optometrist,” adds Heyman. “Putting on sunglasses without UV protection is worse than not having any glasses at all.”

While polarized sunglasses do a better job of shielding the eyes from the sun, the best sunglasses are the ones that can completely block out UVA and UVB rays. You can order prescription sunglasses or check for stickers on over-the-counter sunglasses that specifically say they block both UV rays. If you’re unsure or have an old pair at home, you can take them to your local optometrist, who can assess if they cover UV radiation or not.

Stay in the shade

Another precaution to take is staying in the shade as much as possible. The sun’s rays are the strongest between 10 in the morning and four in the afternoon. Even when it’s cloudy outside, Heyman says UV rays can penetrate through and cause a minor sunburn.

Apply sunscreen to the eyelids

If you’re outside in the sun, apply sunscreen to your eyelids. “If you look at the percentages of skin cancer that happen throughout the body, despite the eyelids having such little surface area compared to the skin of the entire body, it has a much higher percentage of skin cancer,” says Quint. While you want to avoid sunscreen in the eye, cover the entire eyelid with sunscreen, including sunscreen in the narrow corners. You’ll want to reapply sunscreen every couple of hours and much more often if you are doing an activity such as swimming.

There are certain things to look for when purchasing sunscreen. First is using a broad-spectrum sunscreen. The sun protection factor (SPF) number on sunscreen only measures how much it protects against UVB rays. A broad-spectrum sunscreen guards you from UVA and UVB rays. The second is to choose a mineral-based sunscreen, rather than a chemical sunscreen. Quint says some ingredients in chemical sunscreens are harmful to the eyes and can trigger ocular inflammation or dry eye. 

Some makeup brands include sunscreen in their products, but Quint says this does not give enough coverage. “Makeup products will say it has an SPF of a certain amount, and while it’s better than having no SPF, it’s not giving the person the full protection that’s needed.” She recommends starting with a broad-spectrum sunscreen at the base, adding SPF-included makeup or moisturizer, and reapplying sunscreen every few hours. 

What to do when you have sunburned eyes

Pain from a minor sunburn to the eyes can be managed with acetaminophen or other over-the-counter pain relievers. You’ll also want to rest your eyes, which can look like being indoors and keeping your eyes closed or staying in a darkened room. Heyman says that over-the-counter, non-preserved artificial tears can help with dryness and irritation. Additionally, adding a cold compress to the eyes can reduce inflammation and help you avoid rubbing the eyes. If you need to go out, you’ll want to wear sunglasses to avoid worsening symptoms. 

If your eye sunburn persists for more than 24 hours, visit your optometrist for medical attention.

The post Are you wearing the right sunglasses? How to prevent eye sunburn. appeared first on Popular Science.

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3 marketing myths the supplement industry wants you to swallow https://www.popsci.com/health/3-marketing-myths-the-supplement-industry-wants-you-to-swallow/ Wed, 10 Apr 2024 12:00:26 +0000 https://www.popsci.com/?p=610257
supplements on a spoon
They act kind of like drugs, but they aren’t regulated like them. DepositPhotos

The supplement industry likes to capitalize on the idea that ‘doing something is better than doing nothing’ when it comes to your health.

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supplements on a spoon
They act kind of like drugs, but they aren’t regulated like them. DepositPhotos

This article was originally featured on The Conversation.

Americans seem to have quite a positive view of dietary supplements. According to a 2023 survey, 74% of U.S. adults take vitamins, prebiotics and the like.

The business of supplements is booming, and with all the hype around them, it’s easy to forget what they actually are: substances that can powerfully affect the body and your health, yet aren’t regulated like drugs are. They’re regulated more like food.

Thanks in large part to a 1994 law, the Food and Drug Administration is essentially toothless when it comes to supplements. As the agency acknowledges: “FDA does not have the authority to approve dietary supplements before they are marketed. Companies can sell supplements without going through any sort of approval process, or even having to share safety evidence.”

As a research faculty member in graduate medical education, I’m responsible for teaching resident physicians how to understand and critically engage with health research. I also write about healthwellness and supplements for a broader audience. As a result, I spend a lot of time thinking about supplements.

It’s important to consider why so many people believe supplements can help them lead a healthier life. While there are many reasons, how supplements are marketed is undeniably an important one. In my years following the industry, I’ve found that three mistaken assumptions appear over and over in supplement marketing.

1. The appeal to nature fallacy

The appeal to nature fallacy occurs when you assume that because something is “natural” it must be good. The word natural is used a lot in the marketing of supplements. In the context of health, it often feels right to want natural medicine, remedies, prevention techniques and so forth.

For example, if I say “vitamin C,” what do you immediately think of? Probably oranges or citrus in general and flu prevention. But if I say “the flu shot,” what immediately comes to mind? Probably doctor’s offices, a little bit of pain and pharmaceutical companies. One of these is clinically proven to prevent flu infections and lessen the severity of illness. The other has been marketed as though it does those same things, but there’s no clinical evidence to support this.

The supplement industry is awash with brand names that incorporate the word “nature,” invoking the appeal to nature fallacy. Also, look at websites and advertisements that urge customers to forgo “artificial” products in favor of “pure” and “natural nutrition.” Using the word artificial to describe other products and natural to describe a specific supplement is intended to make you feel like that product will be superior to the competition and that you need it to be healthy.

To be clear, “natural” does not equate to “better,” but that’s what the marketing wants you to think.

2. The belief that more of a good thing is always better

There’s another assumption that piggybacks on the appeal to nature fallacy: If something is natural, it must be good, and more of it must also always be better. If a little vitamin C is good for us, then a lot of it must be great!

The truth is that our bodies tightly regulate levels of the vitamins and minerals we consume. If you don’t have a deficiency, consuming more of a particular vitamin or mineral through a supplement won’t necessarily lead to health benefits. That’s why supplement skeptics sometimes say, “You’re just paying for expensive pee”–since your body will excrete the excess.

For an example of the more-is-better myth, look at basically any vitamin C supplement. The packaging often prominently displays dosages that can reach 750 or 1,000 milligrams. But adults need only about 75 to 120 milligrams of vitamin C per day. Similarly, look at vitamin D supplements that can come in dosages of 5,000 IU, or international units–a fact also often prominently displayed on packaging. But adults should have no more than 4,000 IU daily. Again, it’s easy to exceed what we need.

3. The action bias

Finally, the supplement industry likes to capitalize on the idea that doing something is better than doing nothing. This is the action bias. Taking action makes people feel like they have more control of a situation, which is especially powerful when it comes to health. “Even if I don’t need the extra vitamin C,” they might think, “I’ll take it just to be sure. What’s the harm?”

The examples in the last section show that supplements often contain many times the recommended daily intake of a particular vitamin or mineral. This assumes that taking that much of any of those particular substances is safe.

It is possible to have too much of a good thing. Too much vitamin C can lead to diarrhea, nausea, stomach cramps and more. Too much vitamin D can lead to conditions including nausea, vomiting and kidney stones. Supplements can also interact with prescribed medications. For example, St. John’s wort is famous for interacting with contraceptives, immunosuppressive drugs, statins and chemotherapy by exacerbating or dulling their effects. When it comes to supplements, taking them isn’t necessarily better than not.

Be on the lookout for these marketing messages–they aren’t necessarily correct or good for your health. And talk with your doctor before taking any supplements.

The post 3 marketing myths the supplement industry wants you to swallow appeared first on Popular Science.

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The best headphones for working out in 2024, tested and reviewed https://www.popsci.com/gear/best-headphones-for-working-out/ Fri, 17 Mar 2023 21:00:00 +0000 https://www.popsci.com/?p=519976
A lineup of the best headphones for working out on a white background
Amanda Reed

Throw on some of these high-performance audio accessories and load up your perfect soundtrack to take workouts to the next level.

The post The best headphones for working out in 2024, tested and reviewed appeared first on Popular Science.

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A lineup of the best headphones for working out on a white background
Amanda Reed

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Best overall Beats fit pro amazon deal earbuds Apple Beats Fit Pro
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A snug fit, balanced sound, and seamless iOS connectivity make these easy to add to any workout routine.

Best battery life Dark Grey Jabra Elite 8 Active best battery life earbuds for workouts Jabra Elite 8 Active
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These earbuds are extremely impervious to dust and water and feature an amazing combination of ANC performance and battery life.

Best budget A pair of Anker Sport headphones on a blue and white background soundcore by Anker Sport X10
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The soundcore by Anker Sport X10 headphones are great for runners on a budget.

Using headphones for working out can transform your frame of reference and put you in the mood to grind like nothing else. Of course, exercise can be strenuous and involve tons of movement, so it’s essential to find a pair that leaves you unencumbered by wires and fit securely enough that they won’t be flung to the ground every time you move your head. In this list, we’ll break down the best headphones for working out and optimizing your circuit(s) with your favorite music and podcasts.

How we chose the best headphones for working out

The best headphones for working out are wireless, and Bluetooth requires power. And, in all honesty, the best headphones for working out are earphones, which is why they make up the majority of our selections. We picked pairs that offer at least five hours of single-charge battery life, and all of the earbuds include charging cases. Considering the battery life of your audio device is extremely important for keeping the flow going—you wouldn’t want the music to stop mid-workout. All of the selections on our list fit securely around the head or in the ear to ensure that they move very little or not at all during workouts. Everyday headphones made for walking or when you’re stationary aren’t typically designed with extreme movement in mind.

Sound quality was also a big factor in considering headphones for this list, and many of the earbuds we picked either come with a full and balanced sound profile or offer the option to adjust their sound via an app. Staying aware of the activity around you is always important while wearing headphones, especially if you’re on the go. For our list, we picked headphones/earphones that either feature a transparency mode or are completely open-ear.

The best headphones for working out: Reviews & Recommendations

Prepping for a workout is all about getting your mind and body in the right place, and apart from stretching, putting on the right clothes, and making sure you have a favorite water bottle and your fitness tracker, pumping up the jams properly can pump you up for a regular training run. One of our choices is sure to put a spring in your step the next time you go for a jog or lift weights.

Best overall: Apple Beats Fit Pro

Stan Horaczek

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Why it made the cut: The Apple Beats Fit Pro features a snug fit, balanced sound, and seamless iOS connectivity that make them easy to add to any workout routine.

Specs

  • Weight: 0.2 ounces/earbud; 2.3 ounces with case
  • IP rating: IPX4 (splash-resistant)
  • Battery life: 6 hours single-charge; 24 hours with case

Pros

  • High-performance active noise canceling in a compact earbud design
  • Secure design stays in ear when running or working out
  • Compatible with dynamic head tracking on iOS devices
  • Includes pocket-sized travel case and three eartip options

Cons

  • No wireless charging
  • iOS device required for full functionality
  • Not protected against water immersion
  • No multipoint pairing

We’ve thoroughly reviewed the Apple Beats Fit Pro, and they take the best overall award on this list thanks to their sound quality, workout-friendly design, and fantastic iOS compatibility. They contain the same proprietary H1 chip found in Apple’s AirPods, which enables near-instantaneous pairing and steady, reliable connections to iOS devices along with battery life optimization. Like AirPods, the Beats Fit Pro earbuds are also fully compatible with iOS head-tracking and spatial audio features for simulated surround sound and immersive media listening. Their inclusion of active noise cancellation (ANC) and transparency modes make them equally useful on the road and at the gym. We also love the range of colors these buds come in.

The Beats Fit Pro earbuds are designed to sit securely in your ears using small rubber wings that rest comfortably against your outer ear along with three sets of variously sized ear tips. A quick optional setup step uses the earbuds’ onboard microphones to test your fit for sound leaks. Once your optimal fit is achieved, the Beats Fit Pro can endure almost every exercise imaginable, including rowing, without budging. They’re some of the best running headphones around. The earbuds’ conveniently pocked-sized charging case brings their total battery life to around 24 hours. While it would be nice to see wireless charging in a product with this price tag, we appreciate that the case is chargeable via USB-C rather than Apple’s proprietary Lightning connector.

While the Beats Fit Pro earbuds are unmistakably great for iPhone users, it’s unfortunate that the instant pairing and steady connectivity of the earbuds’ H1 chip aren’t extended to Android users. For their price, it would also be nice to see features like multipoint pairing and more robust weatherproofing rather than the same IPX4 rating found in standard AirPods. Still, if you work out regularly and are an iPhone user, you’d be seriously hard-pressed to find a better in-ear option. If you’re sold on the Beats features but are looking for an option with earhooks, the Powerbeats Pro earbuds are also a solid choice.

Best on-ear: JBL Live 670NC

JBL

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Why it made the cut: The JBL Live 670NC boasts full, energetic sound with up to a 65-hour battery life, making them perfect for spur-of-the-moment workouts.

Specs

  • Weight: 9.3 ounces
  • IP rating: N/A
  • Battery life: Up to 65 hours (50 with ANC)

Pros

  • Long-lasting 65-hour battery life
  • Quick charge gives 4 hours operation in 5 minutes
  • Adaptive noise cancelling
  • JBL app offers EQ and other advanced features

Cons

  • Variable fit affects noise cancellation performance
  • Integrated voice assistant button is easy to press accidentally
  • No IP rating

If you prefer the fit and look of over-ear headphones for working out, the JBL Live 670NC’s are worth considering, thanks to their snug fit and battery life. They offer up to 65 hours of operation on a single charge (50 with ANC, but aided by auto play/pause), a full recharge in two hours, and a burst charge for four hours of operation in 5 minutes, so they’re almost always ready to go on a moment’s notice. The 670NC’s also feature noise-canceling and ambient-aware modes fed by four noise-sensing mics, making them equally suitable for use in noisy gyms and on busy streets. We had inconsistent results with their noise-canceling abilities due to the on-ear earcups sealing differently on different peoples’ heads, so if the best noise-canceling is an absolute must in your book, you’ll want to consider noise-canceling over-ears or earbuds instead. But the 670NC is easy to pull off if you need situational awareness (or you can keep them on with Smart Ambient activated).

Thanks to their 40mm drivers and Bluetooth 5.3, the sound of the JBL 670NC is energetic and immersive with a pronounced “Pure Bass” response that makes them great for listening to pop, dance, and other beat-heavy music while working out. The JBL Headphones app offers further sculpting of the 670NC’s’ sound with EQ (including Personi-Fi 2.0 custom sound profile) and ambient-aware level adjustments, as well as access to battery life indicators and more. The headphones also feature their own onboard suite of control buttons. Still, they require a bit of studying to master, and the voice assistant button that covers the entirety of the left earcup is easy to press accidentally.

Lastly, the 670NCs have no official IP rating, and while we didn’t experience any technical issues from getting them a little sweaty, you’ll still want to be mindful of using them in heavy rain or other settings where they might get doused. If you absolutely need to work out with water-resistant over-ear headphones, the Treblab Z2 headphones are a uniquely light, comfy option with IPX4 and a long battery life that makes them great for taking on a run.

Best bone-conduction: SHOKZ OpenRun

SHOKZ

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Why it made the cut: The unique design of the SHOKZ OpenRun keeps your ears fully open, so you can stay aware of your surroundings.

Specs

  • Weight: 0.92 ounces
  • IP rating: IP67 (dustproof, waterproof for 30 minutes)
  • Battery life: 8 hours

Pros

  • Fully sweatproof and weatherproof for high-impact workouts
  • Open-ear bone conduction design for improved situational awareness
  • Long battery life with quick charge function

Cons

  • Lacks bass response
  • Proprietary magnetic charger isn’t interchangeable
  • Not silent—others can hear what you’re listening to

The SHOKZ OpenRun is one of the best bone-conduction headphones on the market, boasting a unique open-ear design that allows you to listen to music and podcasts while maintaining full situational awareness. Unlike traditional headphone designs, bone conduction headphones employ a clever hack of human anatomy to transfer sounds directly to the inner ear by gently vibrating your facial bones from the outside in, leaving the entire ear canal unobstructed. The drawbacks to this design include that they provide no passive or active noise cancellation, and the vibrations can be audible to others, so they’re not the best choice for quiet environments or taking public transit. Bone conduction headphones also produce markedly less bass frequencies than traditional designs, making them less ideal for immersive music listening.

On the functionality side of things, the SHOKZ OpenRun packs about eight hours of battery life on a single charge and boasts a substantial IP67 rating, making them completely impervious to dust ingress and fully waterproof for up to 30 minutes. They have a comfy and lightweight headband design with easy-to-use control buttons that makes them particularly suited for running and cycling on roads and trails. While there’s no way to adjust the headband’s fit, the OpenRun does come in two different sizes. Another minor design gripe is that the OpenRun uses a proprietary magnetic charger instead of USB-C, making it more of a hassle to replace if it breaks or goes missing.

Best for running or cycling: Bose Ultra Open Earbuds

Tony Ware

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Specs

  • Weight: 0.2 ounces/earbud
  • IP rating: IPX4
  • Battery life: 7.5 hours (4.5 hours with Immersive Audio enabled)

Pros

  • Situational awareness of the world around you
  • Guaranteed to fit
  • Surprisingly good bass

Cons

  • Absolutely no isolation or ANC

It may come as a surprise that Bose, so well-known for industry-leading noise cancellation that shuts the world out, is also responsible for earbuds on this list that are purpose-built to do the exact opposite. Its new Ultra Open Earbuds have a unique design; instead of inserting buds into your ear canal, you wrap it cuff-like around the helix (the edge) of your ear, then settle the speaker end into the concha right above the ear canal. This lets the earbud play into your ear while leaving it exposed to outside noise, which is practical when running or biking or when you need to hear an instructor’s directions/motivation. You’ll be able to hear obstacles like cars or other runners/cyclists coming behind you. And, unlike with bone-conduction headphones, there is ample bass response and a convincing Immersive Audio mode, so the sound appears far more outside your head.

Getting the hang of how to properly wear the Ultra Open Earbuds takes a couple of tries. The buds are very flexible as you clip them on. This curled design ensures they can fit behind virtually any sized ear comfortably. There’s no worrying about which eartips will create a proper seal or whether they’ll fall out of your ear, which allows you to grab and go and focus on whatever you’re listening to or doing with your body. Once settled, the control buttons sit atop the body held securely behind the ear, allowing you push patterns to pause/play, skip/repeat a track, answer calls, toggle the Immersion mode, and adjust volume. And the polished exterior doesn’t interfere with the style or fit of your jewelry, glasses, hats, etc. They grip snugly around our ears even during jogs without indicating they’d slip or fall off. That said, it never felt like the earbuds were pinching our ears or irritating them in any other way.

Musically, Bose’s Ultra Open Earbuds are a great addition to the company’s lineup. They support Bluetooth 5.3 (including AAC for iPhones) and, surprisingly, delivered a lot of bass, which we didn’t think would be possible from earbuds that created no seal around our ears. Perhaps even more surprisingly, there was very little sound bleed; the directional drivers do an excellent job of beaming sound into the canal so that you could feel comfortable wearing these without worrying about disturbing someone doing their set next to you. But really where they excel is when you’re actively exercising outdoors and want to enjoy that perfect playlist without sacrificing safety.

Best battery life: Jabra Elite 8 Active

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Why it made the cut: The Jabra Elite 8 Active earbuds are highly resistant to dust and water and feature the best combination of ANC performance and battery life we’ve encountered in a pair of workout headphones.

Specs

  • Weight: 0.2 ounces/earbud; 1.8 ounces with case
  • IP rating: IP68 (dust-tight, waterproof against extended submersion)
  • Battery life: 8 hours single-charge w/ ANC; 32 hours with case

Pros

  • Very long battery life for frequent use without charging
  • Snug and secure fit with three eartip sizes
  • Balanced sound profile with customizable EQ via app
  • Multipoint pairing
  • Military Standard (MIL-STD-810h) durability

Cons

  • Case can be tough to open
  • Low-frequency noise cancellation could be improved
  • Hit-and-miss phone call quality in loud environments

If you often find yourself in situations where you forget to charge your headphones—maybe you’re an endurance athlete, parent, or every overworked person in the modern world—the Jabra Elite 8 Active, much like the Elite 7 before it, is a great-sounding and reliable option to add to your workout routine. The low-profile design of the Elite 8 Active is utilitarian and doesn’t belie the wealth of tech and battery life within the military-grade, liquid silicone rubber-covered shells—available in dark grey, caramel, or navy. Despite weighing only 0.2 ounces per bud, the Elite 8 Active can run up to 8 hours with ANC on (14 hours with ANC off) and up to 32/56 hours when used with their charging case, making them great for infrequent charging and ideal for stowing in a gym bag or glove compartment.

The Elite 8 Active’s Adaptive Hybrid ANC is also very good in the midrange and high-frequency ranges where human conversation and music from speakers live. However, they didn’t beat our top picks when dealing with car engines, rumble from inside an airplane, and other very loud low-frequency information. This can be mitigated somewhat by selecting the best-fitting “EarGels” (aka tips) from the three pairs included with the buds. Still, if you’re using them for a workout or to listen to podcasts while your kid burns through some energy, the ANC might not be your first concern, as you’ll probably want to stay aware of your surroundings and use the earbuds’ HearThrough mode anyway (which benefits from upgrades to its wind noise detection and suppression technology).

Music sounds great on the Elite 8 Active earbuds thanks to their stable Bluetooth 5.3 (SBC, AAC) connection and flat and balanced sound profile, which you can sculpt further using the EQ settings in the Jabra Sound+ app. The app can also toggle Dolby Audio (spatial sound) and offers battery life indicators, pairing options, and firmware updates, among other features. Call quality through the buds is quite good, with six built-in mics sometimes to discern your own voice from ambient chatter when taking public transit or in other loud environments. The sleek charging case is also a great size and shape for keeping in a pocket during your workouts, but if you’ve worked up a sweat, its shape and smooth finish can make it difficult to open. Still, the ShakeGrip coating and drop resistance ensure these earbuds stay secure throughout strenuous exercises and survive in the unlikely event of a slip.

Best budget: soundcore by Anker Sport X10

Jen McCaffery

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Why it made the cut: The Anker Soundcore Sport X10 offers an incredibly secure fit and long battery life for runners on a budget.

Specs

  • Weight: 0.2 ounces/earbud; 1.9 ounces with case
  • IP rating: IPX7 (waterproof for 30 minutes, not dustproof)
  • Battery life: 8 hours single-charge; 32 hours with case

Pros

  • Very secure swiveling ear hook design
  • Controls customizable via a smartphone app
  • Transparency mode enhances situational awareness

Cons

  • No multipoint connection
  • ANC performance is lacking in loud environments
  • Multi-press controls are confusing and uncomfortable

If you’re less concerned about noise cancellation performance, the Anker Soundcore Sport X10s are a great budget option for working out thanks to their secure fit and long battery life. They have a unique swiveling ear hook design that folds into a compact shape for storage in their charging case and unfolds to loop securely around the front of your earlobe, keeping them snug during even the most vigorous exercise routines. The Sport X10s also features a six-microphone array that provides relatively good phone call quality and an effective transparency mode. Still, their ANC performance falls short of quieting most common midrange sounds like speech, engines, and other urban noise.

The Sport X10’s sound profile is a bit muddy and heavy in the low-mids, but this can be adjusted using the EQ settings within the Soundcore app, which includes several presets to choose from. The app also allows you to rebind custom functions to the earbuds’ onboard control buttons, which are clicky and provide some nice feedback but tend to shift the earbud around with minor discomfort. You also don’t get multipoint pairing with the Sport X10, but at their price point, that’s understandable.

What to consider before buying the best headphones for working out

You could take the best headphones to the gym, but you would probably have very sweaty ears and potentially ruin your precious investment. Heck, even some of the best Bluetooth earbuds might not be suited for more than a brisk stroll. So here is what to think about before clicking “add to cart” on the best headphones for working out and going all in on that next set:

Sweat level

Sweating is a normal part of any workout, but if you tend to sweat more than the average person while you exercise, you should consider a pair of headphones with an Ingress Protection rating of at least IPX7. Most of the headphones on our list are designed with that level of waterproofing, including the Jabra Elite 8 Active and SHOKZ OpenRun. If you sweat a lot, you’ll probably also want to steer clear of over-ear designs, which can heat up your ears and exacerbate the problem.

Workout intensity

If you do CrossFit or other forms of intense workouts, choose earbuds that use an ear hook or another type of external fastener to ensure that they don’t go flying. We like the Powerbeats Pro earbuds for heavy exertion, though the soundcore by Anker Sport X10 is an inexpensive alternative.

Charging capacity

If you use your headphones frequently, have limited access to charging capabilities, or just find yourself constantly running devices on low battery, picking a set of headphones with a high battery capacity can increase the likelihood that they’ll be ready come workout time. The 8-hour single charge and 30-hour charging case with the Jabra Elite 8 Active are the best we’ve tested in the battery life department, though our budget pick, the soundcore by Anker Sport X10, also performs well.

Situational awareness

If you spend lots of time exercising near traffic or in busy locations, it’s important to maintain a good level of situational awareness for your own safety. Many headphones include a transparency mode that allows you to hear your surroundings in addition to your music, including the Apple Beats Fit Pro and the Jabra Elite 8 Active. For maximum situational awareness, nothing beats the open-ear design of bone-conduction headphones, and we prefer the SHOKZ OpenRun.

FAQs

Q: How much do headphones for working out cost?

Headphones for working out cost between $70 and $200, depending on features.

Q: Is it OK to sweat with headphones?

It’s generally OK to sweat with headphones as long as they were designed with some measure of waterproofing. The easiest way to tell if your headphones are waterproof is by looking for an IP rating in their specs—anything above IPX4 should be just fine for everyday workouts. If you sweat a bit more than average, it might be safer to choose something around IPX7 or higher. All of the picks on our list, except for the JBL Live 670NC, are water-resistant to fully waterproof.

Q: Are bone-conduction headphones good for working out?

Bone conduction headphones are very good for working out thanks to their open-ear design that keeps you fully in touch with your surroundings. Runners and cyclists are particularly good candidates for using bone-conduction headphones due to their proximity to road traffic, though anyone can benefit from the increased situational awareness that these designs provide.

Q: Do noise-canceling headphones work in the gym?

Noise-canceling headphones work in the gym to an extent, but not every pair of ANC headphones is created equal. The best headphones for canceling out human conversation and ambient music that we’ve tested include the Apple Beats Fit Pro and the Jabra Elite 8 Active, both of which are aided by their secure earplug designs to deliver passive and active noise canceling at the same time.

Final thoughts on the best headphones for working out

The best headphones for working out will fit securely in your ears or on your head while delivering great sound and a good level of situational awareness. We love the Apple Beats Fit Pro for its overall sound quality and secure fit. If you need the longest and most reliable battery performance, the Jabra Elite 8 Active and JBL 670NC are the best earbuds and over-ears for working out, respectively. And if you want the best situational awareness possible while cycling and running, the SHOKZ OpenRun bone conduction headphones and the surprisingly immersive Bose Ultra Open Earbuds have our vote.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

The post The best headphones for working out in 2024, tested and reviewed appeared first on Popular Science.

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The best gallon water bottles in 2024 https://www.popsci.com/gear/best-gallon-water-bottles/ Fri, 15 Jul 2022 15:00:00 +0000 https://www.popsci.com/?p=455945
Best gallon water bottles
Stan Horaczek

Here’s one way to make sure you drink enough water every day.

The post The best gallon water bottles in 2024 appeared first on Popular Science.

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Best gallon water bottles
Stan Horaczek

We may earn revenue from the products available on this page and participate in affiliate programs. Learn more ›

Best overall Yeti Rambler Gallon Jug is the best gallon water bottle overall. Yeti Gallon Jug
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Yeti’s stainless steel gallon water jug is rugged and cleverly designed.

Best insulated Hydro Flask Oasis is the best insulated gallon water bottle. Hydro Flask Oasis
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Hydro Flask’s 1-gallon Oasis can quench a big thirst after a long day.

Best motivational Fidus Motivational Water Bottle is the best motivational gallon water bottle. Fidus Motivational Water Bottle
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The Fidus motivational water bottle has markings to help you hit your hydration goals.

The gallon water bottle is the ultimate hydration vessel. Carrying 128 ounces of liquid, these giant vessels are the perfect companion for balmy beach days, backcountry hikes, and sweaty gym sessions. They’ve also recently grown popular as a way to push yourself to drink more water every day. If your average 40-ounce water bottle just isn’t cutting it, an absolutely immense gallon bottle will ensure you never feel parched again. Chances are, you’ll have plenty left over to share with your friends and family after you absolutely crush those hydration goals. Here are the best gallon water bottles for aspirational drinkers, fitness obsessives, and anyone who wants to catch the big water bottle wave.

How we chose the best gallon water bottles

I consider myself an outdoorsy guy, so I spend a lot of time at the beach, in the mountains, and far away from clean running water. I was particularly excited to look into gallon water bottles since I’ve been thinking about picking one up myself. To make our selections, I performed hands-on testing and did hours of research, surveying critical viewpoints from water-obsessed coworkers alongside user impressions before settling on our picks.

At Popular Science, I cover a little bit of everything. I’ve researched all kinds of products, from the best energy-efficient air conditioners to the best smoke detectors. Before PopSci, I wrote about and reviewed gadgets for over 10 years for sites like iMore, XDA Developers, and CNN Underscored

The best gallon water bottles: Reviews & Recommendations

The type of gallon water bottle you buy depends on how you plan to use it. If you want to keep liquids hot or cold, a stainless steel bottle that’s vacuum insulated is your best option. Otherwise, plastic bottles tend to be more affordable and weigh less. Since there aren’t that many trustworthy brands making gallon water bottles, we feel confident that one of these picks is the best option for you.

Best overall: Yeti Rambler Gallon Jug

YETI

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Why it made the cut: The Yeti Gallon Jug features tough stainless steel construction and double-wall vacuum insulation to keep drinks icy cold all day long.

Specs

  • Material: Stainless steel
  • Height: 15 inches
  • Weight: 4.5 pounds
  • Dishwasher safe: Yes
  • BPA Free: Yes

Pros

  • Clever magnetic lid to store spout cap
  • Double-wall insulation
  • Sturdy handle

Cons

  • Expensive
  • Heavy

The Yeti Gallon Jug will keep your water cold if you’re out in the field and away from refills. It’s made of durable stainless steel and features vacuum insulation so that it will keep liquids hot or cold for several hours. It also keeps your bottle from sweating, so surfaces are safe from condensation.

The Gallon Jug’s lid features a sturdy metal handle with soft grip padding, making it easier to carry on long hauls. The lid also contains a neat magnetic design, so users can store the cap when the spout is open. You can also screw the entire lid off for easy cleaning and refills. It’s a clever design that reinforces Yeti’s attention to the small details.

Like all Yeti’s other stainless steel bottles, the Gallon Jug is BPA-free and dishwasher safe. It weighs 4.5 pounds before putting water in it, or over 12 pounds full. That’s heavy on a hike. Still, it is far and away the nicest water bottle of this size.

Best insulated: Hydro Flask Oasis

Hydro Flask

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Why it made the cut: The Hydro Flask Oasis is big and heavy, but it’ll keep your liquids cold for up to 24 hours or hot for up to 12 hours.

Specs

  • Material: Stainless steel
  • Height: 14.8 inches
  • Weight: 4.96 pounds
  • Dishwasher safe: Yes
  • BPA Free: Yes

Pros

  • Easy grip base
  • Double-wall insulation
  • Keeps liquids cold for up to 24 hours

Cons

  • Expensive
  • Heavy

Like our top pick, the Hydro Flask Oasis is a large, heavy stainless steel bottle with double-wall vacuum insulation that ensures liquids stay cold. Hydro Flask claims water stays chilled in the Oasis for up to 24 hours, making it the perfect companion for the summer months. It’s also rated for hot liquids and keeps coffee, tea, or soup hot for up to 12 hours. It’s an excellent option for skiers who want a piping hot cup of joe after a long day on the slopes.

In addition to its superior insulation, we like the Oasis’ beveled base, which makes it easier to grab and pour. It’s a nice touch that you won’t find elsewhere. On the other hand, the Oasis’ lid doesn’t provide a place to store the spout cap, and the plastic handle isn’t as durable or easy to hold.

Like the Yeti Rambler, the Hydro Flask Oasis weighs nearly 5 pounds and pushes 13 pounds when filled with water. The weight isn’t a significant hurdle if you’re keeping hydrated at home, but the Oasis’ weight could be an issue on a camping trip or climbing up a mountain when every ounce counts.

Best for the gym: Coleman One-Gallon Beverage Cooler

Coleman

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Why it made the cut: The Coleman One-Gallon Beverage Cooler features a simple flip-top spout, insulation, and a classic design you remember from childhood.

Specs

  • Material: Plastic
  • Height: 12.8 inches
  • Weight: N/A
  • Dishwasher safe: No
  • BPA Free: Yes

Pros

  • Sturdy design
  • Insulation
  • Flip-top spout

Cons

  • Not dishwasher safe

If you played sports as a kid, you may remember the Coleman gallon jug. Your coach may have brought it along to keep your whole team hydrated, but now it’s just for you.

The fact of the matter is that Coleman still makes a great bottle, and it’s specifically the perfect option for the gym. It has a leakproof lid, flip-top spout, and insulation to keep liquids cold. It’s also incredibly durable and features a handle that makes the Coleman Chiller easy to carry. It’s a simple, classic design that will keep you hydrated through every workout step.

Best motivational: Fidus Motivational Water Bottle

Fidus

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Why it made the cut: For people buying a big water bottle to drink more water, the Fidus Motivational water bottle gives you regular hydration goals.

Specs

  • Material: Plastic
  • Height: 13.8 inches
  • Weight: 0.83 pounds
  • Dishwasher safe: Yes
  • BPA Free: Yes

Pros

  • Paracord handle
  • Button cap
  • Available in several colors

Cons

  • No insulation

Drinking a gallon of water in a single day is hard work. As we mentioned, you don’t actually need to do it to stay healthily hydrated. But if you want to, this water bottle from Fidus is a trendy Tritan plastic water bottle with markers and motivational quotes to keep you on track to hit that daily goal. 

The 1-gallon water bottle from Fidus features eight motivational quotes to keep users focused and energized about hitting their water intake goals. It also features a cap that covers the spout and straw, so it’ll stay shielded from dust and particles throughout the day, and comes with a detachable paracord handle for easier carrying. Who doesn’t like a bit of encouragement?

Best budget: Simple Modern Gallon Water Bottle

Simple Modern

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Why it made the cut: The Simple Modern Gallon Water Bottle offers a basic bottle at an affordable price.

Specs

  • Material: Plastic
  • Height: 13.8 inches
  • Weight: 1.15 pounds
  • Dishwasher safe: Yes
  • BPA Free: Yes

Pros

  • Silicone straw
  • Button cap

Cons

  • No insulation

The Simple Modern 1-gallon bottle is, just like the brand name implies, a simple gallon water bottle. The dishwasher-safe Tritan plastic bottle comes in a variety of colors, including some calming color gradients like the green-to-purple “Tropical Seas,” and warm coral-to-cyan “Havana.” The best part of the Simple Modern bottle is its lid, which features a silicone mouthpiece with a lockable cover to keep it from getting dirty between sips. Press, Flip, Hydrate. Simple!

What to consider when buying the best gallon water bottles

So let’s get one thing out of the way: You don’t actually need to drink 8 cups of water every day. Giant water bottles have recently seen a surge in popularity, as people see them as a means of motivating themselves to drink more water. While you should never deny yourself water if you’re thirsty, it turns out that you don’t need to push yourself to drink that much.

That doesn’t mean there aren’t good reasons to carry around an absolutely gigantic jug of water. If you frequently go camping or spend long stretches of time away from a clean water source, it pays to bring a lot of water along. 

There aren’t as many manufacturers making gallon water bottles as the standard 32-ounce and 40-ounce options, so there isn’t as much room to get picky about style and design. That said, it still pays to know the essentials of water bottle construction so you can tell the best gallon water bottles from the knockoffs. Once you know where to look—and what to look for—in a gallon water bottle, you’ll find options that offer excellent durability, insulation, and clever designs for comfortable transportation and enhanced hydration.

Material

Most water bottles, no matter the size, are made of durable plastic or stainless steel. You may also find gallon jars made from shatter-resistant glass, but it’s fairly uncommon among bottles made for daily drinking.

Stainless steel water bottles are popular because they’re light but durable. They’re usually made from 18/8 stainless steel, which refers to its elemental composition—18% chromium and 8% nickel. It is considered food safe and is resistant to corrosion and oxidation. Many stainless steel bottles are also vacuum insulated (like the best insulated water bottles) or designed to create a sealed buffer between the liquid in the container and the environment outside the bottle, which reduces conduction and keeps liquids hot or cold for several hours. 

Reusable plastic water bottles offer a great balance of durability and affordability. High-quality plastic bottles are arguably more resistant to superficial wear and tear, though they generally lack stainless steel’s insulation. There is far more variability among the material to make plastic water bottles than there is among stainless steel water bottles. 

When buying plastic, make sure to get a plastic water bottle that’s made from BPA-free Tritan plastic, which is light, ultra-durable, and safe. Some studies suggest that containers made from plastics with bisphenol A, or BPA, can seep into what’s stored in the container and cause adverse health effects, so avoid plastic bottles unless the manufacturer specifies that they use a BPA-free material.

Durability

The gallon water bottle you buy will likely be by your side day and night, so it needs to withstand the pitfalls of everyday use. Stainless steel can get dented and scratched, but it’s pretty resilient over the long run and should last for several years. Stainless steel can also handle sudden temperature changes, making them more versatile than other materials on this list.

Tritan plastic water bottles are generally more scratch-resistant and won’t ding, but are by no means indestructible. Both materials are strong enough to withstand everyday wear and tear, even hiking or running. However, if you’re likely to drop your bottle off a cliff (or off a car’s roof), maybe go with stainless steel.

Weight

Here’s where things get a little tricky. There’s no way around the fact that our stainless steel picks are heavy. When filled up with water, they feel like small kettlebells. We don’t feel like their weight disqualifies them from consideration because, well … a gallon of water is always going to feel heavy. (Remember: A gallon of water weighs approximately 8 pounds.) That said, if you really want to minimize your bottle’s weight, a plastic bottle will generally weigh less than a stainless steel one.

FAQs

Q: How much does a gallon water bottle cost?

Depending on the bottle material, a gallon water bottle can cost between $20-$130.

Q: How often should I clean a gallon water bottle?

Some experts argue that you should clean your water bottle once a day. That may not be feasible for everyone, especially if you’re using your gallon water bottle off the grid. We’d argue that cleaning it a few times per week is a more achievable goal.  What you don’t want to do is go several weeks without washing your reusable bottle. Even if it looks clean, water bottles can build up bacteria over time, so you should clean them often.

Q: Can I put other liquids besides water in a gallon water bottle?

You can put other liquids in your gallon water bottle besides water, but some things are safer than others. For example, you can put hot coffee in the Yeti Rambler, but the company says to avoid using the jug’s lid with carbonated beverages because of potential pressure build-up. For the plastic bottles on our list, you should stick to room temperature or cold water.

Q: How long is water good in a gallon jug?

According to the Centers for Disease Control (CDC), you should replace stored water every six months. If you plan to keep water for an extended period, make sure it’s in an FDA-approved food-grade storage container. If you can’t find a food-grade water storage container, be sure the container has a top that can close tightly, is made of durable, unbreakable materials, and has a narrow neck for easy pouring.

Q: Is it safe to drink a gallon of water per day?

Drinking a gallon of water daily isn’t harmful but you probably don’t need to drink so much for optimal health. Optimal water intake varies from person to person based on a variety of personal and environmental factors, including height, weight, their activity level, and the current temperature. Rather than aiming for “eight cups a day,” simply try and drink water whenever you feel thirsty. 

Final thoughts on the best gallon water bottles

Gallon water bottles are for people who either won’t have access to a water source for a while or need to hit a specific intake goal. Otherwise, their size and weight make them too cumbersome for most people. If you want something easier to manage, you’re better off checking out our picks for the best water bottles. And if you’ve got young ones, there’s our guide to the best kids’ water bottles.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

The post The best gallon water bottles in 2024 appeared first on Popular Science.

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The best compression socks of 2024 https://www.popsci.com/reviews/best-compression-socks/ Tue, 10 Aug 2021 20:30:00 +0000 https://www.popsci.com/?p=387909
A lineup of the best compression socks on a white background
Amanda Reed

Give your circulation a boost—and your legs some love—with these supportive socks.

The post The best compression socks of 2024 appeared first on Popular Science.

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A lineup of the best compression socks on a white background
Amanda Reed

We may earn revenue from the products available on this page and participate in affiliate programs. Learn more ›

Best overall Sockwell's Men Elevation Compression Socks are the best compression socks overall. Sockwell Firm Compression Socks
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These all-around winners provide strong compression and reliable support for people who stand all day and look good to boot.

Best ankle-length A black pair of Comrad ankle compression socks on a wooden floor. Comrad Ankle Compression Socks
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These ankle socks provide 15-20 mmHg compression to gently boost circulation and support the foot.

Best budget ACTINPUT Compression Socks for Men and Women are the best budget compression socks. ACTINPUT Compression socks for Men & Women
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Light compression you can buy in bulk.

Compression socks, also known as compression stockings or support stockings, gently squeeze and apply pressure to the legs to improve circulation while preventing and reducing swelling. These socks are a common part of post-injury or surgery recovery, but they’ve gained popularity among long-distance travelers and athletes for their recovery benefits, too. Whether you’re an athlete, recovering from an injury, or in an occupation that keeps you on your feet all day, pressure socks encourage blood flow and help you stay comfortable. However, compression socks come in different pressures, lengths, and sizes that determine how well they’ll work for your particular issues. We’ve rounded up some of the best compression socks for swelling, athletics, and general use to get your feet back in working order. 

How we chose the best compression socks

Pressure socks should not cause pain or uncomfortably pinch the skin. A sock that causes numbness, tingling, or discoloration is too tight. To inform our judging and avoid these shortcomings, we conducted user testing with feet of all sizes, conducted extensive research, and reviewed critical reviews.

The best compression socks: Reviews & Recommendations

We picked a range of socks for various needs, from socks that help runners with performance and recovery time to those that alleviate pain from plantar fasciitis, arch and heel pain, and Achilles tendonitis. Any one of these picks should get your blood pumping and your feet jumpin’.

Best overall: Sockwell Firm Compression Socks

Sockwell

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Why they made the cut: Sockwell’s Firm Compression Socks provide plenty of support while you’re on the job and still look stylish. 

Specs

  • Materials: Merino wool, rayon, nylon, Spandex
  • Compression: 20-30 mmHG
  • Machine washable: Yes

Pros

  • Designed with graduated compression to reduce swelling
  • Comes with arch support and cushioned sole
  • Provides moisture-wicking and odor-control

Cons

  • Not designed for athletic performance

If you’re looking for a compression sock you can wear all day, Sockwell’s Firm Compression Socks provide plenty of support while not looking like medical socks. Created to improve circulation in the legs of people who sit or stand all day, these socks are designed with graduated compression that minimizes swelling and cuts down on fatigue. They also wick away moisture and provide odor control thanks to the power of merino wool, and come in a range of colors from black to putty.

Best for men: Physix Gear Sport Compression Socks

Physix Gear Sport

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Why they made the cut: These compression socks provide moderate pressure and come in a range of fun designs that will look great when working out.

Specs

  • Materials: Lycra
  • Compression: 20-30 mmHG
  • Machine washable: Yes

Pros

  • Great for extreme races
  • Ankle cuff stays put
  • Range of colors and designs

Cons

  • Not particularly suited for the cold

The Physix Gear Sport Compression Socks provide 20-30 mmHg of pressure, which is adequate for running and other sports, as well as post-workout recovery. Their graduated pressure provides higher pressure through the feet and ankles and gradually decreases toward the top of the calf. These socks come in three sizes and include “stay put” cuffs to keep the sock in place. They also come in 12 colors.

Best for women: Hi Clasmix Graduated Medical Compression Socks

Hi Clasmix

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Why they made the cut: These socks are designed to promote blood flow, discourage blood clots after surgery, and are also great for people working on their feet all day. 

Specs

  • Materials: Nylon, polyester, copper fiber
  • Compression: 20-30 mmHG
  • Machine washable: Yes

Pros

  • Comfortable for all-day wear
  • Encourages blood flow and circulation
  • Moisture-wicking and breathable fabric that eliminates odor

Cons 

  • Striking design may not work with professional outfits

The Hi Clasmix Graduated Medical Socks are the best compression socks for women and fit shoe sizes 6 to 15.5. They feature graduated compression between 20-30 mmHg, enough for daily wear, athletics, or recovery. A copper-infused fabric helps prevent odors and wicks moisture for more comfortable wear.

Best for running: 2XU Vector Cushion

2XU

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Why they made the cut: These athletic compression socks are specifically designed to improve runners’ performance with decreased recovery time and streamlined comfort. 

Specs

  • Materials: Nylon, Lycra
  • Compression: 15-20 mmHG at base of foot (20-30 mmHG at ankle) 
  • Machine washable: Yes

Pros

  • Support feet and legs
  • Cushioning provides plantar fascia and arch support
  • Lock-in technology reduces blistering

Cons

  • Expensive

Runners, if you’re looking for compression socks to enhance performance without looking stodgy, the 2XU Vector Cushion Socks are a solid option. Designed with graduated compression, these socks for running increase circulation in your feet and legs to get more blood to your muscles. They come with arch and plantar fascia cushioning to absorb shocks and with technology that helps reduce blistering. That said, they’re an expensive pair of socks. 

Best design: VIM & VIGR Cotton Graduated Compression Socks

Amanda Reed

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Why they made the cut: If boring socks aren’t your jam, the fun patterns and colors of VIM & VIGR’s compression socks will fit right in with the rest of your color rainbow collection.

Specs 

  • Materials: Cotton, nylon, spandex
  • Compression: 15-20 mmHg 
  • Machine washable: Yes

Pros

  • Lots of sizes and colors available
  • Ideal for all-day wear
  • Cotton gives socks breathability

Cons

  • Expensive

Socks are one of the ways we can show our personality without dressing too loud. It’s also titillating to have your own little fun secret hidden by the hem of your pants, only shown once you sit down. VIM & VIGR combines the whimsy of fun patterns like foxes, stripes, butterflies, and parasols with the practicality of compression. Its light compression—15-20 mmHg of it, to be exact—is perfect for traveling, exercising, sitting, standing, walking, and more. They’re soft, stretchy, and easy to put on. They’re also, at $38 per pair, expensive for this type of product.

Best ankle-length: Comrad Ankle Compression Socks

Amanda Reed

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Why they made the cut: These ankle socks are designed with light compression and provide 360 degrees of support that cradle feet and aid recovery.

Specs

  • Materials: Nylon, Spandex
  • Compression: 15-20 mmHg 
  • Machine washable: Yes

Pros

  • Designed with targeted compression zones
  • Moisture wicking 
  • Comfortable

Cons

  • Pill in the wash after a few wears

The Comrad ankle compression socks feature light, 15-20 mmHg compression in a side-specific design. Compression provides progressive pressure throughout the foot and ankle. They’re made of a moisture-wicking fabric that improves breathability for more comfortable wear, and feature extra toe and heel padding. That said, they’re not the best for cold weather, so you may also want to check out some heated socks. They feel just like a regular pair of socks, which is a plus for comfort. As you can see in the photo, the sock’s fabric pills after a few washes. It doesn’t affect their effectiveness, however.

Best toeless: SB SOX Plantar Fasciitis Compression Socks

SB SOX

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Why they made the cut: These compression socks are designed to relieve pain and are created specifically for people with foot ailments such as plantar fasciitis, arch and heel pain, and Achilles tendonitis.

Specs 

  • Materials: Nylon, Spandex
  • Compression: 15-20 mmHg 
  • Machine washable: Yes

Pros

  • Provides arch support
  • Moisture wicking 
  • Comfortable

Cons

  • Not designed for cold weather

SB SOX Plantar Fasciitis Compression Socks feature compression and ribbing designed to follow the foot arch. The ribbing through the arch mimics the natural movement of the foot’s ligaments to provide better support. A thin heel lets you fit it under your regular socks without changing the fit of your shoes. Moisture-wicking fabric keeps the SB SOX cool even under another pair of socks. They come in four sizes and nine colors.

Best budget: ACTINPUT Compression Socks for Men and Women

ACTINPUT

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Why they made the cut: If you’re looking for light compression, this eight-pack of socks provides great value for everyday use for people who stand all day.

Specs 

  • Materials: Nylon, polyester, elastane
  • Compression: 15-20 mmHg 
  • Machine washable: Yes

Pros

  • Comes in an eight-pack
  • Moisture wicking 
  • Good value

Cons

  • Not designed for foot ailments

The ACTINPUT Socks for Men and Women are made with 15-20 mmHG compression and come in eight-packs. These knee-high compression socks provide uniform pressure from toe to knee in two sizes. You get many options, from a pack of all black to nude, white, gray, and colorful patterned designs.

What to consider when buying the best compression socks

Let’s start with the most basic question—what are compression socks used for? Compression socks apply gentle pressure to the tissues beneath the skin of the legs. That extra pressure prevents fluid leakage and promotes fluid absorption. That generally means less swelling and further swelling prevention. 

Pressure socks support vein and capillary walls, boosting weakening veins and valves. Even if your veins are perfectly healthy, blood can pool in your legs after long periods of sitting or time on your feet. Consequently, people who work while standing, walk all day, and travel for several hours at a time find relief from swelling with the added pressure of compression socks. 

These socks come in different types and designs. For example, gradient or graduated compression socks apply higher pressure toward the toes, feet, and ankles, with less pressure through the calf. Ankle compression socks only apply pressure to the foot and ankle. Toeless designs make it easier to wear with regular socks for greater cushioning and comfort. 

Pressure levels

Compression socks also come in different pressure levels, with socks available to the average consumer having light to medium compression. Pressure is measured in millimeters of Mercury (mmHg). People with certain health issues may require a specific sock pressure level recommended by a doctor, while others can just choose a comfortable level from the following:

  • 15-20 mmHg (light compression): Daily wear, general sports, and travel.
  • 20-30 mmHg (medium compression): Daily wear (especially for varicose veins and swelling), mild symptoms of discomfort, sports recovery.
  • 30-40 mmHg (strong compression): Often recommended for blood clot prevention, medical recovery, or post-surgery.

Alleviating ankle swelling

Pregnancy, poor circulation, temperature fluctuations, and fatigue are only a few of the reasons your feet and ankles may swell. Capillaries, the very small blood vessels, help carry blood to the arteries and veins and back again. Their thin walls are easily damaged, leading to fluid buildup and poor circulation. 

Pressure socks gently squeeze the legs, helping fluids reabsorb and blood flow more easily. These pressure socks also decrease the diameter of veins, increasing the velocity of blood flow and its volume. In short, they keep the blood moving and fluid from pooling. If swelling plagues you during and after a long airplane, car ride, or a long shift on the job, these socks may help. 

Potential improved running performance

Here’s the deal: The jury is still out on the benefits of compression socks for running performance. Some studies have found a correlation between pressure socks and improved running performance and muscle fatigue, while others have found no difference

It comes down to what you need and want the compression socks to do. If you have swelling when you run, which is pretty normal, pressure socks can definitely reduce fluid buildup in your feet and legs. That may or may not benefit your running time and recovery. Runners who travel long distances to get to their events, such as marathons or triathlons,  may also reap the benefits of compression socks because they can reduce swelling due to prolonged periods of sitting or standing.

However, a fairly universal finding is that if the wearer believes the socks help, they report less fatigue, better circulation, and quicker recovery. The mental “race” can be just as difficult for runners as the actual race. If the socks work for you and help with recovery, you may want to consider a purchase. 

Style of sock

Something that goes to your knees or beyond is too much sock for the occasion. In other cases, you may only need compression and extra support in the arch, heel, or low ankle. Ankle socks may offer a solution to any of the aforementioned issues. 

These socks sometimes rise above the ankle bone, but many stay below this visible landmark. They have similar pressure levels as taller socks. Some of these designs feature targeted pressure through the arches or heels to relieve plantar fasciitis or support foot injuries. These socks also cover less surface area, making them a cooler option when temperatures rise.

FAQs

Q: How much do compression socks cost?

A pair of socks costing $15 each or more can quickly get expensive! However, you can get comfortable compression for much less, but you do have to let go of a few things. First, budget compression socks usually have less pressure. They’re more likely to fall in the 15-20 mmHg range. The quality of the fabric may be lower compared to higher-priced socks. For example, you won’t find moisture-wicking fabric among the less expensive designs. The seams may come apart quicker, too. That said, you can buy several cheap pairs for the price of a single pair of pricier designs.

Q: What does 15-20 mmHg mean for compression socks?

The 15-20 mmHg means the socks provide 15-20 millimeters of Mercury in pressure. It’s a measure of the sock’s tightness. Socks range from 15-40 mmHg, with 15 being the lowest pressure offered. 

Q: Can compression socks lower your blood pressure?

Unfortunately, no, compression socks cannot lower or raise your blood pressure. They increase the velocity at which the blood moves in the lower limbs, but not enough to change your blood pressure measurements.

Q: What level of compression socks do I need?

The compression level depends on your activities, comfort level, and the socks’ purpose. To improve general circulation throughout daily activities, 15-20 mmHg socks usually do the trick. At 20-30 mmHg, athletes and those with medical issues like poor circulation or injury get more support. Socks at the 30-40 mmHg level are typically reserved for injury recovery. No matter the pressure level, the socks must be comfortable for you. They shouldn’t cut off circulation, cut into your skin, or cause skin discoloration. 

Q: How many hours per day should I wear compression socks?

You can wear compression socks all day except when you’re showing or bathing. Then make sure to take them off at night, the National Health Service recommends.

Final thoughts on the best compression socks

Keeping your tootsies happy can help you stay on the move when your feet start to get tired. The best compression socks allow your blood to flow and reduce swelling without pinching or cutting off circulation. They also make great gifts. You may need a sock without toes or an ankle compression sock to support your arch. If you have a medical condition that requires a compression sock, talk to your doctor to determine the right pressure and sock style. These socks can express your personality with bright colors and patterns or blend in with your natural skin tone. If you need a pair, there’s a design out there that will work for you.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

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After 100 years, new guidelines propose rules for common food allergy treatment https://www.popsci.com/health/food-allergy-treatment/ Mon, 08 Apr 2024 13:19:18 +0000 https://www.popsci.com/?p=609792
shelled and unshelled peanuts on a table
Oral immunotherapy attempts to desensitize patients to common allergens, including eggs, milk, and peanuts. Deposit Photos

A new study aims to help clinicians standardize care and improve outcomes for their patients.

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shelled and unshelled peanuts on a table
Oral immunotherapy attempts to desensitize patients to common allergens, including eggs, milk, and peanuts. Deposit Photos

Food allergies are a growing health and safety risk, with the Centers for Disease Control and Prevention (CDC) estimating that about 1 in 3 children in the United States are affected. To help combat this, physicians use a technique called oral immunotherapy to try to build a child’s tolerance to some common food allergens. Now, a study published April 8 in the Journal of Allergy and Clinical Immunology aims to create the first set of international guidelines for clinicians to use to help families and clinicians succeed in this sometimes life saving process. These guidelines are not currently mandatory and aim to help standardize care to improve patient outcomes. 

“These families must provide the therapy every single day. That’s why these guidelines are so important,” Douglas Mack, study co-author and a clinical professor at McMaster University in Canada, said in a statement. “Safety can be optimized to make sure that they understand what they’re taking on, while ensuring that they are aware of the kinds of side-effects that can be dangerous.”

What is oral immunotherapy?

Oral immunotherapy involves giving very small amounts of a food allergen like peanuts, walnuts, milk, or egg to a child with a documented allergy. The amount is then gradually increased in an attempt to build up the body’s tolerance and the process has been used for over a century. In 1908, oral immunotherapy helped desensitize a 13-year-old patient with an egg allergy. In that study, the starting dose was 1/10,000th of an egg every day. After six months, the patient could safely eat eggs. More recent analysis found that it can induce desensitization in most patients who are allergic to peanuts, milk, and egg by 76.9 percent

This process is not without risks, as it is administered every day at home to children by their caregivers, which requires caregivers to act like “amateur medical professionals” by observing a child’s reactions and deciding if medical treatment is necessary. These new guidelines are intended to help prepare families and standardize the approach to the process. 

[Related: Babies who grow up around pets may be less likely to develop food allergies.]

“Families need to learn about food allergies, anaphylaxis, immunotherapy, how to safely dose the food, which things to look out for, when to treat, and when to contact the medical team,” Julia Upton, a clinical immunologist at the Hospital for Sick Children in Toronto, Canada, told DW. Upton is not a co-author of the new study. 

What’s in the new guidelines?

A panel of 36 international oral immunotherapy experts worked together to craft a detailed standardized consent form and topics to discuss with families. This includes mentioning that oral immunotherapy is not a cure, that asthma should be controlled before starting the therapy, and stress all caregivers must understand how the process works. This should ensure that all parents and caregivers know the risks and benefits, and alternative treatments if they are unwilling to take on oral immunotherapy. 

“If they decide they want to do it after following these guidelines, they’re prepared for what they’re getting into,” said Mack. “They understand the risks and most importantly, it makes it safer because they can anticipate the challenges. This protocol sets the standard moving forward.”

The guidelines also stresses adequate adult supervision of dosing before treatment begins and that potential risk factors to the patient should be identified before the therapy begins. Some of these risk factors include uncontrolled asthma in the patient and an unwillingness for the caregiver to use epinephrine in case of a reaction. Failure to administer epinephrine in the event of a severe allergic reaction can result in death. 

[Related: A peanut allergy patch is making headway in trials with toddlers.]

The team estimates that as many as one-third of patients were not getting any degree of counseling or preparation before starting the treatment. It took about 30 to 60 minutes for a clinicing to provide adequate counseling about all of the risks and benefits of oral immunotherapy, according to the study. 

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How to look at the eclipse without damaging your eyes https://www.popsci.com/how-to-not-damage-eyes-during-eclipse/ Tue, 22 Aug 2017 01:02:11 +0000 https://www.popsci.com/uncategorized/how-to-not-damage-eyes-during-eclipse/
a couple wearing glasses sits on the grass watching the eclipse
You need proper eclipse eyewear. DepositPhotos

It’s always a bad idea to look directly at the sun.

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a couple wearing glasses sits on the grass watching the eclipse
You need proper eclipse eyewear. DepositPhotos

Today, millions of people will have a chance to watch a total solar eclipse. If you’re one of them, be careful: looking directly at a solar eclipse without eye protection can permanently damage your vision.

It doesn’t matter if our rocky satellite is blocking all or some of our nearest star—the sun is still an incredibly bright source of light. Don’t risk your eyesight for a quick glimpse or even a once-in-a-lifetime event. Thankfully, it’s pretty easy to protect your eyes while watching an eclipse.

What happens if you look at a solar eclipse

We are able to see thanks to photoreceptors. These cells, also known as rods and cones, are located at the backs of our eyes, and convert the light reflected by the world around us into electrical impulses that our brain interprets as the image we see. But when strong light, like that from the sun, hits our eyes, a series of chemical reactions occur that damage and often destroy these rods and cones. This is known as solar retinopathy, and can make our eyesight blurry. Sometimes, if the damage is too great in one area, you can lose sight completely.

[Related: Every sunset ends with a green flash. Why is it so hard to see?]

On a typical sunny day, you almost never have to worry about solar retinopathy. That’s because our eyes have natural mechanisms that ensure too much light doesn’t get in. When it’s really bright outside, our pupils get super tiny, reducing the amount of sunlight that can hit your photoreceptors. But when you stare directly at the sun, your pupils’ shrinking power isn’t enough to protect your peepers.

This is where your eyes’ second defense mechanism comes into play. When we look at something bright, we tend to blink. This is known as the corneal or blink reflex, and it  prevents us from staring at anything too damagingly bright. 

Just before a solar eclipse has reached its totality, the moon is partially blocking the sun, making it a lot easier for us to look up at the star without blinking. But that doesn’t mean you should—even that tiny sliver of sunlight is too intense for our sensitive photoreceptors.

[Related: Total eclipses aren’t that rare—and you’ve probably missed a bunch of them]

Unfortunately, if you practice unprotected sun-gazing, you probably won’t know the effects of your actions until the next morning, when the damage to your photoreceptors has kicked in.

And while solar retinopathy is extremely rare, it is by no means unheard of. If you search the term in medical journals, you’ll find case reports after almost every popular solar eclipse. Let’s try really hard to do better this time, eyeball-havers.

How to safely watch a solar eclipse

Watching the eclipse with your own two eyes is easy: just wear legitimate eclipse sunglasses. These are crucial, as they will block the sun’s rays enough for you to safely see the eclipse without burning your eyes out.

And if you don’t have eclipse glasses, you can still enjoy the view, albeit not directly. Try whipping up your own eclipse projector or a DIY pinhole camera so you can enjoy the view without having to book an emergency visit to the eye doctor.

This story has been updated. It was originally published in 2017.

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Stock up on protein shakes and powders from Dymatize and Premier for 30% off at Amazon right now https://www.popsci.com/gear/protein-powder-shakes-amazon-deal/ Mon, 08 Apr 2024 12:55:00 +0000 https://www.popsci.com/?p=609780
A case of Premier Protein shakes on a plain bacckground with other protein powders next to it
Premier Protein

Stock up on your favorite protein supplements for less than $1 per serving and never miss out on gains again.

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A case of Premier Protein shakes on a plain bacckground with other protein powders next to it
Premier Protein

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You can never have too many protein shakes, and right now is a great time to stock up because Amazon has Premier Protein pre-mixed shakes and powders on sale cheaper than I have ever seen them. At $20.99 for 12, you’re paying just under $1.75 per shake. That’s about seven cents more per shake than they cost at Sam’s Club, but Amazon has a ton of different flavors instead of Sam’s basic chocolate and vanilla. Dymatize protein is also on sale if you’re not into the Premier offerings. Whichever you choose, this is a great time to stock up.

Dymatize ISO100 Hydrolyzed Protein Powder, 100% Whey Isolate, Dunkin’ Glazed Donut Flavor $23.42 (was $34)

Dymatize

SEE IT

If you’re sick of normal flavors, Dymatize teamed up with Dunkin’ Donuts to make some wonderful (and a little wacky) flavors. I like to imagine this is what Ben Affleck used to get buff to play Batman because it integrated his love of Dunkin’ into his fitness routine. This a great, clean protein powder with a unique taste that pleasantly surprised me when I tried it. Yes, it sounds weird, but the macros are solid, with just two grams of carbs to go with 25 grams of protein.

Premier Protein Shake, Chocolate Peanut Butter, 30g Protein $20.99 (was $29)

Premier Protein

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You won’t find this flavor at the big box price club stores, but it’s my personal favorite. I bought a couple of cases last time there was a solid sale (more than a year ago, now), and really liked these. Each shake offers 30 grams of protein as well as calcium, vitamin C, vitamin D, and zinc. It’s not quite as clean as the super-designer stuff out there, but the macros are solid, and they taste good, which is important for something you’re going to consume daily.

Premier Protein Powder Plant Protein, Chocolate $16.79 (was $23.99)

Premier Protein

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If you don’t mind mixing your own shakes or you want to add protein to recipes (in a Ninja Creami, perhaps), then the powder is the way to go. This plant-based option offers 15 servings for $16.79, so you’re just over a dollar for each scoop. That gets you an assortment of vitamins and 22g protein. Plus, it’s plant-based, which is great if you’re specifically looking for a vegan protein powder or if your stomach struggles with whey-based supplements. It also comes in Vanilla.

More Dymatize Protein deals

More Premier Protein deals

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Experimental treatment grows livers from lymph nodes https://www.popsci.com/health/grow-second-liver/ Tue, 02 Apr 2024 16:56:47 +0000 https://www.popsci.com/?p=609126
an yellow-ish bag of liver cells in a suspension.
A cell solution with hepatocytes in a suspension. These liver cells are part of an experimental treatment for those with end-stage liver disease. LyGenesis

The first human trial is underway and could transform organ donation if successful.

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an yellow-ish bag of liver cells in a suspension.
A cell solution with hepatocytes in a suspension. These liver cells are part of an experimental treatment for those with end-stage liver disease. LyGenesis

A team of scientists is attempting to grow a new liver inside of a human using lymph nodes. While this sounds like science fiction, Pittsburgh-based biotech company LyGenesis announced that a volunteer has received an injection of liver cells from a living donor that could turn one of their lymph nodes into a second and functioning liver.

The experimental procedure took place in Houston on March 25. It is part of a Phase 2a clinical trial that will test this treatment in 12 adults who have end-stage liver disease (ESLD). This illness occurs when the liver is damaged beyond repair, primarily due to chronic liver disease or acute liver failure. Over 50,000 Americans die of chronic liver disease every year. 

Patients with ESLD typically require a liver transplant, but roughly 10,000 people are currently on the waiting list in the United States alone. In 2021, a record of 9,234 liver transplants were performed in the US, according to the federal government’s Scientific Registry of Transplant Recipients. LyGensis hopes that this procedure will create the growth of enough liver tissue that patients won’t need a transplant. 

[Related: Swiss researchers kept a donor liver healthy for a remarkable 68 hours.]

“This therapy will potentially be a remarkable regenerative medicine milestone by helping patients with ESLD grow new functional ectopic livers in their own body,” LyGenesis co-founder and CEO Dr. Michael Hufford said in a statement. “If our study is successful and we obtain FDA approval, our allogeneic cell therapy could enable one donated liver to treat many dozens of ESLD patients, which could help to tilt the current organ supply-demand imbalance in favor of patients.”

The technique has been in the works for over a decade. It takes liver cells–or hepatocytes–from a donated organ and injects them into the lymph nodes that are found all over the body. In the lymph nodes, the liver cells will hopefully divide, grow, and develop blood vessels. It targets a group of lymph nodes in the abdomen that are connected to the liver via a system of veins.

According to MIT Technology Review, LyGenesis has tested their approach in mice and pigs, finding that the cells can flourish and form an additional liver that will take over the function of an animal’s failing organ. Chief scientific officer of LyGenesis and University of Pittsburgh pathologist Dr. Eric Lagasse published a study in 2020 that found the pigs regained their liver function following the injections. They also noted that the more severe the damage to the pig’s original liver, the bigger the second livers grew. The pig’s body may be able to recognize the more healthy tissue and give the new liver more responsibilities. 

In the trial procedure, the doctors threaded a thin flexible tube down the end of the patient’s throat through the digestive tract, according to Wired. They then used an ultrasound to identify one of the target lymph nodes and put 50 million hepatocytes into it.

[Related: Surgeons complete first-ever gene-edited pig kidney transplant.]

“LyGenesis’ cell therapy platform represents a truly remarkable potential commercial opportunity and may be transformative for chronic liver failure patients who do not have access to a donor liver,” LyGenesis investor Justin Briggs from Prime Movers Lab said in a statement. “Their use of an endoscopic ultrasound as a low risk and low cost route of cell therapy administration is another way this pioneering technology could provide patients with access to life-saving therapies and address complex medical challenges by upending transplant medicine.”

The results won’t be available for a few months and the team will be monitoring how many cells are required to grow a liver that is large enough to filter blood and produce bile. If it works, it could mean a major change for the treatment of liver disease, which affects roughly 4.5 million people in the United States. 

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This cap is a big step towards universal, noninvasive brain-computer interfaces https://www.popsci.com/technology/bci-wearable-cap/ Mon, 01 Apr 2024 18:48:27 +0000 https://www.popsci.com/?p=608932
Users wearing BCI cap to play video game
Machine learning programming enables a much more universal training process for wearers. University of Texas at Austin

Users controlled a car racing video game with the device, no surgery needed.

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Users wearing BCI cap to play video game
Machine learning programming enables a much more universal training process for wearers. University of Texas at Austin

Multiple brain-computer interface (BCI) devices can allow now users to do everything from control computer cursors, to translate neural activity into words, to convert handwriting into text. While one of the latest BCI examples appears to accomplish very similar tasks, it does so without the need for time-consuming, personalized calibration or high-stakes neurosurgery.

AI photo

As recently detailed in a study published in PNAS Nexus, University of Texas Austin researchers have developed a wearable cap that allows a user to accomplish complex computer tasks through interpreting brain activity into actionable commands. But instead of needing to tailor each device to a specific user’s neural activity, an accompanying machine learning program offers a new, “one-size-fits-all” approach that dramatically reduces training time.

“Training a BCI subject customarily starts with an offline calibration session to collect data to build an individual decoder,” the team explains in their paper’s abstract. “Apart from being time-consuming, this initial decoder might be inefficient as subjects do not receive feedback that helps them to elicit proper [sensorimotor rhythms] during calibration.”

To solve for this, researchers developed a new machine learning program that identifies an individual’s specific needs and adjusts its repetition-based training as needed. Because of this interoperable self-calibration, trainees don’t need the researcher team’s guidance, or complex medical procedures to install an implant.

[Related: Neuralink shows first human patient using brain implant to play online chess.]

“When we think about this in a clinical setting, this technology will make it so we won’t need a specialized team to do this calibration process, which is long and tedious,” Satyam Kumar, a graduate student involved in the project, said in a recent statement. “It will be much faster to move from patient to patient.”

To prepare, all a user needs to do is don one of the extremely red, electrode-dotted devices resembling a swimmer’s cap. From there, the electrodes gather and transit neural activity to the researcher team’s newly created decoding software during training. Thanks to the program’s machine learning capabilities, developers avoided the time-intensive, personalized training usually required for other BCI tech to calibrate for each individual user.  

Over a five-day period, 18 test subjects effectively learned to mentally envision playing both a car racing game and a simpler bar-balancing program using the new training method. The decoder was so effective, in fact, that wearers could train on both the bar and racing games simultaneously, instead of one at a time. At the annual South by Southwest Conference last month, the UT Austin team took things a step further. During a demonstration, volunteers put on the wearable BCI, then learned to control a pair of hand and arm rehabilitation robots within just a few minutes.

So far, the team has only tested their BCI cap on subjects without motor impairments, but they plan to expand their decoder’s abilities to encompass users with disabilities.

“On the one hand, we want to translate the BCI to the clinical realm to help people with disabilities,” said José del R. Millán, study co-author and UT professor of electrical and computer engineering. “On the other, we need to improve our technology to make it easier to use so that the impact for these people with disabilities is stronger.” Millán’s team is also working to incorporate similar BCI technology into a wheelchair.

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Spring allergy season is off to an even earlier start this year https://www.popsci.com/health/early-allergy-season/ Mon, 01 Apr 2024 14:11:11 +0000 https://www.popsci.com/?p=608861
a women blows her nose into a facial tissue while standing next to blooming white flowers
Spring allergy season is beginning about 20 days earlier in North America. Deposit Photos

Here's how to cope with more pollen.

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a women blows her nose into a facial tissue while standing next to blooming white flowers
Spring allergy season is beginning about 20 days earlier in North America. Deposit Photos

After a particularly mild winter in most of the United States, which followed a record warm summer for the planet, seasonal allergy season is kicking into high gear. According to the Asthma and Allergy Foundation of America, more than 80 million Americans suffer from sneezing, itchy eyes, runny nose, and other symptoms of seasonal allergies.  

Climate change is making allergy season worse

A 2021 study found that spring allergy season is beginning about 20 days earlier in North America due to human-caused climate change. Pollen concentrations have risen roughly 20 percent across the country since 1990, with the Midwest and Texas seeing the largest increases. A combination of warmer temperatures, higher concentrations of carbon dioxide, and more precipitation can all contribute to plants producing more pollen longer

This year, the pollen count started particularly early, according to allergist and director of the Loyola Medicine Allergy Count Dr. Rachna Shah. She typically looks at pollen counts in Chicago in April, but saw that tree pollen was already at a moderate level in the middle of February. 

[Related: Climate change is pumping more pollen into allergy season.]

“This season has been so nuts,” Shah told the Associated Press. “Granted, it was a pretty mild winter, but I didn’t expect it to be so early.” 

Shah also believes that this season will be longer than other years, if the weather remains unseasonably warm. 

What are some triggers for seasonal allergies?

Pollen from growing trees and other plants is one of the most common triggers of seasonal allergies. In the early spring, tree pollen tends to be the biggest allergy trigger, with grass and weed pollen following. 

Ragweed, goldenrod, dust, and mold can also trigger allergies for some. 

Is it a cold or allergies?

Since allergies typically come with sneezing, coughing, itchy eyes, and sore throat, it can be hard to tell them apart from the common cold. According to Dr. Rita Kachru, chief of clinical allergy and immunology at UCLA Health, muscle pain, joint aches, fatigue, and fever is a sure sign that these symptoms are from a cold and not allergies.

Symptoms flaring up around the same time every year and having a family history of seasonal allergies are also helpful in determining what’s causing the symptoms.

How to manage symptoms

According to the Mayo Clinic, one of the first things to do is reduce exposure. This can mean avoiding going outside on windy days when pollen is blowing around, changing clothes and showering after coming inside, and even rinsing out your nasal passages. The best time to go outside is after a good rainfall, when some pollen has been washed away. You can also monitor pollen counts in your area online or during weather forecasts. 

[Related: It’s time you really understood what allergies mean.]

There are also several over-the-counter remedies available in both oral and nasal spray form that can help with symptoms when taken correctly. These include fexofenadine (Allegra), loratadine (Claritin), levocetirizine (Xyzal), and cetirizine (Zyrtec). Some common steroid nasal sprays include budesonide (Benacort), fluticasone (Flonase), triamcinolone (Nasacort) and mometasone (Nasonex).

Medical professionals do caution against using products that have pseudoephedrine, such as Sudafed, for more than a day or two. These medications can increase heart rate and blood pressure. A task force of physicians also issued guidelines in 2020 that did not recommend using Benadryl to treat allergies. The medication can have sedative effects and cause confusion in some patients.


If symptoms are severe and last for several months, it is important to speak with a medical professional and potentially get tested to see exactly what the body is reacting to. There are also long term allergy shots avaialbe that can help with more severe reactions.

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Why isn’t dental health considered primary medical care? https://www.popsci.com/health/dental-health-not-primary-care/ Mon, 01 Apr 2024 12:00:00 +0000 https://www.popsci.com/?p=608806
Oral health and whole-body health are connected but doctors and dentists typically are not.
Oral health and whole-body health are connected but doctors and dentists typically are not. DepositPhotos

Ailments of the mouth can put the body at risk for a slew of other ills. Some practitioners think dentistry should no longer be siloed.

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Oral health and whole-body health are connected but doctors and dentists typically are not.
Oral health and whole-body health are connected but doctors and dentists typically are not. DepositPhotos

This article was originally featured on Knowable Magazine.

The patient’s teeth appeared to be well cared for, but dentist James Mancini did not like the look of his gums. By chance, Mancini knew the man’s physician, so he raised an alert about a potential problem—and a diagnosis soon emerged.

“Actually, Bob had leukemia,” says Mancini, clinical director of the Meadville Dental Center in Pennsylvania. Though he wasn’t tired or having other symptoms, “his mouth was a disaster,” Mancini says. “Once his physician saw that, they were able to get him treated right away.”

Oral health is tightly connected to whole-body health, so Mancini’s hunch is not surprising. What is unusual is that the dentist and doctor communicated.

Historically, dentistry and medicine have operated as parallel fields: Dentists take care of the mouth, physicians the rest of the body. That is starting to change as many initiatives across the United States and other countries work to integrate oral and whole-body care to more effectively tackle diabetes, cardiovascular disease, joint replacements and many other conditions. The exact relationship between health of mouth and teeth and physical ailments elsewhere in the body is not well understood—and in some cases, is contentious—but experts agree there are links that should no longer be overlooked.

In recent years, dental hygienists have started working in medical clinics; physicians and dentists have started a professional association to promote working together; and a new kind of clinic—with dentists and doctors under one roof — is emerging.

“We are at a pivotal point—I call it the convergence era—where dentistry is not going to be separated from overall health for much longer,” says Stephen E. Thorne IV, founder and CEO of Pacific Dental Services, based in Irvine, California. “Dentistry will be brought into the primary care health-care team.”

Sick mouth, sick body

The list of connections between oral health and systemic health—conditions that affect the entire body—is remarkable. For starters, three common dental issues—cavities, tooth loss and periodontal disease—are all associated with heart disease, the leading cause of death in the United States. “To me, the number one hidden risk factor for the number one killer in our country is oral health,” says Ellie Campbell, a family physician in Cumming, Georgia, and board member of the American Academy for Oral Systemic Health, founded in 2010 to increase awareness of how oral and whole-body health are related.

Periodontal disease, infection and inflammation of the gums and bone that support the teeth, is the main culprit. Nearly half of adults 30 and older have periodontal disease; by age 65, the rate climbs to about 70 percent. In the early stages, called gingivitis, gums are swollen and may bleed. Periodontitis, a more serious condition in which gums can pull away from the teeth, is the sixth most common human disease.

Periodontitis is associated with a slew of systemic ills: heart attacks, strokes, heart failure, diabetes, endocarditis, chronic kidney disease, recurrent pneumonia, chronic obstructive pulmonary disease, gastritis, rheumatoid arthritis, cancer and cognitive impairment.

Bad habits, including tobacco use, alcohol consumption and high-sugar diets, are implicated too. They raise the risk for cavities and most oral diseases, and are also linked to ills such as cancer, chronic respiratory disease and diabetes.

Dental ailments, including gum disease, have been linked to numerous health problems elsewhere in the body. Credit: Knowable Magazine
Dental ailments, including gum disease, have been linked to numerous health problems elsewhere in the body. Credit: Knowable Magazine

Such connections were apparently lost on officials at the University of Maryland in 1837, when the university rebuffed a proposal from two physicians to teach dentistry to the school’s medical students. At the time, medicine wanted nothing to do with dentistry, which was practiced by unregulated and inadequately trained itinerants, says medical and dental historian Andrew I. Spielman, a dentist and oral surgeon at the New York University College of Dentistry. “There were a lot of charlatans,” he says. “They had a very bad reputation.”

The dismissal prompted the rejected physicians, Horace Hayden and Chapin Harris, to establish the world’s first dental school, the Baltimore College of Dental Surgery. Today, dentistry is a highly regulated profession, and the United States has 73 accredited dental schools.

Despite their disparate training, both doctors and dentists are aware that mouth health is important to whole-body health, Campbell says. “Ask a family practice doctor and they will say ‘Oh yeah, if the patient has diabetes, they’re going to have bad teeth and gums, and I can never get their diabetes better until the dentist fixes their gums,’” she says. “And the dentist is going to say, ‘Well, I’ll never get their gums better until the primary care doctor gets their sugar under control.’”

Mancini, the Pennsylvania dentist, says dentists often are asked to examine a patient’s mouth before physicians will proceed with certain treatments. “Physicians know any infection in a patient who’s being treated for cancer could be very much life-threatening,” he says. “The orthopedic guys are now sending all of their patients to the dentist for the same reason.”

Hurdles to holistic care

But working together to improve a patient’s health is not as simple as it might seem. A decade ago, the federal government hired the National Network for Oral Health Access to run a pilot program merging oral and primary health-care centers. The network’s dental consultant, Irene Hilton, a dentist with the San Francisco Department of Public Health, said three barriers to integration became clear.

The fragmented way that health care and dental care are paid for is one of them. While more than 90 percent of Americans have health insurance, only 77 percent of US adults ages 19 to 64 have dental coverage, which typically is sold separately from health insurance. The nation’s largest insurer—the federal Medicare program—generally does not cover dental services, and nearly half of Americans 65 and over have no dental coverage.

That causes problems for patients who need, say, a joint replacement that would be covered by insurance but who cannot afford the dental work that is needed in advance. Surgeons won’t replace a knee until patients first get their dental work done, Mancini says, “so we’re kind of the barrier to them improving their life.”

More than 90 percent of Americans have health insurance, but dental insurance is much less common. The numbers above are likely an underestimate of how many Americans lack dental insurance: The data are from early in 2023, before the Covid-19 public health emergency ended and states had to reassess who was eligible for Medicaid. Credit: Knowable Magazine
More than 90 percent of Americans have health insurance, but dental insurance is much less common. The numbers above are likely an underestimate of how many Americans lack dental insurance: The data are from early in 2023, before the Covid-19 public health emergency ended and states had to reassess who was eligible for Medicaid. Credit: Knowable Magazine

Another barrier is that dentists and physicians are not routinely trained to work with each other, Hilton says.

Dental students study anatomy, physiology and other sciences related to the whole body, then home in on clinical care for mouth and teeth. But many physicians have almost no training in oral health. A 2009 survey found that 10 percent of medical schools that responded offered no oral health curriculum, and 69 percent offered fewer than five hours on the subject.

A third issue is what Hilton calls infrastructure. In most cases, the electronic health records used by physicians are incompatible with those used by dentists, so sharing information electronically is impossible. Likewise, dental offices are typically not embedded in medical clinics, where doctor-dentist referrals might be easier.

If oral and systemic health are to be integrated broadly, “these are the things that have to be overcome or addressed,” Hilton says.

The situation is not much different in other parts of the world. In 2021 the World Health Organization—noting that oral diseases are a global public health problem affecting nearly 3.5 billion people—recommended that dentistry focus more on prevention and be more integrated with primary care services.

Demonstrated links

In the past quarter-century, a great deal of research has demonstrated the links between oral and whole-body health. For example, when researchers followed 15,456 patients from 39 countries with stable coronary heart disease for nearly four years, they found that those who had lost the most teeth had the highest risk of having a stroke, heart attack or cardiovascular death. Similarly, a study that tracked 7,466 US adults ages 44 to 66 for an average of 14.7 years revealed that those who had severe periodontitis had a greater risk of cancer than those with no or mild periodontitis.

In 2015, the Harvard School of Dental Medicine launched an initiative to support integration of the two fields—in education, insurance and professional practice. (The initiative gets funding from dental product brands and health insurance companies, and Thorne, the Pacific Dental Services CEO, serves on its board.) “We’ve published papers identifying links between periodontal disease and diabetes, hypertension, dementia, adverse birth outcomes, low birth-weight babies, preterm birth, spontaneous abortion, kidney disease,” says Jane Barrow, the initiative’s executive director.

But correlation is not the same as cause and effect, and scientists have not nailed down the exact relationship between periodontitis, which affects more than 11 percent of the global population, and various systemic diseases.

Periodontitis is associated with bacteria in the bloodstream and systemic inflammation, which can affect organs such as the liver and bone marrow. That, in turn, can trigger or aggravate other conditions. And the periodontal bacteria—that travel via the bloodstream, inhalation or ingestion—may also cause infections or exacerbate inflammation in other parts of the body.

When the major professional societies for periodontology in the United States and Europe convened a group of global experts in 2012 to review the science, they concluded that it was “biologically plausible” that the inflammation of periodontitis ups the risk of cardiovascular disease and influences type 2 diabetes and other maladies – but “plausible” was as far as they would go.

Seven years later, the European Federation of Periodontology and the World Heart Federation again gathered experts to review new studies on the link between periodontitis and cardiovascular problems. Again, though scientists had made some headway in identifying possible biological mechanisms to explain the link, experts have since concluded that the evidence does not yet prove that periodontitis actually causes strokes, heart attacks or anything else.

Flipping the question on its head, does preventing or treating periodontal disease help to prevent heart problems? Several observational studies, in which researchers observe individuals and measure particular outcomes, but don’t intervene, suggest that oral health care, including toothbrushing and dental cleanings, make a difference. For example, a study that tracked the health habits of 11,869 adults 35 and older in Scotland found that within eight years, those who rarely brushed their teeth had more cardiovascular problems compared with those who brushed twice a day.

Research exploring the link between gum disease and cardiovascular problems suggests that chronic inflammation and oral bacteria play a role. Credit: Knowable Magazine
Research exploring the link between gum disease and cardiovascular problems suggests that chronic inflammation and oral bacteria play a role. Credit: Knowable Magazine

That still does not prove that preventing periodontitis will hold heart problems at bay: Some other habit or feature of the toothbrushing group could have been the important factor. The relationship is difficult to tease out, Barrow says, because people who are taking good care of their mouths tend to take good care of themselves in general. “Could you say that people who are taking care of their mouths are in better health overall? You would probably find that to be true,” she says. “Is it because they’re taking care of their mouth? I can’t say that.”

And nobody else should say that either, according to a 2018 editorial in the Journal of the American Dental Association. The coauthors, a group of dental and public health researchers, cautioned against overstating the oral-systemic health connection. “The main reason for maintaining good oral health is because it is important in and of itself,” they wrote.

One of the contributors, Bryan Michalowicz, a dental researcher at HealthPartners Institute in Minnesota, later led a team that reviewed the medical records and insurance claims of 9,503 patients to see if periodontitis treatment improved the health outcomes of those with coronary artery disease, cerebrovascular disease or type 2 diabetes.

Overall, cardiovascular patients who received dental treatment and follow-up maintenance saw no difference in the rate of heart attacks, strokes, bypass surgeries or angioplasty procedures compared to those who were not treated, the team reported in 2023. Likewise, periodontal treatment did not significantly lower the blood-sugar levels in patients with type 2 diabetes.

Overdue integration

But the data suggesting connections have been enough to spark many grassroots efforts at integration. In addition to the American Academy for Oral Systemic Health, the National Network of Healthcare Hygienists, founded by hygienist Jamie Dooley in 2018, helps prepare hygienists who want to integrate oral health into health-care systems.

And in California, Thorne’s business is trying to make those interactions easy by putting dental and medical services under one roof. In December 2023, Pacific Dental Services opened a clinic, Culver Smiles Dentistry, in a space shared with a medical practice. It’s the first of 25 planned dental-medical practices that will operate through a partnership between MemorialCare, a big Southern California health system, and Pacific Dental.

Health-care leaders, Thorne says, are beginning to realize that they can improve their patients’ health by incorporating dental care into primary care.

It’s sort of crazy, he says, that our mouth and our jaw and our throat have been considered separate from the rest of our body for so long. “It is changing now, and health care is realizing that the mouth is the gateway to so much of our overall health.”

This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.

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The best office chairs for back support in 2024 https://www.popsci.com/gear/best-office-chairs-for-back-support/ Thu, 16 Mar 2023 21:13:15 +0000 https://www.popsci.com/?p=518908
The best chairs for lumbar support composited
Stan Horaczek

Working from home isn’t a pain with these supportive chairs.

The post The best office chairs for back support in 2024 appeared first on Popular Science.

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The best chairs for lumbar support composited
Stan Horaczek

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Best overall The sihoo office chair for lumbar support in orange SIHOO Ergonomic Office Chair
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The SIHOO M18 Classic Office Chair provides adjustable ergonomic features, a simple stylish design and an affordable price.

Best for gamers The Razer office chair for lumbar support in black Razer Iskur XL Gaming Chair
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The Razer Iskur XL features a fully adjustable lumbar curve, 4D armrests, and contoured high-density foam cushions for back support and comfort.

Best budget The Devoko chair for lumbar support in black Devoko Office Desk Chair
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For less than $70, you’ll get a comfortable, basic chair with an ergonomic curved mesh back.

With the shift to remote and hybrid work, getting an office chair that offers back support is more important than ever. Sitting comfortably for hours means you will be more productive during the day, and diminishing back pressure and pain will also help reduce strain on your body over time. So, if you haven’t upgraded yet, it’s time to ditch the dining chair or stool and invest in your home office setup. Technology advancements have made ergonomically correct office chairs easy to find and less expensive. Ergonomically correct chairs follow the natural curve of the spine and offer adjustable settings that properly align your body while working. The best office chairs for back support are designed for dynamic movement, allowing you to move freely while sitting and reducing pressure and pain on your back for more enjoyable workdays.

How we chose the best office chairs for back support

As a remote worker who experiences chronic back/neck tension, I can attest firsthand to how crucial it is to create a functional, comfortable work-at-home office. And at the heart of that is a proper office chair. To find the best office chairs for back support recommendations for this article, I initially researched educational and medical sources to understand the best practices for ergonomically correct seating. After understanding the features that make for an ergonomically correct office chair, I compared over 40 chairs from 30 brands before making recommendations. I considered cost, materials, adjustability, ergonomic construction, and customer reviews. 

The best office chairs for back support: Reviews & Recommendations

Customers with neck and shoulder pain may want to consider ergonomic office chairs with adjustable headrests, which are useful for reclined breaks to reduce neck tension. If you aren’t concerned about neck pain but still wish to support your spine properly, you can get a lower-profile ergonomic office chair that minimally supports your shoulder blades and back. Our selections include chairs with and without a headrest and many other desirable features. (Oh, and while you’re at it, consider a chair mat to make wheeling around easier on you and your floor.)

Best overall: SIHOO Ergonomic Office Chair

Sihoo

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Specs

  • Weight capacity: 330 pounds
  • Height: 42.91 to 51.18 inches
  • Seat width: 20.87 inches
  • Seat depth: 17.72 inches
  • Seat height: 16.93 to 20.87 inches

Pros

  • Affordable list price and extra coupon savings promotion on black and orange colorways
  • Simple, streamlined modern design would be aesthetically pleasing in your home office
  • Available in three colorways: black, gray, and orange
  • Adjustable lumbar support, headrest, height, and tilt

Cons

  • Manual controls to adjust settings

The SIHOO M18 Classic Office Chair is our choice for best overall office chair for back support because it provides adjustable ergonomic features, a simple stylish design, and an affordable price. The chair price varies depending on your color preference; the least expensive colorway is black, and the most expensive is gray. SIHOO chairs retail between $179 and $269.99, including current promotions. 

You can work dynamically with the chair’s easy-to-use turning, tilting, rolling, and reclining functions. The SIHOO M18 offers many adjustments to suit your body size and preferences. You can adjust the headrest up and down 3.9 inches, lumbar support in two directions, armrests in two directions, seat height, and recline tension. 

The chair is comfortable in warmer environments since it’s upholstered with a polyester mesh material, which promotes airflow (and keeps you cool). The fabric is also durable and resistant to UV rays. You’ll be able to take breaks while working to release back pain; in fact, you can recline up to 126 degrees. Considering the price and features as well as the stylish look, we chose SIHOO M18 as the best overall office chair for back support.

Best eco-friendly: Steelcase Karman Chair

Jen McCaffery

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Specs

  • Weight capacity: 350 pounds
  • Height: 39.125 to 43.5 inches
  • Seat width: 20 inches
  • Seat depth: 16.3 inches
  • Seat height: 15.875″ to 20.375

Pros

  • Made from sustainable materials 
  • Sleek design
  • Lightweight
  • Comfort adjustment dial added

Cons

  • Lumbar support is a separate purchase
  • Supports less weight capacity than other ergonomic chairs

Steelcase’s Karman Chair is inspired by the weightlessness of the Kármán Line, where the Earth’s atmosphere meets space. The chair is designed with sustainability in mind and is made from 25 percent recycled and 75 percent recyclable material. Steelcase uses a proprietary mesh material in this offering, combining yarn and filaments to create a weave that responds to your body and ensures you’re consistently comfortable. At 29 pounds, this chair is lighter than many options on the market but still features the same weight capacity as many similar chairs. Functionality was not ceded in the name of sleekness of sustainability.

The Karman features a mechanism that automatically senses your weight to provide the right amount of support for your back when you recline. It also boasts a new comfort dial that adjusts the chair’s tension by up to 20 percent, so you can customize it to your preference. You can also customize the chair when placing your order, choosing between height adjustability, 4-way adjustable arms, or an armless model. These options don’t impact how eco-friendly the chair is, but allow you to make choices based on personal preference and comfort. You can also purchase a cushion for additional lumbar support for an extra $57. Design enthusiasts will also appreciate the ability to choose between 13 colorways and several frame finishes.

Best low-profile: HON Office Chair Ignition 2.0

Hon

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Specs

  • Weight capacity: 300 pounds
  • Height: 44.5 inches
  • Seat width: 20 inches
  • Seat depth: 19 inches
  • Seat height: 16.25 to 19.25 inches

Pros

  • Dynamic sitting with synchro-tilt mechanism and tension control
  • Seat back constructed with breathable stretch mesh
  • Adjustable lumbar support, arms, height and tilt

Cons

  • Manual controls to adjust settings
  • Some customers found the assembly instructions confusing

The HON Ignition 2.0 is our choice for best low-profile office chair or best office chair for back support without a headrest. For a reasonable price, HON delivers an impressive amount of adjustments, which help this chair conform to your specific height and comfort preferences. For example, you can adjust the lumbar support, chair height and armrest height, and width. The chair tilts, and if preferred, the tilt function can be locked into place. The Ignition 2.0 also has a sturdy star base and a 360-degree swivel. The backrest material is a stretchy, breathable mesh, which is both comfortable and cooling. The chair is also highly rated by users, making it a good, sturdy, classic choice for your home office.

Best for gamers: Razer Iskur XL Gaming Chair

Razer

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Specs

  • Weight capacity: 400 pounds
  • Height: 57.1 inches
  • Seat width: 22.83 inches
  • Seat depth: 19.88 inches
  • Seat height: 18.11 to 22.83 inches

Pros

  • Great choice for larger and taller users
  • Plush high-density foam cushions provide hours of comfort
  • 4D armrests allow users to adjust height, angle, and forward or backward preference

Cons

  • Heavy at 74 pounds
  • Separate soft tread castors should be purchased for use on hard flooring

The Razer Iskur XL chair is our choice for best for gamers because it can be used both as an ergonomically correct office chair and as a PC gaming chair. Ergonomic features include a fully adjustable lumbar curve, 4D armrests, and contoured high-density foam cushions for back support and comfort. The Razer Iskur is available in average and XL sizes, making it a solid choice for larger frames. The chair is constructed with a steel-reinforced frame for durable support. The biggest difference between this chair and other ergonomic office chairs is the extra padding and thicker back cushion. The thicker cushions are designed to support long hours of gaming but could also work for long hours of computer work in the office. This chair is styled to coordinate with the Razer line of gaming computers and equipment, so if you like the gamer tech look, this chair is a good option to consider for both office and gaming.

Looking for something far more affordable? Check out our guide to the best gaming chairs under $100.

Best with footrest: Hbada E3 Ergonomic Office Chair

Hbada

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Specs

  • Weight capacity: 330 pounds
  • Height: 45.2 inches
  • Seat width: 19.6 inches
  • Seat depth: 19.5 inches
  • Seat height: 20 inches

Pros

  • Ergonomic 3-zone lumbar support
  • Breathable mesh fabric supports temperature regulation
  • Adjustable headrest, seat depth and back support
  • Allows 125-degree tilt with footrest and headrest for reclining

Cons

  • Manual controls to adjust settings
  • Some customers found the mesh seating too firm with break-in time needed

The Hbada E3 Ergonomic Chair is our choice for best for reclining with footrest because it offers easy adjustability, supportive upright seating, and a comfortable place to place your feet. The Hbada E3 chair is made from a lightweight, breathable, flexible mesh fabric, which isn’t bulky (despite the added headrest and footrest). 

Building in rest is a smart solution for reducing fatigue and back pain from long days of working at the computer. Rather than moving to a different seat, this chair helps productivity by allowing the user to take rest breaks without relocating. Hbada offers two E3 models, Supreme and Upgraded. The Supreme offers 3D armrests that allow users to raise and lower and go forwards, backward, and sideways. The Upgraded armrests can only be adjusted by height. The price difference is $50.

Best budget: Devoko Office Desk Chair

Devoko

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Specs

  • Weight capacity: 280 pounds
  • Height: 41.9 inches
  • Seat width: 20.5 inches
  • Seat depth: 19.25 inches
  • Seat height: 16 to 19.8 inches

Pros

  • Curved mesh chair back for ergonomic back support
  • Flip up arms for easy storage or multi-functional use
  • Rocking backrest with five-star mute rolling wheels for easy mobility

Cons

  • No adjustability for lumbar support, armrests, or seat depth
  • Some customers found the assembly instructions confusing

The Devoko Office Desk Chair is our choice for the best budget back-supporting office chair because, for less than $70, you will get a comfortable, supportive chair. The Devoko chair will allow you to roll, pivot, and lean back. You can’t adjust the settings, but for most average-sized people, this chair will be comfortable for computer work. The design brings an ergonomic back that supports the natural curve of the spine and breathable mesh fabric, which makes the chair comfortable to sit in. When you are looking for a simple, affordable ergonomic desk chair, this is a good budget option. And it’s available in three colors: black, blue, and gray. Looking for additional options? Check out our guide to the best office chairs under $200.

What to consider when choosing the best office chair for back support

With the shift to working at home, investing in products that let you work comfortably is important. Make sure the office chair you select is best for your office setup and is sized to fit your body. You can easily find an ergonomic office chair within your budget. Comfortable options can be found between $100 and $500, while high-end models retail for well over $1,000. Premium models use more expensive materials and construction, making the chair likely to last longer. Before choosing your office chair, consider these key features: 

Lumbar support

Adding lumbar support is one of the most important features of ergonomic office chairs. Ergonomic chairs are designed with a curved seat back to account for the natural curve of the spine. Many chairs offer adjustable lumbar support, which users can shift up or down for comfort, while others offer extra lumbar cushions. If the lumbar support is fixed, be sure the chair is comfortable with your back pressed against it.

Adjustability

The best ergonomic office chairs consider the shape of the spine and the best alignment for the legs, arms, and back. They provide optimal support for long days in the chair but don’t always account for the variance of body height, shape, and weight. Look for models that easily adjust the height, armrests, seat, and lumbar support, which makes them a better fit for that adjustable ergonomic desk when you change its height, etc.

Materials

The best materials will provide both cushion and breathability. High-quality foam seat cushioning will provide hours of comfort. Mesh fabrics are a good choice for comfort as they allow for airflow. Plastics and PVC upholstery, while durable, can make the chair overly warm and uncomfortable in warmer office settings. And low-density foam cushions will not hold up to years of use.

Size

Some ergonomic office chairs provide a high seat back and include a headrest, while others are designed with a lower profile. Make sure your seat is minimally high enough to hit your shoulder blades—this will ensure sufficient support for both the upper and lower back. The seat pan should be at least one inch wider than your hips and thighs. You should have at least a half-inch gap between the front edge of the seat pan and the back of your knees. The best office chairs for back support have a soft contoured seat pan with a waterfall front (one that curves down) to prevent the seat from compressing leg circulation.

Dynamic movement

Even when you’re working at your desk, you’re moving. The best ergonomic office chairs are built with the ability to shift around. Your chair should have at least a five-star base with castors that glide easily, and your chair’s backrest should recline and support your back in different positions. Dynamic sitting is better for the health of the spine. Want to try something completely different? There are always kneeling chairs that relieve pressure and help strengthen your core (which contributes to less back pain, but consult a doctor first if you have concerns).

FAQs

Q: What type of office chair is best for back pain?

The best office chair for back pain is an ergonomic office chair designed with adjustable height, swivel, and lumbar support. Look for features like a curved back, which supports the lower back, adjustable armrests, a comfortable seat cushion, breathable fabrics, and a backrest that supports your back at least to shoulder-blade level.

Q: What is the best office chair for sitting for long hours?

The best office chair for sitting for long hours is an ergonomic office chair that supports dynamic movement. Since dynamic sitting helps maintain a healthy spine, look for chairs that allow you to recline in different postures while maintaining back support, a swivel for easy movement and rotation, and an adjustable-tilt seat pan that helps maintain a balanced seated posture.

Q: What office chairs do chiropractors recommend?

Chiropractors recommend an ergonomically correct office chair to support your posture and balance your spine. Ergonomic office chairs should ideally offer customizable settings, such as adjustable height and armrests, since everyone’s body is different. Chiropractors advise using an office chair that allows your feet to be flat on the floor, your hips and knees at 90 degrees, a swivel base for easy movement, and lumbar support.

Final thoughts on the best office chairs for back support

If you work from home, chances are you spend at least seven hours per day in your office chair. That amount of sitting can damage your spine. But the best office chairs for back support come with cushioning, adjustable headrests, lumbar support, and other features that can help the workday take less of a toll on your body and look great in your office as well.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

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A robot named ‘Emo’ can out-smile you by 840 milliseconds https://www.popsci.com/technology/emo-smile-robot-head/ Fri, 29 Mar 2024 14:00:00 +0000 https://www.popsci.com/?p=608662
Yuhang Hu working on Emo robot head
Emo contains 26 actuators to help mimic human smiles. John Abbott/Columbia Engineering

The bot's head and face are designed to simulate facial interactions in conversation with humans.

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Yuhang Hu working on Emo robot head
Emo contains 26 actuators to help mimic human smiles. John Abbott/Columbia Engineering

If you want your humanoid robot to realistically simulate facial expressions, it’s all about timing. And for the past five years, engineers at Columbia University’s Creative Machines Lab have been honing their robot’s reflexes down to the millisecond. Their results, detailed in a new study published in Science Robotics, are now available to see for yourself.

Meet Emo, the robot head capable of anticipating and mirroring human facial expressions, including smiles, within 840 milliseconds. But whether or not you’ll be left smiling at the end of the demonstration video remains to be seen.

AI photo

AI is getting pretty good at mimicking human conversations—heavy emphasis on “mimicking.” But when it comes to visibly approximating emotions, their physical robots counterparts still have a lot of catching up to do. A machine misjudging when to smile isn’t just awkward–it draws attention to its artificiality. 

Human brains, in comparison, are incredibly adept at interpreting huge amounts of visual cues in real-time, and then responding accordingly with various facial movements. Apart from making it extremely difficult to teach AI-powered robots the nuances of expression, it’s also hard to build a mechanical face capable of realistic muscle movements that don’t veer into the uncanny.

[Related: Please think twice before letting AI scan your penis for STIs.]

Emo’s creators attempt to solve some of these issues, or at the very least, help narrow the gap between human and robot expressivity. To construct their new bot, a team led by AI and robotics expert Hod Lipson first designed a realistic robotic human head that includes 26 separate actuators to enable tiny facial expression features. Each of Emo’s pupils also contained high-resolution cameras to follow the eyes of its human conversation partner—another important, nonverbal visual cue for people. Finally, Lipson’s team layered a silicone “skin” over Emo’s mechanical parts to make it all a little less.. you know, creepy.

From there, researchers built two separate AI models to work in tandem—one to predict human expressions through a target face’s minuscule expressions, and another to quickly issue motor responses for a robot face. Using sample videos of human facial expressions, Emo’s AI then learned emotional intricacies frame-by-frame. Within just a few hours, Emo was capable of observing, interpreting, and responding to the little facial shifts people tend to make as they begin to smile. What’s more, it can now do so within about 840 milliseconds.

“I think predicting human facial expressions accurately is a revolution in [human-robot interactions,” Yuhang Hu, Columbia Engineering PhD student and study lead author, said earlier this week. “Traditionally, robots have not been designed to consider humans’ expressions during interactions. Now, the robot can integrate human facial expressions as feedback.”

Right now, Emo lacks any verbal interpretation skills, so it can only interact by analyzing human facial expressions. Lipson, Hu, and the rest of their collaborators hope to soon combine the physical abilities with a large language model system such as ChatGPT. If they can accomplish this, then Emo will be even closer to natural(ish) human interactions. Of course, there’s a lot more to relatability than smiles, smirks, and grins, which the scientists appear to be focusing on. (“The mimicking of expressions such as pouting or frowning should be approached with caution because these could potentially be misconstrued as mockery or convey unintended sentiments.”) However, at some point, the future robot overlords may need to know what to do with our grimaces and scowls.

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Breaking through the noise https://www.popsci.com/gear/sennheiser-conversation-clear-plus-earbuds-and-hidden-hearing-loss/ Thu, 28 Mar 2024 20:00:00 +0000 https://www.popsci.com/?p=608396
Black Sennheiser Conversation Clear Plus sound amplification earbuds sitting in their case on a table at Padaek Arlington restaurant with Laab and Paa Tawd
Personal sound amplification devices like Sennheiser's Conversation Clear Plus enhance speech in loud environments, letting you enjoy friends dishing the dirt over tasty dishes. Tony Ware

How Sennheiser's new Conversation Clear Plus true wireless earbuds tackle the surprisingly common problem of hidden hearing loss.

The post Breaking through the noise appeared first on Popular Science.

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Black Sennheiser Conversation Clear Plus sound amplification earbuds sitting in their case on a table at Padaek Arlington restaurant with Laab and Paa Tawd
Personal sound amplification devices like Sennheiser's Conversation Clear Plus enhance speech in loud environments, letting you enjoy friends dishing the dirt over tasty dishes. Tony Ware

We may earn revenue from the products available on this page and participate in affiliate programs. Learn more ›

Bustling restaurants provide the ultimate real-world hearing challenge. As diners swap stories, their voices compete with the chatter of other tables, the clatter of dishes, and a smattering of background music that creeps into the foreground. It’s the perfect recipe to overwhelm someone with hidden hearing loss—a poorly understood condition that makes communicating in noisy environments a frustrating ordeal.

A new wave of consumer wearable technologies aims to help people with hidden or mild to moderate high-frequency hearing loss who are not good candidates for traditional hearing aids. For example, Sennheiser’s Conversation Clear Plus looks like and can act just like a regular pair of sleek true wireless earbuds that handle calls and stream content, complete with multiple sizes of eartips and ear fin stabilizers as you’d find with any standard consumer electronics. However, this personal sound amplification product also offers speech enhancement, automatic scene detection, and active noise cancellation technology so wearers can fully participate in everyday conversations without missing a beat.

Tony Ware

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“There’s a gap we try to fill: reaching people who have an issue but there’s not really a solution for it yet. They may not be ready for hearing aids due to stigma or just not feeling that it’s for them yet,” said Laura Jagoda, a psychologist specializing in speech perception and Conversation Clear Plus product manager.

Unlike traditional hearing loss where sounds become inaudible, hidden hearing loss makes distinguishing speech from background noise difficult. The condition is hard to diagnose, and many people with hidden hearing loss may pass standard hearing tests—myself included, as I’ll soon explain. More often than not, sufferers easily understand conversations in one-on-one or quiet settings, so they ignore common signs of hearing loss like asking people to repeat themselves. 

Traditional, always-on hearing aids amplify, but people with hidden hearing loss need clarity more than capacity, and only at certain times. The Conversation Clear Plus hearables combine technology and techniques from the long histories of Sennheiser’s personal audio products—such as the low-profile IE 900 audiophile in-ear monitors and connectivity-rich MOMENTUM True Wireless 4 earbuds—and parent company Sonova’s hearing aid development. 

Multiple beamforming microphones fill each Conversation Clear Plus earbud, allowing them to focus on what’s in front of the wearer while tuning out environmental noise. Active noise canceling blocks frequencies outside of human speech. Tests at Force Technology’s SenseLab, a third-party laboratory, found that 95 percent of users experience significant speech enhancement in noisy environments. 

“We have decades of hearing aid experience that really gives us an advantage,” notes Jagoda. “We’re not just tuning out all noise blindly—our techniques isolate speech while maintaining ambient awareness.”

The author adjusting the settings of the Sennheiser Conversation Clear Plus earbuds while getting a drink in a loud coffee shop
While the Conversation Clear Plus earbuds can automatically adjust to the scene, the app lets you easily refine settings. Tony Ware

I’ve used the Conversation Clear Plus out and about for happy hours and in restaurants and coffee shops, situations where I increasingly found myself asking “What?” more than I’d like. Group conversations seemed to be a thing of the past, presumably thanks to years spent at clubs, concerts, and live sporting events with only a belated adoption of ear protection. I took a hearing test in 2023, fully expecting to be put into hearing aids. Instead, I was told my hearing fell in a normal range and got a few useful tips like trying to pick a table seat that put my back toward the din of a restaurant. It helped, but I still wondered if there was a discreet, over-the-counter solution for someone who needed slightly elevated audibility with a low barrier to entry.

With the earbuds paired to my phone via Bluetooth 4.2, Sennheiser’s simple smartphone app makes it easy to personalize the earbuds to my hearing, whether you use an iOS or Android device. And the system can automatically adjust levels according to the surrounding environment so I’d often put them in as I entered a challenging space. While AirPods have normalized the near-constant presence of earbuds, I felt compelled to point out that I was wearing the Conversation Clear Plus to help with my hearing, not to block out my conversation-mate for more Kylie. Only then did people notice anything was in my ears, proof that nothing about the earbuds screams garish or medical-grade (though I do have long hair). In moderately noisy bars, I successfully participated in small group conversations with just a little adjustment on the simple sliders to let more or less external sound in, plus occasionally toggling the “enhanced clarity” option to switch the mics from omni to directional pickup. 

Let’s talk about the occlusion effect. Popping in hearing aids, ear plugs, or earbuds blocks an ear pathway, which can make the wearer’s voice sound unnaturally hollow. Ultimately, it makes it hard for the wearer to determine the volume of their voice. With other hearing enhancement products, my voice sounded absolutely booming to me but I was often asked to speak up. Apparently, I was basically whispering. Conversation Clear Plus’s use of active noise cancellation mitigates this effect substantially. 

With Sennheiser’s device, I had normal, seamless conversations. And as I left, I simply popped the earbuds back into the charging case in my bag, assuming I didn’t have any podcasts to catch up on (they can last up to nine hours on a full charge—that’s a looooong conversation or playlist—and the case contains two additional charges). And all without using anything that looked like hearing aids. After all, hearing aids are for old people. Or that’s what people think, according to a National Council on Aging (NCOA) study, but signs of hidden hearing loss show up in groups as young as college students. The council found many people overlook or avoid addressing hearing issues for as long as a decade. Symptoms slowly creep into daily life, like turning up the TV or music far louder than other folks and feeling exhausted from concentrating on listening. NCOA found about 37.5 million American adults report perceived hearing issues, but many question whether hearing aids that cost an average of $4,600 are worth it. 

If you're experiencing hidden hearing loss, these could be your best 'buds when meeting up with buds.
If you find hearing in bars and restaurants challenging, these could be your best ’buds when meeting up with buds. Tony Ware

The Conversation Clear Plus—with its $849.95 MSRP—bridges the gap, but there are still hurdles to clear. Part of the problem is a general lack of awareness about hearing loss compared to similar problems like vision impairments. Though they are both physical problems, vision screening and corrective options are more commonly discussed and accepted. 

“You start wearing glasses quite early on, even if your correction is very low, right? It’s even a fashion item,” Jagoda points out. “Your vision can decline. That’s natural; just biology. It’s nobody’s fault. It’s the same for hearing actually. … We’re just not used to paying a lot of attention to that gradual decline and starting to act on it early on.” 

Various stigmas burden hearing loss. Not only can it be dismissed as a problem for the elderly, but others can confuse a sufferer’s physical impairment with a lack of intelligence when they persistently ask others to repeat themselves or miss parts of conversations. Embarrassment and frustration can lead people to retreat from social interactions. Leaving hearing loss untreated can lead to anxiety, depression, social isolation, and dementia, according to the World Health Organization.

“Some people basically give up or just avoid certain situations. This alone can lead to social isolation … depression,” Jagoda explained. “This sounds quite intense, but with an untreated hearing loss, your brain structure and function reorganizes as it reacts through to lacking input.” 

Game-changing solutions like Conversation Clear Plus add a valuable option between hearing aids and leaving hearing loss untreated. They provide people with hidden hearing loss or who need an audible boost with an accessible, affordable, and unassuming means to remain connected to friends and family.

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Please think twice before letting AI scan your penis for STIs https://www.popsci.com/health/calmara-ai-sti/ Thu, 28 Mar 2024 18:45:00 +0000 https://www.popsci.com/?p=608402
person taking photos of themselves in the dark
Calmara offers a QR code taking you to its AI photo scanner. DepositPhotos

Awkward Gen Z buzzwords, troubling tech, and outdated sex ed: Calmara is not your 'intimacy bestie.'

The post Please think twice before letting AI scan your penis for STIs appeared first on Popular Science.

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person taking photos of themselves in the dark
Calmara offers a QR code taking you to its AI photo scanner. DepositPhotos

A website promising its AI service can accurately scan pictures of penises for signs of sexually transmitted infections is earning the ire of healthcare advocates and digital privacy experts, among many other critics. But while the internet (and Jimmy Fallon) have taken the makers of Calmara to task over the past week, it actually took two years to get here.

Where did the AI ‘intimacy bestie’ come from?

Back in 2022, the company HeHealth debuted itself as an online way to “get answers about your penis health in minutes.” To receive this information, the website uses a combination of questionnaires and what the company claims is a “65-96 percent accurate” AI screening tool allegedly trained on proprietary datasets to flag photographic evidence of various STIs, including genital warts, herpes eruptions, and syphilis. “Cancer” is also included in the list of scannable signs. If the results come back “positive”, HeHealth can then refer users to healthcare professionals for actual physical screenings, diagnoses, and treatment options. It’s largely flown under the radar since then, with only around 31,000 people reportedly using its allegedly anonymized, encrypted services over the last two years. And then came Calmara.

Calmara website screenshot
Credit: Calmara

With a website overloaded with Gen Z-centric buzzwords, Calmara sells itself as women’s new “intimacy bestie,” offering to scan pictures of their potential sexual partners’ penises for indications of STIs. According to HeHealth CEO’s latest LinkedIn post, HeHealth and Calmara “are totally different products.” However, according to Calmara’s website, HeHealth’s owners are running Calmara, and it utilizes the same AI. Calmara also markets itself as (currently) free and “really in its element when focused on the D.”

In a March 19 reveal announcement, one “anonymous user” claimed Calmara is already “changing the conversation around sexual health.” Calmara certainly sparked a conversation over the last week—just not the one its makers likely intended.

A novelty app 

Both Calmara’s and HeHealth’s fine print concede their STI judgments “should not be used as substitutes for professional medical advice, diagnosis, treatment, or management of any disease or condition.” There’s an obvious reason why this is not actually a real medical diagnosis tool, despite its advertising. 

It doesn’t take an AI “so sharp you’d swear it aced its SATs” to remember that the majority of STIs are asymptomatic. In those cases, they definitely wouldn’t be visible in a photograph. What’s more, a preprint, typo-laden paper explaining Calmara’s AI indicates it was trained on an extremely limited image database that included “synthetic” photos of penises, i.e. computer-generated images. Meanwhile, determining its surprisingly accuracy is difficult to do—Calmara’s preprint paper says its AI is around 94.4-percent accurate, while the homepage says 95 percent. Scroll down a little further, and the FAQ section offers 65-to-90 percent reliability. Not a very encouraging approach to helping foster safe sex practices that would, presumably, require mutual, trustworthy statements about sexual health.

Calmara website screenshot
Credit: Calmara

“On its face, the service is so misguided that it’s easy to dismiss it as satire,” sex and culture critic Ella Dawson wrote in a viral blog post last week. Calmara’s central conceit—that new intimate partners would be comfortable enough to snap genital photos for an AI service to “scan”—is hard to imagine actually playing out in real life. “… This is not how human beings interact with each other. This is not how to normalize conversations about sexual health. And this is not how to promote safer sex practices.”

No age verification

Given its specific targeting of younger demographics, Dawson told PopSci she believes “it’s easy to see how a minor could find Calmara in a moment of panic and use it to self-diagnose” which would constitute obvious legal issues, as well as ethical ones. For one, explicit images of minors could constitute sexual child abuse material, or CSAM. While Calmara expressly states its program shouldn’t be used by minors, it still lacks even the most basic of age verification protocols at the time of writing.  

“Calmara’s lack of any age verification, or even a checkbox asking users to confirm that they are eighteen years of age or older, is not just lazy, it’s irresponsible,” Dawson concludes.

Side by side of age verification and consent pages for Calmara
Credit: Calmara / PopSci

Dubious privacy practices 

More to the point, simply slapping caveats across your “wellness” websites could amount to the “legal equivalent of magic pixie dust,” according to digital privacy expert Carey Lening’s rundown. While Calmara’s FAQ section is much vaguer on technical details, HeHealth’s FAQ page does state their services are HIPAA compliant because they utilize Amazon Web Services (AWS) “to collect, process, maintain, and store” data—which is technically true.

On its page dedicated to HIPAA regulations, AWS makes clear that there is no such thing as “HIPAA certification” for cloud service providers. Instead, AWS “aligns our HIPAA risk management program” to meet requirements “applicable to our operating model.” According to AWS, it utilizes “higher security standards that map to the HIPAA Security Rule” which enables “covered entities and their business associates” subject to HIPAA to use AWS for processing, maintaining, and storing protected health information. Basically, if you consent to use Calmara or HeHealth, you are consenting to AWS handling penis pictures—be them yours, or someone else’s.

[Related: A once-forgotten antibiotic could be a new weapon against drug-resistant infections.]

That said, Lening says Calmara’s makers may have failed to consider newer state laws, such as Washington’s My Health My Data Act, with its “extremely broad and expansive view of consumer health data” set to go into effect in late June. The first of its kind in the US, the My Health My Data Act is designed specifically to protect personal health data that may fall outside HIPAA qualifications. 

“In short, they didn’t do their legal due diligence,” Lening contends.

“What’s frustrating from the perspective of privacy advocates and practitioners is not that they were ‘embracing health innovation‘ and ‘making a difference‘, but rather that they took a characteristic ‘Move Fast, Break Things’ kind of approach to the problem,” she continues. “The simple fact is, the [online] outrage is entirely predictable, because the Calmara folks did not, in my opinion, adequately assess the risk of harm their app can cause.”

Keep Calmara and carry on

When asked about these issues directly, Calmara and HeHealth’s founders appeared nonplussed.

“Most of the criticism is based on wrong information and misinformation,” HeHealth CEO and Calmara co-founder Yudara Kularathne wrote to PopSci last Friday, pointing to an earlier LinkedIn statement about its privacy policies. Kularathne added that “concerns about potential for anonymized data to be re-identified” are being considered.

On Monday, Kularathne published another public LinkedIn post, claiming to be at work addressing, “Health data and Personally Identifiable Information (PHI) related issues,” “CSAM related issues,” “communication related issues,” and “synthetic data related issues.”

“We are addressing most of the concerns raised, and many changes have been implemented immediately,” Kularathne wrote.

Calmara QR code page screenshot
Credit: Calmara

When reached for additional details, Calmara CEO Mei-Ling Lu avoided addressing criticisms in email, and instead offered PopSci an audio file from “one of our female users” recounting how the nameless user and her partner employed HeHealth’s (and now Calmara’s) AI to help determine they had herpes.

“[W]hile they were about to start, she realized something ‘not right’ on her partner’s penis, but he said: ‘you know how much I sweat, this is heat bubbles,’” writes Lu. After noticing similar “heat bubbles… a few days later,” Stacy and her partner consulted HeHealth’s AI scanner, which flagged the uploaded photos and directed them to healthcare professionals who confirmed they both had herpes.

To be clear, medical organizations such as the Mayo Clinic freely offer concise, accurate information on herpes symptoms, which can include pain or itching alongside bumps or blisters around the genitals, anus or mouth, painful urination, and discharge from the urethra or vagina. Symptoms generally occur 2-12 days after infection, and although many people infected with the virus display either mild or no symptoms, they can still spread the disease to others. 

Meanwhile, Calmara’s glossy (NSFW) promotional, double entendre-laden video promises that it is “The PERFECT WEBSITE for HOOKING UP,” but no matter how many bananas are depicted, using AI to give penises a once-over doesn’t seem particularly reliable, enjoyable, or even natural.

The post Please think twice before letting AI scan your penis for STIs appeared first on Popular Science.

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Cracking open a 117-year-old Antarctic milk time capsule https://www.popsci.com/science/antarctic-milk-time-capsule/ Thu, 28 Mar 2024 17:00:00 +0000 https://www.popsci.com/?p=608405
Sir Ernest Shackleton's ship the Nimrod, among the ice in McMurdo's Sound, Antarctica.
Sir Ernest Shackleton's ship the Nimrod, among the ice in McMurdo's Sound, Antarctica. Photo12/Universal Images Group via Getty Images

Powdered whole milk samples from Ernest Shackleton’s 1908 Nimrod expedition offer a glimpse into dairy’s evolution.

The post Cracking open a 117-year-old Antarctic milk time capsule appeared first on Popular Science.

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Sir Ernest Shackleton's ship the Nimrod, among the ice in McMurdo's Sound, Antarctica.
Sir Ernest Shackleton's ship the Nimrod, among the ice in McMurdo's Sound, Antarctica. Photo12/Universal Images Group via Getty Images

As dairy alternatives such as almond, oat, and soy milk continue to grow in popularity, an centuries old question regarding cow’s milk still remains. How does today’s dairy differ from what previous generations consumed? 

Some clues are now emerging in the form of some 117-year-old whole milk powder that was transported on Sir Ernest Shackleton’s British Antarctic Expedition in the early 20th Century. A study published in the March 2024 issue of the Journal of Dairy Science found that despite advancement in selective cow breeding and changes to farm practices, milk from the present and past have more similarities than differences. 

The Nimrod expedition

The powdered milk in the study was made by New Zealand’s Defiance brand in 1907. On New Year’s Day in 1908, Shackleton and his crew aboard the ship Nimrod set sail on a quest to be the first to set foot on the South Pole. The Nimrod was well stocked with dairy, including 1,000 pounds of dried whole milk powder, 192 pounds of butter, and two cases of cheese. The crew would make it farther south than any known human had been before and made it within 100 nautical miles of the South Pole and left their base camp and its supplies behind

The photo on the top left (A) shows the tin-plated can of Defiance brand dried milk found in Shackleton’s Cape Royds base camp hut, with a close-up label in the bottom photo (C) (courtesy of the Antarctic Heritage Trust, Christchurch, New Zealand). The top-right photo (B) is of the Joseph Nathan & Sons Bunnythorpe Defiance Dried Milk Factory circa 1904 (courtesy of Massey University, Palmerston North, New Zealand).
The photo on the top left (A) shows the tin-plated can of Defiance brand dried milk found in Shackleton’s Cape Royds base camp hut, with a close-up label in the bottom photo (C) (courtesy of the Antarctic Heritage Trust, Christchurch, New Zealand). The top-right photo (B) is of the Joseph Nathan & Sons Bunnythorpe Defiance Dried Milk Factory circa 1904 (courtesy of Massey University, Palmerston North, New Zealand).

About a century later, one remaining container of Defiance whole milk powder was uncovered during a restoration project by the Antarctic Heritage Trust restoration project. The milk powder had been frozen in time and ice at Shackelton’s base camp for 100 years.

“The Shackleton dried milk is possibly the best-preserved sample manufactured during the pioneering years of commercial milk powder production, and its discovery gives us a once-in-a-lifetime chance to understand the similarities and differences between a roller-dried milk powder manufactured over 100 years ago with modern spray-dried counterparts,” Skelte G. Anema, a study co-author and chemist at Fonterra Research and Development Centre in New Zealand, said in a statement

[Related: Ancient milk-drinkers were just fine with their lactose intolerance–until famine struck.]

According to Anema, before vacuum-assisted evaporation, milk powders were made by a roller-drying process. Boiling-hot milk was poured between two steam-heated revolving cylinders so that the water evaporated. A thin sheet of dried milk was left behind that was then milled and sieved. While scientists knew that these early milk powders were not as sophisticated as those available today, they were not sure what other differences existed. 

Analyzing milk powders

In the study, the team analyzed a few hundred grams of the 100 plus year-old Defiance milk. They set out to compare it with two modern-day commercial, non-instantized and spray-dried whole milk powder samples. They compared the composition of the milk’s major and trace components, proteins, fatty acids, and phospholipids. They also looked at the microstructural properties, color, and volatile components in the different whole milk powder samples.

“Despite more than a century between the samples, the composition of bulk components and detailed protein, fat, and minor components have not changed drastically in the intervening years,” said Anema.

The fatty acid composition, phospholipid composition, and protein composition of the samples were generally similar. The major mineral components between the samples were also relatively alike, except for higher levels of lead, tin, iron, and other trace minerals found in the Shackleton whole milk powder. These minerals likely came from the tin-plated can the powder was stored in and the equipment and water supply used during that time period. Using stainless steel and better water has eliminated that issue from modern milk powders, according to the team.

Another notable difference in the Shackleton milk samples was the presence of oxidation-related volatile aroma compounds.

[Related: Tending Sir Ernest’s Legacy: An Interview with Alexandra Shackleton.]

“Perhaps from less-than-ideal collection and storage of the raw milk before drying, but it’s much more likely that—even in frozen conditions—being stored in an open tin for a century is going to result in continued oxidation,” said Anema.

Despite the remarkable similarities between the milk samples, the team points out that modern spray-dried whole milk powders are substantially superior in terms of the powder quality. They look better and dissolve in water more easily. 

This unique Antarctic time capsule still provides a glimpse into dairy food production methods of the past and its evolution over time. 

“The Shackleton samples are a testament to the importance of dairy products—which are rich in protein and energy as well as flexible enough to be powdered for easy transport, preparation, and consumption,” said Anema. 

The post Cracking open a 117-year-old Antarctic milk time capsule appeared first on Popular Science.

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The benefits of barefoot shoes: A beginner’s guide https://www.popsci.com/diy/barefoot-shoes-benefits/ Thu, 28 Mar 2024 13:03:00 +0000 https://www.popsci.com/?p=608203
two sets of legs walking on a wooden boardwalk
Say goodbye to overly structured, rigid, and inflexible footwear. Xero Shoes

Free your feet, but start slow.

The post The benefits of barefoot shoes: A beginner’s guide appeared first on Popular Science.

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two sets of legs walking on a wooden boardwalk
Say goodbye to overly structured, rigid, and inflexible footwear. Xero Shoes

If you think you need over-cushioned, over-supportive, and over-engineered footwear for everything from running errands to running trails, think again. Research has shown many healthful and practical advantages to wearing barefoot or minimalist shoes instead, whether you’re walking, running, hiking, or chasing the kids around the backyard.

Minimalist and barefoot shoes can strengthen muscles and bones in the feet and ankles, which can help prevent injury, stabilize the arch, and help prevent some athletic injuries. Intrinsic foot muscle strength is positively correlated to stability and better balance, especially in older individuals. And in athletes, the strength and flexibility in the big toe area that’s encouraged by barefoot shoes can help with push off, power, and agility. 

However, when you contain your feet in a conventional shoe with excessive cushioning and support and a decidedly un-foot-like shape, you lose much of their natural function and strength—not to mention the childlike joy of feeling the earth beneath your feet. And science seems to corroborate the idea that feet are designed perfectly to perform functions like walking and running in minimalist footwear—or in none at all. After all, for most of human history people trod barefoot or in only minimalist footwear.

But if you’re keen to free your feet and give minimalist shoes a try, whether you’re interested in whole body health and wellness, functional movement, reducing chronic pain, or simply returning to a place of childhood delight that comes only from romping around outside sans footwear, it’s going to take time and strategic effort. Here’s how to transition safely and effectively for a lifetime of healthy, functional feet.

What are barefoot shoes?

Before you start shopping for new shoes, it’s important to know what constitutes minimal or barefoot footwear. Main features include a wide toe box, zero-drop footbed (meaning your heel is the same distance from the ground as your forefoot), no arch support, and a flexible sole. All are designed to let your toes spread and your feet get stronger as they move and flex naturally, as if they were barefoot.

And just about everyone can—and maybe should, according to Emily Splichal, podiatrist and founder of the Center for Functional & Regenerative Medicine—make the transition. There are only a few types of feet she says may not benefit from minimalist footwear, including those with overpronation due to ligament laxity (extra loose ligaments) or high-arched, rigid feet. But most others, including those with bunions, hammer toes, or plantar fasciitis can usually benefit. Just transition wisely.

Start Slow

Like strengthening any other part of your body, strengthening the muscles in your feet will take time, so don’t expect to make the switch to barefoot shoes overnight. “You’re theoretically increasing stress and demands to the foot, which means you need to have sufficient strength to address those demands,” explains Splichal. How much time that takes depends on you and your feet, but it could be anywhere from a few weeks to a few months.

“This kind of transition from overly structured, stiff, and inflexible shoes requires consistency and patience,” adds John Wadley, vice president of product development at barefoot shoe brand Xero Shoes.

After all, you’ve likely been wearing narrow, cushioned shoes for most of your life; your foot and leg muscles aren’t used to all the increased stress, load, and sensation that comes with wearing minimalist footwear. Think of transitioning like getting a cast removed, Wadley suggests: When the cast comes off, your muscles have atrophied a bit and returning your injured appendage to pre-break strength will take time and effort. Conventional footwear is similar to a cast, just less extreme.

So to start, only wear your minimalist shoes at work, to the gym, around the house, or when running errands, but only one day at a time, and maybe just for a few hours. For example, wear them on Monday, switch to your regular footwear for a few days, then don the minimalist shoes again on Thursday. “Introduce your feet to increased demands, but allow sufficient time for recovery and adaptation,” Splichal instructs. “No pain no gain is definitely not something that is involved here.”

Then, as long as your feet and ankles don’t hurt (they’ll likely feel a bit more tired or strained than usual, but that’s normal), slowly increase the number of days per week you wear your shoes while decreasing the number of rest days in between. Listen to your body for cues and don’t push your limits or you may set your journey to foot health back instead of forward.

If you want to start running in barefoot shoes–not just living, hiking, or walking–plan to take even more time to transition. After all, the impact force and demand on your feet is greater when you run, so Wadley, a runner himself, suggests starting with just a mile or two in barefoot shoes. Then slowly increase time and distance on subsequent runs. It’s also important to focus on single leg stability and foot awareness to get better at barefoot running, Splichal says, which involves strengthening your feet via specific exercises.

Strengthen and Recover

Indeed, balancing all the work you put in with recovery and strengthening exercises to increase balance, stability, and foot awareness is just as important as time in your new footwear, Splichal points out.

To aid in your barefoot journey, start with Splichal’s favorite exercise: short foot. To perform the move, stand up straight, lift and spread your toes, and then place them on the floor. Inhale through your nose and, as you exhale, push the tips of your toes into the ground. Press down for the entire exhalation, then relax, inhale, and repeat the cycle five more times. 

Fitness & Exercise photo

Boost single leg stability by standing on one foot while you wash your hands or do dishes, then after time spent in barefoot shoes, use recovery tools like Splichal’s Neuro Ball, a studded sphere with a smaller, harder ball inside, which can be used to massage or release your feet. Place the ball—or a golf ball or lacrosse ball—on the floor and stand up while you roll it around under one foot at a time, using medium pressure, or keep it stationary while you press down on one area of your sole at a time.

Perform calf stretches after activity and wear toe spacers, too, which can both be useful recovery tools that promote flexibility and function, Splichal says.

Give barefoot a chance

Whether you plan to run, walk, or simply wear barefoot shoes for daily life, are looking to increase foot health and function or improve balance, make sure that you listen to your body when transitioning, don’t overdo it, and focus on recovery.

“Give your feet a chance to be healthy and strong,” Wadley encourages. “You won’t regret it.”

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Black licorice can be dangerous for your health https://www.popsci.com/health/back-licorice-can-be-dangerous/ Thu, 28 Mar 2024 12:00:00 +0000 https://www.popsci.com/?p=607794
Black licorice
Black licorice gets its distinctive flavor from licorice root. DepositPhotos

A toxicologist explains the treat's dark side.

The post Black licorice can be dangerous for your health appeared first on Popular Science.

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Black licorice
Black licorice gets its distinctive flavor from licorice root. DepositPhotos

This article was originally featured on The Conversation.

Black licorice may look and taste like an innocent treat, but this candy has a dark side. On Sept. 23, 2020, doctors reported that black licorice was the culprit in the death of a 54-year-old man in Massachusetts. How could this be? Overdosing on licorice sounds more like a twisted tale than a plausible fact.

I am a toxicologist and author of the book “Pleased to Meet Me: Genes, Germs, and the Curious Forces That Make Us Who We Are.” I have a long-standing interest in how chemicals in food and the environment affect the body and mind.

When something seemingly harmless like licorice is implicated in a death, we are reminded of the famous proclamation by Swiss physician Paracelsus, considered the father of toxicology: “All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison.”

Root of the problem

The unfortunate man who succumbed to excessive black licorice consumption is not alone. There is a smattering of similar case reports in medical journals in which patients experienced a sudden severe increase in blood pressuremuscle breakdown or even death.

Adverse reactions are most frequently seen in people over the age of 40 who are eating far more black licorice than the average person. In addition, they are usually consuming the product for prolonged periods of time. In the 2020 case, the Massachusetts man had been eating a bag and a half of black licorice every day for three weeks.

Licorice is a flowering plant native to parts of Europe and Asia. Its scientific name, Glycyrrhiza, is derived from the Greek words “glykos” (sweet) and “rhiza” (root). People have long used the aromatic and sweet extract from its root as an herbal remedy for a wide variety of health maladies, from heartburn and stomach issues to sore throats and cough. However, there is insufficient evidence that licorice is effective in treating any medical condition.

Glycyrrhizin, also called glycyrrhizic acid, is the chemical in black licorice that gives the candy its signature flavor, but it also leads to its toxic effects.

Glycyrrhizin mimics aldosterone, a hormone your adrenal glands make when your body needs to retain sodium and excrete potassium. Sodium and potassium work together as a kind of cellular battery that drives communication between nerves and the contraction of muscles. Too much glycyrrhizin upsets the balance of these electrolytes, which can raise blood pressure and disturb the heart’s rhythm. Other symptoms of excessive licorice intake include swelling, muscle pain, numbness and headache. Examination of the man who died from consuming too much licorice revealed that he had dangerously low levels of potassium, consistent with glycyrrhizin toxicity.

It should be noted that a number of licorice-based foods do not contain real licorice but use a flavoring substitute called anise oil, which does not pose the dangers discussed here. In addition, despite its name, red licorice rarely contains licorice extract. Instead, red licorice is infused with chemicals that impart its cherry or strawberry flavor.

Products that contain real licorice are usually labeled as such and list licorice extract or glycyrrhizic acid among the ingredients. Be advised that some products, such as black jelly beans or Good & Plenty, are mixtures of different candies that contain both anise oil and licorice extract.

Hidden dangers increase risk

Glycyrrhizin has the distinct licorice flavor and is 50 times sweeter than sugar. It has been used in other types of candy, soft drinks, tea, Belgian beers, throat lozenges and tobacco. The prevalence of glycyrrhizin can make it challenging to keep track of how much has been consumed, and a combination of these products could trigger adverse effects.

Some people take dietary or health supplements that already contain licorice, which increases the risk of toxic effects from eating black licorice candy. Certain medications such as hydrochlorothiazide are diuretics that cause increased urination, which can lower potassium levels in the body. Glycyrrhizin also lowers potassium levels, further disrupting the balance of electrolytes, which can produce muscle cramps and irregular heart rhythms.

People with certain preexisting conditions are more susceptible to black licorice overdose. For example, patients who already have low potassium levels, high blood pressure or heart arrhythmia are likely to have greater sensitivity to the effects of excessive licorice. Those with liver or kidney deficiencies will also retain glycyrrhizin in their bloodstream for longer periods, increasing their risk of experiencing adverse effects.

Safely eating black licorice

If you’re a fan of black licorice, there is no need to ban it from your pantry. Eaten in small quantities from time to time, licorice poses no significant threat to otherwise healthy adults and children.

But it is advisable to monitor your intake. A 2024 study conducted in Sweden found that daily ingestion of 100 mg of licorice, which is considered a safe amount, for two weeks was sufficient to raise blood pressure by an average of 3.1 mm Hg. A quarter of the participants also had elevated blood levels of a protein that is made when the heart is working harder.

Be sure to remind your kids that candy is a “sometimes food,” especially black licorice. The U.S. Food and Drug Administration had issued warnings about the rare but serious effects of too much black licorice, advising that people avoid eating more than 2 ounces of black licorice a day for two weeks or longer. The agency advises that if you have been eating a lot of black licorice and experience an irregular heart rhythm or muscle weakness, stop eating it immediately and contact your health care provider.

Some scientists have further cautioned against the routine use of licorice in the form of a dietary supplement or tea for its alleged health benefits, including the treatment of cough associated with COVID-19 or other respiratory infections. A review article from 2012 warned that “the daily consumption of licorice is never justified because its benefits are minor compared to the adverse outcomes of chronic consumption.”

This article, originally published Oct. 26, 2020, has been updated to include results from a 2024 study.

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The best smart home gyms for 2024 https://www.popsci.com/gear/best-smart-home-gyms/ Mon, 20 Mar 2023 13:00:00 +0000 https://www.popsci.com/?p=520816
Smart Home photo

Home fitness has never been so tech-savvy.

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Best smart home treadmill The NridcTrack Treadmill T Series are some of the top equipment for a smart home gym. NordicTrack T Series
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The equipment itself is outstanding and the connected program offers a superior experience.

Best smart home bike A Peloton bike is a great choice for the best smart home gym. Peloton
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Quality equipment with great program options, Peloton is the standard-bearer for a reason.

Best for strength training The Tempo Studio is a great addition to the best smart home gym. Tempo Studio
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Quality AI-powered personal training with a full free-weight setup.

Increasingly, home gyms ain’t like the setup your grandpa used. Modern equipment isn’t just about assembling an exercise circuit; it’s connected by all kinds of high-performance circuitry. It’s providing you with access to digital tools and training that are capable of refining your workout routine and truly pushing it to the next level. Below you’ll find our picks for the best smart home gyms from various realms—from treadmills to stationary bikes, plus much more. Depending on your fitness goals, any of these will deliver an outstanding experience. Pair two together, however—say by mixing a cardio machine with a weightlifting or full-body workout machine—and you’ll essentially bring home a complete gym that can deliver you everything from remote trainers to detailed metrics. To that end, here’s equipment for the best smart home gyms so that you can get your state-of-the-art sweat on.

How we chose the best smart home gyms

The options for working out at home are better than ever. Whether you prefer sparring, yoga, rowing, HIIT, or putting in miles on the treadmill, the best smart home gyms include equipment designed with virtual trainers and tracking to help you maximize your sweat sessions. For our list, we considered all types of activities and accessories so you can achieve the most interactive experience as you maximize your investment and output.

The best smart home gyms: Reviews & Recommendations

These days home workout equipment is getting smart. Sure, the classic versions of fitness equipment will still get the job done. Still, the best smart home gym equipment provides innovative opportunities to maximize your fitness progress and get more results in minimal time. It’s also really cool. Here are our top picks across multiple categories.

Best treadmill: NordicTrack T Series

NordicTrack

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Specs

  • Dimensions: ‎78.5 inches L x 35.5 inches W x 59 inches H
  • Power: Corded
  • Features: Interactive touchscreen, 12% incline

Pros

  • Quiet, cushioned, smooth motion for a pleasant, safe experience
  • Folds easily to save space
  • Immersive touchscreen with a wide range of program options

Cons

  • Must purchase a monthly membership for program access

NordicTrack has been the standard-bearer for treadmills for decades, and that’s still the case. The T Series offers pretty much everything you could want from a connected treadmill, and it does so at a surprisingly affordable price. 

Available in a range of specific model packages to suit a variety of accessories needs, the most basic option provides a solid all-around treadmill with a 5-inch screen and a compact 20-inch by 50-inch deck for just shy of $700, while the top-tier includes an immersive 14-inch screen and an expansive 20-inch by 60-inch deck—and there are several other options in between. Whatever package you choose, it boasts automatic incline and speed adjustments to suit your workout program. The deck itself provides a smooth, cushioned running surface, while the motor is quiet and self-cooling. The deck can also fold to save space.

The iFIT program offers a wide range of live streams, on-demand workouts, and studio classes, and it comes with a 30-day free membership. You will have to purchase a membership after that, though the treadmill provides all its basic functions without access to classes and programs. It is recommended that you buy the expert assembly package for a hundred bucks because putting the thing together is no small task.

Best stationary bike: Peloton

Specs

  • Dimensions: 59 inches D x 23 inches W x 53 inches H
  • Power: Corded electric
  • Features: Touchscreen, camera, stereo speaker system

Pros

  • Sturdy, comfortable equipment provides an enjoyable experience 
  • Superior program selection for quality workouts 
  • Wide, immersive screen makes location courses a pleasure

Cons

  • Must purchase a monthly membership for program access

There are a lot of stationary bikes on the market, and there are a few solid smart bike options, but there’s only one Peloton. It’s become so synonymous with stationary bikes that it’s almost become cliche, but the thing is, they’re really, really high quality. 

First of all, the overall craftsmanship is outstanding. There are no worries about rocking back and forth like with many other bikes—Pelotons stand rock solid. Their seats are comfortable enough for long classes, the setup can be easily adjusted to suit your body size, and the pedal action is smooth. It also has a relatively compact footprint, making it a decent option for small spaces. 

The Peloton programs are fantastic. Viewed via an expansive touchscreen, membership provides access to thousands of wide-ranging classes, games, location courses, and more. It even offers fitness and wellness programs beyond cycling, such as yoga, strength training, boxing, and so on. You do need a membership to get the most out of it, however. Without one, the equipment will still function as a basic stationary bike, but the classes vastly boost the experience.

Best for strength training: Tempo Studio

Tempo

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Specs

  • Dimensions: 72 inches H x 26 inches W x 16 inches D
  • Power: Corded electric
  • Features: AI creates digital personal trainer, range of packages

Pros

  • Expansive screen delivers quality programming and real-time form adjustments
  • Free weights, unlike most dubious home cable weight setups
  • All-in-one setup boasting all the essentials

Cons

  • Not for heavy lifters

There’s no shortage of smart weightlifting options on the market, but Tempo Studio stands out because it provides real-time form adjustments. While most connected strength trainers are essentially videos you follow, Tempo boasts an AI-driven element that analyzes your form and provides adjustment recommendations. It’s essentially a digital personal trainer. 

Another difference: While many similar products come with cheap feeling gear, the weights and bars included with Tempo offer gym-level quality. Tempo Studio comes with three packages. Starter is limited to the screen and a pair of dumbbells. Plus, steps up to include a barbell and bench. Pro goes full package, with a folding bench, squat rack, kettlebell setup, and 215 pounds of weights. Most of the gear stores nicely in the screen platform while the benches fold flat, so the whole thing has a small footprint and eats up very little space. 

The really experienced lifters out there might say that that’s not a lot of weight, and they would be somewhat right. That’s way more than the average lifter will ever need, but the top-tier bodybuilders out there will be left wanting. For typical and even somewhat advanced users, however, Tempo offers more than enough.

Best connected boxing trainer: FightCamp

Billy Cadden

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Specs

  • Dimensions: 67 inches H x 24 inches W
  • Power: N/A
  • Features: Punching bag, punch trackers, range of classes

Pros

  • Fun fusion of cardio and strength training
  • Classes are comprehensive and well-instructed
  • Equipment is of better quality than competitors

Cons

  • Heavy hitters might experience some punching bag creep

When it comes to home boxing trainers, nothing beats FightCamp, period. Not only does it offer a fun and effective fusion of cardio and strength training, but the gear looks great in your living space while taking up very little room.

FightCamp uses a set of punch trackers to collect data on your punching performance, which it gathers as you train to different fighting programs designed to teach basics, footwork, punching styles, and even kickboxing. You then use the data to improve speed and beat your own performance—or compete with other users—which delivers surprisingly solid results in terms of performance improvement. 

The equipment—which includes gloves, punch trackers, and a free-standing bag—is of much better quality than other similar products. The classes are well delivered, and the experience is flat-out fun. The really heavy hitters out there might find that the punching bag creeps a bit if the base is filled with water rather than sand, but other than that, there are few faults with the system. It also comes in two fairly affordable package sizes, which makes it a great option if you’re looking for fitness gifts.

Best connected rower: Hydrow Wave Rowing Machine

Jen McCaffery

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Specs

  • Dimensions: 80 inches D x 19 inches W x 43 inches H
  • Power: Corded electric
  • Features: Touchscreen, access to more than 4,000 classes with membership

Pros

  • Great full body, low impact cardio, and strength workout
  • Sturdy, stable craftsmanship for comfort and durability 
  • Enjoyable, effective workout programs
  • Easy to assemble and store

Cons

  • Expensive
  • Subscription required to track basic data

Rowers can provide an outstanding combination of cardio and strength exercise, but models intended for home use are often wobbly and unstable. Not so with the Hydrow Rower, which is as stable and sturdy as they come, delivering a solid combination of cardio and strength training that is low impact on your joints (as we found in our full review). 

The Hydrow Rower offers thousands of workout programs to choose from to suit any fitness goal, all of which are followed via an expansive 16-inch touchscreen. The screen is bright and colorful, making the location programs that allow you to row digitally through water sites around the world visually pop. It’s also easy to assemble and folds for convenient storage. 

Memberships are offered in two package tiers, with the one negative being that you must purchase a membership to track even the most basic of data like distance, calories burned, and so on. But if you’re in it for the classes anyways, this rower is unsurpassed.

Best fitness watch: Garmin Venu 2 Plus

Garmin

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Specs

  • Dimensions: 1.3-inch screen
  • Power: Lithium polymer battery (included) 
  • Features: ECG, GPS, bright AMOLED display

Pros

  • Wide variety of fitness activity tracking options
  • Full range of smartwatch functions for managing calls, emails, notifications, etc.
  • Extremely long battery life
  • Looks great by every metric

Cons

  • Wireless charging would be nice

A solid fitness tracker is a great tool for supporting home fitness—or fitness in any context really. And while we’ve got recommendations for the best Fitbits, when it comes to wearing a fitness watch that will truly track any and all activities, the Garmin Venu 2 Plus is as good as they get. 

The Venu 2 Plus tracks almost every fitness activity imaginable, even swimming. And while tracking fitness metrics should sometimes be taken somewhat with a grain of salt—so far, there is no single device that tracks everything with total accuracy—the Garmin has been pretty extensively tested and proven to track with reasonable accuracy factors like calories burned, heart rate, SpO2 (oxygen level), skin temperature, stress, sleep, and more. Its GPS tracking for running and hiking is as accurate as can be. And it responds well as you progress through different stages of an interval training session. 

On top of all that, it delivers a pretty comprehensive range of smartwatch functions, like receiving calls and notifications, listening to and controlling music, accessing your phone’s voice assistant, and a lot more. And it looks great, with a bright face that can be endlessly customized. For these and other reasons, Garmin smartwatches definitely rank highly among our best Apple Watch alternatives.

The bottom line is that few accessories can support your fitness routine in as many ways, big and small.

Best budget: MAXPRO Fitness Cable Home Gym

Maxpro

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Specs

  • Weight: Less than 9 pounds 
  • Power: Battery-powered
  • Features: Digital coaching for weightlifting, sensors track your stats

Pros

  • (Relatively) affordable package option
  • Full-body workout with minimal equipment
  • Extremely space efficient

Cons

  • Doesn’t quite compare to a typical gym experience
  • Some users report difficulty achieving coordinated movements

There aren’t a lot of affordable smart home gym setups on the market, at least not ones emphasizing strength training. MAXPRO, however, offers a solid full-body workout fused with digital coaching for significantly less than the competition. 

The MAXPRO achieves this via a cable pulley system capable of producing between 5 and 300 pounds of resistance. The basic package comes with a pulley base that can be attached to a bench, door, or other fixed point, and then you use handles and ankle straps to exercise various muscle groups. Sensors monitor your workout, collect data to monitor your progress, and provide coaching suggestions. The whole setup weighs less than nine pounds and takes up almost no room, so it’s easy to store or pack along while traveling. 

Some users report that it does take some getting used to and that it can be difficult to achieve coordinated movements between both sides of your body. But while it’s not a total replacement for a real gym, it does allow you to bring home a solid workout.

What to consider when buying the best smart home gyms

As you’ve probably realized while reading our recommendations, home fitness equipment comes in an extremely wide range of formats, meaning there are many factors to consider when selecting the right one for you. Here are some of the most important things to keep in mind.

Your fitness goals

What are you looking to get out of your fitness routine? Cardio? Strength training? Classes? Or individual workouts? Some mix of them all? You need to choose the equipment or combination of equipment that will best address your individual goals. A treadmill won’t do much for your fitness training, for example, and a strength trainer isn’t likely your best option for cardio.

Living space requirements

A home gym can be demanding in terms of your living space. Some products require more space than others, but you want something that will look good in your home long after you buy it. Choose a piece that will have a reasonable footprint relative to the available room and suit your aesthetic tastes.

Enjoyment

One of the basic tenets of fitness is that if you can’t enjoy an activity, you won’t stick to it. Choose a home gym you’ll have fun using in the long run. Some people love the repetition of lifting weights, while others need the variety and engagement of classes. Consider what’s right for your personality.

FAQs

Q: Is smart home gym equipment better than regular equipment?

That depends on you more than the equipment. For some people, old-school luddite gear will get the job done fine. But many beginners often prefer to have digital guidance, and even experienced fitness buffs can benefit from having some outside expertise. Data tracking can also be invaluable for maximizing the effectiveness of your efforts.

Q: Do all smart home gyms require a subscription?

In most cases, the smart home gym experience will be vastly expanded with a subscription. Many machines will allow you to use and track basic functions and data without it, but a key benefit to getting a piece of smart gear in the first place is that you can access the many programs and tools it offers.

Q: Can I get a good workout with a smart home gym?

That depends on the gym and on how dedicated you are to using it. Each product we’ve suggested above is 100% capable of providing an outstanding workout—if you’re willing to put in the time and effort necessary.

Q: What makes a piece of fitness equipment “smart”?

It’s kind of a vague term, but typically speaking, if a piece of equipment can be connected to the internet to access classes, live training, or other virtual fitness tools, it can wear the “smart” moniker.

Q: What do I need to have in my home before purchasing a smart gym system?

Generally speaking, just the space a particular piece of equipment requires and a somewhat stable internet connection (perhaps making it a great time to consider upgrading your Wi-Fi router). Some products will ideally require some wall space, but even that can use a stand mount if necessary.

Q: Is a smart home gym worth it?

That’s up to you. No equipment’s “smart” enough to force you to use it. You have to do that yourself. But assuming that you’re putting in the time and effort, smart gyms can offer a range of benefits to help you learn a new fitness routine or improve upon an existing one.

Final thoughts on the best smart home gyms

Whatever your favorite way to work out, smart equipment can enhance the experience. Whether it’s letting you train with rowers from beautiful spots around the world or setting up a sparring session or interactive yoga session, the best smart home gym equipment can help you track your progress, reach your goals, and have fun while you’re doing it.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

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New material neutralizes 96-percent of virus cells using nanospikes https://www.popsci.com/technology/silicon-virus-spikes/ Wed, 27 Mar 2024 20:00:00 +0000 https://www.popsci.com/?p=608272
Microscopic image of virus cell impaled on silicon wafer needles
A virus cell on the nano spiked silicon surface, magnified 65,000 times. After 1 hour it has already begun to leak material. RMIT

This 'smooth' silicon wafer is actually covered in very tiny, virus-slaying needles.

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Microscopic image of virus cell impaled on silicon wafer needles
A virus cell on the nano spiked silicon surface, magnified 65,000 times. After 1 hour it has already begun to leak material. RMIT

Researchers at Australia’s Royal Melbourne Institute of Technology (RMIT) have combined brute force with high tech manufacturing to create a new silicon material for hospitals, laboratories and other potentially sensitive environments. And although it might look and feel like a flat, black mirror to humans, the thin layering actually functions as a thorny deathtrap for pathogens.

As recently detailed in the journal ACS Nano, the interdisciplinary team spent over two years developing the novel material, which is smooth to the human touch. At a microscopic level, however, the silicon surface is covered in “nanospikes” so small and sharp that they can impale individual cells. In lab tests, 96-percent of all hPIV-3 virus cells that came into contact with the material’s miniscule needles either tore apart, or came away so badly damaged that they couldn’t replicate and create their usual infections like pneumonia, croup, and bronchitis. With no external assistance, these eradication levels could be accomplished within six hours.

A virus cell on the nano spiked silicon surface, magnified 65,000 times. After 6 hours it has been completely destroyed.
A virus cell on the nano spiked silicon surface, magnified 65,000 times. After 6 hours it has been completely destroyed. Credit: RMIT

Interestingly, inspiration came not from vampire hunters, but from insects. Prior to designing the spiky silicon, researchers studied the structural composition of cicada and dragonfly wings, which have evolved to feature similarly sharp nanostructures capable of skewering fungal spores and bacterial cells. Viruses are far more microscopic than even bacteria, however, which meant effective spikes needed to be comparably smaller.

[Related: A once-forgotten antibiotic could be a new weapon against drug-resistant infections.]

To make such a virus-slaying surface, its designers subjected a silicon wafer to ionic bombardment using specialized equipment at the Melbourne Center for Nanofabrication. During this process, the team directed the ions to chip away at specific areas of the wafer, thus creating countless, 2-nanometer-thick, 290-nanometer tall spires. For perspective, a single spike is about 30,000 times thinner than a human hair.

Researchers believe their new silicon material could one day be applied atop commonly touched surfaces in often pathogenic-laden settings.

“Implementing this cutting-edge technology in high-risk environments like laboratories or healthcare facilities, where exposure to hazardous biological materials is a concern, could significantly bolster containment measures against infectious diseases,” Samson Mah, study first author and PhD researcher, said on Wednesday. “By doing so, we aim to create safer environments for researchers, healthcare professionals, and patients alike.”

By relying on the material’s simple, mechanical methods to effectively clean spaces (i.e., stabbing virus cells like they’re shish kabobs), the designers believe overall chemical disinfectant usage could also decrease—a major concern as society contends with the continued rise of increasingly resilient “superbugs.”

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Bird flu detected in dairy cow milk samples https://www.popsci.com/environment/bird-flu-detected-in-dairy-cow-milk-samples/ Wed, 27 Mar 2024 18:30:00 +0000 https://www.popsci.com/?p=608207
dairy cows eating animal feed
The virus was found in unpasteurized milk from infected cows. Deposit Photos

The virus was detected in dairy cows from Texas and Kansas.

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dairy cows eating animal feed
The virus was found in unpasteurized milk from infected cows. Deposit Photos

Avian influenza or bird flu has been detected in milk from dairy cows in Kansas and Texas for the first time. Officials from the United States Department of Agriculture (USDA) and the Texas Animal Health Commission confirmed that the Type A H5N1 strain of bird flu virus was present in some samples of unpasteurized milk. This particular strain is known to cause devastating outbreaks in wild and commercial birds and can occasionally infect people. H5N1 is also affecting older dairy cows in New Mexico and causes decreased lactation and low appetite in the animals.

“At this stage, there is no concern about the safety of the commercial milk supply or that this circumstance poses a risk to consumer health,” the USDA wrote in a statement.

The commercial milk supply is still safe and the risk to people is low, according to the USDA. Dairies must only send the milk from healthy animals into the food chain, with milk from infected or sick animals diverted. The pasteurization process also kills viruses and other bacteria and this process is required for milk that is sold through interstate commerce.

[Related: Seal pup die-off from avian flu in Argentina looks ‘apocalyptic.’]

The tests on the cattle did not find any changes to the virus that indicate it would make it spread more easily to people. Texas dairy farmers first became concerned about three weeks ago when their cattle began falling ill. It is likely related to the current outbreak of a highly pathogenic avian influenza strain called H5N1 that has killed millions of birds and been detected in mammals including elephant seals and a polar bear in Alaska. 

“It’s important for people to know that at this point, there are still a lot of unanswered questions,” influenza pathologist Richard Webby tells PopSci. “It’s still a very unusual and interesting finding. These cows are not hosts we typically associate with avian influenza viruses.” 

Webby is the Deputy Director of the World Health Organization Collaborating Centre for Studies on the Ecology of Influenza in Animals and Birds and faculty member in the Department of Infectious Diseases at St. Jude Children’s Research Hospital. According to Webby, the risk to the general population still remains low and studying the cattle is providing scientists with an opportunity to learn more about how the virus spreads, as domestic cows are easy to sample and track in studies.

“In the whole gamut of influenza viruses that make their home in birds, most don’t cause a whole lot of disease,” says Webby. “There are two groups within that (H5N1 and H7N1) that have this ability to make mutations in one of their proteins that makes them much more able to cause a systemic infection.”

These highly pathogenic forms make it easier for the virus to move away from just the lungs and infect other organs and tissues in the body. Webby also points out that as far as viruses go, influenza can be fairly weak, so pasteurization should remain a strong line of defense. Consuming raw or unpasteurized milk is dangerous, no matter what the internet says. Scientists from the Centers for Disease Control and Prevention (CDC) say that raw milk has no added nutritional benefits and it can be contaminated with harmful germs. The CDC even considers raw milk one of the riskiest foods you can consume. 

“It doesn’t survive long under heat. So from that perspective, it’s a good thing that it’s pretty easy to kill flu viruses,” says Webby. 

University of Texas Medical Branch epidemiologist Gregory Gray, told Science that the new detections in cows across multiple states was a “worrisome” development. Gray said it may be a sign that the virus is spreading between cattle instead of from birds alone and has mutated in ways that could make the virus easier to spread among humans. However, the National Veterinary Services Laboratories said that the preliminary studies on the affected cows show no evidence that the virus has changed.  

Bird flu spreads through air droplets and bird feces. According to the Wildlife Conservation Society, it is exacerbated by alterations to bird migration schedules due to human-caused climate change and repeated re-circulation in domestic poultry. There have also been outbreaks of the virus at mink farms in France and Spain and the USDA banned poultry imports from France in October 2023. Scientists confirmed that this virus jumped to wild mammals in May 2022.

[Related: Thriving baby California condor is a ray of hope for the unique species.]

According to USDA and Texas officials, the cows likely contracted the virus from infected wild birds. The infected livestock appear to recover on their own within seven to 10 days, which is very different from how this illness affects commercial poultry. Entire bird flocks must be culled to get rid of the virus. About 82 million wild and commercial birds in the United States have been affected since 2022

While the risk to humans is still low, the World Health Organization has urged public health officials to prepare for a potential spillover to humans in the future. Scientists initially thought that mammals could only catch the virus through contact with infected birds. While cases of humans getting infected and seriously ill from bird flu are rare, the more it spreads among mammals, the easier it will be for the virus to evolve to spread.

Since this situation is evolving quickly, the USDA and other health agencies will continue to share updates. More information on biosecurity measures can be found here.

UPDATE April 2, 2024 9:57 a.m. EDT

According to Texas health officials, at least one person has been diagnosed with bird flu after interacting with infected cows. The CDC said there are currently no signs that the virus has evolved methods that help it spread more easily among humans, but the situation is continuing to evolve.

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The psychology of why video game farming is so satisfying https://www.popsci.com/health/stardew-valley-psychology-farming/ Wed, 27 Mar 2024 18:01:07 +0000 https://www.popsci.com/?p=608214
In the game Stardew Valley, you get to raise crops, tend to animals, and forage for mushrooms.
In the game Stardew Valley, you get to raise crops, tend to animals, and forage for mushrooms. ConcernedApe

If you hate your 9-5, consider working in a farm simulator game like Stardew Valley.

The post The psychology of why video game farming is so satisfying appeared first on Popular Science.

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In the game Stardew Valley, you get to raise crops, tend to animals, and forage for mushrooms.
In the game Stardew Valley, you get to raise crops, tend to animals, and forage for mushrooms. ConcernedApe

In the game Stardew Valley, you clear fields overgrown with weeds. You smash stones and chop down trees. You till the soil. You plant and water crops. You harvest. You build new additions to the homestead. You care for animals. Day in and day out. Sure, these responsibilities are punctuated with the levity of fishing, town festivals, cave explorations, courtship, marriage, and raising a child, but this never-ending cycle of digital labor is the beating heart of Stardew Valley. While it certainly doesn’t compare to the difficulties of actual farming, the rote gameplay can still be very chore-like. So why do hundreds of thousands of people want to spend their real-world leisure time working?

Psychologist Jamie Madigan, writing for his website The Psychology of Gaming, believes it all comes down to personal choice. Actual work may be stressful, but imaginary work like the kind in Stardew Valley is much more satisfying, Dr. Madigan argues, because it removes “the worst of the uncertainty, helplessness, ambiguity, and consequences for failure that come with those real-world jobs” from the equation.

“There will come a day when you feel crushed by the burden of modern life and your bright spirit will fade before a growing emptiness. When that happens, my dear, you’ll be ready for this gift.”

Grandfather in Stardew Valley

“Because they specifically can’t offer you a paycheck,” Dr. Madigan posits, “video games have to rely on the kinds of experiences that every employee longs for and every enlightened manager wishes she could provide: engagement and internal motivators. Why does a gamer slay that giant, radioactive scorpion? Why does he keep trying until he can beat his friend’s best time on a race track? Why does she keep mining materials so he can eventually upgrade her spaceship’s hyperdrive? Because he wants to. Because she has chosen to.”

Put simply, video games provide “clear goals, unambiguous feedback, winnable challenges, and predictable rewards.” When was the last time you got that kind of fulfillment from a 9-to-5?

Stardew Valley allows you to catch dozens of varieties of fish at specific times and locations. Credit: ConcernedApe
Stardew Valley allows you to catch dozens of varieties of fish at specific times and locations. Credit: ConcernedApe

First released in February 2016 by independent developer Eric Barone, this farm life simulator is currently enjoying a renaissance of sorts thanks to the March 20 launch of the long-awaited 1.6 patch–a series. The update includes a massive list of new opportunities ranging from major and game-changing (e.g. new events, mechanics, dialogue, etc.) to minor and silly (e.g. the ability to drink mayonnaise). Since the patch’s arrival last week, the record number of folks playing Stardew Valley on the game streaming platform Steam spiked at over 230,000, further entrenching Stardew Valley as one of the most popular farming games of all time. So what makes it so special?

Stardew Valley opens with you visiting your ailing grandfather as a child. After the old man says his goodbyes, he pulls you aside and hands you a wax-sealed envelope, but asks you not to open it yet.

“There will come a day when you feel crushed by the burden of modern life,” he says, “and your bright spirit will fade before a growing emptiness. When that happens, my dear, you’ll be ready for this gift.”

More than a decade later, your grandfather’s prophecy is fulfilled. You’re sitting in an office building, unhappy and confined to a monitored cubicle, when you finally reach for the mysterious envelope. Inside, you find the deed to your grandfather’s farm and one final message from the family patriarch encouraging you to follow in his footsteps. You immediately quit your job and set off to do just that, trading your life as an unimportant cog in the corporate machine for more peaceful, pastoral pursuits.

“Because he wants to. Because she has chosen to.”

– Psychologist Jamie Madigan

The therapeutic benefits of this fantasy bear out in direct feedback from consumers. During a study of Steam reviews published in October 2021, researchers at the University of Saskatchewan, Canada found substantial evidence of players extolling the benefits of Stardew Valley and other games like it with regards to relaxation and the management of mental health issues. Much like the main character moving to the country to escape the stressors of modern life, Stardew Valley reviews paint the picture of a userbase finding a reliable safety valve to blow off steam in its work-like gameplay loops.

Not all chores, Stardew Valley also offers a yearly night market. Credit: ConcernedApe
Not all chores, Stardew Valley also offers a yearly night market. Credit: ConcernedApe

“[Stardew Valley] allows the player a relatively large degree of freedom over what they build, or what path they take,” the paper reads, echoing Dr. Madigan’s observations on player choice. “Since there is no fixed solution for creative challenges, players can spend as much or as little time on optimizations as they choose. With the player focused on designing and developing their farm for a large number of in-game hours, players have many opportunities to become emotionally invested in their farm.”

The study further cites a report published in the Proceedings of the 2019 CHI Conference on Human Factors in Computing Systems in which several respondents interviewed by researchers from the University of York, UK and the University of Basel, Switzerland specifically named Stardew Valley as helping them cope with “considerable emotional turmoil.” These negative experiences included various mental health issues, family and relationship problems, bereavement, dysphoria, and job loss.

Escapism is a powerful thing. While detaching from the real world isn’t a permanent solution for a stressful situation, it’s clear video games can be a useful tool for those in search of positive feedback they aren’t getting elsewhere, especially if they’re already predisposed to gaming as a pastime. And while the popularity of Stardew Valley, as well as contemporaries Animal Crossing, House Flipper, and Farming Simulator, may appear on the surface like folks trading real chores for digital ones, the difference perhaps lies with the simple fact players are choosing to perform them rather than being forced through necessity. Combined, these two factors create a perfect storm of gratification that gives players both the ability to push the worries of life to the back of their minds for a few hours and feel accomplished for doing so at the same time.

The post The psychology of why video game farming is so satisfying appeared first on Popular Science.

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The best earplugs for concerts in 2024 https://www.popsci.com/gear/best-earplugs-for-concerts/ Mon, 01 Aug 2022 17:00:00 +0000 https://www.popsci.com/?p=459172
Sliced earplugs for concerts header
Tony Ware

Protect your hearing now, so you can keep enjoying music forever.

The post The best earplugs for concerts in 2024 appeared first on Popular Science.

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Sliced earplugs for concerts header
Tony Ware

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Best Overall Eargasm High Fidelity Earplugs are the best overall earplugs for concerts. Eargasm High Fidelity Earplugs
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These crowd pleasers provide balanced sound and a secure fit.

Best Aesthetics Loop Experience Pro are the best aesthetic earplugs for concerts. Loop Experience Pro
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Form meets function in this uber-stylish set.

Best for Musicians Minuendo are the best earplugs for concerts for musicians. Minuendo
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Seamlessly adjust sound attenuation on the fly—no batteries required.

Earplugs for concerts are the MVPs of personal accessories. They’re easy to use, comfortable, and, most importantly, protect your hearing while letting you enjoy shows in full, heart-pounding fidelity. If you spend time at concerts, work or play in noisy settings, or just want to block out the outside world and get a little peace and quiet, hearing protection is essential. When it comes to enjoying music at full volume, we’re biased by what audiologists call the “annoyance factor.” Your favorite song, cranked up in your earbuds, never really feels overly loud, but the pounding jackhammer across the street is unbearably noisy—when often, they’re equally dangerous. People adapt psychologically to loud sounds they like—like music—and assume that if sound doesn’t hurt, it’s not hurting them. But, as anyone who’s woken up after a show with ringing ears knows, nothing could be farther from the truth. Fortunately, there’s a simple, affordable solution with the best earplugs for concerts.

Why you should already be wearing earplugs

Real talk: Noise-induced hearing loss is permanent. It sneaks up on you in a slow, painless progression; by the time you recognize that there’s a problem, it’s usually too late to do anything about it. Making bad decisions now can come back to haunt you decades down the line: Just ask Dave Grohl, Jucifer (the underground duo whose battle with hearing loss inspired the film The Sound of Metal), or the countless artists who have gone public about their severe hearing damage caused by spending their whole careers turning things to 11.

Noise-induced hearing damage manifests in all sorts of insidious ways, from muffled highs and frequency dropouts to tinnitus, a continual ringing or buzzing in the ears. But the great news is this kind of hearing loss is almost always preventable. All you need is basic ear protection.

How we chose the best earplugs for concerts

PopSci’s resident audiophiles and musicians are lifelong fans of hearing protection; we compared our own experiences using earplugs over the years, including many of the products here. It’s difficult to measure the actual attenuation level offered by earplugs without specialized equipment, so, for that, we relied on provided specs. But we were able to evaluate fit and comfort across a broad range of ears and in a range of scenarios, and we put features like apps through the paces wherever possible. Because hearing loss is a medical condition, we consulted audiologists who are also musicians to get their advice on navigating the unique hazards of the concert environment.

The best earplugs for concerts: Reviews & Recommendations

At the risk of sounding like your meddling aunt, nobody can protect your hearing but you. However, you can start your journey to safer, more enjoyable live performance experiences now with our guide to the best concert earplugs.

Best overall: Eargasm High Fidelity Earplugs

Eargasm

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Why it made the cut: These affordable silicone earplugs feel great in your ears and offer balanced attenuation, for a more natural sound profile usually only available in expensive models.

Specs 

  • Attenuation: 21 dB
  • Material: Silicone
  • Customizable fit: Yes
  • Storage case: Waterproof aluminum

Pros

  • Balanced sonic attenuation
  • Durable build quality
  • Two shell options for fine-tuning fit

Cons

  • Blue shell visibly protrudes from ear canal

Many earplugs, including standard-issue disposable foam models, do an excellent job attenuating noise but end up blocking a lot more highs than lows, leading to that dull, muffled sound that makes you want to yank them out of your ears. Perennial crowd favorite Eargasm High Fidelity Earplugs incorporate filters that even out attenuation—it’s like turning down the overall volume knob, not just the treble. Eargasm’s three-tiered, flanged, conical design makes it easy to ensure a seal in your ear canal, which is critical for effective protection. And, the package includes two shells, letting you fine-tune the perfect fit. The included waterproof aluminum case attaches to a keyring for portability. Also available in a Smaller Ears model.

For a lower-priced option, consider Mack’s Hear Plugs flanged silicone earplugs, which preserve clear, natural sound across the frequency spectrum, using an open-air membrane filter system.

Best aesthetic: Loop Experience Pro

Tony Ware

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Why it made the cut: These wildly popular models offer adjustable attenuation—and are so cool looking that you can talk your teenager into wearing them.

Specs

  • Attenuation: 18 or 23 dB
  • Material: Silicone and foam
  • Customizable fit: Yes
  • Storage case: Hard hinged plastic

Pros

  • Removable filters increase attenuation level
  • Seven tip options for a perfect fit
  • Jewelry-inspired style

Cons

  • Case doesn’t include a keychain attachment

Not many earplugs double as fashion accessories. Loop Experience Pro breaks the mold, so to speak, providing robust, high-fidelity hearing protection in sleek, jewelry-inspired enclosures that look way more stylish than sticking orange wads of foam in your ears. Obviously, looks have nothing to do with hearing protection, but we’re fans of anything that ups concert earplugs’ cool factor if it inspires you (or your kids) to wear them.  

Loop Experience Pro earplugs attenuate sound somewhat evenly across the frequency spectrum; two swappable Loop Mute silicon filters let you tailor attenuation (-18 dB or -23 dB) to your surroundings and preferences, and resonant acoustic chambers inside their eponymous “loops” help optimize sound quality.

The Loop Experience Pro package includes four silicone ear tips, three foam ear tips, two sets of Loop Mute filters, and a plastic carry case. Models are available in a variety of colors and metallic finishes (such as silver, shown above) and can be washed with soap and water. A Quiet version, without adjustable filters and set at -27 dB (shown in red above), is just $20. Even more recently, Loop released a multi-mode Switch model, which combines Quiet, Experience, and Engage settings into one $65 set of earplugs. If flash isn’t your thing and you just need to shave off a dozen decibels, check out fully transparent Eardial earplugs, which virtually disappear inside your ears.

Best for musicians: Minuendo

Tony Ware

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Why it made the cut: Dial in the perfect sound attenuation level—and the perfect fit—with these highly customizable passive earplugs.

Specs

  • Attenuation: 7–25 dB
  • Material: Silicone
  • Customizable fit: Yes
  • Storage case: Hard plastic

Pros

  • Stepless adjustable sound attenuation
  • Flat attenuation for clear, natural sound
  • Eleven tip sets cover just about any ear size

Cons

  • Stepless level control is easy to set incorrectly

Designed and manufactured in Norway, Minuendo silicone earplugs are touted as the first passive (non-electronic) earplugs that offer “stepless” sound attenuation. (As someone who can’t live without her active adjustable earplugs, the “battery drain” struggle is real.)

Unlike many earplugs in this class that include switches or removable filters that increase or decrease volume attenuation in specific increments, Minuendo earplugs offer seamless, nuanced adjustment that slides the membrane from “open” (-7 dB) to “closed” ( -25 dB) and anywhere in between. This makes them good in multiple scenarios (the reason why they’re our best overall earplugs for work.)

Minuendo’s low-profile black design features an innovative magnetic locking feature that lets you clasp the earplugs logo-to-logo while leashed around your neck so that you can worry less about losing them. Eleven sets of tips—including foam, silicone, and flange designs—fit just about any ear out there. Wipe clean with water or alcohol.

Like the form factor but don’t need the more conversational or quieted ends of the spectrum? Save $50 and pick up the single setting, 17 dB attenuating Minuendo LIVE with its distinctive copper faceplates. Looking for an even more affordable solution? Check out Earos One High Fidelity Acoustic Filters ($40); developed by audiologists and engineers from MIT’s Acoustics Lab, these flat-response earplugs are modeled after the sound curve of your ear to provide optimal sonic clarity and hearing protection.

Best invisible: Vibes High-Fidelity Earplugs

Billy Cadden

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Why it made the cut: These earplugs are made with a clear tube that makes them nearly invisible, and they filter out up to 22 decibels of sound.

Specs

  • Attenuation: 22 dB
  • Material: Silicone
  • Customizable fit: Yes
  • Storage case: Hard plastic

Pros

  • Low profile
  • Come in three sizes
  • Don’t compromise sound quality

Cons

  • Some users say they can get stuck in ears
  • Noise reduction may compromise audio quality

If you want to protect your hearing but prefer to keep that fact incognito, Vibes High-Fidelity Earplugs are a good choice. Made of silicone, their clear outer sound tubes are discreet. The eartips come in three sizes—small, medium, and large—so you can get the best fit.  

These high-fidelity earbuds filter out up to 22 decibels of sound, but instead of blocking out noise, Vibes’ earplugs use attenuating filters to lower the volume of the surrounding environment as opposed to noise cancellation, so sound quality is preserved, and you can still hear what’s going on around you. These earplugs also come with a hard plastic travel case for protection and are washable.

Best swappable filters: Sennheiser SoundProtex Plus Earplugs

Sennheiser

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Why it made the cut: These Sennheiser swappable-filters earplugs use a two-stage system to maintain clarity and fidelity during shows.

Specs

  • Attenuation: 10 dB (weak filter), 17 dB (medium), 20 dB (strong)
  • Material: Medical-grade TPE
  • Customizable fit: Yes
  • Storage case: Soft pouch

Pros

  • Tab makes them easy to remove
  • Comes with four filters with different strengths
  • Includes three eartip sizes
  • Very comfortable even for long periods

Cons

  • Pricey for earplugs
  • Anything over the medium filter makes conversations tricky

Most earplugs give you a single level of protection, which may mean that you leave them behind when going to certain shows or events. The Sennheiser SoundProtex Plus earplugs are unique in their versatility. This set comes with four different filters (three acoustic and one full-block) with different decibel reduction ratings, making them suitable for just about any situation. The two-stage filter design reduces both high and low frequencies but maintains clarity so you can still enjoy the music fully (tested and confirmed in the crowd at an Amon Amarth-Ghost concert, shown above).

The weak filter offers 10 dB of attenuation, perfect for intimate performances or noisy public places. Medium is ideal for festivals or general travel. Finally, the strong filter is made for loud concerts or heavy machinery. Or, if you want total quiet, opt for the full-block filter, which even keeps water out during swims. You’ll also get three eartip adapters to get the most comfortable fit.

The SoundProtex Pro earplugs are high-quality and made of medical-grade TPE, an ideal material for sensitive skin. It also makes them infinitely reusable, as you can simply wash them and toss them in the included pouch to keep them clean. The tab at the end makes it easy to remove them, so you don’t have to worry about the triple-flange design—which, admittedly, can feel somewhat invasive the first time you try it—getting stuck in your ears.

Best electronic: Elgin Rukus Discord

Elgin

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Why it made the cut: These multitasking wonders let you listen to music, take calls, and command your smart assistant—all while protecting your ears.

Specs

  • Attenuation: 25 dB
  • Material: Industrial-grade polymer
  • Customizable fit: Yes
  • Storage case: Yes, plus collar clips

Pros

  • Multipurpose active earplugs let you listen to music and make calls
  • Bluetooth 5.3 functionality

Cons

  • Not everyone likes a neckband, or a deep-insertion earbud
  • You might be paying for features you don’t need

Elgin Ruckus Discord Bluetooth Earbuds are ideal for anyone looking for sound attenuation in a rigorous environment while also desiring Bluetooth 5.3 functionality. These active earplugs combine Elgin’s rugged design with classic wireless earphone technology for immersive audio with 25 dB reduction in external sound. But that’s just the beginning.

When the music isn’t playing around you, you can pair these earplugs with your phone and listen to your favorite bands privately, just like the best consumer earbuds. A built-in noise-isolating mic lets you make clear, uninterrupted phone calls. Ruckus Discord is compatible with Siri and Google Assistant, allowing you to control playback and volume with your voice. Battery life is impressive, with 14 hours of continuous audio playback on a single charge. Weatherproof enclosures have an IP65 rating, which means they are resistant to sweat, dust, and dirt damage. These earplugs are constructed with industrial-grade, impact-resistant polymer with Kevlar-reinforced cables and come with isolating, medical-grade, triple-flange silicone tips. Once you leave the concert, they’re equally great for a job site, yardwork, or home improvement project. And the neckband form factor means you’re highly unlikely to lose an earplug if/when you need to take one out.

If you’re looking for rugged earplugs that also raise the level of sounds around you during quieter moments (in noisy work environments, or while hunting, for example), Caldwell E-Max Shadows Pro plugs provide even greater noise suppression while amplifying ambient sounds.

Best budget: Etymotic ER20XS

Etymotic Research

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Why it made the cut: From trusted audiology experts, these simple silicone models offer balanced sound attenuation at an entry-level price.

Specs

  • Attenuation: 20 dB
  • Material: Silicone
  • Customizable fit: No
  • Storage case: Plastic

Pros

  • Reduce sound evenly across spectrum
  • Backed by decades of audiology research
  • Low-profile, stemless design

Cons

  • No extra eartips

With deep roots in acoustic and hearing aid research and more than 100 patents, Etymotic has been innovating earphones and earplugs for 40 years. I haven’t left the house without the company’s pro electronic earplugs in a decade—but if $300 sounds like a crazy amount of money to spend on hearing protection, Etymotic’s $20 ER20XS High-Fidelity Earplugs might be for you.

These flanged silicone earplugs reduce sound evenly across the hearing spectrum, which makes them great for enjoying concerts in balanced, natural sound. The ER20XS’ low-profile, stemless design fits snugly in the outer ear without protruding, for a discreet look and comfort under headgear. These silicone earplugs are reusable but may lose elasticity with repeated use, so Etymotic recommends replacing the eartips every three to six months. Standard and Large package options include a neck cord and carrying case that easily attaches to a keychain; a Universal Fit version ($25) includes extra foam and silicone tips.

Things to consider before buying the best earplugs for concerts

The best earplugs for concerts allow you to comfortably listen to music without compromising your hearing—or your experience. Then, it’s about matching features to your lifestyle.

What will you be using earplugs for?

There’s a difference between blocking sound you don’t want to hear and attenuating sound you do want to hear. If you’re in a factory or at a gun range and want to block out a continuous industrial din or potentially hazardous sudden noises, simple foam earplugs or earmuff protectors offer the most robust protection. For sleeping, it’s all about extended comfort. Simple, soft foam or silicone earplugs are ideal, and purpose-designed sleep models, like Loop Quiet, are so comfy you might even forget you’re wearing them. But if you want to safely enjoy music without feeling like there’s cement in your ears, your best option is to invest in a pair of high-quality, flat-response earplugs, which lower sound evenly across the frequency spectrum for a natural, high-fidelity sonic signature.

Types of earplugs

Earplugs run the gamut from cheap, no-frills off-the-shelf earbuds to balanced-response earplugs to electronic systems with adjustable attenuation to professional custom-fit models, which require a visit to an audiologist. Here, we’re focusing on universal, off-the-shelf models.

Expandable foam earplugs are made of pliant material designed to conform to the shape of the ear canal. They’re inserted by first rolling them into compressed cylinders, then placing in the ear canal, where they expand to form a seal. Foam earplugs are the cheapest option and, because they cannot be washed, are considered disposable.

Pre-molded earplugs, constructed from silicone, rubber, or plastic, retain their size and shape when inserted into the ear canal. Because they don’t expand, they’re available in various sizes and often include a range of custom tips to ensure a perfect fit. Pre-molded earplugs can be cleaned and reused.

Earmuffs completely cover the outer ear and are often available with electronic components that suppress sudden noises or let users communicate. If you hate sticking things inside your ear canal and you don’t mind a somewhat bulky profile, earmuff protection might be for you.

Earplug tech innovations

When it comes to off-the-shelf, universal earplugs, technology advancements lean toward expanded feature sets, including noise cancellation, Bluetooth functionality, and companion apps. Some earplugs, such as Loop Experience Pro, feature acoustic innovations, such as resonant chambers, that promise to improve sound quality. Earmuff manufacturers are developing high-tech materials that reduce weight and bulk yet still effectively block noise. These improvements add up to improved sound and a better experience, which is great incentive to wear your earplugs more. And, aesthetic improvements (see: Loop Experience Pro’s jewelry-inspired look) mean your kids might wear them longer, too.

Just like cameras, the best earplugs are the ones you actually have on you when you need them. So, no matter which models you prefer, it can’t hurt to pick up a huge vat of inexpensive, disposables such as Mack’s Ultra Soft Foam Earplugs, which are effective and ridiculously cheap at $8.99 for a tub of 50. (Left yours at home? Some cities, such as San Francisco and Minneapolis, require large venues to make free earplugs available to concertgoers.)

Protecting your ears is all about exposure

Sound-induced hearing damage happens as a result of sudden acoustic trauma (like an explosion) or through chronic exposure to high sound levels. The general rule is the louder the sounds and the longer the length of exposure, the greater the risk of hearing loss. For example, eight hours of exposure to sound levels of 85 decibels (equivalent to heavy street noise) is considered safe according to decibel exposure time guidelines, but at 100 dB—the level of a typical rock concert—safe exposure is limited to 15 minutes. (Free sound-metering apps such as Decibel X can measure surrounding noise and help keep your exposure in check.)

FAQs

Q: Are there any earplugs that block all noise?   

Unfortunately, there aren’t any earplugs that block all noise. Sound waves are vibrations and some vibrations—particularly low-frequency sounds—reach the inner ear through bone conduction. Sounds can travel through skull bones, your mouth, even upward through your body from your hands and feet. Blocking your ears with earplugs will attenuate a large proportion of sound; many foam earplugs block out as much as 33 decibels, which should be enough protection to emerge from even the loudest concert unscathed.

Q: Are silicone earplugs better than foam?

Silicone earplugs are better than foam for some things, but not everything. Foam earplugs are the most popular earplugs: They’re economical and generally offer the most robust sound attenuation, but they need to be inserted correctly, deep within the ear canal. Foam earplugs are also prone to collecting bacteria with re-use and should be considered disposable. Silicone earplugs don’t need to be inserted as far into the ear canal, which makes them easier to wear for some. Because silicone earplugs can be washed, for many, they can be a more economic (and sustainable) choice. And, they’re waterproof, which makes them ideal for swimmers.

Q: How much noise reduction do I need for a concert?  

The amount of noise reduction you need for a concert depends on the loudness of the concert and length of time you will spend there. Every concert is different, but the average sound level at a large rock concert is about 100 decibels; some indoor shows can climb to 120 dB and beyond. Protection comes down to simple math: Sounds above 85 dB can damage your hearing after eight hours, while sounds at 100 dB can cause damage after just 15 minutes. If you’re at an all-day festival, look for earplugs that attenuate sound 20–25 dB. If your exposure is shorter, you can get away with less attenuation. If you love getting down front in the action, go for more attenuation.

Q: How much should I spend on earplugs?  

How much you spend on earplugs depends on how much protection you need, if you want to reuse the earplugs, and if style is important to you. You can easily find disposable foam earplugs for roughly $0.17 a pair, though those won’t offer the same quality as the reusable option listed here. Typically speaking, you’ll likely spend anywhere between $40 and $60 for a pair of high-quality, reusable earplugs for concerts.

Q: How many times can I reuse foam earplugs?  

Foam earplugs are considered disposable and shouldn’t be worn more than a few times. That’s because they collect bacteria, which could cause an ear infection if you continue to use them. Additionally, the foam can wear out, making them less effective at cutting down noise over time.

Final thoughts on the best earplugs for concerts

As musicians and music lovers, we know there’s nothing better than being front and center at your favorite concert, getting lost in the song, feeling every note in your bones. Ultimately, though, loud is loud, and every time you expose your ears to high volume levels, you’re putting your hearing at risk. Luckily, today’s high-fidelity earplugs for concerts let you experience the full spectrum of sound while protecting your hearing: Highs are clear, lows are full, and the overall presentation is rich and detailed, just like without earplugs. All while preserving your precious hearing. Save your ears now; your future self will thank you.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

The post The best earplugs for concerts in 2024 appeared first on Popular Science.

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Rare traces of tooth decay and gum disease found in Bronze Age teeth https://www.popsci.com/science/tooth-decay-gum-disease-bronze-age-teeth/ Wed, 27 Mar 2024 16:00:00 +0000 https://www.popsci.com/?p=608160
a prehistoric tooth in a lab
Finding evidence of tooth decay or gum disease in prehistoric teeth is difficult. Lara Cassidy

Too little sugar and too much acid can make traces of tooth decay difficult to find.

The post Rare traces of tooth decay and gum disease found in Bronze Age teeth appeared first on Popular Science.

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a prehistoric tooth in a lab
Finding evidence of tooth decay or gum disease in prehistoric teeth is difficult. Lara Cassidy

Keeping our teeth clean has been a pain for thousands of years, with some particularly painful methods historically used to take care of our chompers. Two 4,000-year-old human teeth unearthed in a limestone cave in Ireland were recently found to contain an “unprecedented quantity” of the bacteria that cause tooth decay and gum disease. The genetic analysis of these well-preserved microbiomes reveal how changes in diet shaped our oral health from the Bronze Age to today. The findings are described in a study published March 27 in the journal Molecular Biology and Evolution.

Fossilized dental plaques have been one of the best studied parts of the ancient human body. However, very few full genomes from oral bacteria in teeth prior to the medieval era have been uncovered. This means that scientists have limited data on how the human mouth’s microbiome was affected by changes in diet and from events like the spread of farming about 10,000 years ago.

Sugar-munching, acid producing bacteria

Both of the teeth belonged to the same male individual who lived in present day Ireland during the Bronze Age. The teeth contained the bacteria that cause gum diseases and the first 

high quality ancient genome from Streptococcus mutans (S. mutans). This oral bacterium is one of the major causes of tooth decay.

S. mutans is very common in modern human mouths, but is very rare in the ancient genomic record. One potential reason why it’s so sparse may be how the bacterium produces acid. The acid decays the tooth, but also destroys DNA and stops the dental plaque from fossilizing and hardening over time. Most ancient oral microbiomes are found inside these fossilized plaques, but this new study looked directly at the tooth. 

[Related: Vikings filed their teeth to cope with pain.]

Another reason why S. mutans may not have been present in ancient mouths may be due to a lack of sugary mouths for it to thrive in. S. mutans loves sugar and an increase of dental cavities can be seen in the archaeological record after humans began to grow and farm grains. However, the more dramatic increase occurred over the past few centuries when sugary foods became significantly more prevalent.  

The disappearing microbiota hypothesis

The sampled teeth were part of a larger skeleton found in Killuragh Cave, County Limerick, by the late Peter Woodman of University College Cork. Other teeth in the cave show advanced dental decay, but there wasn’t any evidence of any caries–or early cavities. A single tooth turned out to have a ton of mutans sequences. 

“We were very surprised to see such a large abundance of S. mutans in this 4,000 year old tooth,” study co-author and Trinity College Dublin geneticist Lara Cassidy said in a statement. “It is a remarkably rare find and suggests this man was at high risk of developing cavities right before his death.”

A save in Ireland surrounded by green foliage
Killuragh Cave in Ireland where 4,000 year-old skeletal remains were uncovered. CREDIT: Sam Moore and Marion Dowd.

The cool, dry, and alkaline conditions of the cave may have contributed to the preservation of S. mutans DNA. While the S. mutans DNA was plentiful, other streptococcal species were mostly absent from the tooth sample. This indicates that the natural balance or the oral biofilm had been altered–mutans outcompeted the other bacteria species.

According to the team, the study adds more support behind the disappearing microbiota hypothesis. This idea proposes that our ancestors’ microbiomes were actually more diverse than our own today. More evidence that supports this hypothesis came from the two genomes for Tannerella forsythia (T. forsythia) that the team built from the tooth. T. forsythia still exists and causes gum disease

“The two sampled teeth contained quite divergent strains of T. forsythia,” study co-author and Trinity College Dublin PhD candidate Iseult Jackson said in a statement. “These strains from a single ancient mouth were more genetically different from one another than any pair of modern strains in our dataset, despite these modern samples deriving from Europe, Japan, and the USA. This is interesting because a loss of biodiversity can have negative impacts on the oral environment and human health.”

Shifting genes and mouths

Both reconstructed genomes revealed  dramatic changes in the oral microenvironment over the last 750 years. One lineage of T. forsythia has become dominant in global populations in recent years, which is a sign of an event geneticists call a selective episode. This is when one bacteria strain quickly rises in frequency due to a particular genetic advantage. The T. forsythia genomes that arose particularly after the Industrial Revolution acquired genes that helped it colonize the mouth and cause disease.

[Related: Bronze Age cauldrons show we’ve always loved meat, dairy, and fancy cookware.]

S. mutans also had evidence of recent lineage expansions and changes in gene content that both coincide with the popularization of sugar. However, modern S. mutans populations have remained even more diverse than T. forsythia, including some deep splits in the S. mutans evolutionary tree that pre-date the genomes uncovered in Ireland. The team believes that this is driven by differences in the evolutionary behind genome diversity in these bacteria species.

S. mutans is very adept at swapping genetic material across strains,” said Cassidy “This allows an advantageous innovation to be spread across S. mutans lineages, rather than one lineage becoming dominant and replacing all others.”

Both of these disease-causing bacteria have essentially changed dramatically from the Bronze Age to today. However, it’s the very recent cultural transitions like more sugar consumption that appear to have had an outsized impact.

The post Rare traces of tooth decay and gum disease found in Bronze Age teeth appeared first on Popular Science.

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The best air purifiers for 2024 https://www.popsci.com/story/reviews/best-air-purifiers/ Mon, 15 Mar 2021 15:59:00 +0000 https://stg.popsci.com/uncategorized/best-air-purifiers-2/
A lineup of the best air purifiers on a white background
Amanda Reed

Whether you’ve got pets, allergies, or worries about wildfire season, you can look forward to better air quality with one of our well-filtered purifier picks.

The post The best air purifiers for 2024 appeared first on Popular Science.

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A lineup of the best air purifiers on a white background
Amanda Reed

We may earn revenue from the products available on this page and participate in affiliate programs. Learn more ›

Best for large rooms Mila Smart Air Purifier Mila Smart Air Purifier
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This all-purpose smart air purifier adapts to room size and comes with a carbon monoxide detector and sleep and white noise modes.

Best for smoke Alen BreatheSmart 75i Alen BreatheSmart 75i
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This model detects smoke particles and kicks into automatic overdrive to mitigate it.

Best for allergies InvisiClean Aura II Air Purifier InvisiClean Aura II Air Purifier
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Certified to keep you safe from pollen and not contribute to dangerous levels of ozone gas.

Air purifiers suck in pollen, dust, smoke, other allergens, and even viruses—pummeling them and then circulating clean, filtered air. It sounds simple enough, but not all purifiers are created equal, and there isn’t one that’s right for every person. Your particular environment and the size of your home are huge factors in choosing the best option for you. Is allergy season wreaking havoc on your sinuses? Do you live in a smoggy city? Has wildfire smoke been wafting through, blanketing everything in an unnatural haze? In short, even the finest filters aren’t guaranteed to fix all that ails you and your home. But if you’re wondering whether air purifiers are really worth it … we think so. They can help distribute cleaner air, and that’s always a good thing, considering the link between air quality and health. So, read on as we clear the air on what we think are the best air purifiers.

How we chose the best air purifiers

As pet owners and parents, we’ve experienced our fair share of smells and toxins—and that’s just from inside the house. And whether allergy or wildfire season is upon us, there’s always something environmental to consider. With all this in mind, we compiled peer recommendations, critical reviews, online research, user impressions, and plentiful personal testing to create this list of the best air purifiers. We also examined what each air purifier claims to eliminate from the air, its HEPA square footage, and the filters’ MERV (minimum efficiency reporting values) rating ratings.

The best air purifiers: Reviews & Recommendations

Pollen, pet dander, smells, smoke, germs, and other airborne goblins are no match for the best air purifiers. This list includes quiet air purifiers, ones that double as humidifiers, and even ones that claim they can help with a majority of airborne pathogens.

Tony Ware

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Why it made the cut: This three-in-one smart device automatically adapts to changes in air quality and humidity.

Specs

  • Recommended room size: 400 square feet
  • Dimensions: 36.66 x 11.02 x 12.23 inches
  • App connectivity: Yes
  • Max decibels (dB): 59.8 dB

Pros

  • Connectivity with Siri and Alexa
  • Three products in one
  • Air quality reporting

Cons

  • Expensive

Between its TikTok- and Insta-famous Airwrap multistyler to its line of powerful vacuums, Dyson has made a name for itself in sucking—which we don’t mean negatively. The Dyson PH04 Purifier Humidify+Cool Formaldehyde proves yet again that Sir James Dyson really knows what he’s doing when it comes to pushing air out and in. This air purifier uses an intelligent sensing system and Air Multiplier technology to purify, humidify, and cool the air. You don’t even need to touch the stylish, distinctive unit—it automatically senses and reacts to changes in air quality and humidity (we’ve watched one enthusiastically spring to life time and time again after a particularly aggressive sauté session in the kitchen). It even features a solid-state sensor to detect and destroy formaldehyde emitted by household items—a boon if you’re in a newly renovated/refurbished space, as fresh carpet and new mattresses are emitting odd things.

You don’t have to worry about airborne baddies getting re-released into the air since the entire purifier-humidifier is fully sealed to the HEPA H13 standard. If you love numbers, neat tech, and data, this machine will tickle your brain when it reports your air quality in real-time on the LCD screen and DysonLink app (which you can use to tweak/schedule usage). The filters are low-maintenance and easy to replace, and the machine features a deep-clean cycle to get rid of mineral build-up and bacteria that may be lurking in the water system. Although it’s almost $1,000, you’re getting three devices for the cost of one. Talk about smart.

Best for large rooms: Mila Smart Air Purifier

Billy Cadden

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Why it made the cut: This mold- and carbon monoxide-detecting air purifier comes in different filter configurations for custom air purification.

Specs

  • Recommended room size: 1,000 square feet 
  • Dimensions: 12 x 12 x 15 inches
  • App connectivity: Yes
  • Max decibels (dB): 62 dB but lowers to 24 dB while in room

Pros

  • Stylist
  • Small
  • Carbon monoxide, mold detection, and white noise machine built-in

Cons

  • Reviews note excessive air quality notifications

This classy, app-controllable large room air purifier adapts to the size of whatever room it’s placed in. It also looks great in any room it’s placed in. The filter has 45 square feet of HEPA, and with 447 CADR, it’s effective in rooms up to 1,000 square feet. Additional features include a sleep mode and white noise so that it won’t interfere with your sleeping habits. The device also features a carbon monoxide detector. It will monitor your room’s humidity and let you know if it detects any mold. If you’re not a fan of notifications, disable them if you go with the Mila—reviewers note that the Mila app sends lots of alerts.

Best for small rooms: LEVOIT Air Purifier for Home Bedroom

Levoit

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Why it made the cut: Take this lightweight, compact air purifier from room to room to experience dual-filter, three-stage filtration in your entire home.

Specs

  • Recommended room size: 161 square feet
  • Dimensions: 6.69 x 6.69 x 10.43 inches
  • App connectivity: No
  • Max decibels (dB): 52 dB

Pros

  • Aromatherapy
  • Dual-filter, three-stage filtration
  • Specifically targets hay fever

Cons

  • Not for large homes

The Levoit promises to help relieve allergies, congestion, and sneezing and is our pick for the best small air purifier. Although we can’t vouch for the unit’s specific efficacy against rhinitis, we can vouch for the fact that it has three filters (one more than most other units): HEPA for dust, pollen, and dander; carbon for odors; and polyester for lint and hair. One fun additional feature is that this one has an aromatherapy option if you’d like a little lavender to help lull you to sleep at night.

Best for quiet: Blueair Blue Pure 311i Max

Tony Ware

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Why it made the cut: Particles down to .1 microns are no match for this quiet-but-powerful air purifier.

Specs

  • Recommended room size: Up to 929 square feet
  • Dimensions: 19 x 12.5 x 12.5 inches
  • App connectivity: Yes
  • Max decibels (dB): 50 dB

Pros

  • Removes particles down to .1 micron
  • Stylish
  • App connectivity

Cons

  • Reviews note occasional problems with auto-sensing

Blueair makes svelte cylinders with Scandinavian style packed with highly effective electrostatic and mechanical filtration. The Blue Pure 311i Max is HEPASilent but deadly … against microbes in the air. This stylish, small air purifier features five fan speeds and a one-touch auto mode with a fine particles (PM 2.5) sensor to monitor concentration and adjust speed according. This air purifier can clean a 387-square-foot room in 12.5 minutes and a 929-square-foot space in 30 minutes (there are both larger and smaller models, so something for every home). And, it snags all those particles (99.97% of them down to 0.1 micron) all nearly undetected, clocking in at 23 dB on low/night mode—louder than a quiet natural area with no wind but softer than a whisper. And it never runs above 50dB, which makes it QuietMark certified and perfect for a bedroom, TV room, any room … plus it’s only 8 pounds, so it’s easy to move around while you decide between your study and your yoga studio (or realize it’s easiest to buy two).

Is it working? We barely hear it. But we also don’t hear ourselves sneezing and wheezing and complaining about our watery eyes, so we’re going with yes. If we need more confirmation, we can look at a five-color LED that changes according to Air Quality Index (AQI), or we can reference an app that gives insight into indoor vs. outdoor pollution and lets you control mode, tweak LED Brightness, set a schedule, and more (assuming the 311i Max and your phone are connected to WiFi). And if we don’t want it to be working, Google Assistant and Alexa compatibility let us turn it off with voice commands if our phone isn’t convenient (hooray smart-home devices). While some reviews note that the auto-sensing feature is not as accurate as they hoped, we’ve observed the Blue Pure 311i Max react firsthand thanks to a low smoke-point cooking oil incident or two. It was lively even from across a loft apartment—and helped with the post-coming odors. And the washable pre-filter fabric cover (shown above in “Stockholm Fog” color, quietly complementing some audio-video gear) meshed effortlessly with the decor to boot.

Best HEPA: Coway Tower True HEPA Air Purifier

Coway

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Why it made the cut: Stylish-meets-powerful with this True HEPA air purifier that features four levels of filtration.

Specs

  • Recommended room size: 330 square feet
  • Dimensions: 10.5 × 32.7 × 10.7 inches
  • App connectivity: No
  • Max decibels (dB): 52 dB

Pros

  • Real-time air sensing
  • Washable pre-filter
  • Air quality indicator

Cons

  • Noisier compared to other air purifiers

Multiple fan speeds, a timer, an air-quality assessor, and a filter-replacement indicator light make this the best HEPA air purifier—not just quiet and effective, but user-friendly. At just under $200, it’s neither cheap nor exorbitant for an air purifier, and it’s also aesthetically pleasing. Reviewers note that this air purifier is noisier than most.

Best with UV light: Germ Guardian True HEPA Filter Air Purifier

Germ Guardian

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Why it made the cut: This quiet air purifier uses CARB-compliant UVC light and titanium dioxide to reduce airborne bacteria, viruses, and mold spores.

Specs

  • Recommended room size: 153 square feet
  • Dimensions: 10.25 x 6.75 x 21.5 inches
  • App connectivity: No
  • Max decibels (dB): 61.2 dB

Pros

  • Quiet
  • Reduces odors
  • Pre-filter traps allergens

Cons

  • UV light can be bad for the environment

UVC light (the most destructive of all the UVs) in an air purifier works as a UVGI—ultraviolet germicidal irradiation—disinfection method by attacking the DNA of cells floating through the air, like mold spores, viruses, and bacteria. (This means, like all other filters, it cannot do anything for particles that have settled into fabric). An activated charcoal filter reduces odors. The 22-inch purifier filters air four times per hour at maximum speed in rooms up to 153 square feet. The four fan speeds, whisper-quiet operation, and CARB compliance make this air purifier an especially good pick for allergy sufferers. California Air Resources Board (CARB) compliance means you can rest easy about its environmental footprint.

Best for allergies: InvisiClean Aura II Air Purifier

InvisiClean

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Why it made the cut: CARB compliance plus four levels of air purification equals an exorcism for your sneezes.

Specs

  • Recommended room size: 319 square feet
  • Dimensions: 12.34 x 6.25 x 17.75 inches
  • App connectivity: No
  • Max decibels (dB): 55 dB

Pros

  • Four fan speeds
  • Quiet
  • CARB compliant

Cons

  • No auto-sensing

The four fan speeds, whisper-quiet operation, and CARB compliance make this air purifier an especially good pick for allergy sufferers. The California Air Resources Board requires purifiers to produce .050 parts per million of ozone or less, so any device with this certification won’t contribute to unsafe gas levels.

Best for smoke: Alen BreatheSmart 75i

Terri Williams

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Why it made the cut: Detailed air quality indicators, a B7-Pure filter, and a CADR of 347 mean that this air purifier will stop smoke in its tracks.

Specs

  • Recommended room size: 1300 square feet
  • Dimensions: 12 x 19 x 27 inches
  • App connectivity: No
  • Max decibels (dB): 51 dB

Pros

  • 8 colorways
  • Quickly cleans large rooms
  • Auto-adjusts based on air quality
  • Relatively quiet at high speeds
  • Can swap out panel colors to match decor

Cons

  • Expensive
  • Little warranty
  • Heavy

This is an easy pick for the best air purifier for smoke, thanks to its CADR of 347 (out of 450). Thanks to automatic air-quality detection, the unit will kick up to turbo when any type of smoke is present. When no irritants are present, the device goes into energy-saving mode. Five air quality colors give you a more detailed visual indicator of air quality—other air purifiers only include three color indicators. It’s also the “best design” pick in our best air purifiers for smoke buying guide, which you should check out if you want to smash smog and fog (and nicotine-addicted neighbors) specifically.

Best for mold: PuroAir 400 HEPA 14 Air Purifier

Amanda Reed

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Why it made the cut: Put your mold worries to be with this hospital-grade air purifier.

Specs

  • Recommended room size: 2145 square feet
  • Dimensions: 17.5 x 10.6 x 12.5
  • App connectivity: No
  • Max decibels (dB): Not listed

Pros

  • HEPA 14 filter
  • Easy-to-read air quality monitor
  • Lots of trustworthy certifications

Cons

  • No app connectivity
  • A little noisy compared to other air purifiers

If you’re looking to exterminate mold spores that can make you cough, the PuroAir 400 Air Purifier can do just that, thanks to its HEPA 14 air purifier, which is practically hospital-grade. It’s CARB-compliant, and has ETL, ISO, UL, and Energy Star certifications. This all just means it’s safe to use and energy-efficient. A smart sensor works for you, adjusting power when polluted air is detected.

Our only complaint? It’s a little loud on the lowest setting. I personally moved mine to the kitchen since its gentle whoosh was too distracting in my home office. If you’re looking for something quieter, consider our best overall air purifier for mold, the PuroAir 240 HEPA 14 Air Purifier. It has the same HEPA 14 filter found in the 400 but is whisper-quiet.

Best for pets: LEVOIT Core P350 Air Air Purifier

Abby Ferguson

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Why it made the cut: Eliminate “dog smell” from your space without sacrificing features, design, quality, and price.

Specs

  • Recommended room size: 218 square feet
  • Dimensions: 8.7 x 8.7 x 14.2 inches
  • App connectivity: No
  • Max decibels (dB): 24 dB

Pros

  • Quiet and compact
  • Pet Lock prevents pet and child interference
  • Lots of settings and controls

Cons

  • No app connectivity

Our pets are often considered family. And just like regular children, four-legged kin can stinky, get hair everywhere, and mess with electronics. Thankfully, the Core P350 is an air purifier made with pet ownership in mind. has a three-in-one filtration system and Pet-Lock to stop hands/paws from meddling with the settings. It’s powerful enough to purify a 219-square-foot room in 12 minutes, but only produces 24 decibels of noise. Three fan settings let you choose filtering speeds, and its night mode is so quiet you don’t even recognize that it’s still on. It doesn’t include app connectivity or air quality sensor, but you can’t beat its price and effectiveness.

Best budget: LEVOIT Air Purifier for Home, Core 300

Amanda Reed

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Why it made the cut: This compact air purifier tackles smoke, dust, pollen, bacteria, and viruses without hurting your wallet.

Specs

  • Recommended room size: 219 square feet
  • Dimensions: 8.7 x 8.7 x 16.25 inches
  • App connectivity: No
  • Max decibels (dB): 50 dB

Pros

  • Filter life indicator
  • Timer
  • Quiet

Cons

  • Louder than other air purifiers

This cheap air purifier targets smoke, dust, and pollen, along with some bacteria and viruses. Four specialty replacement filters include a pet-allergy option and a toxin absorber for particularly smoky or smoggy areas. Like higher-end air purifiers that are more expensive, this Levoit air purifier features timer settings and a sleep mode. And the display lights can be turned off to ensure a pitch-black room when sleeping. Although the air purifier is louder than some competitors, it resembles a whooshing fan at its highest setting—if you can deal with that, this air purifier is for you.

What to consider when buying the best air purifiers

The best air purifier for you might not be the one your best friend or neighbor loves. You want a HEPA filter with a high MERV rating that’s designed to cover the amount of space you have in your particular room or dwelling. Beyond that, consider whether you want other features like pathogen-killing UV light, smart controls, and/or odor elimination. Do you need the best air purifier for pets or perhaps something portable? Air purifiers for mold or models to get rid of smoke? Air filters work only on airborne particles. To get at anything that’s settled into upholstery or rugs, you’ll need a handy vacuum, a helpful robot, or something else that offers deep-clean suction.

Size of space

There’s an alphabet soup to make sense of when choosing the best air purifier for your home. ACH (air changes per hour) correlates to the airflow of your device. It’s calculated based on the volume of your space, ceiling height, and how many cubic feet per minute the device can cover. It’s independent of other factors, e.g., the filter’s efficacy—to calculate that you need the CADR (clean air delivery rate) rating; because a HEPA filter is more efficient, its CADR rating may be lower, which is deceptive.

The most important thing to note is that an air purifier’s efficacy cannot be calculated based on square footage alone. You can find handy calculators online to determine the proper purifier for your needs, but here’s what to consider with any device: Will it successfully rid your home of odors with carbon or other comparable filters? Is it a good choice for pet owners? Does it feature UV light? Read the fine print.

HEPA

You’ve likely heard of high-efficiency particulate air, or HEPA, filters. They are a type of pleated air filter that, according to the Environmental Protection Agency, “can theoretically remove at least 99.97% of dust, pollen, mold, bacteria, and any airborne particles with a size of .3 microns.” The smaller the particle, the more penetrating and nefarious it can be. So when you’re shopping for air purifiers, check out their filters’ MERV rating—the higher the MERV rating, the better it is at trapping the tiniest particles.

Suppose it’s the coronavirus that has you shopping for purifiers. In that case, it should be said that though a HEPA filter should be able to catch a virus of that size, there’s no conclusive proof that an air purifier can kill airborne COVID-19-carrying air droplets. The Centers for Disease Control and Prevention has stated that any room housing a coronavirus patient “should be exhausted directly to the outside, or be filtered through a high-efficiency particulate air (HEPA) filter directly before recirculation.”

If your main concern about your indoor air quality is lingering food or cigarette smoke odors, make sure the model you’re considering specifically targets fumes and other volatile organic compounds. HEPA filters aren’t good at eliminating odors on their own.

The HEPA filter was initially designed to capture radioactive particles when the atomic bomb was being developed because it can capture 99.97 percent of particles as small as .3 microns, which can evade other types of filters. (This is sometimes referred to as “true HEPA,” as European HEPA standards are required to trap only 85 percent of particles.) It works by ensnaring, sieving, and rerouting irritating particles.

A HEPA air purifier is considered the gold standard, but it does have limitations. Any particle smaller than .3 microns—for example, some viruses and VOCs (volatile organic compounds) like aerosols, ammonia, and other toxins—will slip right through. Changing your filter often enough is key. A HEPA filter does a great job of capturing mold. If you don’t change the filter, the purifier can redistribute that mold back into the air.

Allergies

The best air purifiers for allergies depend on your particular triggers because different filters work on different-sized particles. Pet hair and pollen are large particles, dust is medium-sized, and smoke is small. A combination HEPA-carbon filter is your best bet for filtering the maximum number of irritants to help reduce your allergies.

The addition of an ionizer and UV light, if you’re comfortable with it, adds a belt to your proverbial suspenders. Because UV light does create ozone particles, we recommend choosing an air purifier with UV light that’s approved for sale in California.

Smoke

Pollutants—like smoke and soot—can aggravate asthma, irritate your eyes, and stress your lungs and heart. An intuitive HEPA purifier with multiple fan speeds, maximum air circulation, and zero ozone output is the best one for allergy sufferers and people who are sensitive to smoke. The best air purifiers for smoke have a higher CADR rating. This means your device will be better at eliminating smoke and its odor, whether you’re talking about cigarettes, cannabis, or wildfires.

FAQs

Q: How much does an air purifier cost?

Even cheap air purifiers aren’t that cheap—they range between $50-$900. So, chances are, if you’ve found an option within your budget, you don’t need to second-guess it. Go through all the checkboxes you would for a more expensive model: Does it feature a true HEPA filter? Does your air purifier also feature a carbon filter? Is it ozone-free? If the answer to all those questions is yes, then go for it. What you’re likely sacrificing are bells and whistles you may not even need, like WiFi capability or large-space efficacy, but still possibly getting other extras, like low-noise operation and triple filtration.

Q: Should I sleep with the air purifier on?

Sure, there’s no reason not to sleep with the air purifier on! An air purifier contributes to an overall healthy home environment, even while you sleep. In fact, many models feature white noise or overnight modes, so they can continue to work without disturbing you (and possibly even helping you sleep).

Q: Where is the best place to position an air purifier?

The best place to position an air purifier is probably not where you think. Don’t stick it in a corner or behind a piece of furniture to conceal it. Beyond that, if there’s a particular pollutant (smoke, food odor) that you’re trying to combat, place the purifier near it. You want it 3 to 5 feet off the ground—so on a table or sill if it’s not a tower-style—and, whenever possible, near sites of good airflow, like doorways and windows. Moving your purifier from place to place helps maximize its efficacy.

Q: Will an air purifier affect my plants?

Your plants should be safe and sound in the presence of an air purifier, with one exception: models that expel ozone. Otherwise, purified air is good for plants, just like it’s good for humans.

Q: Do air purifiers with UV light really offer extra sanitation?

Opinions on whether air purifiers with UV lights are worth it differ. UV can conquer indoor air particles that escape other filters, like bacteria and viruses, but the EPA has said there’s no way to measure the effectiveness of UV filtration. The UV lights are technically considered pesticidal devices—”an instrument or other machine that is used to destroy, repel, trap or mitigate any pests, including bacteria and viruses”—according to the EPA, and it does not review, and therefore cannot endorse, those. UV light creates potentially harmful ozone, as well, although the amount is small.

Final thoughts on the best air purifiers

In almost every category, the best air purifiers have true HEPA and carbon filters. Together, they get you the most coverage regarding the breadth of pollutants the purifier will attack. Beyond that, the most important qualities are energy efficiency and picking the right model for the size of your room. Everything else—design, whether the device is app-enabled, UV lighting—is just gravy.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

The post The best air purifiers for 2024 appeared first on Popular Science.

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The best smart water bottles in 2024 https://www.popsci.com/gear/best-smart-water-bottles/ Fri, 16 Jun 2023 17:30:00 +0000 https://www.popsci.com/?p=549271
A lineup of smart water bottles on a white background
Amanda Reed

These bottles can purify your water, track your water intake, and remind you to drink something other than coffee or Diet Coke.

The post The best smart water bottles in 2024 appeared first on Popular Science.

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A lineup of smart water bottles on a white background
Amanda Reed

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Best overall A mint-colored insulated LARQ smart water bottle on a small wooden table in front of a brick background LARQ PureVis Bottle
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A UV-C light zaps away bio-contaminants that could leave you feeling queasy.

Best for hydration A blue HidrateSpark water bottle on a blue and white background HidrateSpark PRO Smart Water Bottle
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Bluetooth automatically updates how much water you’ve sipped.

Best budget A teal HidrateSpark TAP water bottle on a blue and white background HidrateSpark TAP Smart Water Bottle Chug Lid
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An option that’s only $20 packed with top-shelf features.

Among the plethora of “smart” things in this world—televisions, phones, speakers, and even entire homes—water bottles don’t come to top of mind. However, we think that can change, thanks to water bottles now having more capabilities other than “simple receptacle of many liquids.” Now, you can count how many ounces you’re chugging, get reminded to take a sip, and even get your filtered water to a new level of clean. The best smart water bottles make staying hydrated easy as they’re refilled and you’re fulfilled. 

The best smart water bottles: Reviews & Recommendations

Best overall: LARQ PureVis Bottle

Amanda Reed

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Why it made the cut: This high-tech water bottle comes with a self-cleaning cap that uses the power of UV light to give your filtered water a purer taste and keep the bottle clean. 

Specs

  • Cap options: PureVis self-cleaning cap, filter cap with flip top (doesn’t self-clean)
  • Bottle sizes: 17 oz.; 25 oz.
  • Self-cleaning?: Yes
  • Water tracking: No

Pros

  • Clean that you can taste
  • Sleek look
  • Lightweight

Cons

  • No water tracking
  • Largest size is still relatively small
  • MicroUSB vs. USB-C

Although water covers more than 70 percent of the Earth’s surface, only 3 percent is drinkable fresh water. Even deeper than that, only .5 percent of that drinkable fresh water is available, meaning it’s not locked in a glacier or the atmosphere. And water from public water systems isn’t guaranteed to be clean (hello, boil water advisories). Enter the LARQ PureVis bottle, which uses UV-C light to eliminate up to 99% of bio-contaminants (including E.Coli). And it self-cleans every two hours, meaning you don’t even need to think about having a musty water bottle. Double-vacuum insulation keeps things cool, even when you’re getting stress-sweats thinking about how only 3 percent of the world’s water is drinkable fresh water. 

The LARQ makes for a great travel water bottle as well, especially if you really want to make sure the bottled water you’re drinking is A-OK. Just make sure you fill it up after you pass through TSA security—you don’t want to get this fancy, pricey water bottle confiscated by a very strict agent before a flight. If you’re more active, consider the Movement PureVis bottle, which is uninsulated and lighter but has the same PureVis tech as the insulated version. 

A close-up of the microUSB charger on the LARQ smart water bottle
Amanda Reed

At $99-$118, this water bottle is expensive, meaning it’s heartbreaking for you and your wallet if you misplace it, especially since you can’t use Bluetooth to track its location. And its capacity tops out at 25 ounces—practically a sip for those who drink water like a fish. There’s no hydration tracking, meaning it’s up to you to remember how much water you’ve imbibed. A pitcher version lets you get squeaky clean water you can put into your favorite gallon water bottles (or even the other smart water bottles on this list that focus on water intake tracking). Still, if you’re looking for UV cleaning and water tracking … sadly, this ain’t it!

The water problem, considering how things are going with the climate and public infrastructure, isn’t going away anytime soon. The LARQ PureVis bottle gives you more peace of mind and lets you not sip on nasties. It’s not the only self-cleaning water bottle on our list, but it’s definitely the best. Read more of our thoughts on the LARQ.

Best for hydration: HidrateSpark PRO Smart Water Bottle

HidrateSpark

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Why it made the cut: This light-up water bottle uses the power of Bluetooth to keep track of how much water you’ve consumed. It even tells you how much water you should drink based on your height and weight. 

Specs

  • Cap options: Chug or straw lid
  • Bottle sizes: 17 oz.; 21 oz.; 32 oz.
  • Self-cleaning?: No
  • Water tracking: Yes

Pros

  • Lots of size options
  • Seamless water tracking
  • Friendly UX with bottle and app

Cons

  • Straw cap hard to sip out of
  • Heavy
  • Not self-cleaning

If you need the gently pulsing alarm clock version of a water bottle (aka, those bottles with the lines and cute phrases don’t cut it for you—someone with a mushy brain and short attention span caused by social media scrolling), consider the HidrateSpark PRO just that. It works with Bluetooth and a coordinating app to measure your water intake. All you need to do is set the bottle down, and the app automatically updates how close you are to your water goal. You can set that number yourself or allow the bottle to figure that out for you by entering your weight, height, elevation, and other metrics. Setup is super easy and takes less than five minutes, less than the time it takes to wash the bottle when you first get it in. The settings are also super robust: you can set when the bottle glows—every time you take a sip, when you meet your goal, both, or even … not at all! It’s similarly priced to other non-smart water bottles on the market, meaning you’re wallet won’t hurt as much compared to other options on this list. 

Best budget: HidrateSpark TAP Smart Water Bottle Chug Lid

HidrateSpark

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Why it made the cut: Practically all the same capabilities of the HidrateSPARK Pro bottle minus the price tag—and some of the cheapest smart water bottles you can buy. 

Specs

  • Cap options: Chug or straw cap
  • Bottle sizes: 20 oz.; 24 oz.; 32 oz.
  • Self-cleaning?: No
  • Water tracking: Yes

Pros

  • Lightweight
  • Easy setup

Cons

  • Not insulated
  • Water intake only updated with phone tap

Sure, it’s not as packed with features as its PRO sibling, but the HidrateSpark TAP is an excellent option for someone who doesn’t want to spend too much money on a smart water bottle. It doesn’t update as often as the PRO because it lacks Bluetooth tech—it uses near-field communication (NFC) instead of Bluetooth, with a simple phone tap allowing you to update the app with how much you’ve sipped. It comes in a sip-top option and lights up to remind you to drink (although you can’t customize that option; it’s preset at once an hour for 12 hours as soon as you turn the timer on). Look no further if you’re looking for a basic, budget-friendly smart water bottle. 

Here are other options we think are a cool drink of water:

FAQs

Q: How much does a smart water bottle cost?

A smart water bottle costs between $29-$120, depending on size and features. Ones with Bluetooth and UV-C light will be more expensive than those with an NFC tag for updating.  

Q: Is it OK to refill smart water bottles?

Not only is it OK to refill a smart water bottle, but it’s also encouraged! Some smart water bottles let you know how many bottles you need to drink to make your personal hydration goals. 

Q: How do I clean a smart water bottle?

Washing a smart water bottle is incredibly similar to washing a regular insulated water bottle. If your smart water bottle isn’t dishwasher safe, remove any electronic components (batteries, sensors, etc.) and wash by hand with dish soap and warm water. If it’s dishwasher safe, simply throw it in there and wait until the cycle is over. 

Q: Can I microwave a smart water bottle?

Depends. You can’t microwave stainless steel (unless you want to destroy your microwave). You can technically microwave Tritan plastic, but make sure all electronic components aren’t going in the microwave. Would we personally microwave a Tritan plastic water bottle? No, but you do you, boo!

Q: Why do people use smart water bottles?

Some of us consistently rot our brains from too much social media and reach for a Diet Coke, an oatmilk iced latte, or a seltzer before even thinking about regular, plain water. A smart water bottle reminds you to take a sip and takes the guesswork out of how much water you should drink. Your kidneys will thank you!

Final thoughts on the best smart water bottles

Smart water bottles are a great way to easily track how much water you drink daily, ensure your water has no rogue bacteria, and self-clean for mustiness-free sipping. Our favorite smart water bottle is the LARQ PureVis Bottle, which kills potential bacteria in water for results you can taste. If you’re looking for an option to track hydration, we recommend the Hidrate SparkPRO Smart Water Bottle, which syncs seamlessly with incredibly customizable settings to boot. If the cheapest option is your goal, look no further than the HidrateSpark TAP Smart Water Bottle Chug Lid—the HidrateSpark’s formidable and budget-friendly sibling. 

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

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This implant will tell a smartphone app when you need to pee https://www.popsci.com/health/bladder-sensor-implant/ Mon, 25 Mar 2024 19:00:00 +0000 https://www.popsci.com/?p=607873
Bladder sensor next to smartphone displaying its app
The sensor responds to a bladder's natural expansions and contractions throughout the day. Northwestern University

The stretchy, wireless sensor could keep patients with bladder issues informed in real-time.

The post This implant will tell a smartphone app when you need to pee appeared first on Popular Science.

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Bladder sensor next to smartphone displaying its app
The sensor responds to a bladder's natural expansions and contractions throughout the day. Northwestern University

For people dealing with spina bifida, paralysis, and various bladder diseases, determining when to take a bathroom break can be an issue. To help ease the frequent stress, researchers at Northwestern University have designed a sensor array that attaches to the bladder’s exterior wall, enabling it to detect its fullness in real time. Using embedded Bluetooth technology, the device then transmits its data to a smartphone app, allowing users to monitor their bodily functions without far less discomfort and guesswork.

The new tool, detailed in a study published today in the Proceedings of the National Academy of Sciences (PNAS), isn’t only meant to prevent incontinence issues. Lacking an ability to feel bladder fullness extends far beyond the obvious inconveniences—for millions of Americans dealing with bladder dysfunctions, not knowing when to go to the bathroom can cause additional organ damage such as regular infections and kidney damage. To combat these issues, the new medical device mirrors the bladder’s own elasticity. 

[Related: This drug-delivery soft robot may help solve medical implants’ scar tissue problem.]

“The key advance here is in the development of super soft, ultrathin, stretchable strain gauges that can gently wrap the outside surface of the bladder, without imposing any mechanical constraints on the natural filling and voiding behaviors,” John Rogers, study co-lead and professor of material sciences and biomedical engineering at Northwestern University, said in a statement.

As a bladder fills with urine, its expansion stretches out the sensor material, which in turn wirelessly sends data to a patient’s smartphone app. This also works as the organ contracts after urination, providing users with the real-time data throughout the day’s ebbs and flows. In small animal lab tests, the battery-free device could accurately monitor a bladder for 30 days, while the implant lasted in non-human primates as long as 8 weeks.

“Depending on the use case, we can design the technology to reside permanently inside the body or to harmlessly dissolve after the patient has made a full recovery,” regenerative engineer and study co-lead Guillermo Ameer said on Monday

Researchers believe their device could reduce the need for uncomfortable, infection-prone catheters, as well as limiting the use of more invasive, in-patient bladder monitoring procedures. But why stop there?

The team is also testing a separate, biodegradable “patch” using a patient’s own stem cells. Called a pro-regenerative scaffold (PRS), the new material also expands and contracts alongside the bladder’s movements while encouraging the growth of new organ cells. New tissue remains in place as the patch dissolves, allowing for faster, more effective healing possibilities. Researchers hope to one day combine their PRS work alongside their wireless monitoring sensors.

“This work brings us closer to the reality of smart regenerative systems, which are implantable pro-regenerative devices capable of probing their microenvironment, wirelessly reporting those findings outside the body… and enabling on-demand or programmed responses to change course and improve device performance or safety,” said Ameer.

For even more restored functionality, the team believes their sensors could eventually incorporate additional technology to stimulate urination on demand using the smartphone app. Taken as a whole, the trio of medical advances could one day offer a far less invasive, comfortable, and effective therapy for patients dealing with bladder issues. 

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How to fix your sleep schedule without pulling an all-nighter https://www.popsci.com/diy/how-to-fix-your-sleep-schedule/ Sun, 24 Mar 2024 12:08:13 +0000 https://www.popsci.com/?p=607462
illustration of two people in bed, one sleeping, one awake
You need more sleep. DepositPhotos

Sleep experts recommend several strategies for resetting an out-of-sync circadian rhythm.

The post How to fix your sleep schedule without pulling an all-nighter appeared first on Popular Science.

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illustration of two people in bed, one sleeping, one awake
You need more sleep. DepositPhotos

Sleep is one of the most essential activities for human health, but it’s also one of the most neglected. According to the Centers for Disease Control and Prevention, 14.5 percent of adults occasionally have trouble falling asleep. Whether because of work or mindlessly scrolling on your phone, staying up late can throw off your circadian rhythm—the internal clock that tells your body when it’s time to sleep and stay awake. 

So how do you get your sleep cycle back on track? Some online communities have suggested pulling an all-nighter as a quick sleep hack for “resetting” your circadian rhythm. The idea is that forcing yourself awake increases sleep pressure—the urge to sleep more that increases the longer a person is awake—allowing you to knock out at your preferred time. While this may have worked for a person or two, it’s not a recommended practice.

Pulling an all-nighter will actually make sleep problems worse, says Michael Breus, a clinical psychologist known as “The Sleep Doctor.” If your sleep schedule is already off, depriving the body of even more sleep can worsen a person’s cognitive function—stunting their problem-solving, memory, and creative thinking skills. A person’s reaction time also drops dramatically, which can increase the risk of drowsy driving accidents.

[Related: How to wake up]

Thomas Kilkenny, the director of the Institute Sleep Medicine at Northwell Health in New York City, points out that sleep deprivation is considered a form of torture banned in the Geneva Conventions—treaties that list protocols for humanitarian treatment during war. “To voluntarily do this is not a good idea and we should try to do whatever we can to avoid that.”

There’s no way to shift the timing of your circadian rhythm in one night. It actually takes roughly 28 days for your circadian rhythm to reset fully, says Breus. The good news is that while it might take some time, there are other effective methods for getting your sleep schedule back on track. Sleep doctors told Popular Science several strategies to get back into your normal sleep schedule. 

How to fix your sleep schedule

Wake up at the same time every day

If you normally wake up around 8 AM, but last night you didn’t get to bed until 3 AM, Kilkenny recommends still getting up at your usual wake-up hours. You may have to deal with a day of grogginess, but the trade-off is being more likely to maintain your normal sleep schedule. “If you’ve had a bad night, you’ll just have to pretend that one night never happened and get right back into that routine,” Kilkenny says.

You may feel tempted to sleep a few extra hours or sleep in on the weekends. Still, Breus says staying consistent with your normal sleep schedule stabilizes the circadian rhythm and establishes a pattern for sleep and wakefulness. This also means not napping after a poor night of sleep. Kilkenny says a nap will throw off your sleep cycle and make it harder for your body to feel tired at night naturally. 

Set aside time for purposeful worrying

Insomnia is often a result of high stress levels. The body can’t shut down for the night when your brain is actively racing with thoughts of a potential threat, whether that’s a lion prowling your campsite or the stress of paying for rent next month.

Kilkenny advises practicing a technique called purposeful worrying. Like its name, purposeful worrying involves setting aside five to 15 minutes everyday to think and feel anxious about anything troubling you. Giving yourself a time limit to worry about your problems will help manage stress without draining too much of your energy. It also provides an opportunity to really think and plan out solutions to overcome these fears.

When you have a realistic plan for overcoming the problem, the initial concern is not so scary anymore. “The brain has a tendency not to revisit something it’s already figured out,” adds Kilkenny. “You’re much less likely to get into bed and bring up the worry again.”

Exercise in the morning or afternoon

Going to bed physically tired helps increase sleep quality. Ideally aim to exercise every day, even if it is a 20-minute walk in the park. If you do exercise, Breus advises not to exercise four hours before bedtime. 

Body temperature normally increases during the day and slowly drops during the night. When you exercise too close to bedtime, your core body temperature increases, which can give a wrong signal to the circadian rhythm that you need to be awake. Breus explains that giving time to let your body temperature cool down makes you more sleepy.

Prep the body for sleep

You want to make sure your body is set up for rest. Kilkenny recommends avoiding bright lights as they can disrupt your circadian rhythm and lower melatonin levels. This includes turning off all electronics an hour or two before bed and having the bedroom lights dimly lit or off completely. Try to use the time to meditate or read to put yourself in a relaxed state. 

Breus also says not to drink coffee past 2 PM. Caffeine has a mean half-life of five hours, meaning that by 7 PM, about half will be out of your system. Another beverage to limit is alcohol, as it is associated with poor quality sleep and frequent wakings throughout the night. If you decide to drink, Breus advises only consuming two drinks and having them three hours before bed.

It may take a while for your sleep schedule to adjust after a couple of bad nights, but it is possible. Although there are some cases where health problems may cause chronic insomnia. If you continue to have trouble sleeping or your insomnia gets worse, consider speaking with a therapist, sleep specialist, or your doctor to get to the root of the problem.

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Surgeons complete first-ever gene-edited pig kidney transplant https://www.popsci.com/health/gene-edited-pig-kidney-transplant/ Fri, 22 Mar 2024 19:00:00 +0000 https://www.popsci.com/?p=607565
surgeons in an operating room
After around four hours of tense operating, surgeons in the room reportedly said they saw the transplanted kidney producing urine, a key sign the procedure was a success. DepositPhotos

Doctors say ‘the real hero’ is the 62-year-old patient from Massachusetts who underwent the experimental procedure.

The post Surgeons complete first-ever gene-edited pig kidney transplant appeared first on Popular Science.

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surgeons in an operating room
After around four hours of tense operating, surgeons in the room reportedly said they saw the transplanted kidney producing urine, a key sign the procedure was a success. DepositPhotos

In a world first, surgeons at Massachusetts General Hospital successfully transplanted a genetically modified pig kidney into a person with chronic kidney disease. The historic procedure builds off of decades of research into gene editing of animal organs and could mark an inflection point in efforts to cut down on sometimes fatally lengthy transplant wait times. Recent advances in gene editing technology means procedures like these could become more common. 

The patient, a 62-year-old man from Massachusetts named Richard Slayman, has severe diabetes and hypertension and has been on dialysis for seven years. He eventually received a new kidney from a human donor but it began showing signs of failure after five years. Slayman was on a waiting list for another kidney when his doctors suggested the possibility of receiving an experimental kidney from a gene-edited pig.

“I saw [the transplant] not only as a way to help me, but a way to provide hope for the thousands of people who need a transplant to survive,” Slayman said in a statement. 

The modified pig was engineered by Massachusetts-based biotech firm eGenesis. Scientists used CRISPR gene editing technology to produce a pig with 69 gene modifications. Several of these modifications were meant to remove harmful pig genes that could provoke an immune response from the patent. Human genes were also added to the pig to improve the kidney’s compatibility and lessen the likelihood of the human body rejecting it. 

After around four hours of tense operating, surgeons in the room reportedly said they saw the transplanted kidney producing urine, a key sign the procedure was a success. The room filled with applause and cheers. 

“This represents a new frontier in medicine and demonstrates the potential of genome engineering to change the lives of millions of patients globally suffering from kidney failure,” eGenesis CEO Mike Curtis said in a statement

Why are scientists interested in gene-editing animal organs?

Scientists are hopeful that transplanting animal organs into humans, a practice called “xenotransplantation,” could one day supplement human organ transplants and cut down on lengthy transplant wait times. An estimated 36 million people in the US are affected by chronic kidney disease, 800,000 of which have end stage kidney disease or kidney failure according to the Centers for Disease Control. Once at that stage, patients are often forced to choose between going on a dialysis machine that filters their blood or applying for an organ transplant. Over 103,000 people in the US are currently on organ transplant wait list according to the Health Resource and Services Administration (HRSA). 

But lengthy wait times and a limited supply of able organ donors means many of those patients never end up receiving a transplant. The HRSA estimates 17 people die everyday while waiting for a new organ. Those lengthy wait times and lack of donors has also helped fuel an organ black market. 

Potential animal organ transplants aren’t just limited to kidneys. Surgeons at the University of Pennsylvania, for example, successfully implanted a gene-modified pig liver into a brain-stem dead person in 2022. Not long after that surgeons from the University of Maryland Medical Center implanted pig hearts into two fatally-ill patients. Though those two surgeries were successful, their end effect was limited. Both patients reportedly died less than two months after the procedures. Human immune systems react violently to organs from other species and try to reject them, an obstacle which makes these procedures particularly challenging.  

“If it were easy, we’d be doing it by now, but it’s not,” MGH Transplant Center Director Joren Madsen said in a statement. “The barrier to pig xenotransplantation is formidable.” 

Still, researchers are hopeful advancements in gene editing could lead to longer lasting benefits. Surgeons have previously transplanted genetically modified kidneys and livers to baboons. In one case, eGenesis claims a monkey implanted with a gene-edited pig kidney lived for two years following the surgery. Surgeons involved with Slayman’s procedure are similarly hoping his new kidneys could help him live for two more years. The FDA fast tracked approval for his particulate procedure as part of its “compassionate use” program intended for patients nearing the ends of their lives. Wider use of this procedure would require full FDA testing and approval. 

And while the historic procedure is both a feat of scientific and medical prowess, surgeons involved say the real credit belongs to the patient for marching into an unknown territory.

“The real hero today is the patient, Mr. Slayman, as the success of this pioneering surgery, once deemed unimaginable, would not have been possible without his courage and willingness to embark on a journey into uncharted medical territory,” MGH Transplant Center Director Joren C. Madsen said in a statement.

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Telehealth sites promise cure for ‘male menopause’ despite FDA ban on off-label ads https://www.popsci.com/health/telehealth-male-menopause-testosterone-replacement-risks/ Fri, 22 Mar 2024 12:00:00 +0000 https://www.popsci.com/?p=607412
The deluge of ads “has fueled demand for a largely uninsured product, allowing for high markups."
The deluge of ads “has fueled demand for a largely uninsured product, allowing for high markups.". Deposit Photos

In 2015, the FDA said it banned 'low-t' television ads for exaggerating to scare men into buying drugs. Now the ads have moved online.

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The deluge of ads “has fueled demand for a largely uninsured product, allowing for high markups."
The deluge of ads “has fueled demand for a largely uninsured product, allowing for high markups.". Deposit Photos

This article was originally published on KFF Health News.

Online stores sprang up during the covid-19 pandemic’s telehealth boom touting testosterone as a cure-all for men’s age-related illnesses—despite FDA rules issued years ago restricting such “low testosterone” advertising.

In ads on Google, Facebook, and elsewhere, testosterone telemedicine websites may promise a quick fix for sluggishness and low libido in men. But evidence for that is lacking, physicians said, and the midlife malaise for which testosterone is being touted as a solution is more likely caused by chronic medical conditions, poor diet, or a sedentary lifestyle. In fact, doctors urge caution—and the FDA recommends that all testosterone supplements carry a warning that they may increase the risk of heart attack and stroke.

Valid medical reasons do exist for treating some men with testosterone. The hormone as a medication has existed for decades, and today’s patients include men with hypogonadism, some transgender men who use it to help transition physically, and, sometimes, women dealing with menopausal symptoms. It has also been used for decades by bodybuilders and athletes to enhance strength.

However, online dispensaries can overplay the idea of what is sometimes called “male menopause,” or even “manopause,” to drive sales of highly profitable testosterone-boosting injectables, often ignoring safety guidelines that should prevent healthy men from using the hormone. Some of the websites target military veterans.

“I have seen ads online that do cross the line,” said Steven Nissen, a physician and the chief academic officer for the Heart, Vascular, and Thoracic Institute at the Cleveland Clinic. “For mood and low energy, prescribing testosterone provides little to no benefit. They are promoting testosterone for indications that are not on the label.”

Testosterone telehealth websites almost all cite one study published in 2002 by New England Research Institutes scientists who found testosterone levels drop 1% a year in men over 40. Stefan Schlatt, director of the Center for Reproductive Medicine and Andrology at the University of Muenster in Germany, said the data behind the statistic included older men in deteriorating health whose levels declined because of illnesses.

“Healthy men do not show a drop,” he said.

That 2002 study led to a flood of “low-T” ads on U.S. television—ads that were later banned by the FDA in a 2015 ruling that accused the pharmaceutical industry of exaggerating the low-T phenomenon to scare men into buying drugs. According to another study, the market for testosterone supplements stood at $1.85 billion in 2023.

The deluge of ads “has fueled demand for a largely uninsured product, allowing for high markups,” said Geoffrey Joyce, director of health policy at the USC Schaeffer Center for Health Policy & Economics and a research associate at the National Bureau of Economic Research. “The primary driver is manufactured demand.”

Barbara Mintzes, a professor of evidence-based pharmaceutical policy at the University of Sydney’s Charles Perkins Centre in Australia, said low testosterone should really be seen as a sign of a condition that needs to be treated. She said diabetes, heart disease, high blood pressure, obesity, exposure to toxic chemicals like PFAS, and stress can all reduce testosterone levels.

Several websites reviewed by KFF Health News brand themselves as news and fitness magazines, with advertisements embedded in articles steering readers toward order forms for testosterone replacement therapy, shorthanded as TRT. The sites’ prices for TRT range from $120 to $135 a month, not including initial mail-back blood tests for around $60. Some sites promise increased libido and reduced stomach fat.

Male Excel’s ads on Google, for example, say TRT “improves mood” and “restores vitality.” And its site says testosterone treatment will provide “muscular definition,” “weight loss,” “explosive drive,” “deeper sleep,” and “restored energy” above a link to a free assessment on its online telehealth platform. Craig Larsen, the company’s CEO, did not reply to several attempts to contact him by phone and email.

Both Male Excel and Hone Health are among the sites that pitch to military veterans. Hone Health included a video of a veteran who said he was refused testosterone treatment by a Department of Veterans Affairs hospital.

Saad Alam, CEO and co-founder of Hone, said that his company is what he called a “conservative” player in the market. He said that Hone prescribes only to men who are hypogonadal and tests men every 90 days, unlike other companies that operate telehealth websites as what he called a “cash grab.”

“I agree that patients should be treated by their doctors. But the U.S. medical system isn’t at a point where it can service men who have this problem, and some endocrinologists would rather treat patients who are higher-profit,” Hone said. “That’s why people are coming to us.”

One popular form of TRT is injectable testosterone cypionate. According to the Medicare average sales price database, it costs $0.027 per milligram. Online purveyors who sell the drug directly to consumers in 200 mg/mL vials for an average price of $129 per month are charging the equivalent of $1.55 per mg—a markup of more than 50 times the average Medicare price.

According to a 2022 study, the TRT telehealth websites create a way to circumvent doctors who refuse to prescribe the hormone. In that study, Justin Dubin, a urologist at the Memorial Healthcare System in Florida, posed as an online mystery shopper. He reported an above-normal testosterone level, and stated his desire to start a family, even though such therapy can curb sperm production. But six of the seven unnamed online TRT clinics prescribed him testosterone via a medical professional.

“And that’s concerning,” Dubin said. “Telemedicine helps men with hypogonadism who might be too embarrassed to discuss erectile dysfunction. But we need to do a better job of understanding the appropriateness of care.”

Still, while the FDA doesn’t allow off-label marketing, it does allow such off-label prescriptions.

Off-label use of testosterone replacement has become especially commonplace among veterans. And among male service members who received TRT in 2017, fewer than half met the clinical practice guidelines, according to a report by the U.S. military.

Phil Palmer, a 41-year-old Marine Corps veteran who lives outside Charleston, South Carolina, said he pays out-of-pocket for bloodwork and prescriptions for a pellet skin-implant form of testosterone and for clomiphene, a drug that can help counter the male infertility that is a side effect of testosterone treatment. He said the treatment appeals to him and other veterans dealing with the aftermath of military service.

“The environment we served in and stress levels have a lot to do with it,” Palmer said. “We were exposed to burn pits. The military doesn’t teach you to eat well—we ate a lot of processed food.”

In medical settings, TRT can speed recovery of soldiers who have bone density issues or spinal cord injuries, said Mark Peterson, a professor of physical medicine and rehabilitation at the University of Michigan Medical School. But, he said, “for men in the normal-T range, using an online prescription to buy testosterone to reduce stomach fat can be counterproductive.”

Those who use it also risk having to take testosterone medication indefinitely, because TRT can cause the body to cease its own production of the hormone.

Palmer, who founded a nonprofit that helps veterans heal through exercise, nutrition, and mentorship, said the medication has been helpful for him but urges fellow veterans to seek care from their doctors rather than what he called “bro science” websites touting testosterone.

“It’s not a magic pill,” he said.

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

Subscribe to KFF Health News’ free Morning Briefing.

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Neuralink shows first human patient using brain implant to play online chess https://www.popsci.com/technology/neuralink-first-human-video/ Thu, 21 Mar 2024 16:30:00 +0000 https://www.popsci.com/?p=607341
Neuralink logo on smartphone
Neuralink's first human patient is a 29-year-old quadriplegic man from Texas. Deposit Photos

Elon Musk previously said his brain-computer interface company implanted the device in January.

The post Neuralink shows first human patient using brain implant to play online chess appeared first on Popular Science.

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Neuralink logo on smartphone
Neuralink's first human patient is a 29-year-old quadriplegic man from Texas. Deposit Photos

The first human patient to reportedly receive Neuralink’s wireless brain-computer interface (BCI) implant appeared to demonstrate the device’s early capabilities during a company livestream to X on Wednesday night. In late January, Elon Musk publicly stated that the experimental medical procedure was completed, but neither he nor his controversial medical startup had offered evidence of the results until yesterday evening’s 9-minute video.

Neuralink’s first volunteer is 29-year-old Noland Arbaugh from Texas, who dislocated his C4 and C5 vertebrae during a diving accident in 2016, permanently paralyzing him below the shoulders. During the livestream, Arbaugh appears to be playing online chess as a Neuralink BCI implant translates his brain activity into actionable computer inputs.

“If y’all can see the cursor moving around the screen, that’s all me,” he says at one point while highlighting a chess piece. “It’s pretty cool, huh?” According to Arbaugh, the key to successfully employing his new implant involved learning how to mentally differentiate between intentional and attempted movement—i.e, brain activity expressing the desire to move as opposed to activity which literally controls motor functions. “From there, I think it just became intuitive to me to start imagining the cursor moving,” Arbaugh continued, likening the feeling to “using the Force” from Star Wars.

Neuralink’s BCI is implanted using a robotic surgeon that subcutaneously connects the device’s microscopic wiring to a patient’s brain. Once installed, the hardware supposedly cannot be seen externally, and recharges wireless from “outside via a compact, inductive charger,” according to Neuralink’s website. Musk has repeatedly stated his hopes Neuralink will ultimately allow users to connect to the internet, smartphones, and computers through a line of upgradable, reversible BCI implants—and that he intends to one day receive the procedure himself.

“Long-term, it is possible to shunt the signals from the brain motor cortex past the damaged part of the spine to enable people to walk again and use their arms normally,” Musk claimed in a reply to Neuralink’s Wednesday evening post.

During the livestream hosted by Neuralink engineer Bliss Chapman, Arbaugh also described independently playing video games like the turn-based strategy game Civilization 6, which often entails more complex user inputs. Before the implant, Arbaugh says he frequently required assistance from his parents or a friend to play such games. Now, however, he says he has been able to do so for as long as eight hours and that the biggest impediment is simply waiting for the Neuralink’s battery to recharge.

[Related: Elon Musk alleges Neuralink completed its first human trial implant.]

“It’s not perfect. We have run into some issues,” Arbaugh concedes at one point, although he does not elaborate on the hurdles. “I don’t want people to think this is the end of the journey. There’s still a lot of work to be done.”

“We have more work to do. We have a lot to learn about the brain here,” agreed Chapman.

Neuralink is far from the first company to develop and install BCI implants, with the first successful commercial procedure dating back to 2010. Similar devices have since converted imagined handwriting into text, as well as thoughts into words. One competitor’s implant has also enabled users to browse the web as well as conduct online shopping and banking since 2019.

But it’s unclear if the reveal of Neuralink’s first human participant will assuage critics’ concerns regarding the company’s research record. Less than a day after Neuralink announced it would begin screening human volunteers for its multiyear ​​Precise Robotically Implanted Brain-Computer Interface (PRIME) Study last September, Wired released a damning exposé detailing graphic accounts of lab animal abuse during research. At the time, Wired’s coverage was one in a string of similar investigations into Musk’s company, including internal complaints of “hack job” surgical procedures resulting in over 1,500 animal deaths since 2018. The reports have since prompted multiple federal regulatory reviews and human trial delays.

As Wired also noted this week, Neuralink has not registered its PRIME Study on ClinicalTrials.gov, the federal documentation site for human medical studies, so information like how many human subjects Neuralink is seeking, where its procedures are taking place, or how its results will be assessed are not publicly available.

Still, Arbaugh encouraged people to consider applying to Neuralink’s ongoing PRIME Study, saying “there’s nothing to be afraid of” about the “super easy” procedure which he says has resulted in no cognitive impairments for him. Chapman, meanwhile, stated last night that additional updates on both Neuralink’s and Arbaugh’s progress will be released in the coming days.

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What you need to know about cataract surgery https://www.popsci.com/health/what-you-need-to-know-about-cataract-surgery/ Thu, 21 Mar 2024 12:00:00 +0000 https://www.popsci.com/?p=607296
Closeup of an eye
Cataract surgery removes the clouded lens of the eye and replaces it with a new, clear lens. DepositPhotos

Ophthalmologists talk about the procedure that millions are about to have.

The post What you need to know about cataract surgery appeared first on Popular Science.

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Closeup of an eye
Cataract surgery removes the clouded lens of the eye and replaces it with a new, clear lens. DepositPhotos

This article was originally featured on The Conversation.

Cataract surgery is one of the most popular and commonly performed procedures in the world. The vast majority of patients have excellent outcomes with few complications.

Here are the numbers:

As ophthalmologists who have performed thousands of these procedures, we know that many patients have misconceptions about both cataracts and the surgery. For example, some think a cataract is a growth on the eye’s surface.

We like to compare a cataract with the frosted glass of a bathroom window, where light can be transmitted but details cannot. Or when turbulence from a storm causes normally clear water in the ocean to become murky. In much the same way, the eye’s once transparent lens becomes cloudy.

What you need to know about cataract surgery

About the surgery

Cataract surgery removes the clouded lens of the eye and replaces it with a new, clear lens to restore your vision. Most patients report the procedure is painless.

It’s typically an elective surgery that is performed on an outpatient basis. The patient is often awake, under local anesthesia, with sedation similar to that used for dental procedures. We like to say patients receive the equivalent of three margaritas in their IV.

Numbing drops are then applied to the eye’s surface, along with an anesthetic inside the eye. Patients with claustrophobia, or movement disorders such as Parkinson’s disease, may not be suitable candidates for awake surgeries and require general anesthesia.

Before surgery, patients receive dilating drops to make the pupil as large as possible. The surgeon makes a tiny incision, usually with a small pointed scalpel, between the clear and white part of the eye to gain access to the lens capsule, a thin membrane similar in thickness to a plastic produce bag at the grocery store.

This capsule is suspended by small fibers called zonules, which are arranged like the springs that suspend a trampoline from a frame. The surgeon then creates a small opening in the capsule, called a capsulotomy, to gain access to the cataract. The cataract is then broken into smaller parts so they are removable through the small incision.

This is similar to a tiny jackhammer, breaking the large lens into smaller pieces for removal. That sounds scary, but it’s painless. Ultrasound emulsifies the lens and vacuum power then aspirates it from the eye.

Laser-assisted cataract surgery has been found to have similar outcomes to traditional cataract surgery.

Complications are rare

Serious complications, such as postoperative infection, bleeding in the eye or a postoperative retinal detachment are rare; they occur in approximately 1 in 1,000 cases. But even in many of these situations, appropriate management can salvage useful vision.

Capsular complications deserve additional discussion. According to some studies, they occur in up to 2% of cases. If a hole or tear of the posterior capsule is encountered during cataract surgery, the clear gel in the vitreous – the back chamber of the eye – may be displaced into the front chamber of the eye.

If that happens, the gel must be removed at the time of the cataract surgery. This will reduce the likelihood of additional postoperative complications, but those who have the procedure, known as a vitrectomy, have an increased risk for additional complications, including postoperative infections and postoperative swelling.

After the surgery

Patients usually go home right after the procedure. Most surgery centers require that the patient have someone drive them home, more for the anesthesia rather than the surgery. Patients begin applying postoperative drops that same day and must wear an eye shield at bedtime for a few weeks after surgery.

Patients should keep the eye clean and avoid exposure to dust, debris and water. They should try not to bend over and should avoid heavy lifting or straining in the first week or so after surgery. Lifting or straining can cause a surge of blood pressure to the face and eye. Known as a choroidal hemorrhage, it can lead to bleeding into the wall of the eye and be devastating to vision.

Things that cause only moderate increases in heart rate such as walking are OK. Routine postoperative examinations are usually completed the day after surgery, about a week after surgery and about a month after surgery.

What you need to know about cataract surgery

A choice of lens

The plastic lens used to replace the cataract, or intraocular lens, requires careful sizing for optimal results and a nuanced discussion between patient and surgeon.

Early intraocular lens technologies were monofocal, and most patients with these lenses chose distance correction and used reading glasses for near tasks. This is still the preferred approach for approximately 90% of patients having cataract surgery today.

Recent advances have led to intraocular lenses that offer multifocality – the opportunity to have near as well as distance vision, without glasses. Some multifocal lenses are even in the trifocal category, which includes distance, near, and intermediate vision, the latter of which in recent years has become very important for computer and phone use.

Most patients with these advanced technology multifocal lenses are happy with them. However, a small percentage of patients with multifocal lenses can be so bothered by visual disturbances – notably night glare and halos around light sources in the dark – that they request removal of the multifocal lens to exchange it for a standard intraocular lens. These exchanges are a reasonable option for such situations and offer relief for most affected patients.

Determining who’s an ideal candidate for a multifocal intraocular lens is an area of active research. Most clinicians would recommend against such a lens for a patient with a detail-oriented personality. Such patients tend to fixate on the shortcomings of these lenses despite their potential advantages.

As with many technologies, current generation advanced technology intraocular lenses are much better than their predecessors. Future offerings are likely to offer improved vision and fewer side effects than those available today.

But these newer lenses are often not reimbursed by insurance companies and often entail substantial out-of-pocket costs for patients.

Deciding on what type of lens is best for you can be complicated. Fortunately, except in unusual circumstances, such as when a cataract develops after trauma to the eye, there is seldom a hurry for adult cataract surgery.

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EPA says over half of all new cars must be EVs or hybrids by 2032 https://www.popsci.com/environment/epa-car-pollution-standards/ Wed, 20 Mar 2024 17:30:00 +0000 https://www.popsci.com/?p=607265
High traffic road with signs and light trails on sunset
Transportation pollution is the single largest greenhouse gas contributor in the US. Deposit Photos

The Biden Administration’s new policies are the strictest auto pollution regulations yet.

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High traffic road with signs and light trails on sunset
Transportation pollution is the single largest greenhouse gas contributor in the US. Deposit Photos

The Biden administration has announced some of the biggest pollution regulations in US history. On Wednesday, the Environmental Protection Agency revealeded the finalization of new, enforceable standards meant to ensure electric and hybrid vehicles make up at least 56 percent of all passenger car and light truck sales by 2032.

To meet this goal, automotive manufacturers will face increasing tailpipe pollution limits over the next few years. This gradual shift essentially means over half of all car companies’ sales will need to be zero-emission models to meet the new federal benchmarks.

According to the EPA, this unprecedented industry transition could cut an estimated 7 billion tons of emissions over the next three decades. Regulators believe this will also offer a nearly $100 billion in annual net benefits for the nation, including $13 billion of annual public health benefits from improved air quality alongside $62 billion in reduced annual fuel, maintenance, and repair costs for everyday drivers.

[Related: EPA rule finally bans the most common form of asbestos.]

Transportation annually generates 29 percent of all US carbon emissions, making it the country’s largest single climate change contributor. Aggressively pursuing a nationwide shift towards EV adoption was a cornerstone of Biden’s 2020 presidential campaign platform. While in office, Donald Trump rolled back the Obama administration’s previous automotive pollution standards applicable to vehicles manufactured through 2025. He has promised to enact similar orders if re-elected during this year’s presidential election.

The EPA’s new standards is actually a slightly relaxed version of a previous proposal put forth last year. To address concerns of both manufacturers and the industry’s largest union, United Auto Workers, the Biden administration agreed to slow the rise of tailpipe standards over the next few years. By 2030, however, limits will increase substantially to make up for the lost time. The EPA claims today’s finalized policy will still reduce emissions by the same amount over the next three decades.

The new rules are by no means an “EPA car ban” on gas-powered vehicles, as lobbyists with the American Fuel & Petrochemical Manufacturers continue to falsely claim. The guidelines go into effect in 2027, and only pertain to new cars and light trucks over the coming years. The stipulations also cover companies’ entire product lines, so it’s up to manufacturers to determine how their fleets as a whole meet the EPA benchmarks.

Still, fossil fuel companies and Republican authorities are extremely likely to file legal challenges over today’s announcement—challenges that could easily arrive in front of the Supreme Court in the coming years. Earlier today, the vice president of federal policy for the League of Conservation Voters said during a press call that they already discussed such possibilities with the Biden administration, and “they are crystal clear about the importance of getting rules out to make sure that they withstand both legal challenges from the fossil fuel industry and any congressional attacks should Republicans take over the Senate and the White House.”

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As more states target disavowed ‘excited delirium’ diagnosis, police groups push back https://www.popsci.com/health/pushback-excited-delirium/ Wed, 20 Mar 2024 12:00:00 +0000 https://www.popsci.com/?p=607188
A rally to honor George Floyd
A march across the Brooklyn Bridge in honor of George Floyd, on the one year anniversary of his murder. In 2020, excited delirium was cited as a legal defense of Minneapolis police officer Derek Chauvin. Spencer Platt/Getty Images

Critics have highlighted the ‘lack of evidence that this is an actual medical syndrome’ and condoned the ‘junk science’ excuse of ‘police brutality resulting in death.’

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A rally to honor George Floyd
A march across the Brooklyn Bridge in honor of George Floyd, on the one year anniversary of his murder. In 2020, excited delirium was cited as a legal defense of Minneapolis police officer Derek Chauvin. Spencer Platt/Getty Images

This article was originally published on KFF Health News.

Following a pivotal year in the movement to discard the term “excited delirium,” momentum is building in several states to ban the discredited medical diagnosis from death certificates, law enforcement training, police incident reports, and civil court testimony.

In January, California became the first state to prohibit the medical term from many official proceedings. Now, lawmakers in ColoradoHawaiiMinnesota, and New York are considering bills that also would rein in how the excited delirium concept is used.

The new spate of state proposals, driven by families who lost relatives after encounters with law enforcement, marks an important step in doing away with a concept that critics say spurs police to overuse lethal force.

“It’s the law following the science, which is what we want to see,” said Joanna Naples-Mitchell, an attorney who worked on an influential Physicians for Human Rights review of how the term excited delirium evolved into a concept whose legitimacy is largely rejected by the medical community.

But initial momentum in statehouses is being met with fresh resistance from law enforcement agencies and other defenders, including some who agree that excited delirium is a sham diagnosis.

The bills “clearly run afoul of the First Amendment” and violate free speech, said Bill Johnson, executive director of the National Association of Police Organizations. He also argued that law enforcement officers do encounter symptoms and behaviors associated with excited delirium.

Excited delirium is a four-decade-old diagnostic theory that has been used to explain how a person experiencing severe agitation can suddenly die while being restrained. Last year, the American College of Emergency Physicians withdrew a 2009 report that had been the last remaining official medical pillar of support for the theory used increasingly over the prior 15 years to explain away police culpability for many in-custody deaths.

Excited delirium was cited as a legal defense in the 2020 deaths of George Floyd in Minneapolis; Daniel Prude in Rochester, New York; and Angelo Quinto in Antioch, California, among others. The theory proposed that individuals in a mental health crisis, often under the influence of drugs or alcohol, can exhibit superhuman strength as police try to control them, then die suddenly from the condition, not the police response.

The New York City Police Department issued training materials in 2021 and 2022 that tell officers to restrain and stun people they encounter who exhibit signs of excited delirium, such as “elevated body temperatures, increased physical strength and lack of physical fatigue,” according to New York Focus, a nonprofit newsroom. The NYPD did not respond to requests for comment on its training or the new state bill.

“They still have this on the books,” said Democratic New York state Assembly member Jessica González-Rojas, who introduced the bill that calls for banning the term from death certificates, autopsies, law enforcement training, incident reports, and court proceedings. “And it’s pretty concerning the types of restraints they are recommending, given lack of evidence that this is an actual medical syndrome.”

The Minneapolis Police Department, which according to the Star Tribune used the term in trainings, declined to comment on its training materials and the pending state legislation. That bill would prohibit excited delirium and similar terms from being cited as a cause of death, used as a medical diagnosis, or included in law enforcement training.

But the theory’s presence in training materials may also be starting to change. In Colorado — where the term was used, in part, to justify the 2019 killing of Elijah McClain in Aurora — a state board eliminated the term from law enforcement training starting this January. Law enforcement officers restrained the 23-year-old, and paramedics injected him with a lethal dose of ketamine.

This year, Colorado lawmakers are debating a measure that largely mirrors California’s bill but allows the term to remain in civil court proceedings.

At the bill’s hearing before the Colorado House Judiciary Committee on Feb. 6, Rebecca De Luna described her family’s anguish over the 2017 death of her daughter’s father, Alejandro Gutierrez, in Thornton police custody. She said excited delirium was classified as the cause of his death.

“His face was bruised with an imprint of a shoe. His appearance was unrecognizable,” De Luna testified. “The term has been used far too long as an excuse for law enforcement to protect themselves when someone dies in their custody, quite frankly, as a result of excessive force and what I consider police brutality resulting in death.”

Several medical service providers and educators testified in opposition. John Seward, the University of Denver’s emergency medical services program manager, told the committee that he did not object to banning “excited delirium” in death certificates and police training, as police are not health professionals. But banning the term’s use from medical personnel training would amount to legislating medicine and impeding academic freedom, he said.

“If we cannot study and learn from the past, even when that past is hurtful, we are now condemning ourselves to repeat it,” Seward told lawmakers.

Julia Sherwin, a California civil rights attorney who testified in support of the Colorado bill, was surprised by opponents’ arguments that such bills could limit free speech and discussion about the history of the idea.

“That to me felt a little ridiculous,” said Sherwin, who co-authored the Physicians for Human Rights report. Such bills keep a discredited theory from being falsely used to respond to a crisis and keep “junk science” out of official records, she said.

The Colorado bill passed the state’s House in a 42-19 vote in mid-February and is now before the state Senate. It was amended to clarify that “excited delirium” may be used when teaching about the history of the term and that EMS courses are allowed on “safe and effective medical interaction with individuals exhibiting an altered mental state” who have symptoms that include agitation, aggression, or violence.

Some of the push for such legislation comes from families whose loved ones’ deaths were blamed on excited delirium, rather than on use of force during a police encounter. The Hawaii bill was introduced after William and Verdell Haleck learned about California’s effort and began contacting lawmakers in Hawaii. Their son Sheldon died there in 2015 after he was pepper-sprayed, shocked, and restrained by Honolulu police. In a civil trial that the Halecks lost, officers blamed his death on excited delirium.

The Hawaii bill would ban excited delirium from being used in death certificates, police incident reports, and civil cases. It had not been scheduled for a legislative committee hearing as of mid-March, but the Halecks are hopeful it will eventually pass.

“It would give us some sort of closure and justice,” said William Haleck.

The Honolulu Police Department is monitoring the bill and hasn’t taken a position on it, said Michelle Yu, a spokesperson for the department. And the bill would have little impact on Honolulu’s Department of the Medical Examiner, said its director, Masahiko Kobayashi, because doctors there don’t use excited delirium as a cause of death.

One reason such bills are still important is because they prevent policies from fluctuating with each new leadership change, said David Siffert, legal director of the Surveillance Technology Oversight Project, which helped draft model legislation banning excited delirium and is pushing for the New York bill.

“Even if you are doing everything right, you don’t know if your successor will be,” Siffert said. “Historically we have seen those ups and downs in our agencies.”

Supporters of such state legislation say that banning the term excited delirium is just a first step toward reducing deaths in police custody.

“The underlying context doesn’t change with legislation alone,” Naples-Mitchell said. “It is going to take a very long time to address the root causes.”

Mountain States editor Matt Volz contributed to this article.

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

Subscribe to KFF Health News’ free Morning Briefing.

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Silicon Valley wants to deploy AI nursebots to handle your care https://www.popsci.com/technology/ai-nurse-chatbots-nvidia/ Tue, 19 Mar 2024 18:30:00 +0000 https://www.popsci.com/?p=607152
Woman talking with nurse chatbot on iPad
Hippocratic AI is using Nvidia GPUs to power its nurse chatbot avatars. Nvidia / Hippocratic AI / YouTube

Medical startup Hippocratic AI and Nvidia say it's all about the chatbots' 'empathy inference.'

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Woman talking with nurse chatbot on iPad
Hippocratic AI is using Nvidia GPUs to power its nurse chatbot avatars. Nvidia / Hippocratic AI / YouTube

The medical startup Hippocratic AI and Nvidia have announced plans to deploy voice-based “AI healthcare agents.” In demonstration videos provided Monday, at-home patients are depicted conversing with animated human avatar chatbots on tablet and smartphone screens. Examples include a post-op appendectomy screening, as well as a chatbot instructing someone on how to inject penicillin. Hippocratic’s web page suggests providers could soon simply purchase its nursebots for less than $9/hour to handle such tasks, instead of paying an actual registered nurse $90/hour, Hippocratic claims. (The average pay for a registered nurse in the US is $38.74/hour, according to a 2022 U.S. Bureau of Labor Statistics’ occupational employment statistics survey.)

A patient’s trust in AI apparently is all about a program’s “seamless, personalized, and conversational” tone, said Munjal Shah, Hippocratic AI co-founder and CEO, in the company’s March 18 statement. Based on their internal research, people’s ability to “emotionally connect” with an AI healthcare agent reportedly increases “by 5-10% or more” for every half-second of conversational speed improvement, dubbed Hippocratic’s “empathy inference” engine. But quickly simulating all that worthwhile humanity requires a lot of computing power—hence Hippocratic’s investment in countless Nvidia H100 Tensor Core GPUs.

AI photo

“Voice-based digital agents powered by generative AI can usher in an age of abundance in healthcare, but only if the technology responds to patients as a human would,” said Kimberly Powell, Nvidia’s VP of Healthcare, said on Monday

[Related: Will we ever be able to trust health advice from an AI?]

But an H100 GPU-fueled nurse-droid’s capacity to spew medical advice nearly as fast as an overworked healthcare worker is only as good as its accuracy and bedside manner. Hippocratic says it’s also got that covered, of course, and cites internal surveys and beta testing of over 5,500 nurses and doctors voicing overwhelming satisfaction with the AI as proof. When it comes to its ability to avoid AI’s (well documented) racial, gendered, and age-based biases, however, testing is apparently still underway. And in terms of where Hippocratic’s LLM derived its diagnostic and conversational information—well, that’s even vaguer than their mostly anonymous polled humans.

In the company’s white paper detailing Polaris, its “Safety-focused LLM Constellation Architecture for Healthcare,” Hippocratic AI researchers say their model is trained “on a massive collection of proprietary data including clinical care plans, healthcare regulatory documents, medical manuals, drug databases, and other high-quality medical reasoning documents.” And that’s about it for any info on that front. PopSci has reached out to Hippocratic for more specifics, as well as whether or not patient medical info will be used in future training.

In the meantime, it’s currently unclear when healthcare companies (or, say, Amazon, for that matter) can “augment their human staff” with “empathy inference” AI nurses, as Hippocratic advertises. The company did note it’s already working with over 40 “beta partners” to test AI healthcare agents on a wide gamut of responsibilities, including chronic care management, wellness coaching, health risk assessments, pre-op outreach, and post-discharge follow-ups.

It’s hard to envision a majority of people ever preferring to talk with uncanny chat avatars instead of trained, emotionally invested, properly compensated healthcare workers. But that’s not necessarily the point here. The global nursing shortage remains dire, with recent estimates pointing to a shortage of 15 million health workers by 2030. Instead of addressing the working conditions and wage concerns that led unions representing roughly 32,000 nurses to strike in 2023, Hippocratic claims its supposed cost-effective AI solution is the “only scalable way” to close the shortfall gap—a scalability reliant on Nvidia’s H100 GPU.

The H100 is what helped make Nvidia one of the world’s most lucrative, multi trillion-dollar companies, and the chips still support many large language model (LLM) AI supercomputer systems. That said, it’s now technically Nvidia’s third most-powerful offering, following last year’s GH200 Grass Hopper Super Chip, as well as yesterday’s simultaneous reveal of a forthcoming Blackwell B200 GPU. Still, at roughly $30,000-to-$40,000 per chip, the H100’s price tag is reserved for the sorts of projects valued at half-a-billion dollars–projects like Hippocratic AI.

But before jumping at the potential savings that an AI labor workaround could provide the healthcare industry, it’s worth considering these bots’ energy costs. For reference, a single H100 GPU requires as much power per day as the average American household.

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EPA rule finally bans the most common form of asbestos https://www.popsci.com/health/epa-asbestos-ban/ Tue, 19 Mar 2024 15:30:00 +0000 https://www.popsci.com/?p=607109
a sign outside of a construction site reads "danger, asbestos removal in progress"
More than 50 countries have already banned the deadly carcinogen. Deposit Photos

This deadly carcinogen is still used in some products, decades after a first partial ban.

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a sign outside of a construction site reads "danger, asbestos removal in progress"
More than 50 countries have already banned the deadly carcinogen. Deposit Photos

On March 18, the Environmental Protection Agency (EPA) finalized a ban on the last form of ban on asbestos used in the United States. This carcinogen kills upwards of 40,000 Americans annually, has been phased out in many products, but is still used in some capacities in the US. Inhaling the tiny fibrous strands that make up asbestos can lead to numerous illnesses including mesothelioma, asbestosis, and lung and ovarian cancer

While not a complete ban, under this new guidance, the EPA would prohibit the import of any items that contain the only asbestos used in the US called chrysotile asbestos, or “white asbestos.” Most consumer products including building materials and household appliances are no longer made with asbestos. However, some products including sheet gaskets, brake blocks, and other vehicle friction products, still have chrysotile asbestos. The ban on asbestos used in these products will take effect in six months.

Chrysotile asbestos is also used to make chlorine bleach and sodium hydroxide that can be used for water purification. Chlorine is a commonly used disinfectant in water treatment and eight chlor-alkali plants in the US still use asbestos diaphragms to make chlorine and sodium hydroxide. These plants are primarily in Louisiana and Texas and this new requirement requires them to be phased out. The EPA notes that asbestos is not needed to produce chlorine and roughly two-thirds of the chlorine made domestically is done so without using asbestos. The rule will be phased in over five or more years to provide “a reasonable transition period.’’ 

[Related: The EPA is trying to ban asbestos—again ]

“The science is clear–asbestos is a known carcinogen that has severe impacts on public health,” EPA Administrator Michael S. Regan said in a statement.

According to the EPA, it advances one of the goals of the Biden Administration’s Cancer Moonshot, to harness the power of the federal government to end cancer. This new rule also marks a major expansion of EPA regulation under the 1976 Toxic Substances Control Act (TSCA), which made it difficult for the government to ban chemicals. This law remained unchanged until several amendments in 2016 overhauled the regulations of tens of thousands of toxic chemicals found in items found in everything from furniture to clothing and household cleaners. 

The EPA tried to ban asbestos outright during the late 1980s. Manufacturing companies fought back and the EPA’s initial 1989 prohibition of the use of asbestos contained a carve-out for the chlorine industry. 

By 1991, a panel of federal judges stuck down the ban and weakened the EPA’s ability to address human health risks from asbestos or other existing chemicals. This decision went on to hamper additional federal attempts to ban asbestos. More than 50 countries have already outlawed chrysotile asbestos.

[Related: Lung cancer in naval personnel linked to asbestos exposure.]

This rule could be rolled back by future presidential administrations and some legislators are calling on Congress to step in. 

“An immediate ban on the import of chrysotile asbestos for the chlor-alkali industry is a long overdue step forward for public health,” Sen. Jeff Merkley (D-Oregon) said in a statement. However, it cannot be the end of the road when it comes to phasing out other dangerous asbestos fibers, and Congress has a role to play here when it comes to providing stronger protections for our health.”

Drexel University professor of environmental and occupational health Arthur Frank told NPR that asbestos still hides in many existing buildings and products across the US, so continues to pose risks to human health.

“This is not a total ban by any means,” Frank said. “It is a modest step that reduces future exposures.”

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Kissing and eating during the Stone Age ‘could be lethal’ https://www.popsci.com/science/stone-age-teeth-bacteria-illness/ Mon, 18 Mar 2024 17:30:00 +0000 https://www.popsci.com/?p=606957
human remains uncovered in Sweden.
Human remains from Bergsgraven in Linköping, Sweden. They date back about 4,500 years. Östergötland Museum

Bacteria that can cause food poisoning, meningococcal disease, and the plague were uncovered in Scandinavian remains.

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human remains uncovered in Sweden.
Human remains from Bergsgraven in Linköping, Sweden. They date back about 4,500 years. Östergötland Museum

Life in the Stone Age was pretty tough for our ancestors. There were animals to fend off and track for food, new tools to make, and massive swings in climate to adapt to. Stone Age humans also faced off against potentially lethal microbes floating around just like we do today. Some dangerous microorganisms spread through kissing and eating contaminated food were found in remains of Stone Age individuals uncovered in present day Scandinavia. They offer some new clues into a major lifestyle transition in human history. The findings described in a study published March 7 in the journal Scientific Reports

There are six major types of microbes–bacteria, archaea, fungi (yeasts and molds), algae, protozoa, and viruses. Some microbes like probiotics help keep human bodies healthy, while others can make us sick. Bacteria and viruses are the most common microbes and their genetic material is organized in DNA. This is why microbial DNA can be found in the remains of infected humans and helps scientists detect evidence of illnesses caused by bacteria and viruses.

In the study, an international team of researchers examined the different types of microbial DNA present inside the teeth of 38 individual human remains uncovered at several Neolithic settlements in Norway and Sweden. The material collected from Hummerviksholmen in southern Norway is estimated to be about 9,500 years old. The specimens from Bergsgraven in Linköping, Sweden are about 4,500 years old. 

[Related: The deadliest viruses in human history, from COVID to smallpox.]

They identified 660 microbial species from these remains. Yersinia enterocolitica and Salmonella enterica were two of the most prolific bacteria found. They are both commonly associated with contracting food poisoning from undercooked meat or eating food contaminated with human feces. Even with modern medical care and food safety standards, food poisoning is still responsible for about 48 million illnesses and 3,000 deaths per year in the United States. Living during a time before life saving treatments may have made an already unpleasant human experience more deadly. 

“Especially the case of Salmonella enterica shows us how difficult it [food poisoning] could be. In a Battle Axe culture burial, Bergsgraven in Linköping, we find two infected individuals, and it is actually possible that we are witnessing their cause of death,” study co-author and Stockholm University PhD student Nora Bergfeldt said in a statement. “This, and other bacterial diseases we have found among the individuals, are easily treated with antibiotics today, but back then they could be lethal.”

They also uncovered Neisseria meningitidis, which is related to meningococcal disease. It spreads through close contact between infected individuals. It is spread through the droplets of saliva release through sneezing, coughing, and kissing. Evidence of Neisseria gonorrhoeae–the bacteria that causes the sexually transmitted infection gonorrhea–was also found in the microbial DNA uncovered. These communal diseases found in microbial DNA date back to a long transition from a hunter-gatherer and nomadic lifestyle and settling down to a farming life. It’s believed that this transition began as early as 12,000 years ago

“We know when people turned to farming in Scandinavia, but we still do not know how this change in lifestyle affected the general health,” Helena Malmström, a study co-author and biologist at Uppsala University in Sweden, said in a statement

[Related: Plague DNA was just found in 4,000-year-old teeth.]

This transition is possibly reflected in the presence of bacterial diseases, as they saw more infections from contaminated food and water and interactions with livestock and one another. Today, illnesses like norovirus and meningitis can quickly spread in schools, dormitories, and nursing homes, and other places where large groups of people are in smaller spaces. The study also found evidence of Yersinia pestis—the bacteria that causes the plague

“The more people interacted, [the] more possibilities to infect one another occurred,” study co-author and Stockholm University geneticist Anders Götherström, said in a statement. “But even if we do encounter bacteria with potential to impact societies such as Yersinia pestis, it is the infections that spread through food that is most prominent across the lifestyles in this study.”

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Nature wasn’t healing: What really happened with wildlife during pandemic lockdowns https://www.popsci.com/environment/nature-not-healing-animals-lockdown-behavior/ Mon, 18 Mar 2024 16:00:00 +0000 https://www.popsci.com/?p=606911
A pair of mountain goats camera trapped walking along a hiking trail near Lake Louise, Banff National Park, Canada.
A pair of mountain goats camera trapped walking along a hiking trail near Lake Louise, Banff National Park, Canada. Madeleine Wrazej, Parks Canada & UBC WildCo

Despite the memes, new data reveals a more nuanced relationship between humans and animals.

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A pair of mountain goats camera trapped walking along a hiking trail near Lake Louise, Banff National Park, Canada.
A pair of mountain goats camera trapped walking along a hiking trail near Lake Louise, Banff National Park, Canada. Madeleine Wrazej, Parks Canada & UBC WildCo

During the lockdowns of the early pandemic, the canals of Venice went from a mucky green to translucent cerulean; motorboat traffic along the waterways had stopped and sediment settled out of the water. Global carbon emissions dropped a record amount, albeit only briefly. People reported animals re-claiming territory from humans in much-memed (and often fake) posts. Nature was–supposedly–healing. 

Except that it wasn’t, really. The effects of Covid-19 restrictions on peoples’ activity and wildlife were nuanced and varied, according to a study published March 18 in the journal Nature Ecology & Evolution. The “nature is healing” narrative was far too simplistic to capture the full breadth of what really unfolded between humans and animals in the pandemic’s early stage, says Cole Burton, co-lead study author and a conservation biologist at the University of British Columbia. “I can understand why we wanted to believe that,” he adds, “but there was no one-size-fits all response with animals.” 

[Related: Bronze Age village was ‘pretty cozy’—until Britain’s Pompeii]

Instead, Burton and his many collaborators uncovered finer-scale surprises and counterintuitive trends. The scientists took advantage of the rare, experimental opportunity offered by the pandemic and analyzed mammal activity data from 5,400 camera trap locations in 21 countries collected before and during lockdowns. Unexpected patterns emerged. 

Lockdowns didn’t mean less human activity or more animal sightings

They found, among other things, that lockdowns did not reduce human presence everywhere–especially not in the parks and other greenspaces documented by the camera traps. “We saw a lot of variation in what people were doing. In some areas, people were using them a lot more,” explains Burton. In Vancouver, where he lives, he notes that regional parks were open and many people found themselves with more free time and an eagerness for safer outdoor socialization. People were “trying to find solace in these parks,” he says–activity on trails went up. 

Previous research into pandemic impacts on wildlife has used broadscale measures of human activity, like regional lockdown protocols, to infer how peoples’ behavior changed–but the new research highlights the importance of concrete and specific monitoring data. 

 A pair of male mule deer camera trapped in Cathedral Provincial Park, British Columbia, Canada. Credit: Cole Burton, UBC WildCo
A pair of male mule deer camera trapped in Cathedral Provincial Park, British Columbia, Canada. Credit: Cole Burton, UBC WildCo

Yet even in locations where human activity did decline, mammal activity did not uniformly increase. “What animals were doing in response to people was super variable, that surprised us a bit,” Burton says. Amid the variation, the researchers found trends. Larger carnivores were more sensitive to human presence, so where human activity was higher, the cameras captured fewer big meat-eating animals like wolves and wolverines. In more urbanized areas or places heavily frequented by people, some of these larger carnivores disappeared entirely. But conversely, large herbivores boosted their activity alongside humans. The former effect could potentially be causing the latter, says Burton: It’s possible that humans offer herbivores a protective shield from their predators, scaring off the carnivores that the prey animals would otherwise have to avoid. 

Maybe, where humans and development are more prevalent, other species have to work harder to access resources, traveling farther and appearing more active on camera.

Another finding was that animals’ responses to changes in human activity were location- and time-specific. In wilder places, animals appeared warier of people and were more likely to retreat when human activity ticked up. In more developed landscapes, animals seemed more habituated to people, and often either didn’t shift their activity level with humans or became more active alongside people. Though the scientists can’t say for sure why this was the case, Burton says one potential hypothesis is that, in more developed areas, wildlife may be taking advantage of human resources by, say, scouring trash cans for food. But he also highlights a possible competing theory: Maybe, where humans and development are more prevalent, other species have to work harder to access resources, traveling farther and appearing more active on camera. The new research, he notes, highlights that far more work is needed to uncover the why behind their observations. “There’s probably lots of different underlying stories about each different area and species.” Until further analysis is done, those stories will remain obscured. 

 Covid’s lessons for conservation

Already the study is offering hints. In some instances, the camera trap data showed that higher human activity led animals to become more nocturnal, increasing their nighttime activity–bolstering previous research findings that co-existing among people shifts many mammals’ schedules. “We think this is an adaptation that allows animals to share spaces with humans, while minimizing negative encounters,” Burton says. 

In a way, it’s evidence of how animals and humans can, theoretically, achieve harmony. Other species are “working hard to coexist with us, in ways that aren’t always obvious,” he explains. Perhaps, if humans take that into account, and begin meeting other mammals in the middle, nature could truly begin healing. 

Burton hopes the global, yet specific findings will help inform and improve conservation efforts. “We might need to think about different types of management in different contexts,” he notes. Perhaps in more remote settings, park managers could use the new study to support permitting, strategic closures, or other efforts that minimize peoples’ presence. In more urban areas, conservation efforts could focus more on reducing nighttime light and noise pollution, to offer wildlife some nightly refuge. “There’s a lot of nuance,” Burton says. “We have to be humble about that as we’re trying to manage our own impact.”

The post Nature wasn’t healing: What really happened with wildlife during pandemic lockdowns appeared first on Popular Science.

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To rinse or not to rinse? You might be brushing your teeth wrong. https://www.popsci.com/diy/rinse-mouth-after-brushing-teeth/ Thu, 14 Mar 2024 13:20:00 +0000 https://www.popsci.com/?p=606477
three colored bamboo toothbrushes in a ceramic glass on green background
Your teeth deserve better. DepositPhotos

We asked dentists about the best dental hygiene practices.

The post To rinse or not to rinse? You might be brushing your teeth wrong. appeared first on Popular Science.

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three colored bamboo toothbrushes in a ceramic glass on green background
Your teeth deserve better. DepositPhotos

Any good dentist would tell you that oral health starts with brushing teeth. It’s a habit ingrained in us since early childhood, and as adults, the routine hasn’t changed much. Add a pea-sized amount of toothpaste and gently brush in soft circles for at least two minutes. It’s the two minutes after brushing that’s stirring up discussion on TikTok. 

Many people rinse their mouths after brushing their teeth, but some TikTokers argue it’s healthier to only spit out the excess toothpaste. By not rinsing, they claim, you would allow the toothpaste’s ingredients to exert their effects for longer. 

Though TikTok hasn’t always been the most reliable source for dental news—remember when people were giving DIY advice on how to file down teeth—this information is an exception, and something the dentists PopSci spoke to support.

First, let’s consider why we brush our teeth. Dr. Kacie Woodis, a clinical assistant professor at the University of Minnesota School of Dentistry, says that when we eat, so do the approximately 1,000 species of bacteria living in our mouths. These microbes have a strange way of thanking us for the meal. Some bacteria in the back of the tongue, for example, interact with amino acids from the food, producing sulfur-producing compounds that cause bad breath. Other bacterial species produce an acid that can break down minerals and dissolve a tooth’s surface, starting cavity formation. 

[Related: The best cheap electric toothbrushes]

Fluoride, a mineral found in most toothpastes, builds resistance against acid attacks. It does so by aiding in a repair process called remineralization. 

“Fluoride counteracts the demineralization process by partnering with calcium and phosphate to form fluorapatite,” explains Dr. Fatima Khan, a dentist and cofounder of Riven Oral Care in Texas. “Fluorapatite is a crystalline lattice that covers the enamel to remineralize it and restore its integrity.” The longer fluoride sits on your teeth, the more effective it is at creating stronger teeth (so long as you’re only using the recommended pea-size amount of toothpaste to brush). 

The American Dental Association recommends brushing for a full two minutes. However, most people brush for less than the recommended time, for about 45 to 70 seconds a day. Brushing less than two minutes means people are not getting the benefits of fluoride toothpaste, says Khan. 

Spitting instead of rinsing toothpaste gives fluoride more time to assist with the remineralization process—especially since tooth enamel cannot grow back once it is completely destroyed. Woodis recommends everyone spit instead of rinse, especially among people at high risk for cavities. “We’ll prescribe an extra-strength fluoride toothpaste, and we often recommend that people spit and not rinse that prescription toothpaste.”

If you’re a mouth rinser, spitting may not sound the most hygienic. You might imagine loose bacteria and food still trapped in your mouth. If that’s the case, Khan says to floss first and then rinse your mouth with water. This would flush out any residual food and plaque buildup prior to brushing your teeth. 

Another concern is residual charcoal on teeth if using charcoal toothpaste. Both Woodis and Khan warn against using charcoal-based toothpaste in the first place. The material is too abrasive and can strip away tooth enamel, eventually turning teeth yellow.

Some people rinse their mouths for medical reasons. People sensitive to sodium lauryl sulfate (SLS), another common ingredient in toothpaste, can produce canker sores and skin peeling inside the mouth when exposed to it for a prolonged time. Additionally, some people may develop a rash around their mouth called perioral dermatitis from fluoride, SLS, and cinnamon flavorings in toothpaste. Khan says these folks should switch to a natural toothpaste containing hydroxyapatite and wash their face after brushing to wipe off any excess paste.

If you still want to rinse your mouth, Woodis advises delaying it for 20 to 30 minutes to maximize fluoride’s effects. Even if you wanted to rinse with a fluoride-based mouthwash, she says it would be better to wait instead of immediately rinsing since it has a lower fluoride concentration. She says most over-the-counter toothpaste has a fluoride content of around 1000 to 1500 parts per million, whereas most fluoride mouthrinses are usually 100 to 200 parts per million.

The bottom line is the choice is up to you whether you want to spit or rinse after brushing. Your dentist will probably not hold it against you at your next appointment. Although they might raise an eyebrow if you tell them you’re getting dental information from social media. 

The post To rinse or not to rinse? You might be brushing your teeth wrong. appeared first on Popular Science.

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‘Space headaches’ could be a real pain for astronauts https://www.popsci.com/science/space-headaches-astronauts/ Wed, 13 Mar 2024 20:00:00 +0000 https://www.popsci.com/?p=606454
NASA astronaut Scott Tingle is pictured during a 2018 spacewalk to swap out a degraded robotic hand on the Canadarm2.
NASA astronaut Scott Tingle during a 2018 spacewalk to swap out a degraded robotic hand on the Canadarm2. Johnson Space Center

A study of several NASA, ESA, and JAXA astronauts shows an association between long-haul space flight and headaches.

The post ‘Space headaches’ could be a real pain for astronauts appeared first on Popular Science.

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NASA astronaut Scott Tingle is pictured during a 2018 spacewalk to swap out a degraded robotic hand on the Canadarm2.
NASA astronaut Scott Tingle during a 2018 spacewalk to swap out a degraded robotic hand on the Canadarm2. Johnson Space Center

Space travel is certainly not for the faint of heart, for many reasons including its effects on physical health. It can potentially disturb human immune systems and increase red blood cell death. Astronauts can even suffer from bone loss during missions. It could also increase headaches. Astronauts with no prior history of headaches may experience migraine and tension-type headaches during long-haul space flights–over 10 days in space. The findings are detailed in a study published March 13 in the journal Neurology, the medical journal of the American Academy of Neurology.

“Changes in gravity caused by space flight affect the function of many parts of the body, including the brain,” W. P. J. van Oosterhout, study co-author and a neurologist at Leiden University Medical Center in the Netherlands, said in a statement. “The vestibular system, which affects balance and posture, has to adapt to the conflict between the signals it is expecting to receive and the actual signals it receives in the absence of normal gravity.”

[Related: 5 space robots that could heal human bodies—or even grow new ones.]

The study looked at 24 astronauts from NASA, the European Space Agency (ESA), and the Japan Aerospace Exploration Agency (JAXA). All of the astronauts were assigned to International Space Station expeditions for up to 26 weeks from November 2011 to June 2018. Combined, the astronauts studied spent a total of 3,596 days in space. 

The astronauts all completed health screenings and a questionnaire about individual headache history before their space flight flight. Nine of them reported never having any headaches prior to the study, with three reporting a headache that interfered with their daily activities within the last year. None of the astronauts had a history of recurrent headaches or had a migraine diagnosis. 

During space flight, they filled out a daily questionnaire for the first seven days and a weekly questionnaire each following week throughout their stay in the International Space Station. The astronauts reported 378 headaches during their combined days in space

The study found that 92 percent of the astronauts surveyed experienced headaches during space flight, compared to just 38 percent who reported experiencing headaches in the two to six months before going into space. Twenty-two of the 24 astronauts studied also experienced one or more headache episodes during their first week in space. About 89 percent of these headaches were tension headaches and 10 percent were likely a migraine. Headaches were also of a higher intensity and more likely to be like a migraine during the first week of space flight. 

According to van Oosterhout, the changes to the brain’s balance and posture system, combined with adjusting to zero gravity during the first week of space flight, “can lead to space motion sickness in the first week, of which headache is the most frequently reported symptom. Our study shows that headaches also occur later in space flight and could be related to an increase in pressure within the skull.” 

[Related: Why space lettuce could be the pharmacy astronauts need.]

The astronauts were monitored after returning back to Earth and none of them reported any headaches in the three months after returning home. 

One of the study’s limitations is that it relied on self-reporting of symptoms, so the memory recall may not have been fully accurate. It also didn’t say that going into space causes headaches, only shows an association. 

“Further research is needed to unravel the underlying causes of space headache and explore how such discoveries may provide insights into headaches occurring on Earth,” said van Oosterhout. “Also, more effective therapies need to be developed to combat space headaches as for many astronauts this [is] a major problem during space flights.”

The post ‘Space headaches’ could be a real pain for astronauts appeared first on Popular Science.

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The best sex toys in 2024, tested and reviewed https://www.popsci.com/gear/best-sex-toys/ Fri, 23 Jun 2023 19:53:56 +0000 https://www.popsci.com/?p=550874
A lineup of the best sex toys on a white background
Amanda Reed

A sex toy can help you try something new, steam up the bedroom, and make you feel comfortable and confident in your body.

The post The best sex toys in 2024, tested and reviewed appeared first on Popular Science.

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A lineup of the best sex toys on a white background
Amanda Reed

We may earn revenue from the products available on this page and participate in affiliate programs. Learn more ›

Best overall A periwinkle Womanizer OG on a white shag rug Womanizer OG
SEE IT

Get the best of both worlds with clitoral and G-spot stimulation.

Best for beginners teal MysteryVibe Poco on a table with illustrations of the sun, moon, and stars MysteryVibe Poco
SEE IT

Easy-to-locate buttons takes the mystery out of changing settings.

Best budget A pink plusOne Fluttering Arouser on a blue and white background plusOne Fluttering Arouser
SEE IT

Ten different settings, vibration, and a fluttering arouser adds up to eye-fluttering orgasms.

There’s no shame in having a sex toy in your nightstand. Masturbation plays a big role in your sexual health—it’s even good for your mental and physical health! Your body releases endorphins (hormones that block pain and make you feel good) when you orgasm. Orgasms also help you sleep better, reduce stress, and can strengthen your pelvic and anal muscles. Plus, sex toys and masturbation are an excellent way to be in touch with your body and embrace what gives you pleasure. The best sex toys will leave you feeling confident and empowered over and over and over …

How we chose the best sex toys

In order to find the best sex toys, we looked at reviews, recommendations, and … did lots and lots of personal testing. I’ve written about salacious things in the past, so I have no shame in my coworkers knowing too much about my personal life. Someone’s gotta do the testing, after all! Additionally, we looked at versatility in both features, use, and the kinds of bodies they can be used on. In this case, we do believe a toy that is a jack of all trades might be best, but there’s also nothing wrong with being a master of none.  

Also, everything on this list is body-safe, meaning it is non-toxic and non-porous. You don’t want any bacteria going near the thin, delicate skin around your genitals and in your body. 

The best sex toys: Reviews & Recommendations

Astroglide Sexologist Dr. Jess O’Reilly says, “Sex toy use is associated with a range of benefits, including increased sexual functioning and sexual pleasure. Those who use sexual accouterments, such as sex toys and lube, report higher sexual functioning and greater sexual satisfaction.” Masturbation is also a great way to relieve stress and help relieve period cramps

Everybody (and every body) is different when it comes to pleasure—one of our recommendations should butter your biscuit (get your mind out of the gutter, it’s a real turn of phrase!). 

Best overall: Womanizer OG

Amanda Reed

SEE IT

Why it made the cut: This feature-packed vibe has lots of intensity levels, can be used for clitoral stimulation or on your G-spot, and its Smart Silent tech keeps things discreet. 

Specs

  • Settings: 12 intensity levels; 3 vibration levels
  • Waterproof?: Yes
  • Pleasure point: Clitoral, G-spot
  • Battery life: 2 hours

Pros

  • Waterproof
  • Can be used for multiple kinds of stimulation
  • Quiet

Cons

  • Limited flexibility
  • Controls can be finicky

The Womanizer OG takes all that is good in a bullet vibrator and all that is good in a clit stimulation toy and combines it into a versatile, wunderbar vibrator that you can use on multiple erogenous zones. Yes, it’s marketed as a G-spot stimulation, but we also loved its capabilities as a clit suction toy. Being able to control the 12 levels of Pleasure Air intensity and three vibration modes separately can lead you to all kinds of new highs when other toys only scratch the surface. The Afterglow feature—which senses your orgasm and gradually reverts back to its lowest setting—is a lovely touch, and helps bring you down from a potentially intense body high, like your lover rubbing your back and holding you after … well, you get it. 

The vibe itself isn’t super flexible, meaning you can’t change the angle of the head, and the controls can be a little confusing— the short and long presses are super important in changing the features, and it’s easy to go into a different mode than you wanted. However, this is a small qualm when you consider the multitude of possibilities on how—and where—you can use this toy. 

Arcwave

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Why it made the cut: The Arcwave Ion helps you achieve maximum phallic stimulation. 

Specs

  • Settings: 8 intensity levels
  • Waterproof?: Yes
  • Pleasure point: Phallus
  • Battery life: 70 minutes on full power

Pros

  • Easy to clean
  • Intuitive controls
  • Smart Silence tech

Cons

  • Could be a little intense for newbies

When you think of phallus masturbators, a device that resembles a flashlight tends to come to mind. There’s nothing wrong with that, but there’s a sleeker way to beat off. The Arcwave Ion (made by the same people who make the Womanizer OG) kind of looks like a stapler, but it’s infinitely easier to clean than closed-end strokers—simply twist and rinse under the faucet after use. The Ion works by focusing pulsating air pressure the frenulum, the band of tissue on the underside of the penis toward that head that is packed with sensitive Pacinian pleasure receptors. A DryTech stick inside the Ion uses silica to wick away moisture, and vents on the lid encourage air flow, so you won’t be stuck with a musty stroker when you pull it out for use. Multiple reviews note a bit of a learning curve when first using the Ion, but boy, you’ll be happy when you get over it. If you’re new to using a stroker, try out a Tenga Egg, which is an analog stroker (you power it, buddy). If you like it, step up to the Ion. 

Best for vulvas: Satisfyer Pro 2 Gen 3 Air Pulse Toy

Satisfyer

SEE IT

Why it made the cut: It’s like oral without the oral (and you can actually get somewhere when using it). 

Specs

  • Settings: 11 pressure wave settings; 12 vibration programs
  • Waterproof?: Yes
  • Pleasure point: Clitoral
  • Battery life: 90 minutes

Pros

  • Easy-to-clean silicone
  • App control
  • Great cost for features

Cons

  • Need to change Bluetooth settings so neighbors don’t know your business

Sure, using a good ol’ bullet vibrator will get the job done, but what about something that blows the project out of the water? The Satisfyer Pro 2 Gen 3 Air Pulse Toy has a long name, but it yields fast-acting feel-good feelings. In fact, you might even be done using it after saying the name. Air-pulse stimulation and vibration simulate oral sex, and Liquid Air technology mimics pulsing water. Put it together and you get a device that makes reviewers say, “It couldn’t be named any better because it will definitely satisfy!”

We love that it also comes with a Bluetooth app to customize vibration patterns, access remote controls, or play music. However, one reviewer notes that the name of the toy pops up on the list of available Bluetooth devices. Some may be none the wiser, but do take time to change the device’s name in the Bluetooth settings. 

Amanda Reed

SEE IT

Why it made the cut: G-spot, clitoral, and phallus stimulation all at once? Heck yes. 

Specs

  • Settings: 10 pattern modes
  • Waterproof?: Yes
  • Pleasure point: G-spot, clitoral, phallic
  • Battery life: 90 minutes

Pros

  • Comes with a remote control
  • Quiet
  • Sleek charging case

Cons

  • Hard to get clitoral stimulation in some positions
  • App interface wonky 

The Beatles’ “Come Together” makes great points about … coming together. Achieve that harmony with the WeVibe Chorus, which stimulates the G-spot, clitoris, and penis. A remote control means you don’t have to reach anywhere to change the settings, and it also allows someone else to control it in the bedroom or over long distances (we’re enthusiastic advocates of exploring sex toys for couples). Touch-sense modes let your movements control the vibrations, and Squeeze Remote tech lets you use your own body to change intensity—the vibration gets stronger as you squeeze. 

With all new things, there is a bit of a learning curve. It can be hard to get a good angle on your G-spot while trying to get the toy to touch your clitoris. It may also achieve a different kind of premature exit based on positioning. The app interface can be a little confusing, and leaving it could stop the vibrator from doing its thing, which is a bummer in the heat of the moment. After futzing around, WeVibe Chorus should be a welcome addition to your sex life. 

Best for anal: Lovehoney Rump Workout Silicone Butt Plug Training Set

Lovehoney

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Why it made the cut: This butt plug set helps you ease into anal with three beginner-friendly plugs equipped with an essential flared base. 

Specs

  • Settings: N/A
  • Waterproof?: N/A
  • Pleasure point: P-spot
  • Battery life: N/A

Pros

  • Easy to clean
  • Great introduction to anal
  • Different sizes for versatility

Cons

  • More for beginners

Anal doesn’t have to be daunting. If you’ve always wanted to try it and don’t know where to start, consider this Butt Plug training set from Lovehoney. A tapered tip, lengthy neck, and T-bar are all must-haves when it comes to looking for a butt plug—and these three have them all. All three are easy to clean and are made of body-safe silicone for peace of mind as you play. “Start small and work your way up to the desired size and stimulation,” says plusOne Director of Product Development Megan O’Connell.

The small plug is 3 inches long and 2.5 inches in girth; the medium is 3.5 inches long and 3 inches in girth; and the large is 4.5 inches long and 4 inches in girth. And if you don’t like it, Lovehoney has a 100-day money-back guarantee. Being able to try something out and getting a refund if you don’t like it? Sounds good to us. 

If you’re looking for something more advanced, check out the LELO Hugo Butt Plug. It’s remote-controlled and vibrates.

Best rated: Magic Wand Rechargeable Massager

Amanda Reed

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Why it made the cut: The classic remains a classic thanks to buzzy vibration modes and a bevy of separate attachments, making it a true multi-hyphenate. 

Specs

  • Settings: 4 speeds, 4 patterns
  • Waterproof?: No
  • Pleasure point: Anywhere
  • Battery life: 180 minutes

Pros

  • Great battery life
  • A classic made rechargeable
  • Doubles as a percussion massager

Cons

  • Not everyone’s cup of tea
  • Not waterproof

When you think of “sex toy,” the Magic Wand most likely comes to mind. This wand has been around since 1968, and with that history comes with great responsibility. Considering that the Magic Wand has been used in scientific studies, we’ve come to the conclusion that, yeah, it’s pretty legit. And it’s also pretty no-nonsense. You only get four vibration speeds and four vibration patterns. But it lasts for a marathon 180 minutes, which blows the battery life out of every single sex toy on this list. 

The Magic Wand might not be everyone’s cup of tea: it can be a little too intense for you if you don’t like big, buzzy, bed-vibrating sex toys. But, you can always use it for its original use: as a percussion massager.

MysteryVibe

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Why it made the cut: A foldable design and easy-to-press buttons make this a great buy for someone looking for their first sex toy. 

Specs

  • Settings: 8 presets; 16 intensities
  • Waterproof?: Only showerproof
  • Pleasure point: G-spot, but can be used for clitoral stimulation
  • Battery life: 90 minutes

Pros

  • Designed to mimic fingers
  • Easy-to-use app
  • Super customizable

Cons

  • Have to keep app on in order to stay connected to the vibe

The MysteryVibe Poco’s small size (under 6 inches in length and 1.5 inches at the base) makes it an excellent choice for beginners who are looking for something they can use by themselves, with a partner, and on different parts of the body. It’s designed to mimic fingers—an ode to the OG way of getting off—and includes 16 different intensities for all kinds of moods. It’s showerproof and also super portable, making it perfect to bring on a trip with your lover or pack on a sleepover. Like other Bluetooth-connected toys, your vibe might turn out when you try to leave the app. 

Best discreet: Womanizer Wave

Womanizer

SEE IT

Why it made the cut: Instead of your regular showerhead, this showerhead and clitorial stimulator in one was designed for erogenous zones. 

Specs

  • Settings: N/A
  • Waterproof?: Yes
  • Pleasure point: All over
  • Battery life: N/A

Pros

  • Looks like a regular showerhead
  • Saves water
  • Easy installation

Cons

  • Not for anyone who doesn’t want to incorporate toys into daily life.

“Discovering masturbation via the showerhead” is a common trope in coming-of-age movies, but it’s also one that many of us have done in real life. It’s an easy, cheap, accessible way to experiment with masturbation. The showerhead has grown up, thanks to the Womanizer Wave, which is made for water-pressure clitoral stimulation. Believe it or not, it also saves water thanks to EcoSmart tech without sacrificing performance. The Wave is also easy to hold in your hand (you can’t say the same for your heavy showerhead). You can change between the three different water jets—PowderRain, PleasureJet, and PleasureWhirl—with the touch of a button. The Womanizer Wave system is easy to swap in and out—however, it might be even easier to accept that your showerhead was made for masturbation and let no one be none the wiser.

Best budget: plusOne Fluttering Arouser

plusOne

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Why it made the cut: You don’t have to spend $100 to “invite a little pleasure” into your life. 

Specs

  • Settings: 10 vibration speeds
  • Waterproof?: Yes
  • Pleasure point: Clitoral
  • Battery life: 1.5 hours of use

Pros

  • Easy to clean
  • Cheap and good quality
  • Rechargeable

Cons

  • Might not scratch the itch for those who are suction toy stans

“Cheap” tends to get lumped with “poor quality.” And, vibrators under $50 may not be rechargeable. The plusOne rejects those notions with soft, smooth high-quality silicone that yields 1.5 hours of power on a single charge. It combines a fluttering tongue with vibration for extra stimulation and arousal. You just need some warm water and mild soap to clean. And, it’s truly waterproof, so you don’t have to worry about damaging the device when using it in the shower.

However, if suction toys are your jam, you might not get your rocks off with the Fluttering Arouser, since it uses a silicone tongue and vibration. In that case, we recommend the Lovehoney X ROMP Switch Clitoral Suction Stimulator, which has six intensity levels and is less than $35.

What to consider when buying the best sex toys

The world is your oyster when sex toy shopping. However, all sex toys are not built the same. And, like the partnered sex many of us had in college, when a sex toy is bad, it’s bad! Here’s what to look for when looking for a sex toy.

What do you like?

Where do you like to be touched? And how do you like to be touched? Answering those questions can lead you to a perfect match. For example, a vibrating phallus sleeve is going to feel different than a cock ring. Maybe vibration isn’t your style and a stroker sounds more pleasurable to use.  

Experimentation

With this said, sex toys are a great way to try something new. Check to see if the site you’re buying from has a money-back guarantee. Sometimes, you can get a refund if you decide that a toy isn’t making you see fireworks and enter a new dimension. 

What if the vibe isn’t your vibe? Aka, sex toy recycling

Most retailers won’t accept your used sex toys if you change your mind, however. The good news is, there’s a way to not let it sit sad and unused in your nightstand drawer. 

“Should you need to dispose of a product with a lithium-ion battery, the battery should be disposed of in accordance with the local laws and regulations,” Connell says. 

This means its final resting place is not in your home trash can.

“If possible, please recycle it,” adds plusOne Director of Industrial Design Emily Gasta. “Users should not take out or replace the battery by themselves; doing so may damage the product.”

You also don’t want to recycle a used sex toy. Read up on how to clean your sex toys based on what they’re made out of. And if you really want to get rid of it, you can gift it to a treasured and trusted friend (after sanitizing and sterilizing, of course), or you can gift it away on a site like Squeaky Clean Toys, which is like eBay for sex toys. 

Lube up

Not all lubes are made the same, either. You’ll want to use silicone lube like the Shine Silicon lube from Maude on glass toys, when you’re getting frisky in the water, or when you’re just using your hands. However, do not use silicone lube with silicone toys—that will damage them. Instead, use a water-based lube like tried-and-true-blue Astroglide. We also have to recommend Astroglide because of its rocket-science roots

FAQs

Q: Can you get an STI from a sex toy?

Short answer: yes. If you’re only using it on yourself or you have a long-term monogamous partner, you’re all good. However, if you share a sex toy with another person with a sexually transmitted infection (STI) and use it on yourself, you are at risk of catching an STI. Cleaning, sanitizing, and disinfecting sex toys before and after use can keep dangerous germs and bacteria at bay (see below to learn how.) For additional protection, put a condom on the toy to prevent STI spread when using toys with a new person or a different partner.

Q: How do I properly clean a sex toy?

Sanitization and sterilization are a different beast, but if you’re not selling it or giving it to a friend, mild soap and water is perfect to clean your sex toy. You can also buy cleaners like these plusOne Personal Wipes.

Q: How do I warm up a sex toy?

If you’re using a silicone toy, it’s best to warm it up with your hands—any extreme temperatures could damage the toy. However, you can experiment with temperature play with glass toys or metal toys. You can use a bowl with warm water to take the chill off safely. Never use the microwave, boiling water, or freezing temps when adding the elements into your bedroom happenings. You can also indulge on a lube warmer, like this one from Pulse.

Final thoughts on the best sex toys

Sex toys are fun to use, but they’re also an important part of sexual wellness and building confidence. There’s something for everybody when looking for the best sex toys—and the majority of them can be used on almost every body. Shut the blinds, clear 20 minutes off your schedule, and get to work!

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

The post The best sex toys in 2024, tested and reviewed appeared first on Popular Science.

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A robot tried to give me ‘the world’s most advanced massage’ https://www.popsci.com/technology/robot-massage-aescape/ Wed, 13 Mar 2024 13:00:00 +0000 https://www.popsci.com/?p=606313
woman lays on blue table with two robot arms touching her back
Do I look relaxed?. Annie Colbert/PopSci

I fear robots, but love a good back rub.

The post A robot tried to give me ‘the world’s most advanced massage’ appeared first on Popular Science.

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woman lays on blue table with two robot arms touching her back
Do I look relaxed?. Annie Colbert/PopSci

The vibe of Aescape’s massage rooms is familiar: soft lighting, inviting earth tones, a fresh smell, and stylish chairs with fluffy pillows that you only use to daintily pile your clothes on top of. Like a typical spa, the room also has a massage table, but instead of the classic flat surface covered in a white sheet, it’s a large, pill-shaped device. And then there’s the pair of large robotic arms.

Aescape is a New York City-based company that has created an “AI-enhanced” massage table. As a person who is highly skeptical of robots but loves massages, I volunteered to find out if a robot massage can live up to the incredibly satisfying experience of a massage by a human.

Aescape calls itself “The World’s Most Advanced Massage” but will it alleviate the stubborn back knots of a middle-aged mom who walks everywhere but refuses to stretch or properly hydrate and spends all day hunched over a laptop? On a Monday afternoon in February, me and my aches and pains visited Aescape’s offices and test labs for an appointment with the massage table to find out.

room with two chairs, wood on walls, massage table with robot arms
Futuristic spa vibes. Image: Annie Colbert/PopSci

Now at this point you may be wondering but scared to ask: Are you naked for the massage? The answer is no. Instead of stripping down and awkwardly positioning yourself under a sheet, Aescape provides “Aerwar apparel” for rent or purchase. The tight-fitting dark gray pants and matching shirt feel like a combination of yoga gear and a wetsuit. After squeezing into the stretchy ‘fit and pulling my hair back, I took a moment to appreciate how I looked like a humanoid sea lion.

two photos: one of a woman in tight workout clothes and a massage table with white robot arms
L: Mock turtlenecked and ready to go. R: The Aescape massage table. Images: Annie Colbert/PopSci

Now it was massage time. Aescape CEO Eric Litman helped walk me through the setup process, but the machines are designed to be self-service. Litman has spent seven years developing Aescape with $80 million in funding. He says that the idea for a fully automated, AI-driven massage table “was born out of a personal pain point” of being unable to have focused, regular treatment for a chronic pain. 

The entire massage happens while you lay on your stomach. Your face pokes through a hole that’s conveniently large enough to accommodate eye glasses. I would normally remove my glasses for a massage, but the Aescape table includes a tablet about the size of a laptop screen under the face hole that helps you control all aspects of your massage. Without my glasses, I might end up picking a weak calf massage and bad nature sounds music–nightmare scenario. I worried about my face feeling squished or ending up with the dreaded bagel-shaped indent across my forehead, cheeks, and chin but the wide space for my upper face made me forget I was even wearing my glasses. 

a woman with glasses in a hole
My face in a refreshingly comfortable hole. Image: Annie Colbert/PopSci

Before the robot hands get to work detangling my mess of muscles, I use the touchscreen to select a massage type (I go with a 30-minute “Total Back & Glutes Relief”), musical preference (a chill surf music), and pressure (as strong as humanly, errr robotly, possible). The table scans my body for 1.1 million 3D data points to map out my treatment. Aescape also says that the table learns more about your body and preferences with each massage. “We use AI to personalize your massage-going experience. Our data, trained by [massage] therapists, learns from your feedback over time, adjusting treatments to your preferences,” Litman tells PopSci

One issue I’ve encountered while trying robotic back massagers or massage chairs is a one-size-fits-all approach and ending up with rotating massage balls bruising my spine instead of providing any actual relief. By scanning each body, Aescape aims to remedy the fact that bodies come in many different shapes and sizes. The scan takes less than a minute and it’s time for the robot arms to start digging in. 

The massage started with a five-minute full body acclimation that allowed me to adjust to the feeling of warm robot nubs (yes, they’re heated) pushing on my muscles. I worried the robot “hands” would feel like a frisky WALL-E, but the shape felt more like a large, firm human palm. And again, it was warm–like the underside of an overworked laptop. The touchscreen under my face laid out exactly what to expect for the next 30 minutes and showed where I was at in the massage and what was coming next. I found this incredibly comforting as a person who spends half her massages trying to figure out the time instead of relaxing. The screen also shows a live view of exactly what muscles are being worked on, avoiding the surprise of “oh, I guess we’re doing legs now?”

two images: an image of a body and a tablet
L: Butt massage, Image: Annie Colbert/PopSci. R: The Aescape touchscreen. Image: Aescape

Throughout the 30-minute massage, I played with the pressure settings–softer on the legs, harder on the back–and found the minute-by-minute customizations helpful for getting exactly what I wanted. You also have the option to “move on” or “focus” on different body parts as the massage progresses. This is a huge win for people like me who are shy about asking a human masseuse to switch it up for fear of an awkward interaction. 

I thought the screen in my face might distract from the relaxation element of a typical massage but I found it easy to close my eyes and let the robot do its thing. 

Fitness & Exercise photo

OK, but how did it feel? Honestly, great. My expectation was that it would be pleasant, probably not tear off a limb (again, fear of robots), and feel moderately nice. But within the first pass of the robot arms on my extremely tight traps (the vaguely trapezoid-shaped muscles that sit between the shoulders and the neck), I felt pleasantly surprised. On the subway ride home, my body felt more relaxed and the next day I still felt a looseness in my back despite returning to child-lugging and computer-typing duties. 

I wouldn’t say the Aescape massage table is a one-to-one replacement for a traditional massage because it’s currently limited to a face-down position and doesn’t get all the tiny muscles, but it’s a solid supplement to regular body care. The massage tables can be booked via an app and plan to be integrated into hotels, spas, corporate offices, and fitness centers throughout 2024. The convenience and customization are major plus sides for anyone looking for quick relief. 

The Aescape massage table is launching in New York City at 10 Equinox locations this spring with 30-minute massages starting at $60.

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The long battle over fluoride comes to a head https://www.popsci.com/health/fluoride-drinking-water/ Mon, 11 Mar 2024 12:15:00 +0000 https://www.popsci.com/?p=606018
There is a modest and limited body of evidence suggesting that fluoride, at doses considerably higher than what’s generally in the water, might be bad for human brains.
There is a modest and limited body of evidence suggesting that fluoride, at doses considerably higher than what’s generally in the water, might be bad for human brains. DepositPhotos

A court battle brings to the forefront a federal report on fluoride safety, which some say has been stymied by politics.

The post The long battle over fluoride comes to a head appeared first on Popular Science.

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There is a modest and limited body of evidence suggesting that fluoride, at doses considerably higher than what’s generally in the water, might be bad for human brains.
There is a modest and limited body of evidence suggesting that fluoride, at doses considerably higher than what’s generally in the water, might be bad for human brains. DepositPhotos

This article was originally featured on Undark.

In a wood-paneled federal courtroom in downtown San Francisco, experts and litigators gathered last month for hearings on an old question: Is it safe to add fluoride to drinking water?

Around 210 million Americans today have access to artificially fluoridated tap water, and the policy has had a pronounced effect on oral health by reducing tooth decay. It’s widely hailed as a public health success story. In the current lawsuit, plaintiffs are taking a long-standing and, to many experts, provocative stance, arguing that water fluoridation poses a risk to human health, and that the Environmental Protection Agency is obligated to address the issue. The outcome of the case could effectively end water fluoridation in United States. A ruling from Judge Edward M. Chen is expected soon.

In some circles, just entertaining questions about fluoride safety is synonymous with tinfoil-hat conspiracy theorizing. After all, some anti-fluoride activists have, over the years, made wild claims—for example, that fluoride is a form of communist mind control—that don’t have any evidence to back them up.

The lawsuit, though, has put a consequential spotlight on a real scientific debate that has been roiling public health researchers for the past several years.

Today, there is a modest body of evidence suggesting that fluoride, at doses considerably higher than what’s generally in the water, might be bad for human brains, in particular developing fetal brains. A few studies also suggest possible harms from the levels that many municipalities in the U.S. currently add to their drinking water. And most scientists involved agree that the uncertainty warrants more research.

What to make of that uncertainty—and how it should be communicated to the public—has divided researchers. Some experts, especially among dentists, think the evidence is far too weak to be making policy prescriptions. “The best available evidence just doesn’t suggest that this is a real association at the levels to which people are exposed to fluoride in fluoridated water,” said Scott Tomar, a dentist and oral health epidemiologist at the University of Illinois Chicago.

But some current and former federal scientists, as well as academic researchers in toxicology and environmental health, say there’s reason for concern. Some also suggest that something else is going on: Faced with uncomfortable data, they say, water fluoridation proponents have attacked and obstructed fluoride research. And rather than allowing the scientific debate to flourish in the open, dental groups and some public health experts have targeted researchers who study fluoride and brain development, in a pattern that some characterized as suppressing important science.

“I see this as an infringement of scientific integrity, that the scientists have been prevented from getting their information out.”

Central to the debate is an unpublished government report, produced by a little-known federal program, that has been subject to years of bureaucratic wrangling. In fact, that wrangling contributed to delaying the EPA lawsuit for more than two years as the judge awaited the report’s publication, before finally settling on the use of draft documents. They are now a central piece of evidence in the case.

Fluoride safety is exactly the kind of issue the National Toxicology Program was designed to tackle: It’s an interagency program, housed at the National Institutes of Health, that investigates whether things like the “forever chemicals” PFAS and cellphone radiation are harmful to people’s health. In 2016, the NTP asked its scientists to gather all the existing scientific research on fluoride, analyze the data, and say something authoritative about whether fluoride might be damaging to human brains.

After years of research and peer review, a draft of the report concluded there might be reason for concern, mostly at levels of fluoride exposure higher than most, but not all, Americans experience.

In April 2022, the NTP group was ready to publish its findings. “That’s when the wheels fell off,” said Brian Berridge, a former pharmaceutical industry scientist who led NTP’s day-to-day operations at the time. Dental organizations obtained internal drafts of the report. They then began to lobby federal officials, according to documents obtained via public records requests by advocates opposed to water fluoridation. Officials from other agencies, including the Food and Drug Administration and the Centers for Disease Control and Prevention, registered concerns. The report was soon tracked into yet another round of review, blindsiding scientists who thought it was done.

Berridge grew frustrated. “After 17 years in the industry, I’ve seen efforts to modify messages to fit commercial interests,” he wrote in an email to NIH colleagues that May. “I wasn’t party to that there, and I’m not game to do that here.”

Today, nearly two years after NTP scientists were prepared to tell the public that pregnant women should monitor their fluoride intake, and that too much fluoride may “negatively affect children’s cognition and neurodevelopment,” the project remains in a kind of bureaucratic limbo.

Berridge retired from the agency in the spring of 2023, upset by the handling of the fluoride report. “That’s not the way I want to do science,” he said. “So I decided to do something different.”


Fluoride strengthens teeth because teeth are like living rocks: tissue sheathed in a mesh of crystals called enamel. Unlike bone, which grows and mends itself over a person’s lifetime, teeth don’t self-repair. When fluoride washes over tooth enamel, in a smear of toothpaste or a swish of water, some of it can be incorporated into those crystals, helping to repair and strengthen the tooth. The process helps keep damage and decay at bay.

The stuff is found nearly everywhere: in the air and in the dirt; in bottles of soda and in tea leaves. A typical cup of black tea contains fluoride at a concentration of 2.5 milligrams per liter. A liter of ocean water contains around 1.2 mg of fluoride.

In some places, abundant fluoride leaches from soil and rock into the local water supply. A liter of tap water in parts of Cypress, Texas, for example, contains 3.81 mg of fluoride. Meanwhile, in Portland, Oregon, the number is closer to zero.

Researchers in the early 20th century noticed that people living in areas with high levels of fluoride in the drinking water had fewer cavities, and by the 1940s, a campaign was underway to add fluoride to municipal water supplies—today generally at a concentration of 0.7 mg/L.

Almost immediately, some communities objected to having a chemical added to the water supply, even if it often occurred naturally. Portland, for example, has long resisted fluoridation. One of the very first U.S. towns to add fluoride to its water supply, Stevens Point, Wisconsin, did so in secret, before a planned public referendum, fueling wider opposition to the practice, according to a 1985 paper by the historian Donald R. McNeil.

Over the years, the policy came to be associated with broader suspicions about government and public health authority. “The fluoridation question is almost tailor-made for endless controversy in a free-wheeling democratic society,” McNeil wrote, adding that fluoridation’s opponents included “not only the fanatics, the fearful, and the vendors of snake oil, but also a goodly proportion of those Americans who simply distrust authority, government, science.”

More recently, the anti-vaccination activist and presidential candidate Robert F. Kennedy Jr. has promised to halt water fluoridation if he’s elected to the White House.

There’s extensive evidence that fluoridation dramatically improved dental health. In 1999, the CDC named water fluoridation as one of the 20th century’s 10 greatest public health achievements, alongside family planning and vaccination. But since at least the 1980s, there have also been scientists—some working within the federal government—who worry that ingesting fluoride could have toxic effects.

Those concerns were bolstered in the 1990s and 2000s by research coming out of China. In 1991 a team of Chinese disease researchers published a report from Biji village, in the landlocked Shanxi Province of northern China. At the time, the researchers reported, the drinking water in the village had unusually high fluoride levels of 4.55 mg/L. They administered IQ tests to 320 children there, and then compared the scores to those of children in a nearby village, Jiaobei, where fluoride levels were below 1 mg/L. The children in Jiaobei, they found, had significantly higher IQs.

In the next few years, other researchers in China repeated that basic setup: high fluoride village, low fluoride village, cognitive tests. Many scientists today say those and other studies were poorly done, and that there are lots of things besides fluoride that could be affecting any reported differences in IQ. But the consistency of the results raised concerns: Again and again, the research found an association between higher fluoride exposure and lower IQ.

In 2002, the EPA asked a panel of experts to review the evidence on fluoride safety. Based on the data from China, as well as studies conducted in lab rats, the panel determined that there was reason to pay attention. “More research is needed to clarify the effect of fluoride on brain chemistry and function,” they wrote in a 2006 report.

It was unclear, the EPA advisers noted, whether the China data was relevant to most U.S. communities. The dose makes the poison, toxicologists say, and the study subjects in China were generally drinking water with 2.5 mg/L or more of fluoride, well above the recommended levels for U.S. tap water.

Still, there are signs that some federal scientists felt concern. In a 2015 report, the U.S. Public Health Service amended its recommended level of fluoride in U.S. public water supplies, from a range of .7 to 1.2 mg/L to a standard of .7 mg/L. The stated reason was to reduce the unsightly tooth mottling that can occur from prolonged fluoride exposure. But a draft of the report, circulated among federal officials in 2014 and obtained by Undark, suggests that concerns about the possibility of neurotoxic effects had also played a role. “While additional research may address identified gaps in knowledge,” the draft said, “HHS seeks to protect health by lowering the recommended fluoride concentration.”

When the report was published the next year, that paragraph had been removed.


Some scientists did answer the call for more research on fluoride and brain development. Among them was Christine Till, a neuropsychologist at York University in Canada.

Till was a newly tenured professor in 2016, studying the impact of chemical exposures, when she received her first grant to look at possible links between fluoride and brain development. A colleague had suggested studying the Maternal-Infant Research on Environmental Chemicals cohort, or MIREC, in Canada. Starting in 2008, researchers had collected urine and other samples from pregnant women. They had also asked the women lots of questions about their lifestyle and consumption habits. After the babies were born, and as the children aged, the scientists then tested many of the children for all sorts of things. The goal was to create a dataset scientists could use to look for associations: for example, if exposure to a certain chemical in the womb was connected with lowered IQ scores years later.

Till and several colleagues successfully got permission from MIREC to analyze the urine of those women, measuring the amount of fluoride in each sample. Her team also reviewed women’s self-reported consumption patterns, to estimate how much fluoride they were taking in from tap water and other sources during their pregnancies. And they looked at the IQ scores of the children when they were 3 or 4 years old, to see if there was some kind of link between fluoride intake during pregnancy and cognitive performance.

“The fluoridation question is almost tailor-made for endless controversy in a free-wheeling democratic society.”

Their team included experts in environmental health and epidemiology, as well as a dental public health expert, E. Angeles Martinez Mier, a professor at the Indiana University School of Dentistry who has served on the American Dental Association’s National Fluoridation Advisory Committee.

“I really was expecting not to find anything,” said Rivka Green, a lead researcher on the MIREC study who undertook the work as one of Till’s graduate students. Some of Green’s relatives are dentists, and they made fun of her for even considering the topic. She had no particular concern about fluoride, she recalled: “Everyone says it’s safe. Let’s show it safe. And that’s it. That would be great.”

One day in 2017, Green, who was pregnant and driving home from an appointment with her obstetrician, got a call from Till. The statistician on their team had just run the numbers, Till told her. And something had shown up in the data—something significant. “There’s a finding,” Till told Green. There seemed to be some association in the data between higher fluoride exposure and lower IQ.

In 2019, the team published their results in JAMA Pediatrics, a prestigious journal. “The decision to publish this article was not easy,” the journal editor, pediatrics researcher Dmitri Christakis, wrote in a brief note accompanying the paper. “Given the nature of the findings and their potential implications, we subjected it to additional scrutiny.”

Till, Green, and their colleagues had found that women with higher self-reported fluoride exposures had, on average, children with IQs that were around 3 points lower. And higher urinary fluoride measures during pregnancy were associated with lower levels of IQ in boys, but not girls.

That kind of change is small enough that it could have gone unnoticed, according to environmental health experts. But a drop of three IQ points still could have an effect. “That is the average of some people who will lose six points of IQ. And some people will only lose one or two,” said Howard Hu, a physician and epidemiologist at the University of Southern California. That kind of difference, he said, is comparable to the effect that leaded gasoline had on IQ—before its use was banned by Congress. “The effect of fluoride, from what we can see, is not that different from the effect of lead, when we look at the actual magnitude of the impact on IQ,” Hu said.

Was the finding true? The study was a kind of observational study, meaning it could show a correlation between fluoride levels in the urine and slightly lower IQ, but not prove that fluoride ingestion caused the decline.

Such studies are widely used to research environmental toxins, including lead. But in related fields that search for links between diet and certain outcomes—most notably nutritional epidemiology—such studies can be famously finicky, giving mixed results. And experts were quick to raise a host of pointed questions about Till and her team’s paper: How reliable were IQ tests of 3 and 4-year-olds? Could the findings be biased by differences among the people administering the IQ tests? Why did the IQ drop sometimes show up in boys but not girls? And could a few urine samples—or, for that matter, self-reports on beverage consumption—actually provide a good measure of how much fluoride makes it to a developing fetus? (Some experts say such data cannot show such a connection; others point to research suggesting that it can, including a 2020 study from scientists at the University of California San Francisco that found a link between urinary fluoride levels and levels of fluoride in amniotic fluid.)

One other issue: If fluoride did affect the brain, nobody really knew how. In other words, there was no clear mechanism by which this one chemical was affecting brain development, although Till and others have proposed that an effect on thyroid function could be one mechanism behind it.

“Everyone says it’s safe. Let’s show it safe. And that’s it. That would be great.”

Still, some experts who were not involved in the study told Undark it was a strong piece of research. The MIREC research was some “of the very best, actually, in the field,” said Akhgar Ghassabian, an environmental epidemiologist at New York University.

“It’s one study. It’s a good study. And I would say the results are relevant,” said David Eaton, an emeritus professor at the University of Washington and a past president of the Society of Toxicology. “But it’s really hard to know whether the magnitude of the effect and the reproducibility of that effect is the end of the story.”

In a recent Zoom conversation, Green acknowledged that the study had limitations. But, she said, that was true of any study. “At first I was, you know, maybe this is just a standalone, it’s a fluke—which happens,” she said. “We know that happens. And that’s why we don’t rely on one study.”


The NTP process is built, in part, on the insight that no single study is definitive, especially on complicated questions about environmental hazards. Instead, the goal is to do a methodical review of every single study published on a given question, and then look for patterns in that entire body of evidence.

John Bucher helped pioneer those methods at NTP. The soft-spoken toxicologist joined the program in the 1980s, and eventually became its associate director in 2007. In retirement, Bucher still works on some projects for NTP, and he’s one of the lead authors of the fluoride report.

In a series of conversations this winter, from his home in the forested piedmont of central North Carolina, Bucher reflected on the years he and his colleagues had spent reviewing the body of literature on fluoride—including research like the Shanxi study, as well as the work of Till and her colleagues. Compared to scientific research on other hazardous substances, he said, the fluoride literature shows a fairly clear pattern. “My impression is that the findings are generally more consistent in direction of effect,” he said. “That is, they tend to show deficiencies, at least in IQ.”

“As the literature continued to accumulate we were more and more convinced that there were no single flaws that could explain the consistency in the findings.”

A similar study to Till and Green’s paper, conducted in Mexico, also found an association between higher levels of fluoride in pregnant women’s urine and lower IQ. Meanwhile, recent studies on mothers and their children in Spain and Denmark, using similar methods, did not find any clear negative effects from fluoride. (Several researchers have questioned the Spanish result, which showed that higher fluoride levels increased boys’ IQ scores by as much as 15 points.)

In the most recent publicly available draft, the NTP report identifies 19 studies on fluoride and children’s IQ that it rates as high-quality. Of those, 18 find some adverse effect from fluoride. Of the 53 lower-quality studies reviewed by Bucher and his colleagues, 46 suggest some negative effect from fluoride on IQ.

“As the literature continued to accumulate,” Bucher said, “we were more and more convinced that there were no single flaws that could explain the consistency in the findings.”

Most of those studies look at fluoride exposures higher than 1.5 mg/L—in other words, more than double the levels founds in most Americans’ drinking water. Bucher stressed that the report is not—and was never intended to be—an evaluation of the safety of adding fluoride to water. “We don’t have enough data to make any statement with any certainty about it at the lower levels,” he said.

Still, even the findings at higher levels of fluoride may be relevant to some Americans. Individual fluoride exposure can vary a lot, depending on what a person drinks. And according to one recent estimate, more than 2.9 million Americans are served by water utilities that deliver tap water with levels of fluoride at or above 1.5 mg/L. According to CDC data, that includes utilities in Troy, Missouri (12,116 people served; 2.31 mg/L); Seminole, Texas (8,549 people served; 4.40 mg/L); and Abercrombie, North Dakota (258 people served; 2.29 mg/L).

Such communities “are clearly in the range that we would predict would be—we would say they would be presumed neurotoxicants,” said Bucher.


By April 2022, the NTP report was poised to be published. It had, by that point, undergone peer review from five external experts, and been subjected to two rounds of review by a National Academies of Sciences, Engineering, and Medicine panel. In the second round, reviewers mostly took issue with some of the report’s language, rather than the underlying science, and urged the NTP to make clearer that “little or no conclusive information can be garnered” from the report “about the effects of fluoride at low exposure concentrations.”

“Overall, I feel that they have been responsive to many comments,” said Ghassabian, the NYU professor, who served on the NASEM committee.

In the spring of 2022, the NTP notified other agencies that the report was coming. Soon after, some officials expressed concerns about the way the science was being communicated, seemingly worried that it could undermine community water fluoridation programs. At the same time, dental organizations had obtained the document and were raising concerns with officials at the CDC, according to emails obtained via public records requests and shared with Undark.

The report looked to many dental experts like yet another assault on a public health program. According to emails and public statements from around the time, leaders in the field saw the report as issuing alarming conclusions, with too little context, based on evidence that was, at best, highly tentative. They worried that NTP had overstated the quality of some fluoride studies.

“We don’t have enough data to make any statement with any certainty about it at the lower levels.”

According to the internal emails, the report received scrutiny from top government officials, including the NIH’s acting principal deputy director at the time, Tara Schwetz, and assistant secretary of health Rachel Levine. In early May 2022, Rick Woychik, the director of NTP, halted publication. Instead, the report and an accompanying analysis of fluoride research would undergo another round of review, this time overseen by an independent board of scientists that advises the NTP.

The entire process has struck some in the federal government as unusual. “It just seems like it’s just stretching out the scientific review process,” said one federal official with detailed knowledge of the report, who spoke on condition of anonymity because of concerns about professional repercussions. “It’s kind of hard to defend, I think, for something that’s actually slated to just be submitted to a journal for peer review,” the official added.

The official also questioned the decision to allow agencies like the CDC—which has long promoted water fluoridation—to weigh in on the NTP’s research. “You’re talking about having that document reviewed by agencies who have a vested interest in the policy of fluoride,” the official said, adding that the review process now appeared entangled with various policy biases. “That, to me, is really when it crosses the boundary.” (A CDC spokesperson said that the agency routinely reviews draft reports on “emerging science” from other parts of the federal government in order “to assure that our recommendations maximize benefits while minimizing any potential harms.”)

Linda Birnbaum, a toxicologist who served as director of both NTP and the National Institute of Environmental Health Sciences from 2009 until 2019, also criticized the review process. “I see this as an infringement of scientific integrity, that the scientists have been prevented from getting their information out,” she said. That information, she argued, has implications for public health: “I think the data is overwhelmingly clear that fluoride is associated with the potential for neurodeficits.”

Christine Flowers, a spokesperson for the National Institute of Environmental Health Sciences, which houses the NTP, declined to make the program’s current director, Rick Woychik, available for an interview. The ongoing delay in publication, she wrote in an email, “was to ensure that we get the science right.”

So far, progress on the main report appears to be stalled. According to Bucher, the authors have received no revisions to the document since September 2023. The accompanying analysis paper, though, is finally moving forward. The next step would be submission to a journal—where it will undergo yet another round of peer review.


For some scientists, the NTP saga has echoes of another dispute: the response to Christine Till and her team in Canada, after their 2019 paper was published in JAMA Pediatrics.

In 2021, following a series of letters to York University and other institutions criticizing the paper, a group of academics and dental leaders filed a series of misconduct complaints with the researchers’ institutions, as well as the U.S. federal government, which had funded the study.

“That’s fucking mean. I mean, that’s terrible” said Hu, the physician and epidemiologist at the University of Southern California, who previously served as dean of the Dalla Lana School of Public Health at the University of Toronto. Hu was not involved with the paper, but he has collaborated with Till on other research, and he helped lead influential fluoride studies in Mexico. “You don’t do that,” he said of the complaints, “unless you actually have evidence of scientific misconduct.”

Such allegations are typically reserved for cases of data fabrication and fraud, and they can bring immediate consequences, delaying research, freezing funding, and taking up large amounts of a researcher’s time.

“I think the data is overwhelmingly clear that fluoride is associated with the potential for neurodeficits.”

For the scientists who signed the complaints, the stakes felt high. Among them was Jennifer Meyer, an associate professor of public health at the University of Alaska, Anchorage. Meyer first became interested in fluoride when she moved to Juneau, Alaska, a number of years after the city halted water fluoridation. Dentists, she said, observed an immediate rise in tooth decay—a finding that Meyer and two colleagues backed up with hard data in later research.

It was galling for Meyer to see Till’s team make public statements recommending that pregnant women limit their fluoride intake. It seemed to her that the scientists, based on what she saw as one deeply flawed study, were in effect issuing public health advisories. Such activity, she suggested, might be worth silencing: “If you’re out there terrifying the public about a well-known public health intervention on which you have you have no basis to make that claim, and yet you’re continuing to do it, then it becomes, I think, a step too far,” Meyer said. Some people may see that as academic free speech, she added. “But I can’t stand up in a theater and yell ‘Fire!’ There are limits to freedom of speech.”

Meyer connected with other researchers who were concerned about the MIREC study, including Juliet Guichon, a law and ethics scholar at the University of Calgary’s medical school. Guichon had been involved with pro-fluoridation campaigns in Calgary, and she saw the research—and the subsequent statements by Till and others—as linked to a long campaign against fluoridation. The research team, she told Undark, seemed like it had cherrypicked its data in order to find an alarming-sounding result.

Guichon drafted the complaints in 2021. She and Meyer recruited a group of dental and public health experts to sign it, including Howard Pollick, a dentist and clinical professor of health sciences at the University of California San Francisco, who often serves as an American Dental Association spokesperson on fluoridation; Christine Wood, the director of the Association of State and Territorial Dental Directors; William Maas, a former top dental official at the CDC; and Raman Bedi, the former Chief Dental Officer of England. Tomar, the University of Illinois Chicago professor, joined the group as well.

The group fractured over how far to go. Everyone signed the complaints sent to the U.S. government and several universities. But most of the signatories did not sign the complaint to York University, which called for Christine Till to be fired, as well as one other complaint seeking a scientist’s termination.

In copies of the 40-plus pages of allegations obtained by Undark, the complainants describe in detail what they see as inappropriate statistical practices by the research team—practices that, they say, amount to intentional falsification of data to produce a specific result. The document appears to contain no direct evidence of the fabrication or falsification of data, and the complaints were dismissed by all institutions, including the U.S. Department of Health and Human Service’s Office of Research Integrity. (The complaint “was not adjudicated in what anyone would regard as an independent and thorough matter,” Guichon said.)

The group also unsuccessfully petitioned JAMA Pediatrics to retract the paper.

Some researchers suggested that the complainants had been motivated more by a desire to defend fluoridation than by any evidence of scientific misconduct. “It’s one branch of public health, which is dental public health, in tension with another branch of public health, environmental public health,” Hu said. “And we’re supposed to be the same tribe, but we’re not. Some of these dental folks—when you look at their objections, they’re not environmental epidemiologists. Some of them were just unfamiliar with the methodology.”

In interviews, Till described a kind of ongoing campaign against her work. Fluoridation proponents, she said, would email venues where she gave talks, warning against hosting her. “That’s the life of a fluoride researcher,” she said. Till has tenure, but she now warns younger researchers about studying the topic. “It’s not a place for someone who worries about their job security,” she said.

Till and others have taken particular issue with one allegation: that they refused to share their data. Under MIREC policies, research teams do not own the highly sensitive personal data and may not share it. Other researchers must apply directly to MIREC if they wish to access it. In 2020, dental experts petitioned MIREC to access the data. Over the next year they were repeatedly denied. (At one point, Till and a collaborator sent a letter to MIREC encouraging an external review of the data—but only if conducted by people who had no “ideological biases.”) In a statement to Undark, Maryse Bouchard, the scientist who currently oversees the MIREC program, said the dental group “did not demonstrate sufficient expertise or methodological improvement to meet the requirements for a robust reanalysis.”

“MIREC data are not being withheld,” Bouchard wrote.

Those statements have not stopped many critics of Till’s work from continuing to allege that her group has blocked access to the underlying data. Guichon suggested to Undark that Till or others had exercised influence over MIREC’s decision, noting that some of the MIREC leaders had co-published papers with Till’s collaborators. Guichon did not provide any concrete evidence of collusion. But, she said, “I would ask the question, if MIREC is independent of the group of authors who wrote the paper, how would we know that?”


Some of that suspicion has extended to the NTP report. In conversations with Undark, Guichon questioned whether NTP was truly independent, noting an instance in 2020 in which an NTP scientist retweeted a link shared by the Fluoride Action Network, an activist group and EPA lawsuit plaintiff.

Still, the dispute over the report has mostly focused on wording—and on whether the NTP does enough to convey uncertainty about lower levels of fluoride exposure. Pollick, the UCSF dentist and fluoridation spokesperson, has made public statements questioning the NTP report; in an interview, he clarified that his concerns were mostly about how the science is communicated by the NTP team, rather than its substantive claims.

Indeed, what almost everyone seems to agree on is this: There is uncertainty about whether fluoride, at the kinds of doses routinely encountered by Americans, can have neurotoxic effects. And it would be helpful to have more research.

But scientists have been divided over how to proceed amid that uncertainty.

For Bucher, the current evidence likely warrants a recommendation for pregnant women to exercise caution around their fluoride intake. There’s evidence of potential risk, he continued, “and there’s absolutely no documented benefit to an unborn child receiving fluoride through the mom.”

To others, the evidence needs to be far clearer before issuing any kind of public health advice—especially when that advice appears to undermine a policy that has a demonstrated benefit for many people, perhaps especially those from marginalized communities, who have less access to robust dental care. Tomar, the University of Illinois Chicago dentist and epidemiologist, and one of the signatories on the general complaints about Christine Till’s paper, framed the question as, more broadly, about giving up a known good in order to prevent a possible harm. “The preponderance of evidence does not support their conclusion of public health harm in terms of lowered IQ,” he said. “But we are pretty sure that if you stopped water fluoridation tomorrow, there will be public health harm in terms of increased oral disease.”

Today, the CDC advises parents to pay attention to their children’s fluoride intake (such as from swallowing large amounts of toothpaste) in order to protect against tooth mottling. No federal advisory exists for limiting fluoride intake during pregnancy. Nor are there necessarily warnings about potential neurotoxic effects given to people who live in communities where fluoride levels exceed 1.5 mg/L, creeping into the range where many researchers consider the evidence of harm to be more clear-cut.

“The preponderance of evidence does not support their conclusion of public health harm in terms of lowered IQ.”

Eaton, the University of Washington toxicologist, used to chair a board of expert advisers to the NTP, and he oversaw the working group that conducted the most recent external review of the fluoride report. In typical cases where there’s uncertainty about a toxin, he said during a recent interview with Undark, regulators build in a buffer, setting the allowable threshold at 10 or even 100 times lower than the amount that’s considered likely to cause harm. By that standard, “you would come to the conclusion that water fluoridation is problematic,” he said. “But what you have to consider in that is the public health benefits of water fluoridation”—as well as the potential difficulty of dealing with naturally occurring fluoride.

Eaton would like to see the government convene an expert panel to weigh all of those considerations and provide guidance to the federal agencies, he said: “It really needs a good, objective look at balancing the risks and benefits from the public health perspective.”


In November 2023, Woychik, the current director of both National Institute of Environmental Health Sciences and NTP, held an online townhall with institute employees. Someone asked him whether the fluoride report would come out soon, adding that it seemed that “science is being prevented from being published.” His answer seemed to gesture both to the internal pressure to move the report forward—and the veil of concerns and allegations that have come to surround the delays. “There is not a government conspiracy starting with the ASH and the director of the NIH,” he said, using an acronym for assistant secretary for health, according to a transcript of the meeting obtained by Undark.

“These papers are going to be, from my point of view, the most impactful papers that are published from the NIEHS, that will impact public health,” Woychik said, noting that every word would be scrutinized by both pro- and anti-fluoridation camps.

All of this back-and-forth has energized anti-fluoridation activists. Today, the cutting edge of the movement is a family affair. In 2000, environmental chemist Paul Connett became the founding director of the Fluoride Action Network, aiming to fight a policy he saw as harmful to public health. Today his son, Michael, is leading the lawsuit demanding that the EPA to reexamine the way it treats water fluoridation.

The EPA, Connett’s suit alleges, has essentially failed to assess fluoride in the way it would other toxins. “Because of this interest in protecting this oral health program, you are failing to use your own risk assessment framework,” Michael Connett said in an interview with Undark shortly before the trial resumed.

Several researchers testified at the trial, including Hu, the University of Southern California professor, and Berridge, the former NTP official.

Both sides found broad agreement on certain issues: that fluoride at higher concentrations can pose risks, and that the NTP report had real scientific merits. “I think our scientists generally agree that the NTP monograph was a high-quality review,” said one of the EPA’s lawyers, Paul Caintic, during his opening statement. He argued that the evidence “is simply too inconsistent and too unclear to conclude that there’s been a demonstration that low-level fluoride exposure presents an unreasonable risk of neurodevelopmental harm.”

For his part, Connett argued that the agency should move forward based on the evidence available. “We do not need to wait for every piece of the puzzle to fit nicely together before we take action to prevent harm,” Connett said on the final day of the hearing.

During closing arguments, Judge Edward M. Chen appeared to echo concerns that the levels of fluoride in drinking water came relatively close to levels at which there was stronger evidence of harm. “What do I do with the fact that you don’t have to go much higher to find—in the words of Dr. Barone—something is going on?” he asked the EPA’s lawyers at one point during the trial’s final day, naming one of the agency’s senior scientists and key witnesses.

The Fluoride Action Network has been optimistic. “Once we get the victory and the NTP report comes out—or both situations—we’re just going to have a big education campaign, ensuring that water operators, decision makers, state level decision makers all throughout the country are aware of it,” said executive director Stuart Cooper in an interview with Undark in December, shortly before the trial resumed. On its website, the organization has been describing 2024 as “the perfect storm.”

That storm could stoke skepticism of public health institutions at a time when many are facing declines in public trust. Already, the case has drawn enthusiastic attention from people in the world of anti-vaccination activism.

“What do I do with the fact that you don’t have to go much higher to find—in the words of Dr. Barone—something is going on?”

More research is coming. Hu has a large study of fluoride effects in the United States currently under review at a journal; while he declined to say what the paper found, there are indications it shows a link between fluoride and harmful effects, bolstering the findings by Till’s team in Canada. Till has begun work on a population of mother-child pairs in New Hampshire, incorporating another way of measuring fluoride exposure—toenail analysis—in the research.

Berridge, the former NTP leader who resigned over the report’s repeated delays, is frustrated that the public doesn’t have access to the most up to date information from the NTP. “We need to be transparent about the science,” he said, “so that people who need to make decisions—either individuals, regulators, or policymakers—can make those decisions based on whatever the best science of the day is.”

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Your child’s medicine probably wasn’t fully vetted. Here’s why. https://www.popsci.com/health/children-medicine-clinical-trials/ Fri, 08 Mar 2024 14:00:00 +0000 https://www.popsci.com/?p=605870
Child getting medicine from parent
Kids’ medications don’t meet the same bar that everyone expects for adults. E+/Getty Images

Most pharmaceuticals are developed and approved for use only in adults. Researchers are working to create change.

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Child getting medicine from parent
Kids’ medications don’t meet the same bar that everyone expects for adults. E+/Getty Images

This article was originally featured on Undark.

Mark Turner has worked in pediatrics for more than 30 years, and he’s tired of telling parents there’s nothing he can do for their children. Very few medicines are developed with young people in mind, he said. “It’s just very difficult, watching them be sick, watching babies die.”

Turner is referring to the lack of research into how different medications perform in children. When drugs get approved, it’s usually on the basis of how they function in adults. This holds true for nearly all conditions, including mental health disorders, cancer, and rare diseases.

As a result, children are usually prescribed medication “off-label,” meaning the drug is being used differently from what’s specifically outlined on the package insert. Most drugs used for newborns are given off-label, as well as about half of those prescribed for older children, said Vivianna Guzman, executive director of I-ACT for Children, a nonprofit seeking to improve children’s access to drugs.

This can leave physicians and parents with a difficult dilemma. Although the vast majority of drugs that are used off-label for kids appear to be safe, the lack of proper testing puts children at a relatively higher risk of side effects than adults, experts told Undark. And medications that work well in adults might also be less effective in young people. Further, in dire situations, when the need for medication is urgent, physicians and parents may find that they lack access to clinical trials, which historically excluded children. The reasons for all of this, experts said, are both practical and financial.

The American Academy of Pediatrics has stressed that off-label prescribing does not necessarily entail great risk. Rather, it means that the medication has not met FDA guidelines, which call for studies to be conducted in the population that will use the drug: in this case, children.

Absent such evidence, medical groups create dosing guidelines based on expert consensus. That consensus may be based on a combination of clinical expertise and systematic reviews of the literature, and on input from regulators or organizations such as the World Health Organization. It’s not guesswork in the sense of tossing a coin, explained Turner, who is involved in a European effort to support pediatric clinical trials. Still, he added, it’s less-than-ideal when kids’ medications don’t meet the same bar that everyone expects for adults.


Medicines were developed on an ad-hoc basis until the 1960s, when the Thalidomide scandal led to the reform of the U.S. Food and Drug Administration’s drug approval process. The agency began requiring drugs and medical devices to be tested for specific conditions in clinical trials before they could be widely prescribed. For decades, regulators and medical ethicists argued that children should be excluded from these trials because they are a vulnerable population, considered to be at risk of exploitation by researchers.

These days, scientists agree that research is appropriately safe for children, who have much to gain from participation in clinical trials. But change has been slow. “For the most part, drugs are never developed for kids,” said Florence Bourgeois, an associate professor of pediatrics at Harvard Medical School. “Drugs are developed for use in adults, and then in some cases tested for use in kids.” This allows for greater uncertainty about the safety and effectiveness of medications when they are used in pediatric populations.

A 10-year study looking at 1.74 billion outpatient pediatric visits found that roughly 40 percent resulted in an off-label prescription. Antihistamines were the most common off-label medication, followed by antibiotics and antidepressants. One of the study’s authors, Daniel Horton, an associate professor of pediatrics and epidemiology at Rutgers, said there is less evidence supporting antidepressants’ benefits in children than there is for adults.

For decades, regulators and medical ethicists argued that children should be excluded from clinical trials because they are a vulnerable population, considered to be at risk of exploitation by researchers.

Most of the antidepressants kids receive—including Trazodone, Citalopram, and Bupropion (sold as Wellbutrin)—have not been approved to treat depression or any other condition in kids, and potential side effects include suicidal behavior and possible heart problems, he said. (Horton added that he is not a psychiatrist.) Some of the documented risks are known to prescribers, he continued. But some of the risks are not well-known.

Sertraline, also known by the brand name Zoloft, is often prescribed to children and teens with depression, despite the fact that it has only been approved to treat OCD in pediatric populations. Although one study showed modest benefits in young people with depression, Horton wrote in an email, the study also revealed many side effects. “It did not lead to regulatory approval,” he said.

Horton’s paper suggested that off-label ordering was on the rise, which could create greater room for error or surprise. In outpatient care, 1 to 2 percent of children react badly to FDA-approved medicines. With off-label drugs, the rate is about half a percentage point higher, Horton said. So the risk to an individual child is small, and sometimes the bad reaction is nothing more than a temporary rash or diarrhea. But some side effects are life-threatening, including heart arrhythmias or suicidality. The risks of a bad outcome are higher for children with an underlying illness or who are taking multiple medications

2017 paper studied adverse reactions in individuals taking anti-psychotic medications, which are commonly prescribed off-label to young people with aggression and other behavioral issues. Using the FDA’s official reporting system, the authors found that children were more likely than adults to become aggressive, to exhibit abnormal behavior, and to struggle with suicidal thinking when on the medication.

Children are vulnerable to more or different side effects because their bodies differ significantly from those of adults. For one thing, they grow and develop relatively quickly. Ideally, scientific studies would assess the effect of medicines at each developmental stage, experts said. It’s not a question of dividing a dose by two for teens and four for newborns. Practitioners need to take into account how long a medicine taken by mouth spends in a patient’s stomach, and how it interacts with the liver, kidneys, guts, and intestines.

Additionally, some organs function differently in children. Their kidneys, for example, are less active than those of adults, which could lead to a build-up of toxins or could make the drugs less effective. Babies and toddlers also process food more quickly than their grown-up peers, and they have less fat. And newborns are “much more watery, less fatty than everybody else,” Turner said.

These biological realities make it particularly tricky to provide medical care to babies in neonatal intensive care. Nearly all of the medicines they receive, including even food dispensed through intravenous drips, are untested in humans their size. In these children, it can be hard to distinguish disease symptoms from drug side effects. About 10 adverse drug reactions in babies are reported to the U.K.’s national reporting system each year, but that number is too low to be believed, said Turner. When he and his colleagues did a careful study of a single hospital, they found that 35 out of 193 newborns, or roughly 18 percent, experienced adverse drug reactions. These included fever, increased heart rate, and impaired kidney function.

“There must be more adverse drug reactions” than are officially counted, said Turner. Doctors just don’t know how to identify these events with certainty.

And even when the risk of side effects is low, physicians may be unsure about a medicine’s efficacy in pediatric populations, said Harvard’s Bourgeois, who studied the status of off-label prescription in 52 U.S. children’s hospitals. All too often, she said, “we use drugs in kids that ultimately just don’t work.”


The relatively poor state of pediatric research also means that children with rare diseases may struggle to access experimental treatments that are available to adults enrolled in clinical trials. Jillian Arnold wanted to try an experimental drug for her son, Roman, who has a condition called acid sphingomyelinase deficiency, or ASMD. Affecting one in 250,000 people across the U.S., the condition causes severe inflammation in a person’s vital organs, including the brain. On her podcast, Confessions of a Rare Disease Mama, Arnold describes it as a kind of baby Alzheimer’s because children start to forget skills they had acquired, like walking or smiling.

In addition to cognitive symptoms, Roman had gastrointestinal distress and would sometimes throw up five or six times, Arnold recalled. “We got to the point where we wouldn’t even leave the house because he was throwing up so much.”

The options for treatment were sparse, but a clinical trial was under way for a drug that was designed to help with ASMD’s gastrointestinal symptoms. There was just one problem: the enrollment date had already passed. Arnold said she lobbied the drug company intensively, an experience she described as “a beast.” And after a year, she got access to the medication. It eased Roman’s physical symptoms, she said. It also helped her daughter, who was born eight months after Roman was diagnosed, and also has ASMD.

“I call it a miracle drug because it changed our life,” said Arnold.

She subsequently learned of a therapy that could combat her children’s neurological damage. It was primarily given to adults with ASMD. Just one child had been on it before. She presented the idea to her doctors and worked with a charitable organization to obtain access to the drug, attending meetings with the pharmaceutical company. After a year, Roman received the drug and his sister got it a year later.

Children with ASMD sometimes live for just a few years, said Arnold, reflecting on her experience. This is why she worked so hard to access an experimental treatment—and why the waiting was deeply painful. “With us, it’s like, okay, they’re going to die if they don’t get treatment, and they’ll die fast.”


Experts who spoke with Undark pointed to two main reasons for the lack of children in clinical trials: financial incentives and logistics.

Many top-grossing medications are for conditions that primarily affect adults, including rheumatoid arthritis and age-related macular degeneration. In the world of cancer, people under 20 account for just 1 percent of patients, said Max Coppes, a professor of pediatrics and clinical internal medicine at University of Nevada, Reno School of Medicine. “That’s 1 percent of the market,” he said. Drug companies don’t stand to earn much from running additional trials, so they don’t. “That’s the reality,” said Coppes. Pediatricians have never known anything different.

“I call it a miracle drug because it changed our life.”

There are non-monetary hurdles, too. As a group, kids are healthier than adults, making it harder for companies to recruit enough patients for clinical trials. If a hospital wanted to run a clinical trial for a drug to treat ASMD, it would likely need to recruit young patients who live out of state or even in another country. And with neurodevelopmental conditions, such as cerebral palsy, it can take years to understand a therapy’s impact.

Government agencies and politicians have been trying to address the issue. In 2002, Congress passed the Best Pharmaceuticals for Children Act, which offers drug companies six months of extra exclusivity on a patent if they include children in their clinical trial for a drug approval. And in 2003, Congress passed the Pediatric Research Equity Act, which gave the FDA authority to oblige pharmaceutical companies to perform certain initial studies on children. In Europe, these measures were combined in the Pediatric Regulation of 2007.

All of the acts have drawbacks, Bourgeois said. For example, the most lucrative medicines generally treat adult conditions, such as breast or prostate cancer. Pfizer uses an active ingredient called sildenafil in a drug for hypertension and in Viagra, the popular treatment for erectile dysfunction. The company submitted paperwork on the ingredient’s relevance to children with hypertension, and although the ingredient’s safety was never established in kids, the company gained an extra six-months patent on both its hypertension drug and on the wildly profitable Viagra.

This was, “a lucrative outcome,” Bourgeois wrote in a paper published in the New England Journal of Medicine. In an email to Undark, she said that the studies could be useful, helping to inform off-label prescribing to children. But, she added, drug companies will choose what to study “based on the large adult revenue as opposed to considering pediatric need.” Andrew Widger, a spokesperson for Pfizer, noted that the value of pediatric investigations is decided upon by regulators. “I’m not going to comment on other people’s speculation,” he said of the NEJM piece. “You look at each medication case by case, and if there’s a pediatric indication, we explore it.”

These acts also do not affect the many drugs with a lapsed patent. “Once it’s in the generic format. It’s tough,” said Bourgeois.

When the incentives do align, it proves feasible to conduct trials even on the youngest, most fragile patients. Recently two treatments were approved for an eye condition that only affects premature babies or those weighing less than 3 pounds. In severe cases it causes vision loss or even blindness. This is a success story, said Turner—the kind he’d like to see more of going forward.

“We now realize that we want to protect children with research,” said Turner. “We don’t want to protect children from research.”

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VR and electric brain stimulation show promise for treating PTSD https://www.popsci.com/health/vr-ptsd-treatment/ Thu, 07 Mar 2024 21:30:00 +0000 https://www.popsci.com/?p=605809
Concept of human intelligence with human brain on blue background
Patients reported improvements after only three sessions. Deposit Photos

A new study involving military veterans reported ‘meaningful’ improvements after only a couple weeks.

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Concept of human intelligence with human brain on blue background
Patients reported improvements after only three sessions. Deposit Photos

Although it can sound cliché, there’s a lot of truth in the old axiom “face your fears.” In fact, exposure therapy ostensibly puts that adage into practice. For many people, reprocessing their trauma with the help of trained professionals can allow their brains to relearn the important differences between an actual traumatic event and its harmless memories.

Unfortunately, post-traumatic stress disorder often reworks the brain by limiting the ventromedial prefrontal cortex’s ability to control regions like the amygdala. This can lead to memory and safety learning issues that limit exposure therapy’s efficacy.

To potentially solve this issue, researchers wondered if combining the treatment alongside another popular trauma therapy might compensate for this brain barrier. Their results, published this week in JAMA Psychiatry, indicate a workaround may actually be found through a trio of tools: exposure therapy, transcranial direct current stimulation (tDCS), and virtual reality.

[Related: PTSD patients’ brains work differently when recalling traumatic experiences.]

In their recent study, a collaborative team from Brown University and the Providence V.A. Center for Neurorestoration and Neurotechnology asked 54 military veterans to participate in a new, double-blind study. Every volunteer agreed to six VR exposure therapy sessions over two to three weeks that depicted generalized warzone situations.

“It can be difficult for patients to talk about their personal trauma over and over, and that’s one common reason that participants drop out of psychotherapy,” Noah Philip, the study’s author and Brown University psychiatry professor, said in a statement. “This VR exposure tends to be much easier for people to handle.”

During these 25-minute sessions, half of the veterans simultaneously received painless, 2 milliamp tDCS stimulations directed at their ventromedial prefrontal cortex. The other participants, meanwhile, served as controls, and only felt a small sensation meant to mimic tDCS treatment.

According to researchers, veterans who received both therapies reported “meaningful” improvement in their PTSD symptoms after just three sessions, with a “significantly greater” reduction in issues reported during their one month follow-up interviews.

What’s more, the results were achieved much faster than volunteers who only underwent VR exposure therapy. In only two weeks, tDCS/VR approach produced results normally only seen after about 12 weeks of exposure therapy alone.

It’s important to note that this initial participant sample size is relatively small, and researchers need to continue studying the results to better grasp how the treatment works over time. Still, the team hopes to conduct similar experiments on larger populations in the future, potentially alongside additional treatment sessions with longer follow-up times.

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A history of trepanning: Why do we put holes in our skulls? https://www.popsci.com/health/trepanning-history-video/ Thu, 07 Mar 2024 12:03:00 +0000 https://www.popsci.com/?p=605719
a collage featuring a head being drilled into

Humans have been cutting into our skulls for thousands of years. But why?

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a collage featuring a head being drilled into

Why do humans put holes in our heads? It’s a question 7,000 years in the making. 

With the help of a googly-eyed watermelon named Joe Melon, Popular Science host Kevin Lieber tries to find an answer while drilling into the fascinating history of trepanation

A history of trepanning: Why do we put holes in our skulls?

Ten percent of the neolithic skulls discovered by modern humans have at least one man-made hole in them, and trepanning is the oldest surgery we have surviving evidence of. But without the benefit of contemporary surgical tools, how did trepanning even work? Scraping. A lot of scraping. And our friend Joe Melon is the unfortunate fruit subjected to the various methods of trepanning tested through history. 

At Popular Science, we’re no strangers to trepanning. Nearly 150 years ago, the September 1875 issue included a story about a doctor who found trepanned remains in France. The remains also included “cranial amulets” made from bone. So skull charm necklaces basically. And in February 1893, Popular Science covered the story of “Mrs. N,” a woman who wore a trepanned section of her husband’s skull as a brooch. Love is beautiful, right? 

These are just a few of the interesting things you’ll learn about trepanning in the latest video from our newly launched YouTube channel

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Using hearing aids can be frustrating for older adults, but necessary https://www.popsci.com/health/hearing-aids-older-adults/ Tue, 05 Mar 2024 13:00:00 +0000 https://www.popsci.com/?p=605313
Close-up of senior woman holding a modern hearing aid
Hearing problems become pervasive with advancing age, exceeding 90% in people 85 and older, compared with 53% of 71- to 74-year-olds. Moment/Getty

Here's how you can make the most out of the technology available.

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Close-up of senior woman holding a modern hearing aid
Hearing problems become pervasive with advancing age, exceeding 90% in people 85 and older, compared with 53% of 71- to 74-year-olds. Moment/Getty

This article was originally published on KFF Health News.

It was an every-other-day routine, full of frustration.

Every time my husband called his father, who was 94 when he died in 2022, he’d wait for his dad to find his hearing aids and put them in before they started talking.

Even then, my father-in-law could barely hear what my husband was saying. “What?” he’d ask over and over.

Then, there were the problems my father-in-law had replacing the devices’ batteries. And the times he’d end up in the hospital, unable to understand what people were saying because his hearing aids didn’t seem to be functioning. And the times he’d drop one of the devices and be unable to find it.

How many older adults have problems of this kind?

There’s no good data about this topic, according to Nicholas Reed, an assistant professor of epidemiology at Johns Hopkins Bloomberg School of Public Health who studies hearing loss. He did a literature search when I posed the question and came up empty.

Reed co-authored the most definitive study to date of hearing issues in older Americans, published in JAMA Open Network last year. Previous studies excluded people 80 and older. But data became available when a 2021 survey by the National Health and Aging Trends Study included hearing assessments conducted at people’s homes.

The results, based on a nationally representative sample of 2,803 people 71 and older, are eye-opening. Hearing problems become pervasive with advancing age, exceeding 90% in people 85 and older, compared with 53% of 71- to 74-year-olds. Also, hearing worsens over time, with more people experiencing moderate or severe deficits once they reach or exceed age 80, compared with people in their 70s.

However, only 29% of those with hearing loss used hearing aids. Multiple studies have documented barriers that inhibit use. Such devices, which Medicare doesn’t cover, are pricey, from nearly $1,000 for a good over-the-counter set (OTC hearing aids became available in 2022) to more than $6,000 for some prescription models. In some communities, hearing evaluation services are difficult to find. Also, people often associate hearing aids with being old and feel self-conscious about wearing them. And they tend to underestimate hearing problems that develop gradually.

Barbara Weinstein, a professor of audiology at the City University of New York Graduate Center and author of the textbook “Geriatric Audiology,” added another concern to this list when I reached out to her: usability.

“Hearing aids aren’t really designed for the population that most needs to use them,” she told me. “The move to make devices smaller and more sophisticated technologically isn’t right for many people who are older.”

That’s problematic because hearing loss raises the risk of cognitive decline, dementia, falls, depression, and social isolation.

What advice do specialists in hearing health have for older adults who have a hard time using their hearing aids? Here are some thoughts they shared.

Consider larger, customized devices

Many older people, especially those with arthritis, poor fine motor skills, compromised vision, and some degree of cognitive impairment, have a hard time manipulating small hearing aids and using them properly.

Lindsay Creed, associate director of audiology practices at the American Speech-Language-Hearing Association, said about half of her older clients have “some sort of dexterity issue, whether numbness or reduced movement or tremor or a lack of coordination.” Shekinah Mast, owner of Mast Audiology Services in Seaford, Delaware, estimates nearly half of her clients have vision issues.

For clients with dexterity challenges, Creed often recommends “behind-the-ear hearing aids,” with a loop over the ear, and customized molds that fit snugly in the ear. Customized earpieces are larger than standardized models.

“The more dexterity challenges you have, the better you’ll do with a larger device and with lots of practice picking it up, orienting it, and putting it in your ear,” said Marquitta Merkison, associate director of audiology practices at ASHA.

For older people with vision issues, Mast sometimes orders hearing aids in different colors for different ears. Also, she’ll help clients set up stands at home for storing devices, chargers, and accessories so they can readily find them each time they need them.

Opt for ease of use

Instead of buying devices that require replacing tiny batteries, select a device that can be charged overnight and operate for at least a day before being recharged, recommended Thomas Powers, a consultant to the Hearing Industries Association. These are now widely available.

People who are comfortable using a smartphone should consider using a phone app to change volume and other device settings. Dave Fabry, chief hearing health officer at Starkey, a major hearing aid manufacturer, said he has patients in their 80s and 90s “who’ve found that being able to hold a phone and use larger visible controls is easier than manipulating the hearing aid.”

If that’s too difficult, try a remote control. GN ReSound, another major manufacturer, has designed one with two large buttons that activate the volume control and programming for its hearing aids, said Megan Quilter, the company’s lead audiologist for research and development.

Check out accessories

Say you’re having trouble hearing other people in restaurants. You can ask the person across the table to clip a microphone to his shirt or put the mike in the center of the table. (The hearing aids will need to be programmed to allow the sound to be streamed to your ears.)

Another low-tech option: a hearing aid clip that connects to a piece of clothing to prevent a device from falling to the floor if it becomes dislodged from the ear.

Wear your hearing aids all day

“The No. 1 thing I hear from older adults is they think they don’t need to put on their hearing aids when they’re at home in a quiet environment,” said Erika Shakespeare, who owns Audiology and Hearing Aid Associates in La Grande, Oregon.

That’s based on a misunderstanding. Our brains need regular, not occasional, stimulation from our environments to optimize hearing, Shakespeare explained. This includes noises in seemingly quiet environments, such as the whoosh of a fan, the creak of a floor, or the wind’s wail outside a window.

“If the only time you wear hearing aids is when you think you need them, your brain doesn’t know how to process all those sounds,” she told me. Her rule of thumb: “Wear hearing aids all your waking hours.”

Consult a hearing professional

Everyone’s needs are different, so it’s a good idea to seek out an audiologist or hearing specialist who, for a fee, can provide guidance.

“Most older people are not going to know what they need” and what options exist without professional assistance, said Virginia Ramachandran, the head of audiology at Oticon, a major hearing aid manufacturer, and a past president of the American Academy of Audiology.

Her advice to older adults: Be “really open” about your challenges.

If you can’t afford hearing aids, ask a hearing professional for an appointment to go over features you should look for in over-the-counter devices. Make it clear you want the appointment to be about your needs, not a sales pitch, Reed said. Audiology practices don’t routinely offer this kind of service, but there’s good reason to ask since Medicare started covering once-a-year audiologist consultations last year.

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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The decades-long quest for lab-grown organs https://www.popsci.com/science/lab-grown-organs/ Mon, 04 Mar 2024 14:00:00 +0000 https://www.popsci.com/?p=605137
"Now we're groing human life in a laboratory" from the Popular Science June 1962 issue.
"Now we're groing human life in a laboratory" from the Popular Science June 1962 issue. Popular Science

After more than half a century, researchers are still trying to figure out how to engineer individualized organs in a lab.

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"Now we're groing human life in a laboratory" from the Popular Science June 1962 issue.
"Now we're groing human life in a laboratory" from the Popular Science June 1962 issue. Popular Science

From cities in the sky to robot butlers, futuristic visions fill the history of PopSci. In the Are we there yet? column we check in on progress towards our most ambitious promises. Read more from the series here.

Decades before the first “test tube babies,” there were “biological cradles.” In fact, artificial wombs, which may soon be entering human trials for high-risk premature babies, got their start as far back as the early 1960s when researchers developed devices and methods to grow human embryos in a lab for as long as 50–60 days.

“This is not the relatively simple tissue culture,” Popular Science associate editor Joan Steen explained in June 1962, “where highly specialized cells like bone marrow or liver are kept growing in glass dishes fed by nutrient broths.” 

Steen visited the lab of a surgeon in Italy, Daniele Petrucci, who had been developing embryos for their potential to support organ transplants. “This is growing the whole organism from scratch,” Steen wrote. “Taking the microscopic human egg cell and attempting, against all odds, to fertilize it and keep it alive for a long time.” 

Much has changed in embryo research since 1962. From growing and printing synthetic organs to cellular reprogramming to artificial wombs, what scientists have learned from embryo studies has been breathtaking. But we still can’t sustain human embryos outside a womb for very long, and, more than a half century on, Petrucci’s vision of lab-grown organs remains mostly experimental. 

Ectogenesis, the process of growing a human from conception to birth outside a body, is still the stuff of science fiction, ominously portrayed by Aldous Huxley in Brave New World, where lab-grown babies are engineered into social castes. In part, that’s because, by the 1970s, ethical concerns about embryo research led to funding restrictions, laws, and research regulations that have limited what scientists can explore. But it’s also because we have a long way to go in understanding the complex and nuanced placental interchange between the fetus and the pregnant person’s body.

“The challenge is the placenta does the work of a whole bunch of body systems during gestation,” says Michelle Oyen, Director of the Center for Women’s Health Engineering at Washington University in St. Louis. “You can’t just grow something independent of the vascular system, the lymph system, the nervous system—you need to have all of those connections, and that’s why it starts to become so complicated.”

The first successful “test tube baby,” Louise Brown, was born in 1978, paving the way for in vitro fertilization (IVF) as a solution for infertile couples. Since then, at least 12 million babies have been born using IVF, according to the International Committee for Monitoring Assisted Reproductive Technologies. But “test tube babies” are not actually grown in a lab for more than a handful of days before the fertilized egg is transferred to a uterus or frozen and stored for future transfer. (The procedure has recently become the focus of legal scrutiny after the US Supreme Court overturned Roe v. Wade in June 2022 and the Alabama Supreme Court ruled in February 2024 that frozen embryos are children.)

Brown’s birth signaled just how far scientists had come with embryo research, which set off alarms. A year later, in 1979, the US Department of Health Education and Welfare implemented the 14-day rule, prohibiting the growth of embryos in a lab beyond 14 days, citing ethical concerns. The restriction was widely adopted globally, limiting researchers’ ability to study later stages of embryonic development or to grow embryos for organ transplants. 

As a result, human embryo and fetal development between 14 days and viability (roughly 22–24 weeks) is a kind of black box that scientists have been trying to explore in other ways. At the Center for Women’s Health Engineering, Oyen applies engineering tools and techniques to study that crucial developmental period about which so much remains unknown. 

“I do a lot of computational modeling and image-based analysis,” Oyen explains. She also uses organ-on-a-chip models, which involves growing miniature tissues, or organoids—like placentas, lungs, hearts, even brains—on the type of chip that resembles a computer chip, carved with microchannels used to deliver fluids necessary to maintain the tissue while also providing direct means to monitor tissue growth. Organoids have been useful for drug testing and organ-specific research but have yet to advance to the point of providing regenerated organs for replacement therapy.

[ Related: A ‘brain organoid’ biochip displayed serious voice recognition and math skills ]

To grow organoids—and organs—requires some form of stem cell, generally an embryonic stem cell, an adult stem cell, or an adult stem cell that has been reprogrammed to an embryonic state, also known as an induced pluripotent stem cell (iPSC). 

Embryonic stem cells are the most versatile; they start as blank slates, capable of developing into any type of cell, such as brain, skin, or liver. It’s their versatility that makes them so attractive to scientists seeking regenerative cures. The field of epigenetics, which can be traced back to the 1940s, explores the extrinsic factors that influence how an embryonic stem cell develops. 

It wasn’t until 1998 that embryonic stem cells were successfully isolated by scientist James Thomson at the University of Wisconsin in Madison. Thomson’s discovery led to further restrictions on embryonic stem cell research, especially in the US.

By the early 2000s, the quest for human embryonic stem cell lines to fuel research led to therapeutic cloning, which enabled scientists to develop embryonic stem cell lines without relying on fertilization or surplus eggs from IVF clinics. Using such approved embryonic stem cell lines, researchers have been able to grow artificial embryos, or embryoids, that don’t require a separate sperm and egg. Of course, the 14-day rule still applies, which means the embryoid needs to be destroyed before it can develop further, although exceptions have been suggested since embryoids lack potential to develop into a functional fetus. 

The restrictions imposed between the 1970s and early 2000s helped spur other approaches to stem cell research, not for the goal of growing humans artificially, rather with an eye toward understanding the very early stages of human development and toward regenerative medicine, the kind Petrucci envisioned—using stem cells to grow or regrow organs, cure or prevent diseases, and even reverse aging. 

Adult stem cells, for instance, are not bound by the same research restrictions that govern embryonic stem cells. Adult stem cells, like the kind found in cord blood (yes, stem cells in infant cord blood are considered “adult”) and bone marrow, have regenerative properties, but their potential is limited by their advanced developmental stage. They cannot be induced to develop into any other cell unless they are “reprogrammed” first.

Cellular reprogramming, coaxing one cell type to convert to another by reprogramming it into an embryonic state, was first attempted in the 1980s and later advanced by Nobel Prize recipient Shinya Yamanaka. Today, scientists can revert mature cells, like skin cells, back to their embryonic, or pluripotent state (such cells are known as induced pluripotent stem cells, or iPSCs), enabling them to start fresh, regrowing into different tissue, like liver cells. 

Beyond the obvious and significant ethical concerns, Petrucci’s model of growing organs via an embryo—a very small clone with perfectly matched tissue—would have been seriously inefficient, like building an entire house just to use one room.

3D bioprinting, however, using stem cell-based bioinks, shows promise. Researchers have successfully printed a variety of human organs such as kidneys, blood vessels, bones, muscle and skin tissue, and even a functioning heart.

[ Related: Scientists have 3D bioprinted functioning human brain tissue ]

But Oyen thinks it will be a while before growing or bioprinting organs will be reliable, pointing out that “you can’t engineer things without having the science. And that means this black box of early development is a real problem in trying to correctly and successfully recapitulate development of an organ.” She notes that there have been modest commercial successes like growing skin tissue for skin grafts, but “getting to that point where we’re using individualized stem cells from individual people to make a tissue-engineered graft is still in the future.”

It has been more than half a century since Petrucci shared with Popular Science his efforts to grow embryos in a lab for the purposes of human organ replacement. Since then, embryo research has pushed the boundaries of science, ethics, and our social conscience. While significant progress has been made in understanding the behavior and potential of embryonic stem cells (and other stem cells), we still can’t engineer organs reliably.

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A beginner-friendly guide to the perfect push-up https://www.popsci.com/diy/how-to-do-a-pushup-beginner/ Fri, 01 Mar 2024 16:32:00 +0000 https://www.popsci.com/?p=605113
a woman in a pushup position on the floor
You have to start somewhere. E+/Getty

Personal trainers share their advice on how to hit your push-up goals if you're struggling.

The post A beginner-friendly guide to the perfect push-up appeared first on Popular Science.

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a woman in a pushup position on the floor
You have to start somewhere. E+/Getty

With all the exercise machines at the gym and countless number of workout videos online, it can feel intimidating about where to start. When in doubt, you can’t go wrong with the basics. 

Push-ups are a classic way of strengthening your body. Beyond toning your chest, pushups activate muscles in your back, hamstrings, abs, quads, and triceps. Another perk is that you don’t need fancy equipment or a gym membership—just yourself and some space on the floor. There’s only one catch: Push-ups are notoriously hard to do correctly but not impossible.

There are several reasons you might have trouble doing a single push-up. Some might be as minor as correcting your form or practicing breathwork. Others involve working on your current strength level. No matter where you’re at on your fitness journey, mastering the push-up will be challenging but worth the effort.

How to fix improper push-up position

First, check your form. An incorrect stance can make it difficult to engage the right muscles. 

Try this step-by-step guide to conquer the proper push-up position: 

  • A push-up involves getting into a high plank position with arms fully extended and shoulder-width apart. 
  • Your palms are on the floor and wrists are right under your shoulders. 
  • The legs should extend back with your feet hip-width apart. 
  • Bend your elbow to a 90-degree angle (pointing back towards your feet) 
  • Lower your whole body before pushing back up. 
  • Throughout the push-up, you should have your head in line with your spine with your gaze down a few inches in front of your hands instead of looking up.
Fitness & Exercise photo

A common issue for people having trouble with push-ups is maintaining their body in a straight line, says Ashley Carter, a personal trainer and health coach in Washington D.C. People may unknowingly dip their hips or spread their hands too far forward because they have trouble supporting the plank position. If stance is an issue, Carter recommends perfecting your plank first before trying a push-up. You can use a mirror to watch your form and adjust when needed. 

[Related: The 6 essential parts of an effective workout]

Another form issue is flaring the elbows out like chicken wings. Carter says many people tend to angle their elbows down into a V because it takes away some of the tricep work by engaging more of the chest. Additionally, when bringing your elbows up, you’ll want to keep them straight but slightly bent to avoid hyperextension. Locking out the elbows can put more stress on your wrists and lead to possible injury.

Engaging the core is essential for maintaining the proper push-up stance and avoiding pain in your lower back and wrist, which may be used to compensate for the lack of core control. Carter advises to draw your belly button to your spine, a feeling similar to bracing for a punch in the gut. Additionally, squeezing the thighs and glutes activates those muscles, giving you the power to push yourself back up while keeping the spine neutral.

Stop holding your breath

People unconsciously forget to breathe when concentrating on a difficult activity. The same goes when you’re focusing on completing a push-up. 

Sergio Pedemonte, a personal trainer and owner of Your House Fitness in Toronto, says taking a deep breath and holding it can help engage the core. However, releasing the breath is just as important as the muscles need oxygen to get through a strenuous workout. Forgetting to breathe out can tire out your muscles more quickly.

Take a deep breath as you lower yourself down, Pedemonte tells PopSci. You should hold your breath for one to two seconds while engaging the core and then exhale as you are coming back up.

Weak upper body or core muscles 

If your problem is being unable to hold yourself as you lower down, Pedemonte recommends using a chest press machine to strengthen the pectorals, triceps, and deltoid muscles. “It’s great for people who don’t have balance or are starting from zero,” he explains. “I just want you to focus on pushing and then pulling back.” A higher progression is a dumbbell chest press where you lie down on your back with knees flat on the floor and arms extended. Each arm should hold two dumbbells where you’ll lower them to your chest at the same time before lifting them back up again. 

Fitness & Exercise photo

[Related: These heart-pumping exercises burn the most calories]

If you’re sagging your hips, consider adding more core-centric exercises. In addition to planks, Pedemonte recommends anti-rotational movements such as Pallof press exercises to strengthen the abdominal muscles. Standing parallel to a cable machine, you grip the cable at chest height and pull it away until your arms are extended before bringing it back to your chest. Unlike traditional abdominal workouts like crunches, the exercise challenges you to keep your core engaged so your midsection stays still even when your arms are in motion. 

Fitness & Exercise photo

Work your way up to a traditional push-up

Everyone’s fitness level is different, and sometimes that calls for regressions or progressions. If you are someone who’s having trouble with push-ups, there are several variations you can try that are less physically demanding on your body. While regressions scale back the intensity of the workout, it is not an easier workout. It still challenges your muscles but allows you to maintain a more consistent form and complete it at a more consistent pace. 

Carter recommends hand elevated push-ups for someone new to this workout. Also known as an incline push-up, you can place your hands on an elevated surface like a bench or a chair. The workout helps build upper body strength by activating several muscles in your arm, chest, and core while putting less stress on the elbow. Additionally, the higher angle has you lift less of your body weight compared to traditional push-ups. Carter adds that “the farther you are off the ground, the easier it’s going to be.”

Another beginner-friendly variation is wall and knee push-ups. Like a regular push-up, you’re pressing yourself away before pulling back. Doing it against a wall uses less upper body strength, easing pressure off your shoulder joints and wrists. Knee-pushups are slightly more challenging than wall push-ups, but still take some of the body weight load off than if you were pushing up from your toes.

Once you’ve gotten used to some of the easier regressions, you might ask yourself when it’s time to move up to a harder variation. That’s up to a person’s individual goals. Carter recommends having a certain number of reps you want to accomplish and adding one or two harder variations each time. Pedemonte says you can check your progress by seeing if you can complete five repetitions in three to five sets in a slow and controlled manner. 

Fitness & Exercise photo

No matter how you train, don’t beat yourself up if you aren’t seeing results immediately. Pedemonte says the most important thing is consistency. Keep challenging yourself and listen to your body when it is time to rest. The results will show up if you keep showing up. 

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CDC recommends Americans 65 and over get additional COVID-19 vaccine https://www.popsci.com/health/covid-19-vaccine-booster-time-65/ Fri, 01 Mar 2024 14:06:03 +0000 https://www.popsci.com/?p=605101
A doctor puts a bandage on the upper arm of a senior citizen.
The most recent vaccines are about 54 percent effective at preventing symptomatic illness from COVID-19. Deposit Photos

The virus remains a serious threat, particularly to this age group.

The post CDC recommends Americans 65 and over get additional COVID-19 vaccine appeared first on Popular Science.

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A doctor puts a bandage on the upper arm of a senior citizen.
The most recent vaccines are about 54 percent effective at preventing symptomatic illness from COVID-19. Deposit Photos

The Centers for Disease Control and Prevention (CDC) is recommending that Americans ages 65 and older get a second dose of this season’s COVID-19 vaccine. Under this new guidance, an additional dose of the vaccine can be given at least four months after the previous shot. 

[Related: mRNA vaccine innovators win the Nobel Prize in medicine.]

“Most COVID-19 deaths and hospitalizations last year were among people 65 years and older,” CDC Director Dr. Mandy Cohen said in a statement. “An additional vaccine dose can provide added protection that may have decreased over time for those at highest risk.”

A CDC report published in February said that the 2023-2024 COVID-19 vaccine is about 54 percent effective at preventing symptomatic COVID-19, compared with those who had not received the latest vaccine. The CDC estimates that only 22 percent of adults in the US have gotten a COVID-19 booster this season. A little over 40 percent of Americans ages 65 and over have gotten the 2023-2024 shot.

The CDC’s independent Advisory Committee on Immunization Practices voted 11-1 with one abstention on the new recommendations. A subgroup of advisers suggested softer language in the recommendation that would have suggested that older adults “may” get a second dose of the vaccine instead of “should.” These committee members felt that this language shift would have given clinicians added flexibility and also takes growing vaccine hesitancy into account. 

According to The Washington Post, Camille Kotton of Massachusetts General Hospital in Boston pushed for stronger language so that the recommendations would be more clear to patients. Kotton said that using the word “may” is “too soft, especially for the most vulnerable,” and that many Americans remain unaware that they should be getting a COVID-19 vaccine.

CDC data shows that older adults have been the most vulnerable to COVID-19’s most severe effects. Hospitalizations related to the virus have been consistently higher in this age group than others, with about two-thirds of COVID-19 hospitalizations occurring in patients over 65. Senior citizens also make up the largest proportion of those who have died in the hospital from COVID-19 and have the highest numbers to fatalities after being discharged from the hospital. 

[Related: How to check your measles vaccination status amid outbreak.]

COVID-19 remains a threat. The CDC reports that there were roughly 20,000 new hospital admissions and 2,000 COVID-19 deaths per week as of February 17. Even when reported cases were at their lowest in summer 2023, about 500 Americans were still losing their lives to COVID-19 every week. 

Updates vaccines are available at most pharmacies and at doctors offices. 

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Watch the plasma fly in space capsule’s dramatic fall to Earth https://www.popsci.com/science/space-capsule-reentry-video/ Thu, 29 Feb 2024 21:45:00 +0000 https://www.popsci.com/?p=605067
Varda W-1 capsule reentry video screenshot
After 8 months in orbit, Varda's first reusable capsule made a safe return to Earth on Feb. 21. Varda / YouTube

Varda's W-1 spent 8 months in orbit before recording its entire trip home.

The post Watch the plasma fly in space capsule’s dramatic fall to Earth appeared first on Popular Science.

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Varda W-1 capsule reentry video screenshot
After 8 months in orbit, Varda's first reusable capsule made a safe return to Earth on Feb. 21. Varda / YouTube

It took less than 30 minutes for Varda Space Industries’ W-1 capsule to leave its orbital home of eight months and plummet back to Earth. Such a short travel time not only required serious speed (around 25 times the speed of sound), but also the engineering wherewithal to endure “sustained plasma conditions” while careening through the atmosphere. In spite of these challenges, Varda’s first-of-its-kind reentry mission was a success, landing back on the ground on February 21. To celebrate, the company has released video footage of the capsule’s entire descent home.

Check out W-1’s fiery return below—available as both abbreviated and extended cuts:

Installed on a Rocket Lab Photon satellite bus, Varda’s W-1 capsule launched aboard a SpaceX Falcon 9 rocket June 12, 2023. Once in low-Earth orbit, its mini-lab autonomously grew crystals of the common HIV treatment drug ritonavir. Manufacturing anything in space, let alone pharmaceuticals, may seem like overcomplicating things, but there’s actually a solid reason for it. As Varda explains on its website, processing materials in microgravity may benefit from a “lack of convection and sedimentation forces, as well as the ability to form more perfect structures due to the absence of gravitational stresses.”

In other words, medication crystals like those in ritonavir can be grown larger and more structurally sound than is typically possible here on Earth.

Although the experiment wrapped up in just three weeks, Varda needed to delay reentry plans multiple times due to issues securing FAA approval. After finally getting the go-ahead, the W-1 readied for its return earlier this month. All the while, it contained a video camera ready to capture its dramatic fall.

Private Space Flight photo

After ejecting from its satellite host, W-1 begins a slightly dizzying spin that provides some incredible shots from hundreds of miles above Earth. At about the 12-minute mark, the planet’s gravitational pull really takes hold—that’s when things begin to heat up for Varda’s experimental capsule.

[Related: First remote, zero-gravity surgery performed on the ISS from Earth (on rubber)]

At Mach 25 (around 17,500 mph), exterior friction between the craft and Earth’s atmosphere becomes so intense that it literally splits the chemical bonds of nearby air molecules. This results in a dazzling show of sparks and plasma before W-1’s parachute deploys to slow and stabilize its final descent. Finally, the capsule can be seen touching down in a remote region of Utah, where it was recovered by the Varda crew.

Next up will be an assessment of the space-grown drug ingredients, and additional launches of capsules for more manufacturing experiments. While they might not all include onboard cameras to document their returns, W-1’s is plenty mesmerizing enough.

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How to check your measles vaccination status amid outbreak https://www.popsci.com/health/check-measles-vaccination-status/ Tue, 27 Feb 2024 17:00:00 +0000 https://www.popsci.com/?p=604520
A syringe with a measles, mumps, and rubella (MMR) vaccine next to its packaging.
Two doses of the Measles, Mumps, and Rubella (MMR) vaccine are about 97 percent effective at preventing measles. Paul Hennessy/NurPhoto via Getty Images

There have been 35 reported cases of the highly-contagious disease so far this year.

The post How to check your measles vaccination status amid outbreak appeared first on Popular Science.

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A syringe with a measles, mumps, and rubella (MMR) vaccine next to its packaging.
Two doses of the Measles, Mumps, and Rubella (MMR) vaccine are about 97 percent effective at preventing measles. Paul Hennessy/NurPhoto via Getty Images

The Florida Department of Health is investigating eight cases of measles due to an outbreak of the highly contagious disease in a school in Broward County. Six of the previously known cases are in students from Manatee Bay Elementary School, in the town of Weston, near Fort Lauderdale. New data from the state shows two more cases this week in Broward County, one case in a child under five and another in a child between five and nine-years-old. 

[Related: Some vaccinated adults may not be protected against measles.]

The United States officially got rid of endemic measles in 2000. However, the illness has begun to circulate in the US and around the world due to widespread misinformation and challenges from the COVID-19 pandemic

These new cases come just a few days after Florida Surgeon General Doctor Joseph Ladapo contradicted both medical and federal guidance on when students can return to school and how to contain the spread of this preventable disease. 

What is measles?

Measles is a highly contagious respiratory disease. It is estimated that 90 percent of non-immune people exposed to an infected individual will contract the virus. Symptoms may include, cough, runny nose, watery eyes, fever, and red spots that look like a rash. It is spread through coughs and sneezes and can linger in a room for up to two hours. 

In some rare cases, measles may lead to pneumonia, encephalitis, or death. It can also weaken a patient’s immune system, making fighting future illnesses more difficult. 

How do I know if I’ve been vaccinated?

There is no one national organization that maintains vaccination records in the US. According to the CDC, a good first step is to ask parents or guardians for copies of vaccination records. These are sometimes kept in baby books, photo albums, or filing cabinets since most vaccinations are given during early childhood. 

[Related: What to know about polio boosters, oral vaccines, and your medical history records.]

If you do not have a copy at home, contact your pediatrician or doctor’s office. Depending on your age, this could take a while since records may be in deep storage. Your high school or college may also have medical records still on file. Older adults also may need additional doses of the measles vaccine

You can also reach out to your state’s health department, since some have registries called Immunization Information Systems. These may even include adult vaccines, like those for shingles or yearly flu and COVID-19 shots. 

If you have moved to the US from another country, vaccination information may have also been collected during the visa process. Paperwork from the medical exam may have proof of certain vaccinations.

A last step is making an appointment with a doctor or pharmacy to have a blood titer test to see what level of immunity you have to measles, chicken pox, and other diseases. This is also where you can set up an appointment for a booster or first round of vaccinations. Those vaccinated against measles are about 97 percent protected against the virus. 

What is happening in Florida?

Typically, doctors and public health officials recommend children who are not vaccinated for measles isolate for a period of 21 days if they are exposed to the virus at school. In the letter sent to parents and guardians at Manatee Bay Elementary School, Dr. Ladapo, said it was up to individual families to determine when their children can return to school.

“Because of the high likelihood of infection, it is normally recommended that children stay home until the end of the infectious period,” the letter dated February 20 read. However, Ladapo continued saying that the state “is deferring to parents or guardians to make decisions about school attendance. This recommendation may change as epidemiological investigations continue.”

[Related: The deadliest viruses in human history, from COVID to smallpox.]

This break from traditional protocol has some physicians in the area concerned. According to family physician and public health specialist Doctor George Rust, most students in Florida public schools have been vaccinated, but that number has started to decline in recent years.

“There’s the possibility that children who are not immunized and who are susceptible to measles are attending school, potentially getting measles and then transmitting it to other kids,” Rust told CNN. “Now, you’ve, on the one hand, allowed parents to make their own choices for the child who was not immunized, but you’ve also taken away some choices for those parents who may feel that their children should be protected.”

Why is measles having a resurgence?

Florida is one of 11 states who have seen cases this year alone. According to The Centers for Disease Control and Prevention (CDC), there have been 35 measles cases reported in 15 states already this year. By comparison, there were 58 reported cases in 2023 alone. 

The current resurgence can be tied to vaccine hesitancy and misinformation surrounding the Measles, Mumps, and Rubella (MMR) vaccine and a struggle in vaccinating young children due to the COVID-19 pandemic. The CDC warned physicians to “stay alert for measles” in January, as more cases emerged particularly among unvaccinated children and adolescents. 

In the US, about 92 percent of children had received their MMR vaccine by the age of two in 2023. However, this is below the federal target for herd immunity of 95 percent vaccinated. 

The post How to check your measles vaccination status amid outbreak appeared first on Popular Science.

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Gene-edited pigs immune to deadly virus could arrive on farms by next year https://www.popsci.com/environment/gene-edited-pigs/ Fri, 23 Feb 2024 19:00:00 +0000 https://www.popsci.com/?p=604074
Pigs in sty at factory farm
Animal rights groups say the solution remains factory farming reforms, not genetic editing. Deposit Photos

A company used CRISPR to make the animals resistant to deadly diseases, but watchdogs say viruses are not the problem.

The post Gene-edited pigs immune to deadly virus could arrive on farms by next year appeared first on Popular Science.

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Pigs in sty at factory farm
Animal rights groups say the solution remains factory farming reforms, not genetic editing. Deposit Photos

US farmers are closer than ever to raising genetically edited pigs immune to one of the animal’s deadliest diseases. But while millions of dollars could be saved with livestock impervious to highly virulent, diverse strains of porcine reproductive and respiratory syndrome (PRRS), animal rights groups maintain the cutting-edge idea isn’t an ethical solution, but yet another industrial farming stopgap.

PRRS is a dynamic, often fatal virus that affects millions of pigs around the world and costs farmers as much as $2.7 billion each year. Current vaccines only reduce symptom severity, and the antibiotics used to treat an infected pig’s weakened immune system can exacerbate the development of other resistant bacterial diseases.

[Related: Scientists swear their lab-grown ‘beef rice’ tastes ‘pleasant’]

Genus, an international breeding company, believes the best way to solve this major issue is to engineer pigs that are incapable of contracting the virus. As highlighted in a recent New Scientist profile, Genus researchers succeeded through CRISPR gene editing technology. By removing a portion of protein called CD163, the disease cannot infect a pig’s cells and allows the animal to remain “healthy and indistinguishable in appearance and behavior,” according to a Genus research study recently published in The CRISPR Journal.

Doing so isn’t an easy task. Just one-fifth of Genus-bred piglets possessed the desired gene—and even then, only within certain body cells due to a biological condition known as mosaicism. Meanwhile, some lab livestock may have lacked CD163, but at the cost of other unwanted genome changes.

Because of such issues, experts have spent years attempting to create a healthy, gene-edited animal. Genus says it has so far bred hundreds of PRRS-immune pigs, and expects to receive approval from the US Food and Drug Administration to begin public sales as soon as next year. Meanwhile, regulatory approvals are also being pursued globally in countries including China and Mexico—both of which import large amounts of US pork.

But according to factory farming critics and animal rights advocates, the real issue isn’t livestock disease susceptibility—it’s the livestock’s living conditions. According to the international welfare nonprofit World Animal Protection, farm stock receives three-quarters of global antibiotic supplies each year in an attempt to stave off disease, treat infections, and promote faster growth rates. Doing so is directly linked to the rise in treatment-resistant superbugs, which are more likely to leap between animals to humans within a factory farm’s cramped, poorly ventilated environments.

“Crowding animals into stressful, unhealthy conditions has led to the emergence of new virulent pathogens and diseases,” Gene Baur, President and Co-Founder of the animal rights group Farm Sanctuary, said in an email to PopSci. “Rather than developing genetically engineered animals who can survive the horrific cruelties of factory farming, agribusiness should focus instead on addressing the conditions that create these diseases in the first place.”

The post Gene-edited pigs immune to deadly virus could arrive on farms by next year appeared first on Popular Science.

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Everything you need to know about cholesterol https://www.popsci.com/health/what-is-cholesterol/ Fri, 23 Feb 2024 12:00:00 +0000 https://www.popsci.com/?p=603582
Cholesterol is a lipid, a fat-like substance. However, the cholesterol particles circulating in blood vessels come in a variety of forms.
Cholesterol is a lipid, a fat-like substance. However, the cholesterol particles circulating in blood vessels come in a variety of forms. Science Photo Library / Getty Images

The latest science on how blood levels of HDL, LDL and more relate to cardiovascular health.

The post Everything you need to know about cholesterol appeared first on Popular Science.

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Cholesterol is a lipid, a fat-like substance. However, the cholesterol particles circulating in blood vessels come in a variety of forms.
Cholesterol is a lipid, a fat-like substance. However, the cholesterol particles circulating in blood vessels come in a variety of forms. Science Photo Library / Getty Images

This article was originally featured on Knowable Magazine.

When C. Michael Gibson of Boston saw his doctor in the spring of 2023, the blood test results were confusing. His cholesterol levels were decent—he was already taking statins to keep the “bad” cholesterol low—but the arteries delivering blood to his heart were nonetheless crammed with dangerous plaque. “It didn’t make sense,” says Gibson, himself a cardiologist at Beth Israel Deaconess Medical Center.

So Gibson asked his physician to check his blood for a specific kind of cholesterol called lipoprotein(a). And there was the explanation: He had more than double the normal amount of that cholesterol. Gibson turned out to be one of the unlucky people who has inherited a predisposition toward high lipoprotein(a) levels; he suspects that his grandfather, who died of a heart attack at age 45, had it too.

About one in five people have this unfortunate heritage, and there’s nothing they can do to combat it—but soon that might change. Scientists are researching medications that can lower lipoprotein(a), as well as other approaches that could slash the risk of cardiovascular disease more than drugs like statins can.

Statins, approved in the late 1980s to lower levels of low-density lipoprotein (LDL) cholesterol, have been a lifesaving tool: They cut risk of heart attack and stroke by up to 50 percent for the more than 200 million people globally who take the medications. Yet even statin takers still get heart disease, and some still die. Cardiovascular disease remains the leading cause of death in the United States and across the world. Clearly, something’s been missing from the cholesterol picture.

The picture coming into focus today incorporates not just bad, LDL cholesterol and good, high-density lipoprotein (HDL) cholesterol, but also lipoprotein(a) and a poorly understood substance called “remnant cholesterol.” Medical researchers aim to minimize all of these except HDL. And HDL cholesterol itself, though it’s still understood to be beneficial, has turned out to be more complex than anticipated. Various attempts to raise HDL levels haven’t improved people’s health beyond what statins already achieve.

Yet despite this and other disappointments in which medicines haven’t panned out as expected, many researchers feel optimistic about treatments currently in clinical trials. “It’s really an exciting time,” says Stephen Nicholls, a cardiologist at Monash Health in Melbourne, Australia.

The list of drugs used to address high LDL cholesterol is growing. Credit: Knowable Magazine
The list of drugs used to address high LDL cholesterol is growing. Credit: Knowable Magazine

LDL cholesterol

Though it gets a bad rap among the health-conscious, cholesterol plays important roles in our body: It helps to control the stability and fluidity of cell membranes and is an important starting ingredient for making hormones such as testosterone and estrogen. What matters for our health is the company that the cholesterol molecule keeps when it travels.

Its waxy nature means it can’t mix well with water, so it can’t pass through the bloodstream on its own: Lone cholesterol molecules would separate out, like oil does in water. Cholesterol’s solution is to join up with complexes of proteins and fats, called lipoproteins, that carry it around. These lipoprotein carriers include LDL, HDL and other types. Cholesterol, in addition to being cargo, is a structural part of these carriers, too.

Lipoproteins are made in the gut and liver, and they deliver cholesterol and fat to body tissues. Fat goes to muscles, to be used for energy, or to fat tissue for storage. Cholesterol is dropped off in tissues to be incorporated into cell membranes or made into hormones. Cholesterol can also be returned to the liver where it can be stored, incorporated into new lipoproteins, turned into bile acids used by the digestive system to break down fats, or sent to be excreted.

When the delivery particles from the liver have dropped off most of their fats, they become LDL particles, which are still jam-packed with cholesterol. The problem happens when these LDL particles, instead of returning to the liver to be recycled, squeeze into blood vessel walls and get chemically modified. There, they incite or exacerbate an immune reaction called inflammation. In response, immune cells come in to eat LDL particles—but if they eat too much, they can get stuck in the blood vessel wall. This forms the beginnings of an atherosclerotic plaque.

Over time, that plaque accumulates more cholesterol, more fat and more immune cells, reducing the space through which blood can flow and deliver oxygen to tissues. If a plaque limits blood supply to the heart, it might cause chest pain called angina. A plaque might also lead to formation of a blood clot, which may break off and clog vessels elsewhere. The clot might cause a stroke in the brain, for example, or a heart attack.

Today, it’s clear that the less LDL cholesterol in the bloodstream, the better. Statins are good at achieving this, cutting LDL cholesterol levels by up to about half. And for those who need a bigger effect, or who can’t tolerate statins (muscle pain or weakness is an occasional side effect), there are newer medicines. “We now have the ability to get almost anyone’s LDL cholesterol down into the range that we would consider appropriate,” says Steven Nissen, a cardiologist at the Cleveland Clinic in Ohio.

As cholesterol moves around the body within various protein- and fat-containing particles, it aids in important functions but also has the potential to create health risks. Credit: Knowable Magazine
As cholesterol moves around the body within various protein- and fat-containing particles, it aids in important functions but also has the potential to create health risks. Credit: Knowable Magazine

Lipoprotein(a)

But these LDL-cholesterol treatments generally don’t do much against levels of lipoprotein(a), pronounced “lipoprotein-little-a.” This substance, composed of LDL cholesterol particles plus an extra protein, apolipoprotein(a), is mysterious: Scientists don’t know what its natural job is, though since apolipoprotein(a) has some similarity to a protein involved in blood clotting, it might have a role in wound healing. But it can’t be all that important to animal survival: Weirdly, the gene that carries instructions for making apolipoprotein(a) is found only in certain primates. (A similar gene evolved in hedgehogs.)

It’s also unclear why lipoprotein(a) is such a bad version of cholesterol, but it’s clearly up to no good much of the time. It delivers cholesterol to the blood vessel walls like LDL does, promotes blood clotting that blocks arteries and can cause inflammation and increase the risk of clots. And if your lipoprotein(a) is high—too bad. “Statins won’t get it down,” laments Gibson. “Exercise doesn’t get it down. Diet doesn’t get it down.”

Some of the newer LDL cholesterol-lowering drugs can reduce lipoprotein(a) cholesterol a bit, but probably not enough to significantly reduce cardiovascular risk, says Anand Rohatgi, a cardiologist at the University of Texas Southwestern Medical Center in Dallas. The only thing physicians can do, in extreme cases, is to regularly administer a blood-cleaning procedure called apheresis to remove lipoprotein(a).

Lipoprotein particles are made up of a core containing fat in the form of triglycerides and cholesterol in the form of cholesteryl esters, surrounded by phospholipids, free cholesterol molecules and apolipoprotein. Credit: Knowable Magazine
Lipoprotein particles are made up of a core containing fat in the form of triglycerides and cholesterol in the form of cholesteryl esters, surrounded by phospholipids, free cholesterol molecules and apolipoprotein. Credit: Knowable Magazine

For a long time, doctors ignored lipoprotein(a). “Nobody measured it, because you could not do anything about it,” says Prakriti Gaba, a cardiologist at Brigham and Women’s Hospital in Boston. That may be about to change now that several groups are testing medicines that target the substance. (Gaba got her own levels checked at a cardiology conference, where booths offering free tests have sprung up recently.)

Many of these experimental medications use genetic technology to silence the apolipoprotein(a) gene. In a handful of small studies, involving dozens to a few hundred subjects each, different apolipoprotein(a)-silencing therapies cut lipoprotein(a) levels by varying levels, from no change up to 92 percent. But it isn’t yet known whether cutting lipoprotein(a) will actually reduce cardiovascular problems. “We won’t know for a while,” says Leslie Cho, a cardiologist at the Cleveland Clinic who’s coleading one of the trials.

Cho’s HORIZON study, the farthest along, is testing a lipoprotein(a)-gene-silencing treatment compared to a placebo in more than 8,300 people with high lipoprotein(a) and a history of heart problems such as heart attack or stroke. The hope is that reducing lipoprotein(a) will decrease the rate of heart attacks, strokes, need for a medical procedure to improve blood flow, and death, but HORIZON isn’t expected to have results until 2025. Another trial that Gaba is involved in, called OCEAN(a)-Outcomes, is testing a similar approach in about 6,000 people, but is not expected to be completed until the end of 2026.

HDL cholesterol

Just as lipoprotein(a) and LDL cholesterol are known as the baddies, HDL cholesterol has long been considered a good guy. HDL particles are thought to help by sucking cholesterol out of plaques. The HDL then takes this cholesterol to the liver for recycling or disposal. It’s the cardiovascular system’s cholesterol “garbage truck,” says Bob Eckel, a retired cardiometabolic physician and professor emeritus at the University of Colorado Anschutz Medical Campus.

If high levels of HDL cholesterol are good, scientists reasoned, then more of this cleanup crew should be even better. Exercising and weight loss can both raise HDL cholesterol. Scientists have tried to do the same with medications—but with disappointing results. The drugs did raise HDL cholesterol levels, yes, but they didn’t save lives in people already on statins, and they were weaker than statins at stopping heart attacks and strokes. To sum it up very simplistically, approaches to raise HDL failed. Nothing really worked,” says Anatol Kontush, a lipid biochemist at the Sorbonne University in Paris.

Lifestyle changes can help to reduce the risk of heart disease. Credit: Knowable Magazine
Lifestyle changes can help to reduce the risk of heart disease. Credit: Knowable Magazine

It’s not entirely clear why raising HDL cholesterol in statin-takers bombed. It might be that the idea of boosting HDL cholesterol was simply wrong. High HDL cholesterol might be a marker for good cardiovascular health, rather than a direct cause of it, says Rohatgi. If so, artificially amplifying its levels wouldn’t help.

But the problem also might have been an overly simplistic understanding of HDL cholesterol. Scientists now know that HDL comes in many types and can do many jobs. In addition to hoovering up cholesterol from plaques, it can fight inflammation—that’s good. But sometimes, HDL can turn bad and promote inflammation instead, Cho says, though it’s not clear how. And, she adds, people who are genetically wired to make too much HDL cholesterol can have an enhanced risk for heart disease.

The problem, then, may be that various drugs meant to amplify HDL cholesterol focused on quantity over quality, and increased the wrong kind of HDL. For example, one promising category of drugs raised HDL levels by inhibiting an enzyme that transfers cholesterol away from HDL particles, giving it to LDL particles. Several studies found these inhibitors failed to improve heart health. It might be that stopping the transfer of cholesterol away from HDL particles means the particles had less capacity to pick up new cholesterol from plaques, leaving the cholesterol to languish there. In other words, these garbage trucks were already full.

So the new plan, a last-ditch effort to save lives with HDL, is to help HDL do its cholesterol-removal job better, rather than to just make more of it. Gibson, for example, is chairing a clinical trial of a medicine called CSL112. It’s made of the key protein component of HDL particles—that is, it’s the starting material for HDL particles but still empty of cholesterol. These CSL112 molecules seem to work by creating new HDL molecules primed to pack in as much cholesterol as they can possibly hold. In a preliminary study of more than 1,200 people, two-thirds of whom received CSL112 infusions, the treatment was safe. And when the scientists took blood samples for lab tests, they found that the higher the dose of CSL112 participants received, the more their blood was able to suck up cholesterol.

Depending on their composition, lipoprotein particles can be of different sizes and densities, from small and dense like HDL to large and less dense like chylomicrons and VLDL. Credit: Knowable Magazine
Depending on their composition, lipoprotein particles can be of different sizes and densities, from small and dense like HDL to large and less dense like chylomicrons and VLDL. Credit: Knowable Magazine

In another study called AEGIS-II, the researchers tested CSL112 infusions in a larger group of people who had just suffered a heart attack and could be most likely to benefit from treatment. Following 18,200 people for a year, it asked whether CSL112 prevents second heart attacks, strokes and death in this population. “That’s a really big, definitive study, and if that doesn’t work, then I suspect the field will completely abandon HDL,” said Nicholls some months back.

In mid-February, CSL of King of Prussia, Pennsylvania—CSL112’s makers—announced that the study did not achieve its main goal of reducing major cardiac events such as stroke, heart attack or death. The researchers are still analyzing the data and will present results in more depth at the American College of Cardiology conference in April.

Triglycerides

If the HDL waters seem murky, the situation with triglycerides, the fatty component of blood that’s carried around in lipoprotein particles, is muddier still. The amount a person has depends on lifestyle: dietexercise and so on. High triglycerides are linked to a greater risk for cardiovascular disease, and very high levels can lead to inflammation of the pancreas, known as pancreatitis. Thus, it made sense to posit that getting rid of triglycerides would be a healthy thing to do, and many studies have attempted just that—with boggling results.

Lipoproteins are made up of protein, fat in the form of triglycerides, and cholesterol — both free cholesterol and a chemically modified, cholesteryl ester, form. The proportion of each varies with lipoprotein type. Credit: Knowable Magazine
Lipoproteins are made up of protein, fat in the form of triglycerides, and cholesterol — both free cholesterol and a chemically modified, cholesteryl ester, form. The proportion of each varies with lipoprotein type. Credit: Knowable Magazine

One top candidate to reduce triglycerides is based on fish oil, which is high in the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Diets rich in fatty fish or omega-3s have long been linked to lower rates of cardiovascular problems. The fish or fish oil supplements are thought to work by cutting down on fat production by the liver.

So, in a study called REDUCE-IT, researchers tested a highly purified derivative of EPA in more than 4,000 people with cardiovascular disease or diabetes. They compared these patients to a similar number of people who received inert mineral oil as a placebo.

At first glance, the results reported in 2019 looked “really spectacular,” says Nicholls, who wasn’t involved in the trial. In the group that had taken the EPA for about five years, risk of major cardiovascular problems or death dropped by 25 percent or more compared to those getting a placebo. But oddly, this benefit came without a big reduction in the triglycerides themselves.

In other words, “if EPA is working, it’s doing something other than lowering triglycerides,” says Kenneth Feingold, an endocrinologist and emeritus professor of medicine at the University of California, San Francisco. EPA might counter inflammation, for example, or stabilize the membranes of heart cells.

Based on the REDUCE-IT results, the US Food and Drug Administration approved the purified EPA derivative in 2019 as a medicine for people with high triglycerides and other cardiovascular risk factors. But things got more confusing in 2020, when Nicholls, Nissen and colleagues published another trial, called STRENGTH. This study also aimed to lower triglycerides in high-risk patients, about 6,500 of them, using EPA plus DHA. The researchers compared these patients to people who received a corn oil placebo. But the team halted their study early because, although triglyceride levels did fall, EPA plus DHA didn’t seem to have any beneficial effect on the rate of heart attack, stroke, hospitalization for heart problems, or death.

Researchers are still debating why REDUCE-IT hit paydirt but STRENGTH faltered. Looking back at REDUCE-IT, some experts see a problem with the mineral oil placebo that was used. LDL cholesterol levels and signs of inflammation went up in that group—and if the control participants were worse off than if they’d received nothing at all, then their data would make the experimental treatment look better than it really is.

But Gibson, who was part of the REDUCE-IT team, argues for a different explanation: that pure EPA is better than the EPA/DHA combo. And supporting REDUCE-IT’s conclusions, he points to an older, 1990s study that compared people taking EPA plus statins with people taking statins alone and also found fewer major coronary events in the EPA group.

Then, in 2022, came the latest blow to the once-promising idea of lowering triglycerides: the PROMINENT trial, in which Eckel and colleagues tested a drug called pemafibrate that reduces blood triglycerides. The 10,000-plus study participants had type 2 diabetes, high triglycerides and low HDL, and were at risk for cardiovascular events. But even though triglyceride levels fell by about 26 percent, on average, in the group receiving the drug, this made no difference to the rate of cardiovascular events.

Taken together, the results suggest that triglycerides indicate poor cardiovascular health without being the reason behind the problem. “Triglycerides were just innocent bystanders,” concludes Eckel. The exception, he adds, might be people with very high triglycerides who are at risk of pancreatitis and might still benefit from triglyceride-lowering treatment.

Remnant cholesterol

This is a loosely used term, with science still to be settled. In the doctor’s office, physicians assume that any cholesterol that isn’t HDL or LDL is a leftover or “remnant” fraction. From a molecular point of view, remnant cholesterol is a fat-delivering lipoprotein in an intermediate state: It left the liver, loaded with fat and cholesterol, and has dropped off some of its triglycerides in the body’s tissues, but not so much of its cargo that it’s become an LDL lipoprotein. Chylomicrons from the gut, once depleted of fats, also become remnant particles.

In people with healthy metabolisms, the body quickly disposes of remnant particles. But if a person has a problem such as diabetes or obesity, these fatty remnants might stick around. Remnant cholesterol may accumulate in atherosclerotic plaques, potentially making it as dangerous as the classic bad LDL cholesterol. Indeed, high levels of remnant cholesterol have been linked to cardiovascular disease in some studies, quite independently of patients’ LDL cholesterol measurements. That suggests that getting rid of those remnants could be beneficial.

The substances remain a bit of a black box, though. “We still don’t know precisely how to define them, we don’t know precisely how to measure them, so it’s kind of difficult to be precise about remnants,” says Feingold. Nonetheless, some researchers are interested in treatments that might target remnants in addition to, or instead of, triglycerides. For example, Nicholas Marston, a cardiologist at Brigham and Women’s, and colleagues are testing a medication called olezarsen that, he says, appears to promote clearance of the cholesterol-carrying particles. But it will take more study to learn if that translates into fewer cardiovascular problems.

Remnant cholesterol is “probably important,” says Nissen—so even though the science is still nascent, he says he feels hopeful about the potential of treatments targeting it.

In sum, the emerging picture is one in which certain forms of HDL cholesterol are good and all the other lipoproteins are bad. The best approach, experts suggest, may be to reduce all the non-HDL cholesterol—whether by diet and exercise or some of these new medicines, should they prove effective.

“If it’s not HDL, we should minimize it,” says Feingold. “The lower, the better.”

This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.

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Washington puzzles over AI in health care https://www.popsci.com/technology/ai-health-care-regulation-questions/ Thu, 22 Feb 2024 13:00:00 +0000 https://www.popsci.com/?p=603325
Already, AI’s impact on health care is widespread.
Already, AI’s impact on health care is widespread. DepositPhotos

The hype, the risks, and the 'daunting problem' of regulating AI's impact on your medical treatments.

The post Washington puzzles over AI in health care appeared first on Popular Science.

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Already, AI’s impact on health care is widespread.
Already, AI’s impact on health care is widespread. DepositPhotos

This article was originally published on KFF Health News.

Lawmakers and regulators in Washington are starting to puzzle over how to regulate artificial intelligence in health care—and the AI industry thinks there’s a good chance they’ll mess it up.

“It’s an incredibly daunting problem,” said Bob Wachter, the chair of the Department of Medicine at the University of California-San Francisco. “There’s a risk we come in with guns blazing and overregulate.”

Already, AI’s impact on health care is widespread. The Food and Drug Administration has approved some 692 AI products. Algorithms are helping to schedule patients, determine staffing levels in emergency rooms, and even transcribe and summarize clinical visits to save physicians’ time. They’re starting to help radiologists read MRIs and X-rays. Wachter said he sometimes informally consults a version of GPT-4, a large language model from the company OpenAI, for complex cases.

The scope of AI’s impact—and the potential for future changes—means government is already playing catch-up.

“Policymakers are terribly behind the times,” Michael Yang, senior managing partner at OMERS Ventures, a venture capital firm, said in an email. Yang’s peers have made vast investments in the sector. Rock Health, a venture capital firm, says financiers have put nearly $28 billion into digital health firms specializing in artificial intelligence.

One issue regulators are grappling with, Wachter said, is that, unlike drugs, which will have the same chemistry five years from now as they do today, AI changes over time. But governance is forming, with the White House and multiple health-focused agencies developing rules to ensure transparency and privacy. Congress is also flashing interest. The Senate Finance Committee held a hearing Feb. 8 on AI in health care.

Along with regulation and legislation comes increased lobbying. CNBC counted a 185% surge in the number of organizations disclosing AI lobbying activities in 2023. The trade group TechNet has launched a $25 million initiative, including TV ad buys, to educate viewers on the benefits of artificial intelligence.

“It is very hard to know how to smartly regulate AI since we are so early in the invention phase of the technology,” Bob Kocher, a partner with venture capital firm Venrock who previously served in the Obama administration, said in an email.

Kocher has spoken to senators about AI regulation. He emphasizes some of the difficulties the health care system will face in adopting the products. Doctors—facing malpractice risks—might be leery of using technology they don’t understand to make clinical decisions.

An analysis of Census Bureau data from January by the consultancy Capital Economics found 6.1% of health care businesses were planning to use AI in the next six months, roughly in the middle of the 14 sectors surveyed.

Like any medical product, AI systems can pose risks to patients, sometimes in a novel way. One example: They may make things up.

Wachter recalled a colleague, as a test, assigning OpenAI’s GPT-3 to write a prior authorization letter to an insurer for a purposefully “wacky” prescription: a blood thinner to treat a patient’s insomnia.

But the AI “wrote a beautiful note,” he said. The system so convincingly cited “recent literature” that Wachter’s colleague briefly wondered whether she’d missed a new line of research. It turned out the chatbot had made it up.

There’s a risk of AI magnifying bias already present in the health care system. Historically, people of color have received less care than white patients. Studies show, for example, that Black patients with fractures are less likely to get pain medication than white ones. This bias might get set in stone when artificial intelligence is trained on that data and subsequently acts.

Research into AI deployed by large insurers has confirmed that has happened. But the problem is more widespread. Wachter said UCSF tested a product to predict no-shows for clinical appointments. Patients who are deemed unlikely to show up for a visit are more likely to be double-booked.

The test showed that people of color were more likely not to show. Whether or not the finding was accurate, “the ethical response is to ask, why is that, and is there something you can do,” Wachter said.

Hype aside, those risks will likely continue to grab attention over time. AI experts and FDA officials have emphasized the need for transparent algorithms, monitored over the long term by human beings—regulators and outside researchers. AI products adapt and change as new data is incorporated. And scientists will develop new products.

Policymakers will need to invest in new systems to track AI over time, said University of Chicago Provost Katherine Baicker, who testified at the Finance Committee hearing. “The biggest advance is something we haven’t thought of yet,” she said in an interview.

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

Subscribe to KFF Health News’ free Morning Briefing.

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The best earplugs for work in 2024 https://www.popsci.com/gear/best-earplugs-for-work/ Tue, 20 Feb 2024 21:00:00 +0000 https://www.popsci.com/?p=603106
The best earplugs for work in 2024 on a plain white background.
Brandt Ranj / Popular Science

Whether you’re operating a jackhammer, slinging sandwiches, or just want to tune out cubicle chatter, we’ve got hearing protection for you.

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The best earplugs for work in 2024 on a plain white background.
Brandt Ranj / Popular Science

We may earn revenue from the products available on this page and participate in affiliate programs. Learn more ›

Best overall Minuendo Minuendo
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These earplugs have adjustable filters that let you dial in your ideal sound attenuation level; no batteries required.

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Thermoplastic earpieces provide a custom fit without a visit to an audiologist.

Best budget Mack’s earplugs on a plain white background. Mack’s Ultra Soft Foam Earplugs
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Because effective hearing protection doesn’t have to break the bank.

Earplugs for work mean different things to different people. Here at PopSci, we tend to get preachy about wearing earplugs because when worn correctly, they’re just about 100-percent effective at protecting your ears from damage caused by everyday loud sounds.

According to the Centers for Disease Control and Prevention (CDC), 22 million workers are exposed to potentially damaging noise at work each year. When it comes to noise-induced hearing loss, there’s no reset button. The damage can be gradual, creeping up over decades, or it can happen in an instant after, say, an explosion or even a loud rock concert. Once your hearing is compromised, it’s compromised for life. That said, we recognize that people want to wear the best earplugs for work for many reasons, and if you’re in a typical office setting, you’re likely looking for earplugs to block out distractions so you can focus rather than prevent injury (so we have recommendations for that, too). 

How we chose the best earplugs for work

Fortunately or unfortunately for the reviewers here at PopSci, urban environments are incredibly noisy places that present endless opportunities to evaluate hearing protection. (In fact, the UN has declared urban noise pollution a top environmental threat, impacting both physical and mental health.) We compared our own experiences using earplugs, including many of the products here, in various scenarios: working in offices, commuting, attending concerts, and even sleeping. It’s difficult to measure the actual attenuation level offered by earplugs without specialized equipment, so we relied on the provided specs and anecdotal experience for that. However, we were able to evaluate fit, comfort, and usability across a range of ear shapes and sizes, keeping in mind the risk factors that may be encountered on job sites. 

How loud is too loud?

Noise-induced hearing damage results from sudden acoustic trauma or chronic exposure to high sound levels. The general rule is the louder the sounds and the longer the length of exposure, the greater the risk of hearing loss.

Sounds at or below 70 decibels are generally considered safe; repeated or extended exposure to sound above 85 decibels can cause hearing loss. For perspective, here are the decibel ratings of some common sounds:

  • Leaves rustling: 20 dB
  • Normal conversation: 60 dB
  • Hair dryer: 90 dB
  • Emergency vehicle siren: 120 dB
  • Gunshot: 140 dB

OSHA requires employers to implement a hearing conservation program when noise exposure is at or above 85 decibels over 8 hours. If you have to raise your voice to be heard by someone three feet away, noise levels might be above 85 dB. For a more scientific way to gauge the noise levels around you, download a free app like the Sound Level Meter App from the National Institute for Occupational Safety and Health (NIOSH).

The best earplugs for work: Reviews & Recommendations

The good news is that noise-induced hearing loss is preventable. Ear protection can cost pennies or thousands of dollars, but perfectly effective choices are available in every price range, as we’ll show you in our guide to the best earplugs for work.

Best overall: Minuendo

Sarah Jones

SEE IT

Specs

  • Attenuation: 7–25 dB
  • Material: Silicone tips
  • Storage: Zip-close hard plastic case
  • Price: $137

Pros

  • Stepless, adjustable sound attenuation
  • Flat attenuation for balanced, natural sound
  • Eleven tip sets fit just about any ear 

Cons

  • Stepless level control can feel imprecise

Minuendo silicone earplugs are touted as the first passive (non-electronic) earplugs that offer “stepless” sound attenuation, offering seamless, nuanced adjustment to any level between -7 dB and -25 dB. Minuendos feature a detachable cord and magnetic backs that clasp the earplugs together, making it easier to keep track of them. Eleven sets of tips—including foam, silicone, and flanges—fit just about any ear out there, so you can dial out distractions and focus on your task(s). Wipe clean with water or alcohol.

And if you don’t need the more conversational or quieted ends of the spectrum, save $50 and pick up the single setting, 17 dB attenuating Minuendo LIVE with its distinctive copper faceplates. Or, if you want to spend less but like the idea of adjustable attenuation and don’t mind swapping out small parts, also consider the ultra-comfy Sennheiser SoundProtex Plus, which features a two-stage filter design with swappable caps that reduces both high- and low-frequency levels while maintaining clarity so that you can catch just the right amount of office gossip or bandmate soloing. (Read our full profile of those in our guide to the best earplugs for concerts.)

Best custom-molded: Decibullz

Decibullz

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Specs

  • Attenuation: 31 dB
  • Material: Plastic flange and foam tips
  • Storage case: Pouch included; zip-close hard case available
  • Price: $25.99

Pros

  • Remoldable thermoplastic allows repeat fittings
  • Bluetooth headphone option
  • Available in six colors

Cons

  • Hot plastic can feel uncomfortable during molding process

Earplugs that form a perfect seal in your ear provide the best protection against loud sounds, but that was easier said than done for a long time. It used to be that if you wanted custom-molded earpieces like the in-ear monitors musicians wear onstage, you’d have to shell out hundreds if not thousands of dollars and pay a visit to an audiologist. And the best earplugs (so to speak) for performers and mix engineers and audiophiles remain bespoke acrylic sets like the UE Premier, as they provide impeccable isolation from kick drums to commutes while facilitating low-level, high-detail listening.

Your work, however, might involve blocking out the venue but not kicking out the jams. Thankfully, advances in thermoplastics have made it possible to do your own fittings at home for a fraction of the cost and time. That’s why we love Decibullz Custom Molded Earplugs: With Decibullz’ Easy Shape System, simply heat molds in boiling water, let them cool for a few seconds, then insert them in your ear. Don’t panic if you don’t get it right the first time; they’re remoldable. The end result fits and fills the concha, while three sets of triple-flange tips and one set of foam tips are provided for the ear canal, combining multiple layers of isolation.

The company’s Safe + Sound Wireless Earphone Conversion Kit brings Bluetooth audio to Decibullz, plugging directly into the earplugs to convert them into headphones. Safe+ Sound features Qualcomm chips with aptX HD high-definition audio and allows up to 15 hours of continuous use with USB fast charging.

Best for industrial applications: SureFire EP7 Sonic Defenders Ultra

SureFire

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Specs

  • Attenuation: 28 dB (adjustable)
  • Material: Medical-grade polymer foam tips
  • Storage: Snap-close hard carrying case
  • Price: $21.99

Pros

  • Removable filter cap lets you hear full sound
  • Compatible with radio comms systems
  • Available in three sizes

Cons

  • May need to supplement with earmuffs in extreme environments

SureFire’s Sonic Defenders earplugs line is designed for tactical professionals, industrial workers, and shooting enthusiasts. We like EP7 Sonic Defenders Ultra earplugs, which protect your hearing in demanding environments without interfering with your ability to hear safe sounds. Their foam-tipped stem design, featuring soft memory-foam tips, provides a Noise Reduction Rating (NRR) of 28 dB. Snap-on/off filters let users switch between attenuated sound and normal sound levels, making them easier to use with a phone or headset. Their low-profile design fits under hats, helmets, and supplemental muffs, and patented EarLock retention rings feature seven contact points that lock the earplugs in place for all-day comfort. EP7 Sonic Defenders Ultra are available in black, clear, and orange and include a lanyard and carrying case.

A note about ear protection for industrial jobs: Extreme environments call for the highest sound attenuation. According to NIOSH, the maximum NRR for earplugs is -33 dB; earmuffs top out at -31 dB. Combining earplugs and earmuffs can offer an NRR protection level up to -36 dB. Note that the NRR system can sometimes overestimate the hearing protection provided during typical use; if you’re subjected to noise levels that require very high sound attenuation, consult your employer for best practices and resources.

Best noise-canceling: QuietOn 3.1 Sleep Earbuds

QuietOn

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Specs

  • Attenuation: 30 dB
  • Material: Memory foam tips
  • Storage: Hard plastic charging case
  • Price: $289

Pros

  • 28-hour battery life
  • Comfortable enough to sleep in
  • No wireless setup required

Cons

  • No Bluetooth connectivity

Earplugs and some earbuds serve similar purposes in reducing ambient sound, but they work in different ways. Most earplugs and lower-priced wireless earbuds rely on passive noise isolation, physically blocking the ear canal to prevent external noise from entering. Noise-canceling earbuds, meanwhile, use active noise cancellation (ANC), a system of tiny microphones and speakers that detects ambient sound and generates sound waves that cancel it out. (For this reason, ANC earbuds require power, usually decreasing the run time of the earbuds’ rechargeable batteries.) 

QuietOn 3.1 Sleep Earbuds fall into the former category, but unlike other ANC earbuds, which tend to have bulky housings that extend way outside the ear canal, these tiny wonders measure just 20mm end to end. (Billed as the “world’s smallest ANC earbuds,” QuietOns are a third of the size of Apple AirPods Pro.) This makes sense since, technically, they’re designed for sleeping. 

ANC technology doesn’t process information fast enough to protect your ears from sudden explosive sounds, but it can do an even better job attenuating low frequencies than traditional earplugs. If you feel like nerding out, check out QuietOn’s comparison chart.

QuietOn 3.1 comes with foam tips in four sizes, a USB-C cable, and a charger case. Built-in lithium-ion batteries last 28 hours on a single charge, and a fully charged case will juice the earbuds for a week. Note that, unlike noise-canceling earbuds, QuietOns do not offer Bluetooth functionality, so you can’t use them to talk on the phone or listen to music, so they might not be the best choice to keep you in the zone at the gym. But they’ll make up for that in peaceful nights and productive days.

Best budget: Mack’s Ultra Soft Foam Earplugs

Mack’s

SEE IT

Specs

  • Attenuation: 33 dB
  • Material: polyurethane foam
  • Storage case:
  • Price: 100 for $40

Pros

  • Inexpensive
  • Ideal for a range of applications
  • Comfortable for sleeping

Cons

  • Not reusable

In the realm of budget-friendly hearing protection, Mack’s cheap, disposable foam earplugs reign supreme. While Mack’s makes a huge range of foam earplugs for everything from swimming to sleeping to air travel, the all-purpose Ultra Soft Foam Earplugs are our favorites, offering a steep 33 dB of sound attenuation at a staggeringly low price. Their soft, pliable foam molds gently to the contours of your ear canal, providing a snug seal that effectively blocks out unwanted noise. Their low-profile design easily fits under helmets and hats and provides a comfortable, secure fit for long-term wear. The earplugs in this 100-pair package are individually wrapped, making it a cinch to throw pairs in your purse, gym bag, glove compartment, and carry-on so they’re always at the ready. You can pick up a jar of 50 loose pairs for $14.99 if you prefer a more sustainable option.

For a stylish, reusable alternative, check out the ultra-cushy, washable Loop Engage, which offers a modest Noise Reduction Rating of 10 dB sound attenuation, letting you take the sonic edge off while still participating in conversations, or the Loop Quiet with its mid-level NRR 14 dB noise reduction. 

What to consider when choosing the best earplugs for work

When selecting the best earplugs for work, the most important factors are Noise Reduction Rating, durability, hygiene, and ease of insertion/removal. In industrial environments with high noise levels, prioritize earplugs with a higher NRR and durability, while in office settings, comfort and ease of use may be more important—after all, the best earplugs are the ones you’ll actually keep in your ears. If you work in an industrial setting, it’s critical to ensure compatibility with other safety equipment, communication needs, established safety standards, and regulatory compliance. 

FAQs

Q: Is it okay to wear earplugs at work?

Yes, it’s generally safe to wear earplugs at work, and earplugs can be required in work environments with high noise levels. However, consider communication needs or safety requirements specific to your job.

Q: Do silicone or foam earplugs work better?

Silicone and foam earplugs are both effective. Foam earplugs provide a tighter seal than silicone, which can lead to more robust sound attenuation, but they must be inserted correctly, deep within the ear canal. Silicone earplugs don’t need to be inserted as far into the ear canal, which tends to make them easier to fit and wear. Foam earplugs are considered disposable since they collect bacteria with re-use; because silicone earplugs can be repeatedly washed and reused, they can be a more sustainable choice.

Q: Can earplugs hit the eardrum?

Earplugs are designed to fit snugly in the ear canal without reaching the eardrum. However, improper insertion or using earplugs that are too large may increase the risk of accidental insertion deep into the ear canal. It’s important to follow instructions and choose earplugs of an appropriate size to minimize this risk.

Q: Why can I still hear with earplugs?

Earplugs don’t silence all sound; they reduce sound to a safe level. When you wear earplugs, some sound may still penetrate, especially if the earplugs have a lower Noise Reduction Rating (NRR) or are not inserted properly. And certain earplugs are designed to attenuate noise without completely blocking it out to maintain situational awareness or facilitate communication in the workplace.

You’ll never experience complete silence with earplugs. You’ll always perceive some sound, even when you wear earplugs with the highest NNRs, because the bones in your skull conduct sound vibrations to your eardrum. And when you block the ear canal, the sounds you produce when talking, breathing, and chewing can become amplified, known as the occlusion effect.

Final thoughts on the best earplugs for work

When it comes to finding the best earplugs for working, consider your daily grind and what keeps you in the zone. If you’re clocking hours in a bustling office, a pair of reliable earplugs can drown out distractions like chatty coworkers or the hum of office machinery, letting you focus on the task at hand. In industrial settings, durable earplugs are your silent allies, guarding against the roar of heavy machinery and protecting you from serious injury. And if your workday seeps into your personal time, versatile earplugs can transition from the office to the coffee shop to bed, ensuring that you’re always in control of your auditory environment. Whatever your work entails, investing in the best earplugs for to your needs is a sound decision that pays off in productivity and peace of mind.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

The post The best earplugs for work in 2024 appeared first on Popular Science.

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Why scientists are worried about Neuralink https://www.popsci.com/technology/neuralink-ethical-issues/ Tue, 20 Feb 2024 13:00:00 +0000 https://www.popsci.com/?p=603302
Some scientists are troubled by Elon Musk's brain implant company's lack of transparency.
Some scientists are troubled by Elon Musk's brain implant company's lack of transparency. DepositPhotos

Several companies are testing brain implants–why is there so much attention swirling around Neuralink?

The post Why scientists are worried about Neuralink appeared first on Popular Science.

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Some scientists are troubled by Elon Musk's brain implant company's lack of transparency.
Some scientists are troubled by Elon Musk's brain implant company's lack of transparency. DepositPhotos

This article was originally featured on The Conversation.

Putting a computer inside someone’s brain used to feel like the edge of science fiction. Today, it’s a reality. Academic and commercial groups are testing “brain-computer interface” devices to enable people with disabilities to function more independently. Yet Elon Musk’s company, Neuralink, has put this technology front and center in debates about safety, ethics and neuroscience.

In January 2024, Musk announced that Neuralink implanted its first chip in a human subject’s brain. The Conversation reached out to two scholars at the University of Washington School of Medicine–Nancy Jecker, a bioethicst, and Andrew Ko, a neurosurgeon who implants brain chip devices–for their thoughts on the ethics of this new horizon in neuroscience.

How does a brain chip work?

Neuralink’s coin-size device, called N1, is designed to enable patients to carry out actions just by concentrating on them, without moving their bodies.

Subjects in the company’s PRIME study–short for Precise Robotically Implanted Brain-Computer Interface–undergo surgery to place the device in a part of the brain that controls movement. The chip records and processes the brain’s electrical activity, then transmits this data to an external device, such as a phone or computer.

The external device “decodes” the patient’s brain activity, learning to associate certain patterns with the patient’s goal: moving a computer cursor up a screen, for example. Over time, the software can recognize a pattern of neural firing that consistently occurs while the participant is imagining that task, and then execute the task for the person.

Neuralink’s current trial is focused on helping people with paralyzed limbs control computers or smartphones. Brain-computer interfaces, commonly called BCIs, can also be used to control devices such as wheelchairs.

A few companies are testing BCIs. What’s different about Neuralink?

Noninvasive devices positioned on the outside of a person’s head have been used in clinical trials for a long time, but they have not received approval from the Food and Drug Administration for commercial development.

There are other brain-computer devices, like Neuralink’s, that are fully implanted and wireless. However, the N1 implant combines more technologies in a single device: It can target individual neurons, record from thousands of sites in the brain and recharge its small battery wirelessly. These are important advances that could produce better outcomes.

Why is Neuralink drawing criticism?

Neuralink received FDA approval for human trials in May 2023. Musk announced the company’s first human trial on his social media platform, X–formerly Twitter–in January 2024.

Information about the implant, however, is scarceaside from a brochure aimed at recruiting trial subjects. Neuralink did not register at ClinicalTrials.gov, as is customary, and required by some academic journals.

Some scientists are troubled by this lack of transparencySharing information about clinical trials is important because it helps other investigators learn about areas related to their research and can improve patient care. Academic journals can also be biased toward positive results, preventing researchers from learning from unsuccessful experiments.

Fellows at the Hastings Center, a bioethics think tank, have warned that Musk’s brand of “science by press release, while increasingly common, is not science.” They advise against relying on someone with a huge financial stake in a research outcome to function as the sole source of information.

When scientific research is funded by government agencies or philanthropic groups, its aim is to promote the public good. Neuralink, on the other hand, embodies a private equity model, which is becoming more common in science. Firms pooling funds from private investors to back science breakthroughs may strive to do good, but they also strive to maximize profits, which can conflict with patients’ best interests.

In 2022, the U.S. Department of Agriculture investigated animal cruelty at Neuralink, according to a Reuters report, after employees accused the company of rushing tests and botching procedures on test animals in a race for results. The agency’s inspection found no breaches, according to a letter from the USDA secretary to lawmakers, which Reuters reviewed. However, the secretary did note an “adverse surgical event” in 2019 that Neuralink had self-reported.

In a separate incident also reported by Reuters, the Department of Transportation fined Neuralink for violating rules about transporting hazardous materials, including a flammable liquid.

What other ethical issues does Neuralink’s trial raise?

When brain-computer interfaces are used to help patients who suffer from disabling conditions function more independently, such as by helping them communicate or move about, this can profoundly improve their quality of life. In particular, it helps people recover a sense of their own agency or autonomy – one of the key tenets of medical ethics.

However well-intentioned, medical interventions can produce unintended consequences. With BCIs, scientists and ethicists are particularly concerned about the potential for identity theft, password hacking and blackmail. Given how the devices access users’ thoughts, there is also the possibility that their autonomy could be manipulated by third parties.

The ethics of medicine requires physicians to help patients, while minimizing potential harm. In addition to errors and privacy risks, scientists worry about potential adverse effects of a completely implanted device like Neuralink, since device components are not easily replaced after implantation.

When considering any invasive medical intervention, patients, providers and developers seek a balance between risk and benefit. At current levels of safety and reliability, the benefit of a permanent implant would have to be large to justify the uncertain risks.

What’s next?

For now, Neuralink’s trials are focused on patients with paralysis. Musk has said his ultimate goal for BCIs, however, is to help humanity–including healthy people–“keep pace” with artificial intelligence.

This raises questions about another core tenet of medical ethics: justice. Some types of supercharged brain-computer synthesis could exacerbate social inequalities if only wealthy citizens have access to enhancements.

What is more immediately concerning, however, is the possibility that the device could be increasingly shown to be helpful for people with disabilities, but become unavailable due to loss of research funding. For patients whose access to a device is tied to a research study, the prospect of losing access after the study ends can be devastating. This raises thorny questions about whether it is ever ethical to provide early access to breakthrough medical interventions prior to their receiving full FDA approval.

Clear ethical and legal guidelines are needed to ensure the benefits that stem from scientific innovations like Neuralink’s brain chip are balanced against patient safety and societal good.

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5 stretches for relieving ‘tech neck,’ according to physical therapists https://www.popsci.com/diy/tech-neck-stretches/ Tue, 20 Feb 2024 12:00:00 +0000 https://www.popsci.com/?p=603244
a person sitting at a computer stretches their arm behind their head
Stretch without leaving your desk. DepositPhotos

Each stretch can be done right in your seat.

The post 5 stretches for relieving ‘tech neck,’ according to physical therapists appeared first on Popular Science.

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a person sitting at a computer stretches their arm behind their head
Stretch without leaving your desk. DepositPhotos

The world is still far off from flying cars and boots on Mars, but technology has come a long way in the past century. We’re more connected than ever, as Zoom calls and social media let you interact with people worldwide. And as the pandemic showed, many jobs do not need to be onsite, allowing people to work from the comfort of their own home. Though technology has its perks, the constant engagement of our electronic devices has done no favors for the human body. 

Tech neck is a growing phenomenon where people are excessively straining their neck muscles from leaning their head forward and looking down at their devices for long periods of time, says Devin Trachman, an orthopedic physical therapist and clinic director at Physical Therapy Central in Oklahoma. 

The average adult head weighs 11 to 13 pounds, and the more you tilt down and lean forward, the more pressure is placed on your neck and spine. A head turned down at a 45-degree angle—a common position for people looking at their phones—is going to place 49 pounds of force on your spine, Trachman told PopSci. Over time, this excess pressure can limit your mobility and cause neck spasms and headaches.

Physical therapists recommend regularly stretching the neck out for a few minutes to combat the uncomfortable side effects of staring at our glowing devices. Yoga poses like cobra, child’s pose, and cat-cow are great for relieving tension in the neck, shoulders, and spine, but if you don’t have the space to get on the floor, there are five stretches you can hold right at your desk or chair.

1. Stare up at the ceiling

The average person spends 3 hours and 15 minutes staring down at their phones. To ease the neck discomfort from staying in that position for so long, try looking up. 

Jenny Fritts, a physical therapist at Mercy Medical Center in Maryland, says moving your neck in different directions helps, especially when you spend some time stretching your neck in the opposite position. If you’ve had your head staring down at your phone or computer, this would mean staring up at the sky or ceiling. “I always tell people to act like there are cobwebs on the ceiling or in the corners of the room,” she advises.

2. Smell your armpit

Formally known as the levator scapula stretch, Trachman says this pose relieves tension from the base of your neck down to the top of the shoulder blades. Your left hand leans your head over to your left side. Tilting your head down and gently applying pressure as if trying to put your left ear on your left shoulder. The free right hand will reach over your back where you will apply pressure to try and grab your right shoulder blade. Hold the position for 30 seconds on each side. 

5 stretches for relieving ‘tech neck,’ according to physical therapists

3. Give yourself a double chin

A person with good posture can stand up straight with a spine that is not flexing or arching, shoulders pulled back, and with their head directly above the spine. People with tech necks, however, have their heads out of alignment and in a forward position. 

5 stretches for relieving ‘tech neck,’ according to physical therapists

Chin tucks are one way of realigning the head and spine, says Trachman. Sitting up nice and tall, look straight ahead and place a finger or two on your chin. Then you’ll slightly move your head back while tilting your chin down “as if you’re giving yourself a double chin,” Trachman describes. Hold the position for a few seconds and do it for at least three repetitions.

4. Shoulder rolls

If you have pain or stiffness in your shoulders, consider loosening them up with a few shoulder rolls. With your arms to your sides and back straight, rotate the shoulders forward as if you are making small circles. Creating a bigger circular motion will provide more engagement to the upper back muscles, rotator cuff, and deltoids. Trachman says the exercise can also help improve posture by opening your chest up and realigning the shoulders. 

Though forward shoulder rolls might not be the best option if you’re dealing with excessive tension in your neck and shoulders, warns Fritts. She explains that hiking your shoulders up can feed into the stress that’s sitting on your neck. Instead, she recommends reverse shoulder rolls. Reverse shoulder rolls involve moving your shoulder blades back and to the front in a circular motion. “Retracting your shoulder blades back, pinching them together, and pushing down can really help that area,” Fritts says.

5. Desk-friendly child’s pose

A traditional child’s pose gently stretches out your upper back muscles and relieves stress by activating the relaxation response in your parasympathetic nervous system. Trachman recommends a modified child’s pose you can do right at your desk if you’re not in a space to perform it on the floor.

Place your hands on the table, shoulder-distance apart. You’ll then lean forward while gently scooting your chair back until you feel a stretch in your outstretched arms. Trachman advises holding the pose for about 30 seconds.

How to stop tech neck from coming back

Performing the above stretches at least five times a week can significantly improve your tech neck and posture in as little as two to four weeks, Trachman says. Additionally, she says working simultaneously with a physical therapist can speed up the process. 

That being said, the best way to get rid of tech neck is to avoid it in the first place. Trachman and Fritts recommend people look at their devices, whether a phone or computer, at eye level instead of tilting down. If you are staring at a computer screen for long periods of time, Trachman says you’ll want to keep the monitor 20 to 30 inches away from you—an arm’s length worth of distance. Finally, scheduling breaks to get up and walk around can prevent your body from being hunched in one position for too long. Even a five-minute recess can do wonders for your posture.

The post 5 stretches for relieving ‘tech neck,’ according to physical therapists appeared first on Popular Science.

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The uncharted world of emerging pathogens https://www.popsci.com/health/edna-emerging-pathogens/ Mon, 19 Feb 2024 13:00:00 +0000 https://www.popsci.com/?p=603294
Geneticist Chris Mason (right), Evan Afshin (center), and Sofia Ahsanuddin (left) sample turnstiles in New York City’s subway system in June 2016. Their swabs pick up cells that humans, animals, and microorganisms naturally shed, leaving behind genetic fingerprints.
Geneticist Chris Mason (right), Evan Afshin (center), and Sofia Ahsanuddin (left) sample turnstiles in New York City’s subway system in June 2016. Their swabs pick up cells that humans, animals, and microorganisms naturally shed, leaving behind genetic fingerprints. Thos Robinson/Getty Images for Weill Cornell Medicine

In their quest to detect early outbreaks, virus hunters are sampling environmental DNA in water, dirt, and air.

The post The uncharted world of emerging pathogens appeared first on Popular Science.

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Geneticist Chris Mason (right), Evan Afshin (center), and Sofia Ahsanuddin (left) sample turnstiles in New York City’s subway system in June 2016. Their swabs pick up cells that humans, animals, and microorganisms naturally shed, leaving behind genetic fingerprints.
Geneticist Chris Mason (right), Evan Afshin (center), and Sofia Ahsanuddin (left) sample turnstiles in New York City’s subway system in June 2016. Their swabs pick up cells that humans, animals, and microorganisms naturally shed, leaving behind genetic fingerprints. Thos Robinson/Getty Images for Weill Cornell Medicine

This article was originally featured on Undark.

It all started when Christopher Mason’s 3-year-old daughter licked a subway pole.

Like any parent, he was horrified, but also keenly curious: What types of microbes might be clinging to a metal pipe gripped by countless commuters every day?

Mason, a geneticist at Weill Cornell Medicine, soon became obsessed with that question. His toddler’s gross interlude inspired him to embark on a journey to unveil the world of bacteria, fungi, and viruses co-mingling with more than 8 million people in New York City’s urban jungle.

In 2013, he launched a project that began dispatching a small army of students shouldering backpacks crammed with latex gloves, vials, and sterile Q-tips. They sampled turnstiles, benches, and kiosks at every open metro stop in the city. It was an expedition into a largely unexplored terrain, like Mars or a deep-sea canyon, brimming with lifeforms both familiar and unknown.

The swabbers were sampling what’s called environmental DNA, or eDNA, representing the assortment of cells that all humans, animals, and microorganisms naturally shed as they go about their everyday lives, leaving genetic fingerprints. The scientists gradually quantified and mapped the unseen biological diversity—the microbiome—of the entire city. In 2015, they reported that they’d found more than 1,600 different types of microbes, nearly half of which were previously known to science. Most were harmless, associated with human skin and gastrointestinal tracts. About 12 percent were known pathogens, including fragments of genomes similar to Bubonic plague and anthrax, though there was no evidence that these small bits could make anyone sick. They hadn’t found any new deadly viruses lurking in New York’s underground—yet.

Four years later, in late 2019, Mason and his colleagues started hearing about a mysterious pneumonia-like disease circulating in China. “We weren’t immediately worried,” he said, “but by January it was clear that it had jumped across the ocean and was spreading.” Suddenly the subway swabbers became front-line workers monitoring Covid-19’s presence, not only in transit systems, but also in hospitals, and wastewater. “We had a new medical focus,” Mason said, “with protocols and tools that could be deployed anywhere.”

Today Covid-19 has killed nearly 80,000 New Yorkers, almost 1.2 million Americans, and nearly 7 million people worldwide. The pandemic catalyzed a push for new technologies that allow scientists to quickly characterize organisms leaving a genetic trace in the environment. Similar to how city-leveling hurricanes have fueled innovations in weather surveillance and building engineering, the pandemic has helped propel the science of pathogen hunting.

The field of eDNA research has mushroomed in the last 15 years as sequencing, computing technology, and metagenomics—the study of DNA from multiple organisms—has advanced. Now, scientists around the world can sample from a cup of dirt, a vial of water, or even a puff of air, and survey the eDNA present for thousands of microbial species. And while the field at-large has faced concerns about privacy and technical limitations, many scientists see an opportunity to further early detection of emerging pathogens. Wastewater surveillance is the most advanced method for monitoring population-level virus spikes, but other realms are catching up. As a result, health officials are becoming better prepared to detect an outbreak—and quickly take steps to contain it.

Experts say the technology may soon become so advanced that an environmental sample, such as air filtered from a high-risk area—a wet market, a hospital, a conference hotel—could be automatically sequenced in a portable device that will report if a threatening pathogen is present. Researchers are using genomic databases to aid rapid identification of pathogens and other microbes. Scientists are getting close to “being able to monitor these high-risk interfaces in real time,” said Erik Karlsson, a virologist at Institut Pasteur du Cambodge, a nonprofit research institution in Cambodia.

“We like to say, we’re trying to get left of sneeze.”

The ultimate goal in virus hunting is an early warning system: to find a pathogen that could spark a disease outbreak before it has the chance to do so. The key, say scientists, is monitoring high-risk areas where animals and people intermingle. Those places are usually on the boundaries between areas where humans live and tropical forests, where people hunt and capture animals for food, pets, and ingredients in medicine, or in markets where animals are slaughtered for consumption.

“We like to say, we’re trying to get left of sneeze,” said Karlsson, who monitors for avian influenza and other pathogens in Cambodia’s live bird markets. That means they’re trying to identify potentially threatening pathogens before they spill over into humans, or before they jump into a different animal type and causes an outbreak. “We want to be able to get ahead of that,” he said.


Studies show more than 70 percent of the infectious diseases that have emerged in the 21st century—including Ebola, HIV, and mpox (formerly monkeypox)—leapt to humans from wildlife. What’s more, there has been a significant increase in zoonotic disease hopping from wildlife to humans over the past 80 years. These events are commonly known as “spillovers.”

Research shows there is one main phenomenon, often in a remote faraway place, that precedes a spillover: a forest clearing.

As forests are felled for timber, farming, and human development, people living and working in the adjacent areas hunt and scavenge for animals to be used for food, or sold—at times illegally—as pets or made into medicinal products. Those who handle the animals can become exposed to new pathogens. Whether or not one of those pathogens makes the leap to a person and triggers an outbreak depends on a variety of factors, including how the virus evolves and human immunity.

Forested areas in Africa and Southeast Asia, where vast tracts of previously pristine wilderness are being logged, are among the leading hotspots for emerging animal-borne, or zoonotic, disease. In Africa, there has been a 63 percent rise in the number of zoonotic outbreaks in the last decade, according to the World Health Organization. Those outbreaks include Ebola, viral hemorrhagic fevers, dengue, anthrax, plague, and mpox.

Ebola is one of the most famous and feared among the group. First discovered in 1976, the virus kills by storming the immune system, causing it to go into hyperdrive, damaging blood vessel walls so severely the arteries, veins, and capillaries start to leak blood, causing medical shock and organ failure.

The most widespread Ebola outbreak began in December 2013, when a virus living in a bat somehow spilled over to a 18-month-old boy named Emile Ouamouno in southern Guinea. Ouamouno—“patient zero”—was suffering from a fever, passing stool blackened with blood, and vomiting. He died within days, and was quickly followed by his mother, young sister, and grandmother.

Soon the disease appeared in nearby Guéckédou, a city of nearly 350,000, alerting world health officials to an Ebola outbreak. Ultimately the outbreak spread to Sierra Leone, Liberia, Nigeria, and six other countries, including the United States, with three cases in Dallas, Texas. By the time the epidemic ended in 2016, it had killed more than 11,300 people and infected 28,600.

Eeva Kuisma is a veterinary scientist working for the Wildlife Conservation Society, a global nonprofit conservation group. In the Republic of Congo, she is working to expand a project that could become the first long-term surveillance program for Ebola and other diseases based on forest environmental DNA sampling. The research builds on an ongoing public education and disease surveillance program in which researchers visit rural communities to provide information about the dangers of Ebola virus and other animal-borne diseases, and how to minimize the risk of exposure. Hunters and foragers are encouraged to report sightings of animal carcasses in the forest to a hotline. So far, the program has engaged 5,800 hunters in more than 290 villages.

As part of the new study Kuisma is launching, survey teams will spend 12 months every five years walking systematic transects across more than 8 million acres of forest. Along their path, they’ll swab eDNA samples from animal carcasses and feces.

Representing a wide range of animals, from gorillas and chimpanzees to river hogs and antelopes, the samples are being tested for Ebola and other pathogens. Kuisma and her colleagues are using the latest advancements in DNA analysis to compare the genetic material against a database of DNA sequences, revealing the identity of many microorganisms present, from bacteria to pathogens and viruses.

Kuisma said long-term data from the project could become valuable for monitoring the appearance of Ebola or any other pathogens against the backdrop of big landscape changes. One example is a proposed $1.7 billion road project connecting Congo, Chad, and the Central African Republic, “areas which have been really pristine rainforest up until now,” she said.

It’s early days for the research, but ongoing environmental sampling for Ebola virus might one day short circuit a spillover and save lives. “If we have indications, for example from the feces or from carcasses, that there is an active epidemic in the animal population,” Kuisma said, “we can inform people, to warn them that this is happening and to educate them to not go and eat carcasses, not to pick them up, not to touch them.”


Over the last century, Southeast Asia has been another major hotspot for emerging zoonotic diseases, but recently, the risk of a spillover has picked up. Population growth, deforestation, climate change, and the expansion of poultry and pig farming have all led to the emergence of a long list of diseases, including Middle East Respiratory Syndrome, Zika virus, and Highly Pathogenic Avian Influenza, or HPAI.

Karlsson, the virologist in Cambodia, helps oversee researchers in Phnom Penh collecting environmental samples in areas where people and animals intermingle. Whereas previously, researchers would have to hand collect feces, blood, urine, and other biological samples, recent developments in rapid genetic sequencing have made it easier for them to do their work more quickly and safely. “Environmental samples are really, really good for speed,” Karlsson said. “We don’t have to capture animals. We don’t have to get the same kinds of permits. You don’t have to have people that are trained to handle potentially dangerous animals like bats and things like that. You can go out in the environment, get these samples very quickly.”

Recently, a new tool for hunting viruses has become more widely available: air sampling. Karlsson’s team is using air filters designed for construction workers to wear on the job, or to purify the air in hotel lobbies to sample public markets where vendors slaughter, clean, and defeather chickens—high risk areas for an avian influenza outbreak.

In a study published in March 2023, the researchers recruited vendors scattered throughout a market to wear personal air samplers 30 minutes a day for a week while going about their business during periods when the circulation of avian influenza in poultry is predictably high in February and low in May. In February, they found viral RNA in 100 percent of air samples. They could also see the virus decreasing as they got farther from the chicken slaughter area, confirming that slaughter areas are potentially the “most high-risk area of the market,” Karlsson said, and illustrating the need for interventions such as improved ventilation.

Karlsson’s team is now using hand-held air-filtering devices no bigger than a credit card reader to sample for viruses in places that are both challenging and sometimes dangerous for researchers to go swabbing, such as bat caves. Bats are reservoirs for a wide variety of viruses that infect people—including Covid-19. They’re pairing the small samplers with toy drones and remote-control cars that can easily access a cave while the scientists wait outside.

Karlsson often thinks about other types of technology that could be deployed for passive, remote sampling — and one day a comprehensive machine that could not only collect a sample, but also process it on the spot. “Can we hook it up to a Roombaa, or something like that, constantly cleaning the floors and then sucking in the sample,” he said. “You see there’s a lot of options.”

Peter Thielen is a molecular biologist at Johns Hopkins Applied Physics Laboratory, where he leads viral genomic surveillance projects, including in collaboration with Karlsson. He said Karlsson has been uniquely positioned in a high-risk area for disease spillover to pilot some of the latest technologies to improve response time to outbreaks. “This ability to take the lab to the sample is exactly what’s needed,” he said.


While some scientists are working to detect pathogens floating in the air, the Covid-19 pandemic really opened the floodgates to the concept of hunting for viruses in wastewater. Since people shed genetic material from the virus in their feces and urine, wastewater surveillance became one of the best way to track disease spikes, including which city apartment building and what university dormitory contained people with Covid-19—even before they became symptomatic.

It wasn’t a novel concept. Wastewater surveillance dates all the way back to the mid-1800s, when John Snow, a British physician, was investigating a mysterious cholera outbreak in London. Citizens called it the “blue death,” because the dehydration caused by intense diarrhea and vomiting led to sunken eyes, shriveled skin and a bluish-gray pallor that made patients look like living corpses. Many believed a “miasma,” an evil cloud of poisonous air, was to blame.

“We don’t have to capture animals. We don’t have to get the same kinds of permits. You don’t have to have people that are trained to handle potentially dangerous animals like bats.”

Snow, however, had a hunch that cholera was waterborne. He painstakingly mapped the cases and finally traced their origin to a contaminated water pump on Broad Street in London’s West End. When he convinced the local council to remove the pump’s handle, the outbreak ceased. Today Snow is celebrated as the father of modern-day epidemiology.

During the last century, wastewater has become an important tool for monitoring community health, particularly for tracking drug use trends in cities and finding—and quickly eliminating—polio outbreaks. Still, wastewater was on the margins of widespread use in the U.S. a decade ago, when a scientist with the Environmental Protection Agency proposed a nationwide system to monitor community health. He couldn’t get anyone to back the idea then.

In September 2020, the Centers for Disease Control and Prevention finally launched the country’s first National Wastewater Surveillance System, which collects and tests samples as wastewater flows into treatment plants, and reports those results to the CDC to help guide local response. By then, though, more than 200,000 Americans had died from Covid-19. If the surveillance system had been up and running when the virus first came ashore in the U.S., it might have been detected much sooner, said Mason, the geneticist at Weill Cornell Medicine. “We would have known immediately within a day or two where the virus was appearing.”

Wastewater continues to provide important intel about where the virus is circulating and the public’s risk of exposure, particularly as clinical testing has been replaced by readily available home test kits. It’s also helping health officials track the arrival and spread of new Covid-19 variants as they’re emerging.

“We’re out of the pandemic officially, but we still have circulating viruses, so what’s interesting is we can see them in the wastewater,” Mason said. If the abundance of the virus spikes, as it did recently in early September 2023—nearing the same levels as in late 2020—health officials can warn the public to take precautions to minimize exposure, such as mask wearing, hand washing, and social distancing. “It’s good that most people have either been vaccinated or already infected, or both,” Mason added.

Resources spent on developing the infrastructure for pathogen surveillance in wastewater has put the country in a better position to identify and respond to other health threats, including antibiotic resistance, foodborne diseases, mpox, and respiratory syncytial virus (RSV), experts say, but the program is still young, and there are some ethical and privacy concerns too.

It’s a lot cheaper and more time-efficient to test sewage than to swab hundreds of people, or do blood testing, but wastewater is largely unregulated for privacy. What kinds of rights people have over what they flush and what’s done with it is extremely murky. The National Academies of Sciences recently published a report detailing the ways in which the national wastewater surveillance system needs to implement sufficient oversight to protect privacy rights while further developing to monitor more communities, track multiple pathogens at the same time, and pivot to deal with emerging threats when a pathogen spikes.

“I like to joke, and say every time that a toilet flushes and if nobody takes a sample, somewhere an epidemiologist is crying,” Mason said, laughing. “The amount of information that’s present in every bit of wastewater is extraordinary. I think we’re just beginning to tap it.”


Mason’s work mapping New York City’s microbiome prompted researchers around the globe to contact him to discuss plans to swab their cities too. As interest grew, Mason and Evan Afshin, a medical student at New York Medical College, founded a global organization comprised of scientists from more than a hundred cities, known as Metagenomics and Metadesign of Subways and Urban Biomes, or MetaSUB consortium, rubbing Q-tips on surfaces in their countries’ transit systems, sewage canals, hospitals, and other public places.

Similar to how naturalists have assembled volumes representing all the birds in North America, or all the fish in the Pacific, Mason and his colleagues have created an atlas of microorganisms found in urban mass transit systems around the globe. The scientists are now using sequencing technology and AI-powered software to develop a worldwide reference library of microbes and an open-sourced platform that allows users to enter a pathogen DNA sequence and see where else it has appeared in the world. “We want to make it so anybody anywhere can upload their sequence, and compare it to anything else that’s ever been sequenced,” Mason said.

In late October, GeoSeeq Foundation, a nonprofit data platform associated with a health-tech company Mason co-founded, announced it was teaming up with the Pasteur Network, an organization with an international network of scientists. The collaboration’s aim is to closely examine rising infectious disease driven by climate change, including mosquito-borne illnesses like malaria and dengue. An Oct. 31 press release said the partnership could “usher in a new era of global pathogen surveillance and response.” It combines the Pasteur Network’s reach—32 institutes spread across 25 countries on 5 continents—with GeoSeeq’s AI platform pulling from a wide variety of data streams, including climate, genomics, and public health.

“This connects all the labs around the world to be able to see if any new virus is emerging,” Mason said in an email. “We can keep people safe once we know where the risks are, and we also can discover entirely new kinds of creatures in the world!” By identifying all types of microbes, researchers might also discover new antibiotics, and they’re gaining the ability to track and map antibiotic resistance. Whether such an early warning system will catch a future pandemic pathogen remains to be seen.

Still, many pathogen trackers say the big dream is to one day have a worldwide disease surveillance system on par with current weather forecasting. Information about such factors as air pressure, temperature, and wind currents feed into weather maps that help forecasters identify developing storm patterns and aid response plans. The same can be done with microbial data feeding a global disease surveillance system, a costly endeavor, but worth it, Mason said, because “money spent on pathogen surveillance is much cheaper than a shutdown of the entire economy.”

Scientists have learned a lot of lessons during the Covid-19 pandemic, he said. Now they just need to apply them.

The post The uncharted world of emerging pathogens appeared first on Popular Science.

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The best sex toys for couples, tested and reviewed https://www.popsci.com/gear/best-sex-toys-for-couples/ Fri, 09 Feb 2024 21:00:00 +0000 https://www.popsci.com/?p=602071
An array of the best sex toys for couples on a white fuzzy carpet.
Amanda Reed

Come one, come all, and come together with couples-friendly sex toys that make the horizontal tango even spicier.

The post The best sex toys for couples, tested and reviewed appeared first on Popular Science.

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An array of the best sex toys for couples on a white fuzzy carpet.
Amanda Reed

We may earn revenue from the products available on this page and participate in affiliate programs. Learn more ›

Best overall A blue We-Vibe O Sync and remote on a white fuzzy carpet We-Vibe Sync O
SEE IT

A wearable vibe that’s fun during foreplay or during sex.

Best for beginners A blue Unbound Squish sex toy on a plain background Unbound Squish
SEE IT

A squishable entry point to the world of buzzy vibes.

Best budget A periwinkle plusOne personal massager on a plain gray blackground plusOne Personal Massager
SEE IT

Low budget, high quality.

We love masturbation, but using a sex toy as a couple is, for lack of a better phrase, incredibly hot. Being behind the steering wheel of someone else’s desires? Doing some long-distance debauchery with the help of a smart vibe and app? Implementing tools so your hands can go other places? You won’t just get two tickets to Pleasureville—you’ll get a season pass, the keys to the city, a memorial plaque along main street, and even a statue built in your joint honor. Casting sexual stigma aside is a task that doesn’t undo itself overnight. If you decide to take the journey, you’ll be a stronger couple thanks to the communication, direction, and confidence you gain from experimentation. The best sex toys for couples make coming together easy, intimate, and even a little spiritual.

How we chose the best sex toys for couples

I previously covered the best sex toys, so I’ve been around the block when it comes to knowing what to look for. We also looked at reviews and recommendations and spoke to experts. We also … tested them ourselves, so you can feel better a real person has handled what’s in this story. We also looked at versatility in use and the kinds of bodies they can be used on. High-end sex toys are well worth the money, but we want to make sure you get your money’s worth out of them.

Everything on this is body-safe, meaning it’s non-toxic and non-porous. Bad bacteria and your sensitive bits aren’t the best couple here.

PS: We know gender is fake! We use some gendered terms here, but just know all these toys are made for bodies regardless of how you identify.

The best sex toys for couples: Reviews & Recommendations

It’s not every day you get to polish the banister (real euphemism for masturbation, by the way) in the name of product journalism. One of our picks should help you and your honey paddle the pink canoe or shuck corn.

Best overall: We-Vibe Sync O 

Amanda Reed

SEE IT

  • Settings: 10 vibration modes
  • Waterproof?: Yes, IPX7
  • Pleasure point: G-spot, clitoris
  • Battery life: 150 minutes

Pros

  • Secure fit
  • Comfortable to wear
  • Waterproof

Cons

  • Remote is small, so be cognizant not to lose
  • Still hard to keep on the clitoris

I previously tried We-Vibes’ other hands-free C-shaped vibrators, like the Chorus and Sync Go, and found it difficult to keep the internal parts inside my body. I still will recommend both vibes—what isn’t my cup of tea could certainly be yours—but the We-Vibe Sync O is the answer to my personal problem. It provides dual stimulation, and the insertable portion has a little more surface area to stay put. The O-shaped internal arm is flexible and comfortable to insert, and there’s more than one way to use it. You can use it by yourself hands-free, during penetrative intercourse, during foreplay, or with another G-spot toy or dildo. You can control it yourself via the remote or on the device itself. We recommend the remote so your hands can focus on other places.

Its 10 intensity levels range from a low, rumbly purr to a buzzy high. Like the Chorus and the Sync Go, you can control the We-Vibe Sync O on your phone, making it perfect if you’re looking to stay while dating long distance. It’s also IPX7 waterproof rated so that you can use it in the bath or shower, and body-safe silicone gives us peace of mind.

Some reviews mention that you still have to hold the external part in place to really get it on the clitoris. Otherwise, you get overall vulvar stimulation. We also experienced that. Body movement tends to knock anything out of place, so it wasn’t a deal-breaker for us. The remote is very small, which screams “lose me,” so just keep an eye on it or keep it in the included drawstring bag when not in use.

Best rated: Magic Wand Cordless Vibrator

Amanda Reed

SEE IT

Specs

  • Settings: 4 speeds, 4 patterns
  • Waterproof?: No
  • Pleasure point: Anywhere
  • Battery life: 180 minutes

Pros

  • Great battery life
  • A classic, now rechargeable
  • Doubles as a percussion massager

Cons

  • Not everyone’s cup of tea
  • Not waterproof

The Magic Wand is the toy that people think of when talking about sex toys. This wand has been around since 1968, and with that history comes great responsibility. The Magic Wand has been used in scientific studies, so its power (up to 6,300 RPMs) is pretty legit. Its settings are simple but still get the job done: You only get four vibration speeds and four vibration patterns. It lasts for a marathon 180 minutes, which blows the battery life out of almost every single sex toy on this list. You can use it on clits, frenulums, nipples, or on the shoulders for a nice massage. It did originate as a percussion massager, after all.

We’ve also tried the Magic Wand Micro, which packs the Magic Wand’s simplicity and flexible neck into a pint-sized package. I personally prefer it over the Magic Wand. I love a good buzzy, too, but the Magic Wand can be … a little much! If you’ve found that regular wand massagers leave you uncomfortably numb, give the Micro a try. You can also show your sex toy allegiance by using the Micro as a keychain. Two birds, one stone, you get it.

Sarah Tomchesson, a certified sex educator and Magic Wand’s director of marketing, also recommends using the Magic Wand’s smaller cousin in the bedroom.

“Right now, my favorite toy for couples is the Magic Wand Micro,” she says. “It boasts the power of the famous full-sized Magic Wand but starts at a more subtle vibration on its lowest setting. It is ideal for warming up the body to full arousal, using it on both partners, and its compact size fits nicely between bodies or in your bag for date night or a sexy getaway.”

Best for beginners: Unbound Squish

Unbound

SEE IT

  • Settings: 6 total; 4 intensities and 2 patterns
  • Waterproof?: Yes (Rating not listed)
  • Pleasure point: Anywhere
  • Battery life: 2.5 hours on lowest setting; 1 hour on highest

Pros

  • Haptic settings
  • Soft silicone
  • Easy to hold

Cons

  • Reviews note haptic controls are hard to use
  • A little expensive for how the user experience is

A bullet vibrator is most often everyone’s entrance into sex toys. However, they can be hard to hold and don’t give you the power or rumble some may crave. They’re also not that waterproof, depending on the kind you buy. That’s not the case with the Unbound Squish. We love that you can control it via the buttons on the vibe or by squeezing it. The tech isn’t perfect, but it does make for a fun experience. The pointed tip can be used on many erogenous zones, and the ridge at the top provides an extra yummy sensation. It’s waterproof, and it comes in its own little bag for easy travel. It is a little pricey for an entry-level vibe and the experience it provides, which isn’t bed-rocking but great as an entrance to sex toys. We also love the MysteryVibe Poco, which is flexible and the best for beginner choice in our original sex toy story.

Best for men: Fun Factory Manta Vibrating Male Stroker

Fun Factory

SEE IT

  • Settings: 12 total (6 speeds, 6 patterns)
  • Waterproof?: Yes (Rating not listed)
  • Pleasure point: Penis, frenulum
  • Battery life: 40-120 minutes, depending on settings

Pros

  • Finger loop base for easy holding
  • Can be used in many different ways
  • Travel lock
  • Quiet

Cons

  • Motor could be more powerful

Foreplay and masturbation don’t have to be all spit and friction. Consider adding a toy, like a stroker or cock ring, to experience different sensations. We love the Fun Factory Manta Vibrating Male Stroker just for that reason. Its vibrations (it comes with six speeds and six patterns) and ridges are different than a hand, and you can use it by yourself or with a pal. In fact, it’s designed with couples in mind. You can slide it in-between bodies during penetrative sex, or you can position it at the base of the penis to step up oral sex. Its finger loop base makes it easy to hold, and it’s extremely quiet, meaning noise from vibrations won’t wreck your mood. Plus, it’s waterproof so that you can bring it into the shower built-free. Reviews note, however, that the motor could be more powerful. If you’re looking for something gentler, congratulations, you’ve found it.

Best for women: Womanizer Next

Amanda Reed

SEE IT

  • Settings: 14
  • Waterproof?: Yes, IPX7 rated
  • Pleasure point: Clitoris
  • Battery life: 120 minutes

Pros

  • Incredibly quiet
  • Climax control
  • 3D Pleasure Air is a game-changer
  • Extra stimulator head for different bodies

Cons

  • Unwieldy

Suction vibrators are some of my favorite vibes to use by myself or with a partner during foreplay. I’ve tried many of them based on the nature of my work, and some have stood out more than others. The Womanizer Next, with its 14 intensity settings and 3D Pleasure Air tech, is at the head of the pack by a mile. It has everything I want in a vibrator: It’s powerful but quiet, waterproof, easy to clean, and made of oh-so-soft silicone. An extra stimulator head helps you find what fits best with your body, and you can order more online. Climax control is the cherry on top, giving you three Air Wave depths to choose from. You know that one SpongeBob meme? You’ll feel like that after using this vibe.

You can also choose Autopilot mode, which puts the control in Next’s metaphoric hands. You won’t have to worry about pushing buttons, and you get to try something new. Win-win!

It has a chunkier profile compared to others I’ve tried, but frankly, I don’t care. I glean over this con. It’s just that good. If it really worries you, consider the Womanizer Pro 40, which is a little sleeker but just as beloved.

Best budget: plusOne Personal Massager

plusOne

SEE IT

  • Settings: 10 vibration modes
  • Waterproof?: Yes
  • Pleasure point: Everywhere
  • Battery life: 4 hours

Pros

  • Compact
  • Discreet
  • Long battery life

Cons

  • Reviews note performance issues

The brand plusOne makes some of our favorite budget sex toys. They’re high in quality but won’t leave your wallet dry. This compact wand can be used all over the body, making it a perfect addition to foreplay and sex. It’s also waterproof, meaning you can use it in the shower. The battery life is crazy long for how small it is, and its flexible head is reminiscent of the one on the Magic Wand. It fits well in your hand, isn’t unwieldy, and has soft silicone that rivals higher-end vibes. If you’re beginning your vibrator journey, plusOne is a great place to start.

You get what you pay for with this wand, however. Reviews note that it doesn’t have the vibration juice compared to other vibes, and it doesn’t have the shelf life of higher-end toys.

What to consider when buying the best sex toys for couples

In these kinds of stories, we often say, “Not all [blank] are made equal,” but we really mean it this time. Sex toys, despite being products that promote sexual wellness, are not regulated by the FDA, which means anyone can make, market, and produce a sex toy that’s a little shady, just like that one situationship in college.

“Quality toys are worth the investment,” Sarah Tomchesson, Magic Wand’s marketing director and a certified sex educator, says. “A quality sex toy is user-tested, made of body-safe materials, and components that will last. If budget is a concern for a buyer, the best approach is to join the mailing list for a reputable sex toy retailer and take advantage of seasonal sales promotions rather than searching for the lowest-priced toy online.”

Here’s what you should look for before putting anything in or on your partner’s body or your own:

Material

You want to look for body-safe toys. This means you can use them around and inside your body. If you see that it’s made of silicone, stainless steel, and borosilicate glass, you’re in the clear. Body-safe materials are free from phthalates and won’t change forms when exposed to different temperatures.

Generally, be wary of anything porous. You’ll know something is porous if it’s see-through, sticky, stretchy, or has a strong rubbery odor. “Porous” doesn’t mean “inherently dangerous,” however; some porous materials can be phthalate-free and non-toxic, but they can harbor germs and be almost impossible to disinfect. Most cock rings and a few wand heads use porous materials. You’ll want to keep it to yourself if it’s made from cyber skin, jelly, PVC, rubber (even skin-safe rubber), UR3, and vinyl.

“Beware of ‘silicone blends’ as they may contain unknown plastics or materials,” Tomchesson adds.

If you’re working with porous wand heads and toys, cover them with a polyurethane condom to reduce risk if using it with another person (and change the condom with each new person that uses it), emphasis on “reduce risk.”

If you’re unsure if your sex toy material is body-safe, simply ask. Many manufacturers have emails and customer service chats that can answer any questions about a certain toy.

Buying from reputable brands can also give you peace of mind. Platforms like Lovehoney and Spectrum Boutique, buying right from the manufacturer’s website, and buying from the manufacturer’s Amazon storefront are surefire ways to know you’re purchasing from a good place. If you see a storefront name that looks like it was made by your cat walking across your keyboard, you might want to stay clear of it in this case.

Kinds of sex toys

There are so many kinds of sex toys. So many! Tomchesson says toys that are easy to hold, quiet, can be positioned between bodies, and increase access to previously undiscovered nerve endings during a couple’s play are ideal for couples to add into the mix.

Here are just a few that are perfect for partner play:

  • Glass toys: Great for temperature play (can throw it in the freezer/fridge for cold and put it in warm water for hot), also non-porous and easy to clean and maintain.
  • Wands: Fun and rumbly, you can use these all over, even for sore shoulders.
  • Bullets: Perfect on nipples, clitorises, frenulums, perineums … the world is your oyster.
  • Strokers: Great to assist during oral play or add some pizazz to solo play.
  • C-shaped toys: Can use them on your partner during foreplay, on yourself during solo play, or with your partner. You can also use them while having sex or with a G-spot vibrator (we’re huge fans of the We-Vibe Rave 2) or dildo. You have options!

When buying a sex toy for the first time, Tomchesson says the first question couples should ask themselves is what their goal is with using a toy. Other follow-up questions include: Is there a new kind of play or sex position they are interested in exploring? Are they experiencing an orgasm gap in the relationship where one partner is experiencing pleasure and orgasms while the other is not? Are they interested in taking their bedroom explorations in a new direction? 

“Once a couple is clear on what they are hoping to achieve with a new toy, the search narrows, and it is easier to find a good fit,” she says. “From there, couples can read online reviews, visit a sex-positive store, or search a Reddit thread for inspiration. A quality sex toy will have positive reviews on reputable online sexual wellness shops, and detailed specs and product information, including the materials.” 

Tomchesson recommends looking for products with versatility, such as variable speeds and the ability to use them in a variety of ways, all over the body, and in solo play and couples play. She says that, for your first toy purchase, find a pleasure product that looks and feels inviting and is simple to use. 

“Your first sex toy should excite you and make you eager to get into the bedroom,” she says. 

Then, she says to test it out before using it with your partner. “Read the instructions, charge it up, and get familiar with the settings before you are in the heat of the moment with your partner. This way, you can intuitively integrate the toy into your play rather than fumbling your way through it.”

Regardless of the sex toy you choose and use, we also recommend the Liberator Fascinator Throw to protect soft surfaces from bodily fluids.

A note on lube and cleaning

Lubes are perfect for getting things slippery, which reduces friction and increases fun. You’ll want to use silicone lube like the Shine Silicon lube from Maude on glass toys, when you’re getting frisky in the water, or when you’re just using your hands. However, do not use silicone lube with silicone toys—that will damage them. Instead, use a water-based lube like good ‘ol Astroglide. We also have to recommend Astroglide because of its rocket-science roots

“Lubricant reduces friction and increases your sensitive nerve endings’ receptiveness to pleasurable sensations,” Tomchesson says. “Using a toy for the first time will be more enjoyable with lubricant.”

If you’re using a toy with someone who isn’t fluid bonded to you (aka, you both haven’t had the conversation and taken steps to stop using barrier contraception with each other), or you just want to keep your body fluids separate from your honey’s, use a polyurethane condom with your toy and change it after playtime is over, or when a new partner comes into the mix.

When you’re cleaning toys, don’t submerge non-waterproof toys in water. You can wash them with warm water and mild, fragrance-free soap, or you can use sex toy cleaner like this one from Hello Cake.

“Sex toy cleaners are a great option for cleaning because they are body-safe and designed to be compatible with every sex toy material,” Tomchesson says. “Soap and warm water can be an effective way to keep your toys clean as long as you use a body-safe soap that you would also feel comfortable using on your sensitive bits. Sometimes people think they need to wash their toys in alcohol to get them clean, but alcohol and harsh cleaners can irritate the skin and therefore should not be used to clean sex toys.” 

Add a soft toothbrush if your toy has crevices, like suction toys. You can also boil toys made from silicone, borosilicate glass, and stainless steel to disinfect them. You can even disinfect your toy in the dishwasher. If your toys have mechanical parts, it’s best to keep them out of boiling water. As we mentioned, ask the manufacturer before you mix your vibrator with last night’s dishes. Last, air dry your toys to prevent lint and fibers from sticking to your toys.

FAQs

Q: Is it normal for couples to use sex toys?

Yes! Absolutely! Duh! The myth that couples only use sex toys when they’re unsatisfied has been busted. They can strengthen relationships and sexual satisfaction, create intimacy, and liven up the moves already in use. Using sex toys promotes open communication and direction. And, it’s OK if your partner doesn’t feel comfortable introducing toys into the dynamic. After all, consent is always key.

Q: Are high-end sex toys worth the investment?

Personally, we think yes. Although you can get an affordable toy that does the job safely (as seen by the plusOne personal massager), you get better materials, designs, and features when you spend a little extra. It will also last longer and be less prone to breaking. If you do the “cost per orgasm” math, you’ll find that your investment was worth it.

Q: Can I get an STI from a sex toy?

Tl;dr: Yes. The longer explanation: If you’re only using it on yourself or you have a long-term monogamous partner and both of you have already tested, you’re all good. However, if you share a sex toy with another person with a sexually transmitted infection (STI) and use it on yourself, you are at risk of catching an STI. Cleaning, sanitizing, and disinfecting sex toys before and after use can keep dangerous germs and bacteria at bay, as we mentioned above. Put a condom on the toy to prevent STI spread when using toys with a new person or a different partner.

Final thoughts on the best sex toys for couples

There is nothing wrong with good old regular missionary. But what if you could add some seasoning—say, something spicy and rich like Tajín or harissa—to your vanilla sex life? Sex toys for couples do just that, making foreplay and partnered play more pleasurable than it already is. Trying something new in the bedroom can bring you and your sweetie closer and rekindle a flame into a roaring fire.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

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This pet-friendly air purifier from Shark is 38% off at Amazon right now https://www.popsci.com/gear/pet-air-purifier-shark-amazon-2024-deal/ Fri, 16 Feb 2024 16:55:00 +0000 https://www.popsci.com/?p=603147
Shark Sense IQ air purifiers in a pattern on a plain background
Imagine having this many Shark air purifiers in your house. The air would be so pure. Stan Horaczek

This powerful purifier covers 500 square feet and is down to $149 from $229—reducing allergens and cost!

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Shark Sense IQ air purifiers in a pattern on a plain background
Imagine having this many Shark air purifiers in your house. The air would be so pure. Stan Horaczek

We may earn revenue from the products available on this page and participate in affiliate programs. Learn more ›

Spring is coming, which means allergies are on their way. Right now, Amazon has Shark’s compact-but-powerful air purifier on sale for $149, which is 38 percent off its regular price and even cheaper than last year during Black Friday. It’s a powerhouse of a purifier, and Shark stuff tends to go quickly when it’s on deep discount like this, so grab one while they’re still in stock.

Shark HP102PETBL Clean Sense Air Purifier for Home $149 (was $239)

Shark

SEE IT

This purifier stands 14.5 inches tall and combats air pollutants with three filter layers. It has an outer pre-filter to catch big particles, a charcoal filter to capture smelly stuff in the air, and a HEPA filter to scrape out the truly nasty allergy-inducing stuff that leads to itchy eyes and endless sneezing. Thanks to the powerful fan system inside, this unit covers up to 500 square feet of space. But, despite all that air-moving oomph, it’s still quieter than you’d expect. This is a crucial piece of home gear, especially if you have pets.

More air purifier deals at Amazon:

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First remote, zero-gravity surgery performed on the ISS from Earth (on rubber) https://www.popsci.com/technology/remote-surgery-robot-iss/ Fri, 16 Feb 2024 15:00:00 +0000 https://www.popsci.com/?p=602988
Surgeon using spaceMIRA remote surgery tool on ISS
A team of surgeons used rubber bands to represent human tissue aboard the ISS. Credit: Virtual Incision

Surgeons in Nebraska controlled spaceMIRA from 250 miles below the ISS as it cut through simulated human tissue.

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Surgeon using spaceMIRA remote surgery tool on ISS
A team of surgeons used rubber bands to represent human tissue aboard the ISS. Credit: Virtual Incision

Researchers successfully completed the first remote, zero-gravity “surgery” procedure aboard the International Space Station. Over the weekend, surgeons based at the University of Nebraska spent two hours testing out a small robotic arm dubbed the Miniaturized In Vivo Robotic Assistant, or spaceMIRA, aboard the ISS as it orbited roughly 250 miles above their heads. 

But don’t worry—no ISS astronauts were in need of desperate medical attention. Instead, the experiment utilized rubber bands to simulate human skin during its proof-of-concept demonstration on Saturday.

[Related: ‘Odie’ is en route for its potentially historic moon landing.]

Injuries are inevitable, but that little fact of life gets complicated when the nearest hospital is a seven-month, 300-million-mile journey away. But even if an incredibly skilled doctor is among the first people to step foot on Mars, they can’t be trained to handle every possible emergency. Certain issues, such as invasive surgeries, will likely require backup help. To mitigate these problems in certain situations, remote controlled operations could offer a possible solution.

Designed by Virtual Incision, a startup developing remote-controlled medical tools for the world’s most isolated regions, spaceMIRA weights only two pounds and takes up about as much shelf-space as a toaster oven. One end of its wandlike is topped with a pair of pronglike arms—a left one to grip, and right one to cut.

[Related: 5 space robots that could heal human bodies—or even grow new ones ]

Speaking with CNN on Wednesday, Virtual Incision cofounder and chief technology officer Shane Farritor explained spaceMIRA’s engineering could offer Earthbound the hands and eyes needed to perform “a lot of procedures minimally invasively.”

On February 10, a six-surgeon team in Lincoln, Nebraska, took spaceMIRA (recently arrived aboard the ISS via a SpaceX Falcon 9 rocket) for its inaugural test drive. One arm gripped a mock tissue sample, and the other used scissors to dissect specific portions of the elastic rubber bands.

spaceMIRA prototype on desk
A version of the spaceMIRA (seen above) traveled to the ISS earlier this month. Credit: Virtual Incision

While researchers deemed the experiment a success, surgeons noted the difficulty in accounting for lag time. Communications between Earth and the ISS are delayed about 0.85 seconds—while a minor inconvenience in most circumstances, even milliseconds can mean a matter of life or death during certain medical emergencies. Once on the moon, Artemis astronauts and NASA headquarters will deal with a full 1.3 seconds of delay between both sending and receiving data. On Mars, the first human explorers will face a full hour of waiting after firing off their message, then waiting for a response. Even taking recent laser communications breakthroughs into consideration, patience will remain a virtue for everyone involved in future lunar and Mars expeditions.

This means that, for the time being, devices like spaceMIRA are unlikely to help in split second medical decisions. But for smaller issues—say, a lunar resident’s stitch up after taking a tumble, such medical tools could prove invaluable for everyone involved. In the meantime, Virtual Incision’s remote controlled equipment could still find plenty of uses here on Earth.

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First Alaskapox death reported: What you should know about the virus https://www.popsci.com/health/what-is-alaskapox/ Fri, 16 Feb 2024 14:00:00 +0000 https://www.popsci.com/?p=603025
A common vole in a wooded area.
Small mammals like voles can carry orthopoxviruses like Alaskapox. They typically cause skin legion, muscle and joint pain, fatigue, and fever. Deposit Photos

It is carried by small mammals like shrews and voles and can spillover into humans in rare cases.

The post First Alaskapox death reported: What you should know about the virus appeared first on Popular Science.

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A common vole in a wooded area.
Small mammals like voles can carry orthopoxviruses like Alaskapox. They typically cause skin legion, muscle and joint pain, fatigue, and fever. Deposit Photos

Health officials in Alaska reported the first known fatality from an uncommon virus known as Alaskapox. An elderly man who contracted the disease died in January, according to a bulletin from Alaska’s Department of Health released on February 9. The department notes that the man’s immune system was weakened due to cancer treatment, which likely contributed to the severity of the illness. 

[Related: The deepest known ocean virus lives under 29,000 feet of water.]

Authorities are urging doctors across Alaska to be on the lookout for signs of the virus. Here is what we know about the virus.

What is Alaskapox?

Alaskapox was first discovered in an individual in Fairbanks, Alaska in July 2015 and six cases have been detected since. It is a type of orthopoxvirus that infects mammals and can spillover into humans and cause skin lesions. Other orthopoxviruses include the now-eradicated smallpox and mpox. Previously known as monkeypox, an mpox outbreak in 2022 and 2023 caused over 93,000 cases around the world.

Alaskapox generally affects small mammals including shrews and red-backed voles and rodents like red squirrels. More cases of this virus in humans coming to light does not necessarily mean that Alaskapox is becoming more prevalent.

“It’s very possible that this virus has been present in Alaska for hundreds, if not thousands, of years,” state epidemiologist and chief of the Alaska Section of Epidemiology at the Alaska Department of Health Joe McLaughlin, told CNN. “What has changed is clinician awareness and the general public’s awareness that Alaskapox virus is something that’s a possibility. It’s possible that cases occurred prior to 2015 and were just subclinical or mildly clinical and just were not diagnosed.”

How does the virus spread?

No human-to-human transmission has been documented to date, according to Alaska’s Department of Health.

“We are not sure exactly how the virus spreads from animals to people but contact with small mammals and potentially domestic pets who come into contact [with] small wild mammals could play a role,” the Division of Public Health wrote on its website.

Some orthopoxviruses can be passed through direct contact with skin lesions. Cats and dogs may also spread these types of viruses. The unnamed man who died in January told doctors he had been caring for a stray cat and that the cat often scratched him. While the cat tested negative, it could still have been carrying the virus on its claws from scratching rodents. Health officials still can’t say if this is exactly how the man contracted the virus. 

[Related: Virus observed sucking on another virus’ ‘neck’ for the first time.]

What are its symptoms and treatment?

One or more skin lesions that appear rid like a spider or insect bite are usually the first symptom. Muscle and joint pain, swollen lymph nodes, and fever can also occur.  The Department of Health reported that nearly all had mild illnesses that resolved on their own after a few weeks. You can see what Alaskapox lesions look like here

Vanderbilt University Medical Center infectious disease specialist William Schaffner encouraged individuals experiencing these symptoms to seek medical attention. 

“Even if you haven’t been to Alaska and you have symptoms like that, you have to ask, could it be smallpox? That’s yet another reason to go to a medical care provider and get it looked at and diagnose it,” Schaffner told CBS News.

Healthcare providers may prescribe antiviral and immune-globulin treatments to help stop the disease’s progression. 

How is Alaska responding?

This most recent case was detected on the Kenai Peninsula, about 500 miles south of Fairbanks. This indicates that the virus may be more widespread than previously known. Currently, epidemiologists with Alaska’s Department of Health, the Centers for Disease Control and Prevention (CDC), and the University of Alaska Museum, are testing small mammals for the virus. They are also urging physicians to familiarize themselves with the symptoms. 

The virus is also a threat to anyone outside of Alaska at this time. However, the CDC recommends that people everywhere maintain a safe distance from wildlife and thoroughly wash their hands after going outside. 

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This edible, wriggling robot mimics experience of eating moving food https://www.popsci.com/technology/edible-moving-soft-robot-japan/ Thu, 15 Feb 2024 22:00:00 +0000 https://www.popsci.com/?p=603044
Edible soft robot on table
The gelatin gummy component wriggles when inflated with air. Osaka University

In Japanese ‘odorigui’ cuisine, food is still alive. This gyrating robot is not.

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Edible soft robot on table
The gelatin gummy component wriggles when inflated with air. Osaka University

Remember the old reality show competition stunt of getting contestants to eat live bugs on primetime television? Consuming “food” while it’s still alive spans numerous cultures around the world. In Japan, for example, odorigui (or “dance-eating”) is a centuries’ old tradition often involving squid, octopus, and tiny translucent fish known as ice gobies. Diners pop these still-living creatures into their mouths, as the wriggling is part of the overall meal experience.   

To potentially better understand the psychology and emotional responses associated with consuming odorigui dishes, researchers designed their own stand-in—a moving gelatin robo-food combining 3D-printing, kitchen cooking, and air pumps. The results appear not only tastier than your average reality show shock snack, but a potential step towards creative culinary and medical applications.

… And yet, judging from this video, it’s undeniably still a little odd.

Engineering photo

Detailed in a study published earlier this month in PLOS One, a team at Japan’s University of Electro-Communications and Osaka University recently devised a pneumatically-driven handheld device to investigate what they dub “human-edible robot interaction,” or HERI. For the “edible” portion of HERI, researchers cooked up a gummy candy-like mixture using a little extra sugar and apple juice for flavor. 

After letting the liquid cure in molds that included two hollow airways, the team then attached the snack to a coffee mug-like holder. The design allowed researchers to inject air through the gelatin in different combinations—alternating airflow between each tube produced a side-to-side wagging motion, while simultaneous inflation offered a (slightly unnerving) pulsating movement.

And then, the taste tests.

The team directed 16 Osaka University students to grab the device holding their designated, writhing soft robot morsel, place the edible portion in their mouth, allow it to move about for 10 seconds, then chomp. Another (possibly relieved) group of control students also ate a normal, immobile gelatin gummy. Following their meals, each volunteer answered a survey including questions such as:

– Did you think what you just ate had animateness?

– Did you feel an emotion in what you just ate?

– Did you think what you just ate had intelligence?

– Did you feel guilty about what you just ate?

Perhaps unsurprisingly, it seems that a meal’s experience can be influenced by whether or not the thing you just put in your mouth is also moving around in your mouth. Students described this sensation using the Japanese onomatopoeic terms gabu, or “grappling,” and kori-kori, meaning “crisp.” Movement also more frequently caused volunteers to feel a bit of guilt at eating a “still living” dish, as well as attach a sense of intelligence to it.

[Related: Scientists swear their lab-grown ‘beef rice’ tastes ‘pleasant’]

While only an early attempt at looking into some of the dynamics in odorigui, researchers believe more intricate soft robot designs can allow for more accurate experiments. Meanwhile, such research could lead to a “deepening understanding of ethical, social, and philosophical implications of eating,” as well as potential uses in medical studies involving oral and psychological connections. There’s also a possibility for “innovative culinary” experiences down the line, so who knows what might be coming to high-brow restaurants in the future—perhaps gyrating gyros, or wobbly waffles. Hopefully, nothing too macabre will wind up on menus. It’s certainly something researchers took into consideration during their tests.

“NOTE: During the experiment, we did not draw a face on the edible robot,” reads the fine print at the bottom of the demonstration video, presumably meaning they were just having a bit of fun with the project.

Which is good to hear. Otherwise, this whole thing might have come across as weird.

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FDA’s plan to ban hair relaxer chemical called too little, too late https://www.popsci.com/health/hair-relaxers-straighteners-formaldehyde-carcinogen-fda/ Thu, 15 Feb 2024 13:21:11 +0000 https://www.popsci.com/?p=602903
woman hair straightened
A 2018 study found that hair products used primarily by Black women and children contained a host of hazardous ingredients. Investigators tested 18 products, from hot-oil treatments to anti-frizz polishes, conditioners, and relaxers. Getty

The FDA’s recent notice that it would move to ban formaldehyde in hair-straightening products comes more than a decade after researchers raised alarms about health risks.

The post FDA’s plan to ban hair relaxer chemical called too little, too late appeared first on Popular Science.

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woman hair straightened
A 2018 study found that hair products used primarily by Black women and children contained a host of hazardous ingredients. Investigators tested 18 products, from hot-oil treatments to anti-frizz polishes, conditioners, and relaxers. Getty

This article was originally published on KFF Health News.

In April, a dozen years after a federal agency classified formaldehyde a human carcinogen, the Food and Drug Administration is tentatively scheduled to unveil a proposal to consider banning the chemical in hair-straightening products.

The move comes at a time of rising alarm among researchers over the health effects of hair straighteners, products widely used by and heavily marketed to Black women. But advocates and scientists say the proposed regulation would do far too little, in addition to being far too late.

“The fact that formaldehyde is still allowed in hair care products is mind-blowing to me,” said Linda Birnbaum, a former director of the National Institute of Environmental Health Sciences and the National Toxicology Program. “I don’t know what we’re waiting for.”

Asked why it’s taking so long to get the issue on the FDA’s agenda, Namandjé Bumpus, the regulatory agency’s chief scientist, told KFF Health News: “I think primarily the science has progressed.”

“Also,” she added, “the agency is always balancing multiple priorities. It is a priority for us now.”

The FDA’s glacial response to concerns about formaldehyde and other hazardous chemicals in hair straighteners partly reflects the agency’s limited powers when it comes to cosmetics and personal-care products, according to Lynn Goldman, a former assistant administrator for toxic substances at the Environmental Protection Agency. Under the law, she said, the FDA must consider all chemical ingredients “innocent until proven guilty.”

Critics say it also points to broader problems. “It’s a clear example of failure in public health protection,” said David Andrews, a senior scientist at the Environmental Working Group, which first petitioned the agency to ban formaldehyde in hair straighteners in 2011 and sued over the issue in 2016. “The public is still waiting for this response.”

Mounting evidence linking hair straighteners to hormone-driven cancers prompted Reps. Ayanna Pressley (D-Mass.) and Shontel Brown (D-Ohio) last year to urge the regulatory agency to investigate straighteners and relaxers.

The FDA responded by proposing to do what many scientists say the agency should have done years ago—initiate a plan to eventually outlaw chemical straighteners that contain or emit formaldehyde.

Such a ban would be a crucial public health step but doesn’t go nearly far enough, scientists who study the issue said. The elevated risk of breast, ovarian, and uterine cancers that epidemiological studies have recently associated with hair straighteners is likely due to ingredients other than formaldehyde, they said.

Formaldehyde has been linked to an increased risk of upper respiratory tract cancer and myeloid leukemia, Bumpus said in a video announcement of the proposed ban on X, formerly known as Twitter. But Kimberly Bertrand, an associate professor at the Boston University Chobanian & Avedisian School of Medicine, and other scientists said they were unaware of any studies linking formaldehyde to the hormone-driven, or reproductive, cancers that prompted recent calls for the FDA to act.

“It’s hard for me to imagine that removing formaldehyde will have an impact on the incidence of these reproductive cancers,” said Bertrand, an epidemiologist and lead author on a study published in December, the second linking hair relaxers to an increased risk of uterine cancer.

Hair products targeted to African Americans contain a host of hazardous chemicals, said Tamarra James-Todd, an associate professor of epidemiology at the Harvard T.H. Chan School of Public Health who has studied the issue for 20 years.

Studies have shown that straightener ingredients include phthalates, parabens, and other endocrine-disrupting compounds that mimic the body’s hormones and have been linked to cancers as well as early puberty, fibroids, diabetes, and gestational high blood pressure, which is a key contributor to Black women’s outsize risk of maternal mortality, James-Todd said.

“We have to do a better job regulating ingredients that people are exposed to, particularly some of our most vulnerable in this country,” she said. “I mean, children are being exposed to these.”

The first study linking hair relaxers to uterine cancer, published in 2022, found that frequent use of chemical straighteners more than doubled a woman’s risk. It followed studies showing women who frequently used hair relaxers doubled their ovarian cancer risk and had a 31% higher risk of breast cancer.

Bumpus praised the studies as “scientifically sound” and said she would leave to epidemiologists and others questions about whether straightener ingredients besides formaldehyde might be contributing to an elevated risk of hormone-driven cancers.

She could not offer a timeline for a formaldehyde ban, except to say the agency was scheduled to initiate proceedings in April. The schedule could change, she said, and she did not know how long the process of finalizing a rule would take.

Brazilian Blowouts and similar hair-smoothing treatments sometimes use formaldehyde as a glue to hold the hair straight for months. Stylists usually seal the product into the hair with a flat iron. Heat converts liquid formaldehyde into a gas that creates fumes that can sicken salon workers and patrons.

In addition to cosmetics, formaldehyde is found in embalming fluid, medicines, fabric softeners, dishwashing liquid, paints, plywood, and particleboard. It irritates the throat, nose, eyes, and skin.

If there are opponents to a ban on formaldehyde in hair straighteners, they have not raised their voices. Even the Personal Care Products Council, which represents hair straightener manufacturers, supports a formaldehyde ban, spokesperson Stefanie Harrington said in an email. More than 10 years ago, she noted, a panel of industry-paid experts deemed hair products with formaldehyde unsafe when heated.

California and Maryland will ban formaldehyde from all personal-care products starting next year. And manufacturers already have curtailed their use of formaldehyde in hair care products. Reports to the California Department of Public Health’s Safe Cosmetics Program show a tenfold drop in products containing formaldehyde from 2009 to 2022.

John Bailey, a former director of the FDA’s Office of Cosmetics and Colors, said the federal agency often waits for the industry to voluntarily remove hazardous ingredients.

Cheryl Morrow co-founded The Relaxer Advocates late last year to lobby on behalf of California Curl, a business she inherited from her father, a barber who started the company, and other Black hair care companies and salons. “Ban it,” she said of formaldehyde, “but please don’t mix it up culturally with what Black people are doing.”

She insisted the relaxers African Americans use contain no formaldehyde or other carcinogens and are safe.

A 2018 study found that hair products used primarily by Black women and children contained a host of hazardous ingredients. Investigators tested 18 products, from hot-oil treatments to anti-frizz polishes, conditioners, and relaxers. In each of the products they found at least four and as many as 30 endocrine-disrupting chemicals.

Racist beauty standards have long compelled girls and women with kinky hair to straighten it. Between 84% and 95% of Black women in the U.S. have reported using relaxers, studies show.

Black women’s often frequent and lifelong application of chemical relaxers to their hair and scalp might explain why hormone-related cancers kill more Black women than white women per capita, Bertrand and other epidemiologists say. Relaxers can be so habit-forming that users call them “creamy crack.”

As a public health educator, Astrid Williams, director of programs and initiatives at the California Black Health Network, has known the health risks associated with hair relaxers for years. Nonetheless, she used them from age 13 until two years ago, when she was 45.

“I felt I had to show up in a certain way,” she said.

A formaldehyde ban won’t make creamy crack safe, she said. “It’s not even a band-aid. The solution is to address all chemicals that pose risk.”

This article was produced by KFF Health News, which publishes California Healthline, an editorially independent service of the California Health Care Foundation. 

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

Subscribe to KFF Health News’ free Morning Briefing.

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Scientists swear their lab-grown ‘beef rice’ tastes ‘pleasant’ https://www.popsci.com/environment/hybrid-beef-rice-food/ Wed, 14 Feb 2024 22:00:00 +0000 https://www.popsci.com/?p=602780
Pink lab-grown beef rice in white bowl
It might not be the most appetizing, but it is definitely more eco-friendly. Yonsei University

Anyone hungry for a 'novel flavor experience?'

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Pink lab-grown beef rice in white bowl
It might not be the most appetizing, but it is definitely more eco-friendly. Yonsei University

The whole point of lab-grown meat, by and large, is to create a sustainable product capable of… you know, replacing meat. Researchers at universities and startup companies across the world have spent years and a lot of money on attempts to accurately imitate chicken, beef, fish, and even extinct woolly mammoths.

It’s an uphill battle, but convincing a substantial portion of the population to reduce, if not entirely cut, animal meat from their diets is widely considered a key way to combat industrial farming’s massive global carbon emissions. But instead of trying to replicate the minutiae of a burger’s mouthfeel and flavor, one group of scientists decided to sidestep those goals entirely for a new dish: “beef rice” grown from lab-cultured cow fat cells.

Beef rice lab culture on table next to equipment
Looks delicious. Credit: Yonsei University

But if you are skeptical at the thought of spoonfuls of synthetic meat-grain meals, fear not: Its makers swear their pinkish globules offer its consumers a “unique blend of aromas” including that “slight nuttiness and umami” usually associated with meat… or, at least, that’s what research lead Jinkee Hong swears.

“We tried it with various accompaniments and it pairs well with a range of dishes,” he relayed in a Wednesday profile at The Guardian.

Hong and his collaborators have detailed their process in a new paper published with Matter. Before unleashing their Frankenstein concoction into the world, the team first slathered regular rice grains with fish gelatin and injected them with lab-grown muscle and fat stem cells. The resultant hodgepodge then cultured anywhere from 9-to-11 days before being steamed for dinner time.

[Related: Scientists made a woolly mammoth meatball.]

Depending on the meat-to-fat cell ratios, taste tests of Hong’s reportedly yielded different scent and taste palates. Higher muscular contents predictably gave hints of meat and almond, while fattier variants offered notes of cream, butter, and coconut oil. Due to the altered chemical compositions, however, the rice generally proved firmer and more brittle than standard grains. Generally, the new dish also contains 8 percent more protein and 7 percent more fat than its naturally grown source rice.

Of course, rice isn’t exactly known for its high amounts of protein or fat, so those numbers aren’t going to factor into anyone’s pre-workout meal prep anytime soon. The real benefits to such a food alternative, argues researchers, is its impressively sustainability and cost-saving potential.

By their calculations, beef rice “has a significantly smaller carbon footprint at a fraction of a price.” Real beef farming releases nearly 50 kg (110 lbs) of CO2 emissions per 100 g of protein—the hybrid grain, meanwhile, releases less than 6.27 kg (14.8 lbs) for the same amount. And while beef costs less than $14.90 per kg (2.2 lbs), the equivalent rice might only set you back $2.23.

For what it’s worth, it doesn’t sound like the mad scientists behind beef rice expect their pink granules to replace your next hot pot’s bottom layer anytime soon. Instead, such a creation could find its way into emergency food supplies in regions struck by famine or natural disaster, as well as potentially within astronaut and military rations.

“While it does not exactly replicate the taste of beef, it offers a pleasant and novel flavor experience,” Hong said. Hungry yet?

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Get this massager that’s actually for your neck https://www.popsci.com/gear/percussion-massager-amazon-2024-deal/ Tue, 13 Feb 2024 19:25:00 +0000 https://www.popsci.com/?p=602545
A person using a Hyperice Volt 2 percussion massager on their shoulders
Hyperice

Really. It's for your neck and shoulders. Get your head out of the gutters and chill out with this powerful percussion massager.

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A person using a Hyperice Volt 2 percussion massager on their shoulders
Hyperice

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The Magic Wand laid its claim to muscle-relaxing fame after launching as a percussion massager. It’s known for a different kind of muscle relaxation now, but your shoulders, neck, and feet don’t care about that. Still, you might want to avoid the stigmas if you accidentally leave your massager out on the couch. Some of our favorite percussion massagers are on sale just in time to help you or your sweetie unwind after a long day of hunching over your desks like a gargoyle. If you are actually looking for a “percussion massager,” (wink) we have you covered.

Hypervolt 2 Pro $279 (Was $329)

Hyperice

SEE IT

The Hypervolt 2 Pro is our pick for the best percussion massager for athletes, but you’ll still love to use it after taking your daily hot girl walk. A pressure sensor lets you know how hard you need to push into your muscles, and a 3-hour battery life means you can use it all night long. Five speeds and five attachments—fork, ball, cushion, flat, and bullet—allow you to get a little crazy with it. Connecting it to the Hyperice app (for iOS and Android) opens you up to a world of personalized massage programs, targeted regimens, and progress scores based on use.

While these percussion massagers might not make it in time for Valentine’s Day, you don’t have to reserve giving special attention to your significant other (or yourself) for only one day. Imagine the look on your honey’s face when you tell them you booked them a long, back-tingling session with Bob and Brad. Technically, you’re not lying.

Here are more percussion massagers perfect for necking and loosening shoulders:

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How feeling ‘bad’ can help you https://www.popsci.com/health/negative-emotions-useful/ Tue, 13 Feb 2024 14:00:00 +0000 https://www.popsci.com/?p=602453
Sadness can help you recover from a failure.
Sadness can help you recover from a failure. DepositPhotos

Anger, sadness, boredom, and anxiety all have their purposes in your emotional toolkit.

The post How feeling ‘bad’ can help you appeared first on Popular Science.

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Sadness can help you recover from a failure.
Sadness can help you recover from a failure. DepositPhotos

This article was originally featured on The Conversation.

Remember the sadness that came with the last time you failed miserably at something? Or the last time you were so anxious about an upcoming event that you couldn’t concentrate for days?

These types of emotions are unpleasant to experience and can even feel overwhelming. People often try to avoid them, suppress them or ignore them. In fact, in psychology experiments, people will pay money to not feel many negative emotions. But recent research is revealing that emotions can be useful, and even negative emotions can bring benefits.

In my emotion science lab at Texas A&M University, we study how emotions like anger and boredom affect people, and we explore ways that these feelings can be beneficial. We share the results so people can learn how to use their emotions to build the lives they want.

Our studies and many others have shown that emotions aren’t uniformly good or bad for people. Instead, different emotions can result in better outcomes in particular types of situations. Emotions seem to function like a Swiss army knife–different emotional tools are helpful in specific situations.

Sadness can help you recover from a failure

Sadness occurs when people perceive that they’ve lost a goal or a desired outcome, and there’s nothing they can do to improve the situation. It could be getting creamed in a game or failing a class or work project, or it can be losing a relationship with a family member. Once evoked, sadness is associated with what psychologists call a deactivation state of doing little, without much behavior or physical arousal. Sadness also brings thinking that is more detailed and analytical. It makes you stop and think.

The benefit of the stopping and thinking that comes with sadness is that it helps people recover from failure. When you fail, that typically means the situation you’re in is not conducive to success. Instead of just charging ahead in this type of scenario, sadness prompts people to step back and evaluate what is happening.

When people are sad, they process information in a deliberative, analytical way and want to avoid risk. This mode comes with more accurate memoryjudgment that is less influenced by irrelevant assumptions or information, and better detection of other people lying. These cognitive changes can encourage people to understand past failures and possibly prevent future ones.

Sadness can function differently when there’s the possibility that the failure could be avoided if other people help. In these situations, people tend to cry and can experience increased physiological arousal, such as quicker heart and breathing rates. Expressing sadness, through tears or verbally, has the benefit of potentially recruiting other people to help you achieve your goals. This behavior appears to start in infants, with tears and cries signaling caregivers to help.

Anger prepares you to overcome an obstacle

Anger occurs when people perceive they’re losing a goal or desired outcome, but that they could improve the situation by removing something that’s in their way. The obstacle could be an injustice committed by another person, or it could be a computer that repeatedly crashes while you’re trying to get work done. Once evoked, anger is associated with a “readiness for action,” and your thinking focuses on the obstacle.

The benefit of being prepared for action and focused on what’s in your way is that it motivates you to overcome what’s standing between you and your goal. When people are angry, they process information and make judgments rapidly, want to take action, and are physiologically aroused. In experiments, anger actually increases the force of people’s kicks, which can be helpful in physical encounters. Anger results in better outcomes in situations that involve challenges to goals, including confrontational games, tricky puzzles, video games with obstacles, and responding quickly on tasks.

Expressing anger, facially or verbally, has the benefit of prompting other people to clear the way. People are more likely to concede in negotiations and give in on issues when their adversary looks or says they are angry.

Anxiety helps you prepare for danger

Anxiety occurs when people perceive a potential threat. This could be giving a speech to a large audience where failure would put your self-esteem on the line, or it could be a physical threat to yourself or loved ones. Once evoked, anxiety is associated with being prepared to respond to danger, including increased physical arousal and attention to threats and risk.

Being prepared for danger means that if trouble brews, you can respond quickly to prevent or avoid it. When anxious, people detect threats rapidly, have fast reaction times and are on heightened alert. The eye-widening that often comes with fear and anxiety even gives people a wider field of vision and improves threat detection.

Anxiety prepares the body for action, which improves performance on a number of tasks that involve motivation and attention. It motivates people to prepare for upcoming events, such as devoting time to study for an exam. Anxiety also prompts protective behavior, which can help prevent the potential threat from becoming a reality.

Boredom can jolt you out of a rut

There is less research on boredom than many other emotions, so it is not as well understood. Researchers debate what it is and what it does.

Boredom appears to occur when someone’s current situation is not causing any other emotional response. There are three situations where this lack can occur: when emotions fade, such as the happiness of a new car fading to neutral; when people don’t care about anything in their current situation, such as being at a large party where nothing interesting is happening; or when people have no goals. Boredom does not necessarily set in just because nothing is happening–someone with a goal of relaxation might feel quite content sitting quietly with no stimulation.

Psychology researchers think that the benefit of boredom in situations where people are not responding emotionally is that it prompts making a change. If nothing in your current situation is worth responding to, the aversive experience of boredom can motivate you to seek new situations or change the way you’re thinking. Boredom has been related to more risk seeking, a desire for novelty, and creative thinking. It seems to function like an emotional stick, nudging people out of their current situation to explore and create.

Using the toolkit of emotion

People want to be happy. But research is finding that a satisfying and productive life includes a mix of positive and negative emotions. Negative emotions, even though they feel bad to experience, can motivate and prepare people for failure, challenges, threats and exploration.

Pleasant or not, your emotions can help guide you toward better outcomes. Maybe understanding how they prepare you to handle various situations will help you feel better about feeling bad.

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Scientists made a ‘zinc trap’ to prevent noise-induced hearing loss (in mice) https://www.popsci.com/health/free-zinc-noise-hearing-loss/ Mon, 12 Feb 2024 20:00:00 +0000 https://www.popsci.com/?p=602284
A woman puts a yellow earplug into her ear.
Wearing ear plugs in loud areas can help prevent hearing loss. Deposit Photos

Traumatic injury to the ear can cause major problems. 'Free zinc' in our bodies plays a part.

The post Scientists made a ‘zinc trap’ to prevent noise-induced hearing loss (in mice) appeared first on Popular Science.

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A woman puts a yellow earplug into her ear.
Wearing ear plugs in loud areas can help prevent hearing loss. Deposit Photos

Music at a blaring concert, racket from tools at a construction site, or the firing of weapons can all cause noise-induced hearing loss. An acute traumatic injury to the ear from loud sounds can even progress into some more severe conditions including tinnitus and hyperacusis. People with tinnitus hear ringing or buzzing that isn’t there, while those with hyperacusis generally experience normal levels of sound as painful. 

“Noise-induced hearing loss is very common and debilitating. It is a major cause of hearing loss, and one in every five people globally suffers from it,” University of Pittsburgh otolaryngologist Thanos Tzounopoulos, tells PopSci. “Hearing loss, especially noise-induced hearing loss, is very common, yet its biological mechanism is not fully understood.”

[Related: It’s never too early to start protecting your hearing.]

Tzounopoulos is a co-author of a new study that is putting this type of hearing loss in focus. His research found the molecular mechanisms of noise-induced hearing loss in mice and showed that medication can be used to mitigate it. The findings are described in a study published February 12 in the journal Proceedings of the National Academy of Sciences (PNAS).

What does zinc have to do with hearing loss?

Zinc is an essential nutrient for living things. It helps the immune system, metabolism function, the senses of taste and smell, and even helps wounds heal. 

About 90 percent of the zinc in the human body is bound to proteins to help them keep their structure and function, while the other 10 percent is considered “free zinc.” It is not tied to proteins and is stored in tiny vesicles inside of the cells and dysregulation zinc can cause problems at the cellular level.

“As previous literature showed, dysregulation in zinc signaling can cause cell degeneration and death and contributes to conditions like ischemia and optic nerve degeneration,” says Tzounopoulos.

A zinc trap

In the study, the team used mice to explore if zinc dysregulation plays a role in the damage that loud noises can do to the inner ear. Only a few hours after the mice were exposed to loud sounds, a robust release of zinc into the space between cells occurred. This extra zinc eventually damaged the cells and disrupted normal communication between them. 

[Related: Why what we see influences what we hear.]

The team then administered a slow-releasing compound that trapped excess free zinc in two ways–through a mouse’s inner ear or through the abdomen. The mice that were treated with this compound were less prone to hearing loss and protected from noise-induced damage. 

“The fact that both options were effective at protecting mice from hearing loss suggests that, in the future, we could develop a pill that a person could take before a known loud sound exposure to protect oneself from hearing loss,” says Tzounopoulos. “We could achieve mitigation of hearing loss after the noise exposure occurred or even prevent the hearing loss if it was administered in anticipation of noise exposure.”

How to prevent hearing loss

The team is currently developing treatment for preclinical safety studies with the eventual goal of making it an over-the-counter option to protect from hearing loss. According to Tzounopoulos’ research, only 100 decibels–the sound at an average soccer game or a lawn mower–is enough to trigger the rapid zinc release that damages the inner ear and causes hearing issues.

Prevention is the best way to protect yourself from hearing loss,” says Tzounopoulos. “Always wear earplugs when you go to a loud concert or expect to be in a loud environment.”

Other options include turning down music in headphones, limiting excessive exposure to noise, and moving away from noises whenever possible.

The post Scientists made a ‘zinc trap’ to prevent noise-induced hearing loss (in mice) appeared first on Popular Science.

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Lessons from sports psychology research https://www.popsci.com/health/lessons-from-sports-psychology-research/ Sun, 11 Feb 2024 17:00:00 +0000 https://www.popsci.com/?p=602222
Travis Kelce #87 of the Kansas City Chiefs reacts after a play during the AFC Championship NFL football game against the Baltimore Ravens at M&T Bank Stadium on January 28, 2024 in Baltimore, Maryland.
Travis Kelce #87 of the Kansas City Chiefs reacts after a play during the AFC Championship NFL football game against the Baltimore Ravens at M&T Bank Stadium on January 28, 2024 in Baltimore, Maryland. Kara Durrette/Getty Images

Scientists are probing the head games that influence athletic performance, from coaching to coping with pressure.

The post Lessons from sports psychology research appeared first on Popular Science.

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Travis Kelce #87 of the Kansas City Chiefs reacts after a play during the AFC Championship NFL football game against the Baltimore Ravens at M&T Bank Stadium on January 28, 2024 in Baltimore, Maryland.
Travis Kelce #87 of the Kansas City Chiefs reacts after a play during the AFC Championship NFL football game against the Baltimore Ravens at M&T Bank Stadium on January 28, 2024 in Baltimore, Maryland. Kara Durrette/Getty Images

This article was originally featured on Knowable Magazine.

Since the early years of this century, it has been commonplace for computerized analyses of athletic statistics to guide a baseball manager’s choice of pinch hitter, a football coach’s decision to punt or pass, or a basketball team’s debate over whether to trade a star player for a draft pick.

But many sports experts who actually watch the games know that the secret to success is not solely in computer databases, but also inside the players’ heads. So perhaps psychologists can offer as much insight into athletic achievement as statistics gurus do.

Sports psychology has, after all, been around a lot longer than computer analytics. Psychological studies of sports appeared as early as the late 19th century. During the 1970s and ’80s, sports psychology became a fertile research field. And within the last decade or so, sports psychology research has exploded, as scientists have explored the nuances of everything from the pursuit of perfection to the harms of abusive coaching.

“Sport pervades cultures, continents, and indeed many facets of daily life,” write Mark Beauchamp, Alan Kingstone and Nikos Ntoumanis, authors of an overview of sports psychology research in the 2023 Annual Review of Psychology.

Their review surveys findings from nearly 150 papers investigating various psychological influences on athletic performance and success. “This body of work sheds light on the diverse ways in which psychological processes contribute to athletic strivings,” the authors write. Such research has the potential not only to enhance athletic performance, they say, but also to provide insights into psychological influences on success in other realms, from education to the military. Psychological knowledge can aid competitive performance under pressure, help evaluate the benefit of pursuing perfection and assess the pluses and minuses of high self-confidence.

Confidence and choking

In sports, high self-confidence (technical term: elevated self-efficacy belief) is generally considered to be a plus. As baseball pitcher Nolan Ryan once said, “You have to have a lot of confidence to be successful in this game.” Many a baseball manager would agree that a batter who lacks confidence against a given pitcher is unlikely to get to first base.

Various studies suggest that self-talk can increase confidence, enhance focus, control emotions and initiate effective actions.

And in fact, a lot of psychological research actually supports that view, suggesting that encouraging self-confidence is a beneficial strategy. Yet while confident athletes do seem to perform better than those afflicted with self-doubt, some studies hint that for a given player, excessive confidence can be detrimental. Artificially inflated confidence, unchecked by honest feedback, may cause players to “fail to allocate sufficient resources based on their overestimated sense of their capabilities,” Beauchamp and colleagues write. In other words, overconfidence may result in underachievement.

Other work shows that high confidence is usually most useful in the most challenging situations (such as attempting a 60-yard field goal), while not helping as much for simpler tasks (like kicking an extra point).

Of course, the ease of kicking either a long field goal or an extra point depends a lot on the stress of the situation. With time running out and the game on the line, a routine play can become an anxiety-inducing trial by fire. Psychological research, Beauchamp and coauthors report, has clearly established that athletes often exhibit “impaired performance under pressure-invoking situations” (technical term: “choking”).

In general, stress impairs not only the guidance of movements but also perceptual ability and decision-making. On the other hand, it’s also true that certain elite athletes perform best under high stress. “There is also insightful evidence that some of the most successful performers actually seek out, and thrive on, anxiety-invoking contexts offered by high-pressure sport,” the authors note. Just ask Michael Jordan or LeBron James.

Many studies have investigated the psychological coping strategies that athletes use to maintain focus and ignore distractions in high-pressure situations. One popular method is a technique known as the “quiet eye.” A basketball player attempting a free throw is typically more likely to make it by maintaining “a longer and steadier gaze” at the basket before shooting, studies have demonstrated.

“In a recent systematic review of interventions designed to alleviate so-called choking, quiet-eye training was identified as being among the most effective approaches,” Beachamp and coauthors write.

Another common stress-coping method is “self-talk,” in which players utter instructional or motivational phrases to themselves in order to boost performance. Saying “I can do it” or “I feel good” can self-motivate a marathon runner, for example. Saying “eye on the ball” might help a baseball batter get a hit.

Researchers have found moderate benefits of self-talk strategies for both novices and experienced athletes, Beauchamp and colleagues report. Various studies suggest that self-talk can increase confidence, enhance focus, control emotions and initiate effective actions.

Moderate performance benefits have also been reported for other techniques for countering stress, such as biofeedback, and possibly meditation and relaxation training.

“It appears that stress regulation interventions represent a promising means of supporting athletes when confronted with performance-related stressors,” Beauchamp and coauthors conclude.

Pursuing athletic perfection

Of course, sports psychology encompasses many other issues besides influencing confidence and coping with pressure. Many athletes set a goal of attaining perfection, for example, but such striving can induce detrimental psychological pressures. One analysis found that athletes pursuing purely personal high standards generally achieved superior performance. But when perfectionism was motivated by fear of criticism from others, performance suffered.

Similarly, while some coaching strategies can aid a player’s performance, several studies have shown that abusive coaching can detract from performance, even for the rest of an athlete’s career.

Beauchamp and his collaborators conclude that a large suite of psychological factors and strategies can aid athletic success. And these factors may well be applicable to other areas of human endeavor where choking can impair performance (say, while performing brain surgery or flying a fighter jet).

But the authors also point out that researchers shouldn’t neglect the need to consider that in sports, performance is also affected by the adversarial nature of competition. A pitcher’s psychological strategies that are effective against most hitters might not fare so well against Shohei Ohtani, for instance.

Besides that, sports psychology studies (much like computer-based analytics) rely on statistics. As Adolphe Quetelet, a pioneer of social statistics, emphasized in the 19th century, statistics do not define any individual—average life expectancy cannot tell you when any given person will die. On the other hand, he noted, no single exceptional case invalidates the general conclusions from sound statistical analysis.

Sports are, in fact, all about the quest of the individual (or a team) to defeat the opposition. Success often requires defying the odds — which is why gambling on athletic events is such a big business. Sports consist of contests between the averages and the exceptions, and neither computer analytics nor psychological science can tell you in advance who is going to win. That’s why they play the games.

This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.

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Do we simply not care about old people? https://www.popsci.com/health/do-we-simply-not-care-about-old-people/ Fri, 09 Feb 2024 18:00:00 +0000 https://www.popsci.com/?p=602132
Many seniors at high risk aren’t getting antiviral therapies for covid, and most older adults in nursing homes aren’t getting updated vaccines.
Many seniors at high risk aren’t getting antiviral therapies for covid, and most older adults in nursing homes aren’t getting updated vaccines. DepositPhotos

'Covid has pushed us back in whatever progress we were making in addressing the needs of our rapidly aging society. It has further stigmatized aging.'

The post Do we simply not care about old people? appeared first on Popular Science.

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Many seniors at high risk aren’t getting antiviral therapies for covid, and most older adults in nursing homes aren’t getting updated vaccines.
Many seniors at high risk aren’t getting antiviral therapies for covid, and most older adults in nursing homes aren’t getting updated vaccines. DepositPhotos

This article was originally published on KFF Health News.

The covid-19 pandemic would be a wake-up call for America, advocates for the elderly predicted: incontrovertible proof that the nation wasn’t doing enough to care for vulnerable older adults.

The death toll was shocking, as were reports of chaos in nursing homes and seniors suffering from isolation, depression, untreated illness, and neglect. Around 900,000 older adults have died of covid-19 to date, accounting for 3 of every 4 Americans who have perished in the pandemic.

But decisive actions that advocates had hoped for haven’t materialized. Today, most people—and government officials — appear to accept covid as a part of ordinary life. Many seniors at high risk aren’t getting antiviral therapies for covid, and most older adults in nursing homes aren’t getting updated vaccines. Efforts to strengthen care quality in nursing homes and assisted living centers have stalled amid debate over costs and the availability of staff. And only a small percentage of people are masking or taking other precautions in public despite a new wave of covid, flu, and respiratory syncytial virus infections hospitalizing and killing seniors.

In the last week of 2023 and the first two weeks of 2024 alone, 4,810 people 65 and older lost their lives to covid—a group that would fill more than 10 large airliners—according to data provided by the CDC. But the alarm that would attend plane crashes is notably absent. (During the same period, the flu killed an additional 1,201 seniors, and RSV killed 126.)

“It boggles my mind that there isn’t more outrage,” said Alice Bonner, 66, senior adviser for aging at the Institute for Healthcare Improvement. “I’m at the point where I want to say, ‘What the heck? Why aren’t people responding and doing more for older adults?’”

It’s a good question. Do we simply not care?

I put this big-picture question, which rarely gets asked amid debates over budgets and policies, to health care professionals, researchers, and policymakers who are older themselves and have spent many years working in the aging field. Here are some of their responses.

The pandemic made things worse

Prejudice against older adults is nothing new, but “it feels more intense, more hostile” now than previously, said Karl Pillemer, 69, a professor of psychology and gerontology at Cornell University.

“I think the pandemic helped reinforce images of older people as sick, frail, and isolated—as people who aren’t like the rest of us,” he said. “And human nature being what it is, we tend to like people who are similar to us and be less well disposed to ‘the others.’”

“A lot of us felt isolated and threatened during the pandemic. It made us sit there and think, ‘What I really care about is protecting myself, my wife, my brother, my kids, and screw everybody else,’” said W. Andrew Achenbaum, 76, the author of nine books on aging and a professor emeritus at Texas Medical Center in Houston.

In an environment of “us against them,” where everybody wants to blame somebody, Achenbaum continued, “who’s expendable? Older people who aren’t seen as productive, who consume resources believed to be in short supply. It’s really hard to give old people their due when you’re terrified about your own existence.”

Although covid continues to circulate, disproportionately affecting older adults, “people now think the crisis is over, and we have a deep desire to return to normal,” said Edwin Walker, 67, who leads the Administration on Aging at the Department of Health and Human Services. He spoke as an individual, not a government representative.

The upshot is “we didn’t learn the lessons we should have,” and the ageism that surfaced during the pandemic hasn’t abated, he observed.

Ageism is pervasive

“Everyone loves their own parents. But as a society, we don’t value older adults or the people who care for them,” said Robert Kramer, 74, co-founder and strategic adviser at the National Investment Center for Seniors Housing & Care.

Kramer thinks boomers are reaping what they have sown. “We have chased youth and glorified youth. When you spend billions of dollars trying to stay young, look young, act young, you build in an automatic fear and prejudice of the opposite.”

Combine the fear of diminishment, decline, and death that can accompany growing older with the trauma and fear that arose during the pandemic, and “I think covid has pushed us back in whatever progress we were making in addressing the needs of our rapidly aging society. It has further stigmatized aging,” said John Rowe, 79, professor of health policy and aging at Columbia University’s Mailman School of Public Health.

“The message to older adults is: ‘Your time has passed, give up your seat at the table, stop consuming resources, fall in line,’” said Anne Montgomery, 65, a health policy expert at the National Committee to Preserve Social Security and Medicare. She believes, however, that baby boomers can “rewrite and flip that script if we want to and if we work to change systems that embody the values of a deeply ageist society.”

Integration, not separation, is needed.

The best way to overcome stigma is “to get to know the people you are stigmatizing,” said G. Allen Power, 70, a geriatrician and the chair in aging and dementia innovation at the Schlegel-University of Waterloo Research Institute for Aging in Canada. “But we separate ourselves from older people so we don’t have to think about our own aging and our own mortality.”

The solution: “We have to find ways to better integrate older adults in the community as opposed to moving them to campuses where they are apart from the rest of us,” Power said. “We need to stop seeing older people only through the lens of what services they might need and think instead of all they have to offer society.”

That point is a core precept of the National Academy of Medicine’s 2022 report Global Roadmap for Healthy Longevity. Older people are a “natural resource” who “make substantial contributions to their families and communities,” the report’s authors write in introducing their findings.

Those contributions include financial support to families, caregiving assistance, volunteering, and ongoing participation in the workforce, among other things.

“When older people thrive, all people thrive,” the report concludes.

Future generations will get their turn

That’s a message Kramer conveys in classes he teaches at the University of Southern California, Cornell, and other institutions. “You have far more at stake in changing the way we approach aging than I do,” he tells his students. “You are far more likely, statistically, to live past 100 than I am. If you don’t change society’s attitudes about aging, you will be condemned to lead the last third of your life in social, economic, and cultural irrelevance.”

As for himself and the baby boom generation, Kramer thinks it’s “too late” to effect the meaningful changes he hopes the future will bring.

“I suspect things for people in my generation could get a lot worse in the years ahead,” Pillemer said. “People are greatly underestimating what the cost of caring for the older population is going to be over the next 10 to 20 years, and I think that’s going to cause increased conflict.”

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

Subscribe to KFF Health News’ free Morning Briefing.

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What do your blood test results mean? https://www.popsci.com/health/what-do-blood-test-results-mean/ Tue, 06 Feb 2024 13:00:00 +0000 https://www.popsci.com/?p=601583
Blood tests provide clinicians with more information to guide diagnoses and treatment decisions.
Blood tests provide clinicians with more information to guide diagnoses and treatment decisions. FluxFactory/E+ via Getty Images

A toxicologist explains the basics of how to interpret blood test results.

The post What do your blood test results mean? appeared first on Popular Science.

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Blood tests provide clinicians with more information to guide diagnoses and treatment decisions.
Blood tests provide clinicians with more information to guide diagnoses and treatment decisions. FluxFactory/E+ via Getty Images

This article was originally featured on The Conversation.

Your blood serves numerous roles to maintain your health. To carry out these functions, blood contains a multitude of components, including red blood cells that transport oxygen, nutrients and hormones; white blood cells that remove waste products and support the immune system; plasma that regulates temperature; and platelets that help with clotting.

Within the blood are also numerous molecules formed as byproducts of normal biochemical functions. When these molecules indicate how your cells are responding to disease, injury or stress, scientists often refer to them as biological markers, or biomarkers. Thus, biomarkers in a blood sample can represent a snapshot of the current biochemical state of your body, and analyzing them can provide information about various aspects of your health.

As a toxicologist, I study the effects of drugs and environmental contaminants on human health. As part of my work, I rely on various health-related biomarkers, many of which are measured using conventional blood tests.

Understanding what common blood tests are intended to measure can help you better interpret the results. If you have results from a recent blood test handy, please follow along.

What do your blood test results mean?

Blood samples go through several processing steps after they’re drawn.

Normal blood test ranges

Depending on the lab that analyzed your sample, the results from your blood test may be broken down into individual tests or collections of related tests called panels. Results from these panels can allow a health care professional to recommend preventive care, detect potential diseases and monitor ongoing health conditions.

For each of the tests listed in your report, there will typically be a number corresponding to your test result and a reference range or interval. This range is essentially the upper and lower limits within which most healthy people’s test results are expected to fall.

Sometimes called a normal range, a reference interval is based on statistical analyses of tests from a large number of patients in a reference population. Normal levels of some biomarkers are expected to vary across a group of people, depending on their age, sex, ethnicity and other attributes.

So, separate reference populations are often created from people with a particular attribute. For example, a reference population could comprise all women or all children. A patient’s test value can then be appropriately compared with results from the reference population that fits them best.

Reference intervals vary from lab to lab because each may use different testing methods or reference populations. This means you might not be able to compare your results with reference intervals from other labs. To determine how your test results compare with the normal range, you need to check the reference interval listed on your lab report.

If you have results for a given test from different labs, your clinician will likely focus on test trends relative to their reference intervals and not the numerical results themselves.

Interpreting your blood test results

There are numerous blood panels intended to test specific aspects of your health. These include panels that look at the cellular components of your blood, biomarkers of kidney and liver function, and many more.

Rather than describe each panel, let’s look at a hypothetical case study that requires using several panels to diagnose a disease.

In this situation, a patient visits their health care provider for fatigue that has lasted several months. Numerous factors and disorders can result in prolonged or chronic fatigue.

Based on a physical examination, other symptoms and medical history, the health practitioner suspects that the patient could be suffering from any of the following: anemia, an underactive thyroid or diabetes.

Blood tests would help further narrow down the cause of fatigue.

Anemia is a condition involving reduced blood capacity to transport oxygen. This results from either lower than normal levels of red blood cells or a decrease in the quantity or quality of hemoglobin, the protein that allows these cells to transport oxygen.

complete blood count panel measures various components of the blood to provide a comprehensive overview of the cells that make it up. Low values of red blood cell count, or RBC, hemoglobin, or Hb, and hematocrit, or HCT, would indicate that the patient is suffering from anemia.

Hypothyroidism is a disorder in which the thyroid gland does not produce enough thyroid hormones. These include thyroid-stimulating hormone, or TSH, which stimulates the thyroid gland to release two other hormones: triiodothyronine, or T3, and thyroxine, or T4. The thyroid function panel measures the levels of these hormones to assess thyroid-related health.

Diabetes is a disease that occurs when blood sugar levels are too high. Excessive glucose molecules in the bloodstream can bind to hemoglobin and form what’s called glycated hemoglobin, or HbA1c. A hemoglobin A1c test measures the percentage of HbA1c present relative to the total amount of hemoglobin. This provides a history of glucose levels in the bloodstream over a period of about three months prior to the test.

Providing additional information is the basic metabolic panel, or BMP, which measures the amount various substances in your blood. These include:

  • Glucose, a type of sugar that provides energy for your body and brain. Relevant to diabetes, the BMP measures the blood glucose levels at the time of the test.
  • Calcium, a mineral essential for proper functioning of your nerves, muscles and heart.
  • Creatinine, a byproduct of muscle activity.
  • Blood urea nitrogen, or BUN, the amount of the waste product urea your kidneys help remove from your blood. These indicate the status of a person’s metabolism, kidney health and electrolyte balance.

With results from each of these panels, the health professional would assess the patient’s values relative to their reference intervals and determine which condition they most likely have.

Understanding the purpose of blood tests and how to interpret them can help patients partner with their health care providers and become more informed about their health.

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Scientists have 3D bioprinted functioning human brain tissue https://www.popsci.com/science/3d-printed-brain-tissue/ Mon, 05 Feb 2024 22:00:00 +0000 https://www.popsci.com/?p=601526
Illustration of 3D printed brain tissue culture with 25nm scale
The new brain tissue culture production offers more precise customization for researchers. Yan et al. / UW-Madison

A new method for assembling neuron cultures horizontally instead of vertically helps solve for a longstanding issue.

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Illustration of 3D printed brain tissue culture with 25nm scale
The new brain tissue culture production offers more precise customization for researchers. Yan et al. / UW-Madison

Scientists have created brain “organoids” for years, but there are limitations to the tiny, lab-grown cultures. One of the most frustrating issues is a lack of control over their design, which often limits an organoid’s functionality and use. Although researchers long suspected 3D-printing could offer a solution, the workaround has so far proven difficult and ineffective. A new production breakthrough, however, could solve the longstanding barrier, and one day offer new ways of exploring treatment for diseases such as Parkinson’s and Alzeheimer’s.

As detailed in the new issue of the journal Cell Stem Cell, University of Wisconsin-Madison researchers have developed a novel 3D-printing approach for creating cultures that grow and operate similar to brain tissue. While traditional 3D-printing involves layering “bio-ink” vertically like a cake, the team instead tasked their machine to print horizontally, as if playing dominoes.

Related: A ‘brain organoid’ biochip displayed serious voice recognition and math skills.]

As New Atlas explains, researchers placed neurons grown from pluripotent stem cells (those capable of becoming multiple different cell types) within a new bio-ink gel made with fibrinogen and thrombin, biomaterials involved in blood clotting. Adding other hydrogels then helped loosen the bio-ink to solve for the 3 encountered during previous 3D-printed tissue experiments.

According to Su-Chun Zhang, a research lead and UW-Madison professor of neuroscience and neurology, the resultant tissue is resilient enough to maintain its structure, but also sufficiently malleable to permit adequate levels of oxygen and nutrient intake for the neurons. 

“The tissue still has enough structure to hold together but it is soft enough to allow the neurons to grow into each other and start talking to each other,” Zhang explains in a recent university profile.

Because of their horizontal construction, the new tissue cells formed connections not only within each layer, but across them, as well—much like human neurons. The new structures could interact thanks to producing neurotransmitters, and even created support cell networks within the 3D-printed tissue.

In these experiments, the team printed both cerebral cortex and striatum cultures. Although responsible for very different functions—the former associated with thought, language, and voluntary movement; the latter tied to visual information—the two 3D-printed tissues could still communicate, “in a very special and specific way,” Zhang said.

Researchers believe their technique isn’t limited to creating just those two types of cultures, but hypothetically “pretty much any type of neurons [sic] at any time,” according to Zhang. This means the 3D-printing method could eventually help study how healthy portions of the brain interact with parts affected by Alzheimers, examining cell signal pathways in Downs syndrome, as well as use tissue to test new drugs.

“Our brain operates in networks,” Zhang explained. “We want to print brain tissue this way because cells do not operate by themselves. They talk to each other. This is how our brain works and it has to be studied all together like this to truly understand it.”

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The untapped potential of stem cells in menstrual blood https://www.popsci.com/health/the-untapped-potential-of-stem-cells-in-menstrual-blood/ Mon, 05 Feb 2024 16:00:00 +0000 https://www.popsci.com/?p=601419
Stem cells found in menstrual blood could unlock new therapies and diagnostic tests.
Stem cells found in menstrual blood could unlock new therapies and diagnostic tests. DepositPhotos

Long overlooked, menstrual stem cells could have important medical applications, including diagnosing endometriosis.

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Stem cells found in menstrual blood could unlock new therapies and diagnostic tests.
Stem cells found in menstrual blood could unlock new therapies and diagnostic tests. DepositPhotos

This article was originally featured on Knowable Magazine.

Roughly 20 years ago, a biologist named Caroline Gargett went in search of some remarkable cells in tissue that had been removed during hysterectomy surgeries. The cells came from the endometrium, which lines the inside of the uterus. When Gargett cultured the cells in a petri dish, they looked like round clumps surrounded by a clear, pink medium. But examining them with a microscope, she saw what she was looking for—two kinds of cells, one flat and roundish, the other elongated and tapered, with whisker-like protrusions.

Gargett strongly suspected that the cells were adult stem cells—rare, self-renewing cells, some of which can give rise to many different types of tissues. She and other researchers had long hypothesized that the endometrium contained stem cells, given its remarkable capacity to regrow itself each month. The tissue, which provides a site for an embryo to implant during pregnancy and is shed during menstruation, undergoes roughly 400 rounds of shedding and regrowth before a woman reaches menopause. But although scientists had isolated adult stem cells from many other regenerating tissues—including bone marrow, the heart, and muscle—“no one had identified adult stem cells in endometrium,” Gargett says.

These purple blobs are clones of the stem cells that Caroline Gargett and colleagues identified in menstrual fluid. Each cluster began as a single cell. On the right, a close-up view of one blob, magnified at least 20 times, reveals the tightly packed cells’ whiskery, spindled shapes. CREDIT: K. SCHWAB, C. TAN AND C. GARGETT, THE RITCHIE CENTRE, HUDSON INSTITUTE OF MEDICAL RESEARCH AND MONASH UNIVERSITY DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY, MELBOURNE AUSTRALIA
These purple blobs are clones of the stem cells that Caroline Gargett and colleagues identified in menstrual fluid. Each cluster began as a single cell. On the right, a close-up view of one blob, magnified at least 20 times, reveals the tightly packed cells’ whiskery, spindled shapes. CREDIT: K. SCHWAB, C. TAN AND C. GARGETT, THE RITCHIE CENTRE, HUDSON INSTITUTE OF MEDICAL RESEARCH AND MONASH UNIVERSITY DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY, MELBOURNE AUSTRALIA

Such cells are highly valued for their potential to repair damaged tissue and treat diseases such as cancer and heart failure. But they exist in low numbers throughout the body, and can be tricky to obtain, requiring surgical biopsy, or extracting bone marrow with a needle. The prospect of a previously untapped source of adult stem cells was thrilling on its own, says Gargett. And it also raised the exciting possibility of a new approach to long-neglected women’s health conditions such as endometriosis.

Before she could claim that the cells were truly stem cells, Gargett and her team at Monash University in Australia had to put them through a series of rigorous tests. First, they measured the cells’ ability to proliferate and self-renew, and found that some of them could divide into about 100 cells within a week. They also showed that the cells could indeed differentiate into endometrial tissue, and identified certain telltale proteins that are present in other types of stem cells.

Gargett, who is now also with Australia’s Hudson Institute of Medical Research, and her colleagues went on to characterize several types of self-renewing cells in the endometrium. But only the whiskered cells, called endometrial stromal mesenchymal stem cells, were truly “multipotent,” with the ability to be coaxed into becoming fat cells, bone cells, or even the smooth muscle cells found in organs such as the heart.

Stem cells from the endometrium can be collected through a biopsy or in menstrual blood. Under the right conditions, they can differentiate into cell types including neurons and cartilage, fat, bone, heart, liver and skin cells.
Stem cells from the endometrium can be collected through a biopsy or in menstrual blood. Under the right conditions, they can differentiate into cell types including neurons and cartilage, fat, bone, heart, liver and skin cells. Credit: Knowable Magazine

Around the same time, two independent research teams made another surprising discovery: Some endometrial stromal mesenchymal stem cells could be found in menstrual blood. Gargett was surprised that the body would so readily shed its precious stem cells. Since they are so important for the survival and function of organs, she didn’t think the body would “waste” them by shedding them. But she immediately recognized the finding’s significance: Rather than relying on an invasive surgical biopsy to obtain the elusive stem cells she’d identified in the endometrium, she could collect them via menstrual cup.

More detailed studies of the endometrium have since helped to explain how a subset of these precious endometrial stem cells — dubbed menstrual stem cells — end up in menstrual blood. The endometrium has a deeper basal layer that remains intact, and an upper functional layer that sloughs off during menstruation. During a single menstrual cycle, the endometrium thickens as it prepares to nourish a fertilized egg, then shrinks as the upper layer sloughs away.

Gargett’s team has shown that these special stem cells are present in both the lower and upper layers of the endometrium. The cells are typically wrapped around blood vessels in a crescent shape, where they are thought to help stimulate vessel formation and play a vital role in repairing and regenerating the upper layer of tissue that gets shed each month during menstruation. This layer is crucial to pregnancy, providing support and nourishment for a developing embryo. The layer, and the endometrial stem cells that prod its growth, also appears to play an important role in infertility: An embryo can’t implant if the layer doesn’t thicken enough.

Endometrial stem cells have also been linked to endometriosis, a painful condition that affects roughly 190 million women and girls worldwide. Although much about the condition isn’t fully understood, researchers hypothesize that one contributor is the backflow of menstrual blood into a woman’s fallopian tubes, the ducts that carry the egg from the ovaries into the uterus. This backward flow takes the blood into the pelvic cavity, a funnel-shaped space between the bones of the pelvis. Endometrial stem cells that get deposited in these areas may cause endometrial-like tissue to grow outside of the uterus, leading to lesions that can cause excruciating pain, scarring and, in many cases, infertility.

Researchers are still developing a reliable, noninvasive test to diagnose endometriosis, and patients wait an average of nearly seven years before receiving a diagnosis. But studies have shown that stem cells collected from the menstrual blood of women with endometriosis have different shapes and patterns of gene expression than cells from healthy women. Several labs are working on ways to use these differences in menstrual stem cells to identify women at higher risk of the condition, which could lead to faster diagnosis and treatment. Menstrual stem cells may also have therapeutic applications. Some researchers working on mice, for example, have found that injecting menstrual stem cells into the rodents’ blood can repair the damaged endometrium and improve fertility.

Other research in lab animals suggests that menstrual stem cells could have therapeutic potential beyond gynecological diseases. In a couple of studies, for example, injecting menstrual stem cells into diabetic mice stimulated regeneration of insulin-producing cells and improved blood sugar levels. In another, treating injuries with stem cells or their secretions helped heal wounds in mice.

Stem cells differ in abilities. Totipotent stem cells are the most powerful: They can form any cell, and even an entire organism. Pluripotent stem cells are almost as versatile, while multipotent stem cells—which include the mesenchymal stem cells in menstrual blood—can make a limited range of cell types. Oligopotent stem cells can make just a few cell types within the same organ or tissue. Unipotent stem cells replace one specific cell type, like sperm or skin cells. Credit: Knowable Magazine
Stem cells differ in abilities. Totipotent stem cells are the most powerful: They can form any cell, and even an entire organism. Pluripotent stem cells are almost as versatile, while multipotent stem cells—which include the mesenchymal stem cells in menstrual blood—can make a limited range of cell types. Oligopotent stem cells can make just a few cell types within the same organ or tissue. Unipotent stem cells replace one specific cell type, like sperm or skin cells. Credit: Knowable Magazine

A handful of small but promising clinical trials have found that menstrual stem cells can be transplanted into humans without adverse side effects. Gargett’s team is also attempting to develop human therapies. She and her colleagues are using endometrial stem cells—those taken directly from endometrial tissue, rather than menstrual blood—to engineer a mesh to treat pelvic organ prolapse, a common, painful condition in which the bladder, rectum or uterus slips into the vagina due to weak or injured muscles.

The condition is often caused by childbirth. Existing treatments use synthetic meshes to reinforce and support weak pelvic tissues. But adverse immune reactions to these materials have led these meshes to be withdrawn from the market. Gargett’s research—so far conducted only in animal models—suggests that using a patient’s own endometrial stem cells to coat biodegradable meshes could yield better results.

Despite the relative convenience of collecting adult multipotent stem cells from menstrual blood, research exploring and utilizing the stem cells’ power—and their potential role in disease—still represents a tiny fraction of stem cell research, says Daniela Tonelli Manica, an anthropologist at Brazil’s State University of Campinas. As of 2020, she found, menstrual stem cell research accounted for only 0.25 percent of all mesenchymal cell research, while bone marrow stem cells represented 47.7 percent.

Manica attributes the slow adoption of menstrual stem cells in part to misogynistic ideas that uteruses are outside the norm, and to reactions of disgust. “There’s certainly something of an ‘ick factor’ associated with menstrual blood,” agrees Victoria Male, a reproductive immunologist at Imperial College London who coauthored an article about uterine immune cells in the 2023 Annual Review of Immunology.

Cultural taboos surrounding menstruation—and a general lack of investment in women’s health research—can make it difficult to get funding, says Gargett. Immunologist Male has faced similar challenges—it was easier to obtain funding when she used to study immune cells in liver transplantation than it is now that she works on immune cells in the uterus, she says.

“If we want more research on menstrual fluid, we need more funding,” says Male, noting that the logistics of collecting menstrual fluid over multiple days can be expensive. For that to happen, “we have to tackle sex and gender bias in research funding.” Through more equitable investments, she and others hope, menstruation will be recognized as an exciting new frontier in regenerative medicine—not just a monthly inconvenience.

This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.

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Possibility of wildlife-to-human crossover heightens concern about chronic wasting disease https://www.popsci.com/health/chronic-wasting-disease-wildlife-to-human-crossover/ Sat, 03 Feb 2024 17:00:00 +0000 https://www.popsci.com/?p=601289
Chronic wasting disease currently is known to infect only members of the cervid family—elk, deer, reindeer, caribou, and moose.
Chronic wasting disease currently is known to infect only members of the cervid family—elk, deer, reindeer, caribou, and moose. Matthias Bein/picture alliance via Getty Images

'The bottom-line message is we are quite unprepared.'

The post Possibility of wildlife-to-human crossover heightens concern about chronic wasting disease appeared first on Popular Science.

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Chronic wasting disease currently is known to infect only members of the cervid family—elk, deer, reindeer, caribou, and moose.
Chronic wasting disease currently is known to infect only members of the cervid family—elk, deer, reindeer, caribou, and moose. Matthias Bein/picture alliance via Getty Images

This article was originally published on KFF Health News.

Each fall, millions of hunters across North America make their way into forests and grasslands to kill deer. Over the winter, people chow down on the venison steaks, sausage, and burgers made from the animals.

These hunters, however, are not just on the front lines of an American tradition. Infectious disease researchers say they are also on the front lines of what could be a serious threat to public health: chronic wasting disease.

The neurological disease, which is contagious, rapidly spreading, and always fatal, is caused by misfolded proteins called prions. It currently is known to infect only members of the cervid family—elk, deer, reindeer, caribou, and moose.

Animal disease scientists are alarmed about the rapid spread of CWD in deer. Recent research shows that the barrier to a spillover into humans is less formidable than previously believed and that the prions causing the disease may be evolving to become more able to infect humans.

A response to the threat is ramping up. In 2023, a coalition of researchers began “working on a major initiative, bringing together 68 different global experts on various aspects of CWD to really look at what are the challenges ahead should we see a spillover into humans and food production,” said Michael Osterholm, an expert in infectious disease at the University of Minnesota and a leading authority on CWD.

“The bottom-line message is we are quite unprepared,” Osterholm said. “If we saw a spillover right now, we would be in free fall. There are no contingency plans for what to do or how to follow up.”

The team of experts is planning for a potential outbreak, focusing on public health surveillance, lab capacity, prion disease diagnostics, surveillance of livestock and wildlife, risk communication, and education and outreach.

Despite the concern, tens of thousands of infected animals have been eaten by people in recent years, yet there have been no known human cases of the disease.

Many hunters have wrestled with how seriously to take the threat of CWD. “The predominant opinion I encounter is that no human being has gotten this disease,” said Steve Rinella, a writer and the founder of MeatEater, a media and lifestyle company focused on hunting and cooking wild game.

They think, “I am not going to worry about it because it hasn’t jumped the species barrier,” Rinella said. “That would change dramatically if a hunter got CWD.”

Other prion diseases, such as bovine spongiform encephalopathy, also known as mad cow disease, and Creutzfeldt-Jakob disease, have affected humans. Mad cow claimed the lives of more than 200 people, mostly in the United Kingdom and France. Some experts believe Parkinson’s and Alzheimer’s also may be caused by prions.

First discovered in Colorado in captive deer in 1967, CWD has since spread widely. It has been found in animals in at least 32 states, four Canadian provinces, and four other foreign countries. It was recently found for the first time in Yellowstone National Park.

Prions behave very differently than viruses and bacteria and are virtually impossible to eradicate. Matthew Dunfee, director of the Chronic Wasting Disease Alliance, said experts call it a “disease from outer space.”

Symptoms are gruesome. The brain deteriorates to a spongy consistency. Sometimes nicknamed “zombie deer disease,” the condition makes infected animals stumble, drool, and stare blankly before they die. There is no treatment or vaccine. And it is extremely difficult to eradicate, whether with disinfectants or with high heat—it even survives autoclaving, or medical sterilization.

Cooking doesn’t kill prions, said Osterholm. Unfortunately, he said, “cooking concentrates the prions. It makes it even more likely” people will consume them, he said.

Though CWD is not known to have passed to humans or domestic animals, experts are very concerned about both possibilities, which Osterholm’s group just received more than $1.5 million in funding to study. CWD can infect more parts of an animal’s body than other prion diseases like mad cow, which could make it more likely to spread to people who eat venison—if it can jump to humans.

Researchers estimate that between 7,000 and 15,000 infected animals are unknowingly consumed by hunter families annually, a number that increases every year as the disease spreads across the continent. While testing of wild game for CWD is available, it’s cumbersome and the tests are not widely used in many places.

A major problem with determining whether CWD has affected humans is that it has a long latency. People who consume prions may not contract the resulting disease until many years later—so, if someone fell sick, there might not be an apparent connection to having eaten deer.

Prions are extremely persistent in the environment. They can remain in the ground for many years and even be taken up by plants.

Because the most likely route for spillover is through people who eat venison, quick testing of deer and other cervid carcasses is where prevention is focused. Right now, a hunter may drive a deer to a check station and have a lymph node sample sent to a lab. It can be a week or more before results come in, so most hunters skip it.

Montana, for example, is famous for its deer hunting. CWD was first detected in the wild there in 2017 and now has spread across much of the state. Despite warnings and free testing, Montana wildlife officials have not seen much concern among hunters. “We have not seen a decrease in deer hunting because of this,” said Brian Wakeling, game management bureau chief for the Montana Department of Fish, Wildlife & Parks. In 2022 Montana hunters killed nearly 88,000 deer. Just 5,941 samples were taken, and 253 of those tested positive.

Experts believe a rapid test would greatly increase the number of animals tested and help prevent spillover.

Because of the importance of deer to Indigenous people, several tribal nations in Minnesota are working with experts at the University of Minnesota to come up with ways to monitor and manage the disease. “The threat and potential for the spread of CWD on any of our three reservations has the ability to negatively impact Ojibwe culture and traditions of deer hunting providing venison for our membership,” said Doug McArthur, a tribal biologist for the White Earth Nation, in a statement announcing the program. (The other groups referenced are the Leech Lake Band of Ojibwe and Red Lake Band of Chippewa.) “Tribes must be ready with a plan to manage and mitigate the effects of CWD … to ensure that the time-honored and culturally significant practice of harvesting deer is maintained for future generations.”

Peter Larsen is an assistant professor in the College of Veterinary Medicine at the University of Minnesota and co-director of the Minnesota Center for Prion Research and Outreach. The center was formed to study numerous aspects of prions as part of the push to get ahead of possible spillover. “Our mission is to learn everything we can about not just CWD but other prionlike diseases, including Parkinson’s and Alzheimer’s disease,” he said. “We are studying the biology and ecology” of the misfolded protein, he said. “How do prions move within the environment? How can we help mitigate risk and improve animal health and welfare?”

Part of that mission is new technology to make testing faster and easier. Researchers have developed a way for hunters to do their own testing, though it can take weeks for results. There’s hope for, within the next two years, a test that will reduce the wait time to three to four hours.

“With all the doom and gloom around CWD, we have real solutions that can help us fight this disease in new ways,” said Larsen. “There’s some optimism.”

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

Subscribe to KFF Health News’ free Morning Briefing.

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Computer modeling is tracing the hidden evolution of sign languages https://www.popsci.com/technology/sign-language-evolution-study/ Thu, 01 Feb 2024 19:00:00 +0000 https://www.popsci.com/?p=601227
In tracing signed vocabularies’ evolutions, researchers applied phylogenetic analysis typically associated with biologically inherited traits to physically conveyed communications.
In tracing signed vocabularies’ evolutions, researchers applied phylogenetic analysis typically associated with biologically inherited traits to physically conveyed communications. Deposit Photos

A new program analyzed 19 different sign languages from around the world to help understand their connections.

The post Computer modeling is tracing the hidden evolution of sign languages appeared first on Popular Science.

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In tracing signed vocabularies’ evolutions, researchers applied phylogenetic analysis typically associated with biologically inherited traits to physically conveyed communications.
In tracing signed vocabularies’ evolutions, researchers applied phylogenetic analysis typically associated with biologically inherited traits to physically conveyed communications. Deposit Photos

It’s relatively easy to trace a written linguistic history—there’s generally a lot of written documentation and records to study. Things get trickier, however, when attempting to examine a sign language’s evolution. Most transformations within the currently over 300 known sign languages (or SLs) around the world occurred sans text over generations of learners. Add in the centuries of marginalization experienced by Deaf and hard of hearing communities, and establishing concrete relationships between SLs becomes extremely difficult.

To help correct this long standing issue, researchers recently created a novel computational program capable of analyzing the relationships between various SLs. The result, published today in Science, is a first-of-its-kind large-scale study that greatly expands on linguists’ understanding of sign language development while challenging long held beliefs about its evolution.

[Related: Online classes are difficult for the hard of hearing. Here’s how to fix that.]

“Many people mistakenly think that sign language is shared around the world, but really the world is full of a vibrant tapestry of different sign languages,” Natasha Abner, study lead author and an associate professor of linguistics at the University of Michigan, writes in an email to PopSci.

For their study, Abner and her colleagues first compiled a video dictionary of core, “resilient” vocabulary across 19 modern sign languages, such as American, British, Chinese, French, Japanese, and Spanish, among others. For example, while a sign for “oak tree” may only occur in languages spoken in regions with oak trees, the concept of just a “tree” is much more ubiquitous. Researchers then broke down video demonstrations for the 19 signing variants for “tree” (along with many other words) into basic phonetic parameters, then entered it all into a massive database.

“What we do in the study is look at how the sign languages refer to these commonplace, universal objects in the world and we work backwards to build a history of the language and languages,” Abner says. “This built history helps us understand the histories of the communities in ways that the historical records cannot because they are so limited and sparse.”

The computational analysis program then examined the signed vocabulary glossary, categorizing each entry based on intricate factors like handedness (one- or two-handed signs), handshape, location, and movement.

“This coding system avoids outcomes driven by superficial similarities or differences in two key ways,” reads a portion of the team’s study. “One, possible character values in the coding system range from two distinct values (handedness) to 10 distinct values (handshape), so it is a highly articulated system capable of capturing and tracking fine-grained differences.”

In tracing signed vocabularies’ evolutions, researchers applied phylogenetic analysis typically associated with biologically inherited traits to physically conveyed communications.

“In our study, the ‘genes’ of language are the words that the languages use to describe the world around them,” says Abner. Pursuing this strategy meant that, instead of simply applying existing computational methods to sign language data, Abner’s team used sign languages “as the empirical basis for advancing the computational methods themselves.”

[Related: The language you speak changes your perception of time.]

After examining the dataset, the team’s program established two wholly independent European and Asian sign language families alongside family trees for each one, as well as two distinct Asian sign language subfamilies. Some of the findings reinforced the already known, lasting effects of Western colonization, such as the relationship between British, Australian, and New Zealand sign languages at the expense of endangered or extinct indigenous variants. 

Meanwhile, the documented influence of French sign language within the Western European language tree is backed up by France’s help in expanding Deaf education schools during the 18th century. At the same time, the new computational analysis also revealed previously undocumented connections between British Sign Languages and Western European varieties. To back up the program’s claim, Abner’s team referred back to limited historical records, and found them to corroborate these links.

Abner believes these findings, alongside future advances, will allow sign language linguists the ability to study even more languages and Deaf communities.

“We view this as an important component of demonstrating the equity between signed and spoken languages, and the fact that both are rooted in the biological capacity for language that is part of what makes us human,” she tells PopSci.

“If we want to understand our humanity, then we cannot limit ourselves to spoken languages.”

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13 percent of AI chat bot users in the US just want to talk https://www.popsci.com/technology/ai-chatbot-chatgpt-survey-talk/ Wed, 31 Jan 2024 21:30:00 +0000 https://www.popsci.com/?p=601017
As AI becomes more ubiquitous and naturalistic, many industry critics have voiced concerns about a potentially increasing number of people turning to technology instead of human relationships.
As AI becomes more ubiquitous and naturalistic, many industry critics have voiced concerns about a potentially increasing number of people turning to technology instead of human relationships. Deposit Photos

A Consumer Reports survey says many adults who used programs like ChatGPT in the summer of 2023 simply wanted to 'have a conversation with someone.'

The post 13 percent of AI chat bot users in the US just want to talk appeared first on Popular Science.

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As AI becomes more ubiquitous and naturalistic, many industry critics have voiced concerns about a potentially increasing number of people turning to technology instead of human relationships.
As AI becomes more ubiquitous and naturalistic, many industry critics have voiced concerns about a potentially increasing number of people turning to technology instead of human relationships. Deposit Photos

Most people continue to use AI programs such as ChatGPT, Bing, and Google Bard for mundane tasks like internet searches and text editing. But of the roughly 103 million US adults turning to generative chatbots in recent months, an estimated 13 percent occasionally did it to simply “have a conversation with someone.” 

New national surveys from Consumer Reports explore how and why people are interacting with the increasingly influential technology.

[Related: Humans actually wrote that fake George Carlin ‘AI’ routine.]

According to the August 2023 survey results released on January 30, a vast majority of Americans (69 percent) either did not regularly utilize AI chat programs in any memorable way, or did not use them at all within the previous three months. Those that did, however, overwhelmingly opted to explore OpenAI’s ChatGPT—somewhat unsurprising, given the company’s continued industry dominance. With 19 percent of respondents, ChatGPT usage was more than triple that of Bing AI, as well as nearly five times more popular than Google Bard.

Most AI users asked their programs to conduct commonplace tasks, such as answering questions in lieu of a traditional search engine, writing content, summarizing longer texts, and offering ideas for work or school assignments. Despite generative AI’s relative purported strength at creating and editing computer code, just 10 percent of those surveyed recounted using the technology to do so—three percent less than the number of participants who used it to strike up a conversation.

The desire for idle conversation with someone else is an extremely human, natural feeling. Despite chatbots likely presenting a quick fix for some of those surveyed by Consumer Reports, however, there are already signs that it’s not necessarily the healthiest of habits.

As AI becomes more ubiquitous and naturalistic, many industry critics have voiced concerns about a potentially increasing number of people turning to technology instead of human relationships. Numerous reports in recent months highlight a growing market of AI bots explicitly marketed to an almost exclusively male audience as “virtual girlfriends.” Meanwhile, countless examples showcase men repeatedly engaging in behavior with their digital partners that would be considered abusive in the real world.

Of course, it’s important to note simply putting the “chat” in “chatbot” to the test isn’t in any way concerning on its own. This is a shiny, new technology, after all—one that is being aggressively pushed within a largely unregulated industry. Extrapolating Consumer Reports’ survey results, it’s unlikely that a large portion of the estimated 10.2 million Americans who recently had a “conversation” with a chatbot are planning on putting a (digital) ring on it. Still, that’s quite a lot of people looking to gab—roughly about as many as those visited with an AI chatbot for “no particular task, I just wanted to see what it was like.”

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Watch ‘tiny tornadoes’ spread plant pathogens https://www.popsci.com/science/watch-tiny-tornadoes-spread-plant-pathogens/ Wed, 31 Jan 2024 19:00:00 +0000 https://www.popsci.com/?p=600988
Green dots representing spores are dispersed from a leaf.
A high-speed camera shows how spores and pollen are scattered around a wheat plant leaf. Bio-inspired Fluid Lab/Cornell University

Understanding how deadly fungal spores move could help protect plants from deadly diseases.

The post Watch ‘tiny tornadoes’ spread plant pathogens appeared first on Popular Science.

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Green dots representing spores are dispersed from a leaf.
A high-speed camera shows how spores and pollen are scattered around a wheat plant leaf. Bio-inspired Fluid Lab/Cornell University

Pathogens and germs don’t just make humans and animals sick. Diseases from bacteria and fungi can wreak havoc on all kinds of plants. One particularly bad pathogenic fungus for plants is called rust. This is not the same rust you can find on metals, but it has a similar bright red, orange, yellow, and brown color that can take away from a more decorative plant’s appearance. Importantly, it can also wipe out important crops including wheat and barley

[Related: Fungi spores and knitting combine to make a durable and sustainable building material.]

Rust is airborne–just like COVID-19–and it spreads to healthy plants by way of cells called spores. Understanding how these spores move around is key to designing better ways to protect plants. Using high-speed cameras, a study published January 31 in the journal Science Advances analyzed how plant spores are dispersed. It revealed how tiny ‘tornadoes’ spread pathogens from infected plants to healthy ones.

Agriculture photo

When a raindrop hits a leaf of a wheat plant that is infected with rust, the leaf will flutter and create these tiny swirling vortices of air that spreads the spores around. Like virus particles in a sneeze of cough, they can then infect healthy plants. 

In the study, a team from Cornell University used a high-speed camera to analyze this process. It could be a step towards designing a strategy to help reduce pathogens from viruses, bacteria, and oomycete fungi from spreading from a plant’s leaves. 

The footage enabled the team to predict the trajectory of the spores and how they are carried by the swirling cyclone-like vortex created by the leaves. The team used techniques that are usually used to study geophysical flows–large-scale oceanic and atmospheric air currents like the jet stream. They downsized these airflows by a few orders of magnitude to both understand and predict the swirls in the air around a bouncing wheat leaf. 

“It’s kind of a tiny tornado in the air,” study co-author and Cornell University biophysicist Sunghwan Jung, said in a statement. “We describe the magnitudes of these kinds of swirling motion, and then when they will form and how spores move around, so everything is predictable.”

[Related: To protect the world’s pasta, scientists peered inside fettuccine’s DNA.]

The team used miniature hollow glass particles to mimic actual spores due to restrictions to working with live spores. This method helped them gauge how many spores might come off a leaf, what direction they may fly in, and how they travel away from an infected plant. 

The team hopes that the data from this study could help develop new methods for keeping spores from infecting healthy plants that go right to the source of the spore dispersal. 

“We couldn’t figure out the solution yet,” said Jung. “But if we can control these kinds of vortex structures around the leaf somehow, then we can reduce the spread of spores to new plants.”

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What can we do about ultraprocessed foods? https://www.popsci.com/health/what-can-we-do-about-ultraprocessed-foods/ Wed, 31 Jan 2024 17:30:00 +0000 https://www.popsci.com/?p=600896
Industrially processed foodstuffs that are engineered to be highly palatable are doing our health no good, researchers say.
Industrially processed foodstuffs that are engineered to be highly palatable are doing our health no good, researchers say. DepositPhotos

Researchers are figuring out the features of these foods that harm our health—and proposing ways ahead.

The post What can we do about ultraprocessed foods? appeared first on Popular Science.

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Industrially processed foodstuffs that are engineered to be highly palatable are doing our health no good, researchers say.
Industrially processed foodstuffs that are engineered to be highly palatable are doing our health no good, researchers say. DepositPhotos

This article was originally featured on Knowable Magazine.

From breakfast cereals and protein bars to flavored yogurt and frozen pizzas, ultraprocessed foods are everywhere, filling aisle upon aisle at the supermarket. Fully 58 percent of the calories consumed by adults and 67 percent of those consumed by children in the United States are made up of these highly palatable foodstuffs with their highly manipulated ingredients.

And ultraprocessed foods are not just filling our plates; they’re also taking up more and more space in global conversations about public health and nutrition. In the last decade or so, researchers have ramped up efforts to define ultraprocessed foods and to probe how their consumption correlates to health: A wave of recent studies have linked the foods to heightened risk for conditions ranging from cardiovascular disease and cancer to obesity and depression.

Still, some researchers—and perhaps unsurprisingly, industry representatives—question the strength of the evidence against ultraprocessed foods. The category is too poorly defined and the studies too circumstantial, they say. Plus, labeling such a large portion of our grocery carts as unhealthy ignores the benefits of industrial food processing in making food affordable, safe from foodborne pathogens, easy to prepare and in some cases more sustainable—such as through the development of plant-derived products designed to replace meat and milk.

“You cannot throw the baby out with the bathwater and decide that you’re going to just dump everything” that’s ultraprocessed, says Ciarán Forde, a sensory science and eating behavior researcher at Wageningen University in the Netherlands and coauthor of a 2022 look at food processing and diets in the Annual Review of Nutrition.

As the debate about ultraprocessed foods roils on, one path forward is to invest in understanding the mechanisms by which ultraprocessed foods affect health. If the foods are indeed harmful, what about them—what features?—makes them so, and why? Through feeding volunteers carefully formulated diets and watching their consumption behavior, researchers can identify the qualities that make these foods both so appealing and so unhealthful, they say. Such studies could help to pinpoint the most harmful types of ultraprocessed foods—ones that might be targeted with warning labels and other policies—and guide companies in tweaking their recipes to produce more healthful options.

“I think the biological mechanisms are really important both to strengthen the evidence, but also to find solutions,” says Filippa Juul, a nutritional epidemiologist at New York University. That said, Juul adds, she thinks there’s already enough evidence about the harms of ultraprocessed foods to recommend that people eat less of them.

Sifting the evidence on ultraprocessed foods

To study ultraprocessed foods, researchers must be able to define them, and even this is contentious. Food preparation involves processes like grinding, cooking, fermenting and pasteurizing — methods that have long been used to make foods safer and more digestible, palatable and storable. But according to the most widely used classification system, called NOVA, ultraprocessed foods are distinguished by additional industrial techniques, like hydrolysis, hydrogenation and extrusion, and with ingredients like emulsifiers, thickeners, flavors and other additives that are rarely found in home kitchens.

Lots of foods are processed to some degree — think canning and bottling or the use of preservatives and antioxidants. But ultraprocessed foods are manipulated far beyond that. Here are the attributes of ultraprocessed foods according to NOVA, a broadly used food classification system developed by researchers at the University of Sao Paulo, Brazil. Credit: Knowable Magazine
Lots of foods are processed to some degree—think canning and bottling or the use of preservatives and antioxidants. But ultraprocessed foods are manipulated far beyond that. Here are the attributes of ultraprocessed foods according to NOVA, a broadly used food classification system developed by researchers at the University of Sao Paulo, Brazil. Credit: Knowable Magazine

Most of the evidence that ultraprocessed foods are harmful comes from observational studies in which participants are asked about the foods they eat and have their health tracked over time. These studies have consistently found that people who ate more ultraprocessed foods were more likely to develop cardiovascular diseasehigh blood pressuretype 2 diabetessome types of cancerobesitydepression and inflammatory diseases of the gastrointestinal tract such as Crohn’s disease, as well as to die during the course of the studies.

Such observational studies can’t prove that ultraprocessed foods caused these health problems, in part because other factors in people’s lives could account for their greater risk of illness and death, Juul says. In the United States, for example, people who eat more ultraprocessed foods also tend to have lower incomes and education levels and to live in poorer neighborhoods; and unmeasured factors such as stress, sleep and exposure to racism and weight bias could confound the correlation between food processing and health.

However, Juul adds, the association between ultraprocessed foods and poor health is remarkably consistent in research from around the world. And though ultraprocessed foods often have poor nutritional profiles—containing more sugar, sodium and saturated fat than their minimally processed counterparts—that’s not the whole story: Studies that have adjusted for differences in nutritional quality have found an association of similar magnitude remains. “There seems to be something else about these foods; it’s not just about the nutrients,” Juul says.

Unlike observational studies, randomized controlled trials can provide direct evidence that a particular diet causes health issues, but so far, only one short-term trial of this type has been published. In the tightly controlled study, led by National Institutes of Health nutrition and metabolism scientist Kevin Hall and published in 2019, 20 participants lived at a clinical center for one month and were offered either minimally processed foods or ultraprocessed foods for two weeks, then the other for two weeks. The meals were matched for overall calories, carbohydrates, sugar, fiber, fat, protein and salt, and participants were told they could eat as much or as little as they liked.

During two weeks on the ultraprocessed diet, participants ate an average of 508 more calories per day and gained about two pounds, the study found; during two weeks on the minimally processed diet, they lost about the same amount.

Participants in a 28-day trial comparing ultraprocessed and unprocessed diets consumed more calories during the two-week ultraprocessed portion of their regimen. The ultraprocessed diet was also associated with weight gain and a faster eating rate.
Participants in a 28-day trial comparing ultraprocessed and unprocessed diets consumed more calories during the two-week ultraprocessed portion of their regimen. The ultraprocessed diet was also associated with weight gain and a faster eating rate. Credit: Knowable Magazine

That result was surprising to Hall, who had predicted that the level of processing wouldn’t matter since the two diets had similar nutrient levels. It also raised new questions: What is it about ultraprocessed foods that makes us eat more? And do all ultraprocessed foods have similar effects on us? The answer to the second question is probably not, Hall says. For example, in a 2023 study, overall intake of ultraprocessed food correlated with a greater risk of type 2 diabetes, but some food types—including cereals, whole grain breads, yogurt and dairy-based desserts like ice cream—were linked with a lower risk.

Hall says it will take a lot more research to figure out which subcategories of ultraprocessed foods are unhealthy and why; different mechanisms may underlie different maladies. A long list of mechanisms could contribute, adds Juul—such as food additives that affect the microbiome; the foods’ rapid and easy digestibility; chemicals absorbed from packaging; or the displacement of healthy foods from the diet. “It’s likely a combination of all of these things,” she says.

Why do we eat more ultraprocessed foods?

If people outside of lab settings eat about 500 extra calories per day on an ultraprocessed diet, as they did in Hall’s 2019 study, it could help to explain why obesity rates have grown in recent decades, he believes. Hall is now focused on understanding why ultraprocessed foods would drive us to do this.

One possible explanation is energy density, or the number of calories per gram of food. In Hall’s 2019 NIH trial, for example, energy density was higher for the ultraprocessed foods, primarily because they contained less water, than for the minimally processed foods. Previous research has shown that people tend to consume more calories when they eat energy-dense foods, perhaps because the foods are less physically filling to the gastrointestinal tract and allow for more calories to be consumed in a shorter amount of time, interfering with normal satiety signaling. When Hall and colleagues looked back at 2,733 meals served in two NIH trials comparing different types of diets, they found that energy density was one of the most important determinants of calorie intake within a given meal.

Hall and colleagues also saw in the study that participants ate more when they were offered foods containing greater amounts of certain pairs of nutrients — fat and sugar, fat and sodium, or carbohydrates and sodium — than are found in nature, or in whole foods. Such foods are “hyperpalatable,” explains Tera Fazzino, a behavioral psychologist at the University of Kansas who defined the term. Hyperpalatable foods have been shown in animal and human studies to excessively activate reward-sensing circuits in the brain, and it’s more difficult to stop eating them, she says.

That’s different from the way we enjoy other foods, Fazzino adds. An apple, for example, contains naturally occurring sugars that make it pleasant to eat, but it’s not hyperpalatable because it doesn’t also contain lots of fat. In a similar manner, many of the foods that Fazzino enjoys when she visits family in Italy, such as fish lightly seasoned with olive oil and salt, and biscotti made with butter and a touch of sugar, leave her feeling perfectly satisfied, she says.

In contrast, it can feel like an act of resistance to stop eating hyperpalatable foods, such as the many packaged snack foods formulated with tasty combinations of carbohydrate, fat and salt, Fazzino says. And that’s a worry, because Fazzino’s research indicates that the prevalence of hyperpalatable foods in the US increased from 49 percent in 1988 to 69 percent in 2018.

At the NIH, Hall is currently running another clinical trial to try to tease apart the contributions of energy density and hyperpalatability to how much food people eat. In this study, participants will try four different diets, all matched for nutrient levels, for one week each. One is minimally processed. The other three are ultraprocessed, and either dense in calories or hyperpalatable, or both.

Researchers want to know what qualities make some ultraprocessed foods so alluring, or “hyperpalatable.” One observed pattern is that the foods are often high in pairs of nutrients — either fat and sodium, fat and sugars, or carbs and sodium. Credit: Knowable Magazine
Researchers want to know what qualities make some ultraprocessed foods so alluring, or “hyperpalatable.” One observed pattern is that the foods are often high in pairs of nutrients—either fat and sodium, fat and sugars, or carbs and sodium. Credit: Knowable Magazine

In the Netherlands, meanwhile, eating behavior researcher Forde is focused on yet another food characteristic to explain greater calorie intake of ultraprocessed foods: texture. Many ultraprocessed foods are “effectively prechewed when they arrive on your plate because they’re softly textured,” Forde says — and that makes them easier to eat more quickly.

Research by Forde and others has found that people eat meals with harder textures more slowly. And in a recent trial, participants consumed 26 percent fewer calories from hard-textured lunches than they did from softly textured ones. Calorie intake was lowest of all when people ate a meal that was both hard-textured and also minimally processed.

Forde’s group is now planning a randomized controlled trial, funded in part by food companies, that will test participants’ intake of two different ultraprocessed diets for two weeks. Forde predicts that people will eat more of the “fast diet” that is soft in texture than the “slow diet,” which has been designed to have harder textures.

Other researchers are looking at ultraprocessed foods from the perspective of addiction biology. Because we can eat these foods quickly, and they often lack much structure or fiber to slow their digestion, they deliver a quick dose of calories and a rewarding spike in the neurotransmitter dopamine to the brain, says Alexandra DiFeliceantonio, a neuroscientist who studies eating behavior at the Fralin Biomedical Research Institute at Virginia Tech Carilion.

In an ongoing study, she and colleagues are giving people calorie-matched, rapidly digested sugar (“fast calories”) or slowly digested sugars with added fiber (“slow calories”) along with previously unfamiliar flavors. DiFeliceantonio hypothesizes that people will develop a stronger preference for the flavors paired with the fast calories. And this, she adds, could help explain why we might struggle to stop eating certain ultraprocessed foods that were “literally engineered to be delicious,” she says.

Regulate? Or reformulate?

DiFeliceantonio hopes that studies like hers will help disentangle what it is about ultraprocessed foods that cause overeating, and support new regulations that lead to more healthful choices. “Then,” she says, “you have a really strong scientific foundation for making changes in the environment, and not just asking people to make changes on an individual level.” Regulations might include limiting how the foods are advertised (for example, not during television shows for children) or requiring neighborhood markets to carry fresh foods in addition to packaged ones.

Some public health experts say that regardless of the mechanisms, we know enough that we should be taking steps to reduce the consumption of ultraprocessed foods right now. “Whether they’re hyperpalatable, whether they’re energy-dense, whatever the cause is, the effect has been huge,” says Barry Popkin, an economist and nutrition epidemiologist at the University of North Carolina at Chapel Hill.

Popkin points to countries that have already imposed regulations and restrictions on certain ultraprocessed foods. Chile, for example, has added warning labels on the front of food packages and taxed sugary drinks; the country has also banned certain foods in schools and restricted their marketing to children — policies associated with a drop in sugary beverage purchases and improved nutritional quality of packaged foods. More than 50 countries, covering about 20 percent of the world’s population, now tax sugary drinks because of their effects on health, and many other countries, including Israel, Canada, Brazil and Mexico, are adding warning labels to unhealthy foods, Popkin says.

Forde worries that such policies will only make food more expensive and slow progress in developing more sustainable foods. It would be more productive, he says, to encourage food companies to leverage their processing technologies to make healthier products. (Forde sits on an advisory council of Kerry Group, a food and ingredient company.) They could use food-processing techniques to reduce the caloric density of foods or incorporate more texture so that people eat a bit slower, he says. “If processing is the problem, processing is also by far the best solution we currently have,” he adds.

Hall would also like to see food scientists work with nutrition scientists to take on this challenge. Take a chicken nugget, for example. By adding a bit of fiber and tweaking the salt and fat content, skilled food scientists might be able to make it less energy-dense and remove its hyperpalatable qualities, he says. Whether people will still want to eat such a nugget remains to be seen.

This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.

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Elon Musk alleges Neuralink completed its first human trial implant https://www.popsci.com/technology/neuralink-first-human-trial/ Tue, 30 Jan 2024 19:22:09 +0000 https://www.popsci.com/?p=600798
Smartphone showing Elon Musk X profile against Neuralink logo backdrop
Neuralink first solicited its first human trial applicants in September 2023. Jakub Porzycki/NurPhoto via Getty Images

Musk, posting on X, claimed that the volunteer is ‘recovering well,’ but did not offer evidence.

The post Elon Musk alleges Neuralink completed its first human trial implant appeared first on Popular Science.

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Smartphone showing Elon Musk X profile against Neuralink logo backdrop
Neuralink first solicited its first human trial applicants in September 2023. Jakub Porzycki/NurPhoto via Getty Images

Elon Musk recently claimed that the first human patient has received a Neuralink brain-computer interface (BCI) implant, but stopped short of offering any substantial additional information or proof. In a series of messages posted on Monday evening to X, his social media platform formerly known as Twitter, Neuralink’s majority owner alleged an anonymous volunteer underwent the company’s experimental procedure on January 28 and “is recovering well” while showing “promising neuron spike detection.” In a separate tweet, Musk also announced the first Neuralink product will be called Telepathy.

Despite the potential company milestone, no other official details have been made available in the nearly 24 hours since Musk’s announcement. At the time of writing, Neuralink’s most recent news update is still an initial solicitation on their official website for human trial volunteers published last fall.

[Related: Neuralink is searching for its first human test subjects.]

Co-founded by Musk in 2016, Neuralink is a tech startup aiming to create BCI implants for a variety of uses. However, its first devices are specifically tailored for physically impaired and paralyzed patients suffering from diseases such ALS to restore motor functions and the ability to communicate. 

Musk, in turn, has repeatedly voiced hopes of designing implants capable of connecting anyone’s brain to smartphones, computers, and the internet. The devices are intended to be completely reversible and ungradable, with Musk likening them to iPhones. In 2022, Neuralink’s “N1” was reportedly the size of a quarter, and employed a robotic surgeon machine to subcutaneously connect microscopic wiring to the brain. Musk has also suggested users could eventually summon Teslas using their Neuralink implants, and stated he plans to eventually receive the implant.

Although the FDA approved Neuralink to begin human trials in September 2023, regulators initially rejected the medical startup’s application earlier that year due to multiple safety concerns. Numerous bombshell reports have accused Musk’s company of conducting horrific “hack job” surgeries, some of which resulted in severe injuries, psychological damage, and the death of over 1,500 lab test animals. A graphic exposé from Wired, for example, described dozens of botched spinal surgeries, severe self-harm behaviors, and fatal infections as a result of sheep, monkeys, and pigs receiving experimental implants. These investigations subsequently prompted multiple ongoing federal probes regarding Neuralink’s potential animal abuse, and improper transportation of hazardous materials.

Neuralink had already fallen far behind Musk’s ambitious timeline goals before word spread of the company’s allegedly troubling strategies. In 2019, for example, the SpaceX and Tesla CEO expressed a desire to receive an FDA greenlight by the end of 2020, only to later blow past a revised 2022 deadline.

If Sunday’s surgery is confirmed outside of Musk’s X posts, Neuralink will only be the latest company to successfully demonstrate human-BCI devices. Guger Technologies unveiled the world’s first BCI in 2010, while numerous other designs have since debuted, including Synchron’s “Stentrode” neuroprosthesis and one from BrainGate allowing a paralyzed man to convert imagined handwriting into text.

“Imagine if Stephen Hawking could communicate faster than a speed typist or auctioneer. That is the goal,” Musk tweeted last night.

[Related: Neuralink’s human trials volunteers ‘should have serious concerns,’ say medical experts.]

Musk’s nebulous Monday tweets recall his reportedly impulsive social media habits, a pattern that has earned its share of regulatory fallout. Problematic tweets from Musk in 2018 eventually resulted in an SEC security fraud settlement that included relinquishing his position as Tesla chairman, alongside agreeing to separate $20 million fines levied against him and his company. He is currently appealing the decision, as well as a National Labor Relations Board’s ruling pertaining to alleged union busting threats posted by Musk to Twitter.

It’s unclear why Neuralink has not released any more information supporting Musk’s tweets. Company representatives did not respond to PopSci at the time of writing.

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What’s going on with CRISPR gene editing? https://www.popsci.com/health/what-is-crispr-now/ Fri, 26 Jan 2024 20:00:00 +0000 https://www.popsci.com/?p=600383
Just cutting DNA to bits isn’t a big deal. The special trick that CRISPR systems add is to make those cuts only in precise, targeted spots.
Just cutting DNA to bits isn’t a big deal. The special trick that CRISPR systems add is to make those cuts only in precise, targeted spots. Gregor Fischer/picture alliance via Getty Image

With the first medical therapy approved and systems like CRISPR-Cas showing up in complex cells, there’s a lot happening in the genome editing field.

The post What’s going on with CRISPR gene editing? appeared first on Popular Science.

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Just cutting DNA to bits isn’t a big deal. The special trick that CRISPR systems add is to make those cuts only in precise, targeted spots.
Just cutting DNA to bits isn’t a big deal. The special trick that CRISPR systems add is to make those cuts only in precise, targeted spots. Gregor Fischer/picture alliance via Getty Image

This article was originally featured on Knowable Magazine.

Around the turn of the century, microbiologists at Danisco USA Inc. had a problem: The bacteria they used to make yogurt and cheese were getting infected with viruses. Investigating more deeply, the scientists found that some bacteria possessed a defense system to fight off such viral invaders.

These virus-resistant bacteria carried weird, repetitive collections of DNA letters in their chromosomes—bits of DNA from their encounters with past viruses that the microbes had “saved” in their own genomes. It was a form of molecular memory akin to the way that our own immune system remembers invaders so it can make antibodies against a recurring infection.

In this case, the microbes’ immune system, dubbed CRISPR-Cas, or more casually, just CRISPR, shreds any viral genome that matches the sequences in their molecular memory banks.

The yogurt-makers weren’t looking for biotechnology’s Next Big Tool. They just wanted to preserve the products in their vats. But other scientists soon realized the potential value of CRISPR for their own designs: With some modifications, CRISPR allowed them to cut any genetic sequence they wanted to, greatly easing the challenge of genetic engineering.

CRISPR systems have taken the biotechnology world by storm, nabbing a Nobel Prize and kicking off a new era of gene therapy. In December 2023, the US Food and Drug Administration approved the first CRISPR-based gene-changing treatment: a new gene therapy for the excruciatingly painful blood disorder sickle cell anemia.

“It’s been revolutionary for research,” says Kevin Esvelt, an evolutionary engineer at the MIT Media Lab in Cambridge, Massachusetts. “It’s accelerating all of biotech.”

Traditional gene therapy was tested in the late 20th century, but toxicity and cancer were major setbacks. CRISPR systems were first discovered in bacteria and the technology has now been successfully incorporated into human gene therapy. Credit: Knowable Magazine
Traditional gene therapy was tested in the late 20th century, but toxicity and cancer were major setbacks. CRISPR systems were first discovered in bacteria and the technology has now been successfully incorporated into human gene therapy. Credit: Knowable Magazine

Ever since scientists discovered CRISPR, there’s been a nagging question: Do similar gene-altering systems also occur in animals, plants and fungi—life forms known as eukaryotes, defined by the nucleus in which they store their genetic material?

The answer, now, is a definitive yes, according to a June 2023 paper in the journal Nature, authored by molecular biologist Feng Zhang and colleagues at the Broad Institute of MIT and Harvard in Cambridge, Massachusetts. The team found CRISPR-like DNA-snippers called Fanzors in an odd menagerie of eukaryotic critters, including fungi, algae, amoebae and a clam called the northern quahog (pronounced coe-hog).

Researchers hailed the finding as a fascinating addition to the CRISPR family tree. And the discovery raises more questions: What are Fanzors up to? Can they, too, make a splash in biotechnology? And might Fanzor and CRISPR be the tip of an iceberg’s worth of DNA-slicing systems awaiting discovery?

Here’s some of what we know about microbial CRISPR systems and the Fanzors-come-lately.

What is CRISPR?

Just cutting DNA to bits isn’t a big deal. The special trick that CRISPR systems add is to make those cuts only in precise, targeted spots. This requires two elements: One is a guide to that location, a short piece of RNA that matches the target DNA sequence. The other is a protein, an enzyme to act as the “scissors.” Microbes have evolved a handful of scissor enzymes that make this cut, with names like Cas9 and Cas12.

When microbes are infected by viruses, the microbes collect small pieces of the viral genetic sequences and stow them together in a segment of their genome called CRISPR repeats. The next time that virus comes along, the microbe can use those sequences to create the guide RNAs. It can then use the enzyme scissors to snip up the genetic material of the virus and defend itself.

About half of known bacteria, as well as most of other microbes known as archaea, have CRISPR-Cas systems. Bizarrely, even some viruses have co-opted the CRISPR-Cas machinery, to fight back against microbes. So until the new study, eukaryotes were the only group totally left out of the fun.

In CRISPR-Cas gene editing, the Cas9 enzyme uses associated pieces of RNA to bind to a portion of the DNA genome. The enzyme then breaks both strands of DNA. The cell repairs this break — either imperfectly, creating a broken gene (left), or using a provided DNA template, resulting in a controlled change (right). Credit: Knowable Magazine
In CRISPR-Cas gene editing, the Cas9 enzyme uses associated pieces of RNA to bind to a portion of the DNA genome. The enzyme then breaks both strands of DNA. The cell repairs this break—either imperfectly, creating a broken gene (left), or using a provided DNA template, resulting in a controlled change (right). Credit: Knowable Magazine

What does CRISPR offer biotechnology?

Every living organism uses the same basic DNA code and proteins, so the CRISPR-Cas system can theoretically work in any organism scientists drop it into—though in reality, some tweaking is generally required.

The simplest application is to cut out undesirable DNA. Once the Cas enzyme cuts a target gene, the cell will glue the DNA back together, but imperfectly, creating a broken gene. For some applications, breaking a gene is all that’s needed, and it’s one possible approach to sickle cell gene therapy.

Sickle cell anemia occurs when the body has defective genes for the blood protein hemoglobin. But the body also has a separate hemoglobin gene used only by fetuses. Scientists want to reactivate the effective fetal hemoglobin in adult blood cells. There’s another gene, BCL11A, that keeps the fetal hemoglobin gene turned off. The new FDA-approved treatment uses CRISPR to break BCL11A, allowing the functioning fetal hemoglobin to spin back up in adult cells. The FDA also approved, in January 2024, this treatment for the blood disorder beta thalassemia.

Using a few extra molecular tricks, researchers can also use CRISPR to add a novel genetic sequence or to repair a broken gene.

Scientists are also trialing CRISPR-Cas-based therapies to treat diabetes; a form of amyloidosis; infections, including HIV; and a variety of cancers. And that’s not all. Researchers are applying CRISPR to turn pigs into possible organ donors for people, create better-quality, disease-resistant fruits, and eradicate mosquitoes that transmit malaria.

There are downsides. Breaking a strand of DNA in people is a risky business: If Cas cuts in the wrong place or the repair process goes wrong, the therapy could change the genome in a way that triggers cancer. Thus, many modern CRISPR-based approaches use modified versions of the Cas protein that don’t fully cut the DNA but edit it more subtly and safely.

How was Fanzor discovered?

Fanzor has been “hiding in plain sight,” says David J. Segal, a geneticist at UC Davis who wrote about the new age of genome engineering for the Annual Review of Genomics and Human Genetics in 2013. The Fanzor genes were first described that same year, but no one knew they encoded a Cas-like enzyme.

Weidong Bao, a researcher at the Genetic Information Research Institute in Cupertino, California, coauthored the 2013 Fanzor study. He and his colleague weren’t looking for DNA scissors; they were interested in what are commonly called “jumping genes.” These are DNA sequences that can hop out of one spot in the genome and reinsert themselves somewhere else. The most famous examples of these elements, known formally as transposons, are the jumping genes found to control kernel color in corn—work that led to a Nobel Prize for geneticist Barbara McClintock. In fact, about half of the human genome consists of transposons, but don’t worry: Most are no longer jumpers.

Bao knew that bacterial jumping genes often contain a gene of unknown function called TnpB. He went looking for similar genes and found them in the genomes of more than two dozen eukaryotes, including a fly, yeasts and molds, amoebas and several algae. The researchers named the eukaryotic version of this mysterious gene Fanzor instead of TnpB.

Researchers have found Fanzor genes in a variety of eukaryotic life forms. Clockwise from upper left: the soil-dwelling fungus Spizellomyces punctatus, the alga Guillardia theta, the northern quahog Mercenaria mercenaria and the amoeba Naegleria lovaniensis. CREDIT: M. SAITO ET AL / NATURE 2023
Researchers have found Fanzor genes in a variety of eukaryotic life forms. Clockwise from upper left: the soil-dwelling fungus Spizellomyces punctatus, the alga Guillardia theta, the northern quahog Mercenaria mercenaria and the amoeba Naegleria lovaniensis. CREDIT: M. SAITO ET AL / NATURE 2023

In a 2021 study, Zhang and his colleagues also stumbled onto Fanzor. They were building a CRISPR-Cas family tree, showing how these RNA-guided cutting systems had evolved, so they scanned genes and proteins from diverse organisms for similar components. They discovered that Fanzor is a cousin of the bacterial Cas genes, and that both gene families were descended from TnpB.

Are Fanzor genes involved in DNA-cutting like CRISPR-Cas systems are?

Zhang and colleagues reasoned that if the Fanzor genes and the Cas genes found in CRISPR systems are long-lost cousins, then Fanzor genes might also carry instructions for a protein that can cut DNA. Following that hypothesis further, the Fanzor protein might also use RNA guides to find and cut a specific DNA sequence.

So they tested it out by letting Fanzor genes loose in dishes of human kidney cells. The genes were translated to make Fanzor proteins. Then the scientists introduced guide RNAs to these Fanzor proteins and left them to stew for three days. If the Fanzor protein was a DNA-slicing enzyme, the cell would glue the DNA back together, but imperfectly, creating odd deletions or insertions at the sites matching the guide RNAs. That’s just what the team found.

Yep, Fanzor was a bona fide, RNA-guided, DNA-cutting enzyme.

The TnpB gene is the ancestor of both Cas-based and Fanzor-based DNA-cutting systems. Credit: Knowable Magazine
The TnpB gene is the ancestor of both Cas-based and Fanzor-based DNA-cutting systems. Credit: Knowable Magazine

Will Fanzor complement or supplant CRISPR-Cas in biotech?

Snipping a handful of genes in dishes is a long way from being biotechnology’s next big tool. So far, the best Zhang’s team has been able to do is to cut the target gene site 18.4 percent of the time, and they haven’t even tried to repair a faulty gene with it. That’s not nearly as good as CRISPR-Cas, which has the benefit of the years scientists have spent optimizing the system.

One potential advantage Fanzor has over CRISPR-Cas is its diminutive size. The Cas enzyme, plus a guide RNA, and potentially other needed elements, is a lot to deliver to a cell one wants to modify. Scientists often stuff those ingredients into a benign virus for delivery, but all the components won’t fit into the most commonly used viruses. The shrimpier Fanzor enzyme is a better fit. Still, scientists have already designed miniature versions of the Cas12 and Cas 13 enzymes that can fit into the viruses. So that’s a bit of a draw between the two.

And there’s a potential disadvantage to genetic engineering with Fanzor, says Esvelt. CRISPR-Cas systems usually require the guide RNA to match up with a DNA sequence that’s some 18 to 20 genetic letters, or bases, in length. Chances are, Esvelt calculates, there’s no more than one such perfect lineup in a genome. That means the Cas enzyme is unlikely to chop the genome anywhere except at the target site—good news for safe gene therapy. But Fanzor makes a match with just 15 DNA bases.

There’s a much higher chance, Esvelt says, that the smaller sequence might be repeated multiple times in a genome. Then Fanzor would cut the target site but also the other identical sites, which could spell disaster for gene therapy. Advantage: CRISPR-Cas.

The fact is, CRISPR works “just fine in most organisms,” says Sophien Kamoun, a plant pathologist at the Sainsbury Laboratory in Norwich in the United Kingdom who has reviewed the use of CRISPR to engineer crop plants. But Fanzor might still be useful for scientists working with certain bacteria where Cas enzymes are toxic, suggests Kamoun.

So overall, there’s no reason for most CRISPR-Cas labs to switch. “I’d rather use the thing that we know,” says Segal, who is working on treatments for neurodevelopmental disorders. “There’s enough mystery in what I do that I don’t need to worry about using a new enzyme.”

What do Fanzor systems do naturally?

Still, Fanzor is a very cool biological discovery. “It’s fascinating that there are CRISPR-like systems across so many kingdoms of life,” says Esvelt.

While we know what CRISPR-Cas systems do for microbes, it’s not clear exactly what Fanzor proteins do in nature. Researchers believe they’re somehow partnered with transposons—maybe helping them, or perhaps hitching a ride.

One possibility the Zhang group has considered is that Fanzor might create a defense system for the transposons. After all, a piece of DNA that can spring in and out of the genome, altering the DNA whenever it does so, is usually not good for a cell, so cells might fight back. Such a hypothetical Fanzor-based defense might work like this: A transposon would jump into spots in the genome that have the same genetic sequence that its associated Fanzor likes to cut. By jumping into that site, the transposon destroys the Fanzor target site, protecting the cell’s genome from being cut.

But if the cell were to remove the transposon, it would recreate the Fanzor target site, making its genome once again vulnerable to Fanzor’s snipping action.

In essence, Zhang speculates, the transposon would be telling the cell, “If you get rid of me, I’ll go somewhere else, I’ll make the Fanzor enzyme and it will come back and chop up the site you kicked me out of.” Better, then, to just leave the transposon where it is.

That’s just a possibility, though.

One organism that doesn’t naturally have Fanzors, Zhang says, is humans. But it remains possible that people possess some other, similar DNA-cutting system in the Fanzor-Cas family. Zhang’s group is actively hunting for new ones. “We’re trying to discover as many as possible,” he says.

This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.

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